isomethyleugenol has been researched along with Leucocythaemia in 130 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (28.46) | 18.7374 |
| 1990's | 20 (15.38) | 18.2507 |
| 2000's | 26 (20.00) | 29.6817 |
| 2010's | 37 (28.46) | 24.3611 |
| 2020's | 10 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Arimondo, PB; Barbachowska, M; Bon, C; Cadet Daniel, V; Djikić, T; Djokovic, N; Halby, L; Jallet, C; Levi-Acobas, E; Nikolic, K; Pernak, M; Ruzic, D; Si, Y | 1 |
| Li, N; Liu, H; Lv, S; Ma, X; Song, T; Sun, L; Tang, B; Yan, Y; Zhao, X; Zou, Q | 1 |
| Geil, CN; Lee, TH; Li, D; McGinty, RK; Smith, CB; Spangler, CJ; Wang, GG; Yadav, SP | 1 |
| Abdel-Wahab, O; Fujino, T | 1 |
| Cosgrove, MS; Namitz, KEW; Tan, S | 1 |
| Asou, N; Benoukraf, T; Matsumura, T; Matsuoka, M; Muddineni, SSNA; Nakamura-Ishizu, A; Okuda, T; Osato, M; Sian, S; Suda, T; Tan, DQ; Tirado-Magallanes, R; Tokunaga, K; Wang, CQ | 1 |
| Ahn, JH; Allison, DF; Cai, L; Chen, WY; Diao, Y; Fan, H; Geng, H; Gong, W; Guo, Y; He, S; Li, D; Lu, J; Pi, WC; Song, J; Strahl, BD; Tsai, YH; Wang, GG; Xiang, Y; Zhang, ZM | 1 |
| Cully, M | 1 |
| Richter, WF; Ruthenburg, AJ; Shah, RN | 1 |
| Berthelet, J; Bui, LC; Chomienne, C; Dulphy, N; Dupret, JM; Guidez, F; Le Coadou, L; Michail, C; Rodrigues-Lima, F; Sirri, V; Wang, L | 1 |
| Bartenhagen, C; Bäumer, N; Berdel, WE; Cui, C; Dugas, M; Farouq, D; Garcia-Cuellar, MP; Gerloff, D; Göllner, S; Hébert, J; Hüttelmaier, S; Klein, HU; Köhn, M; Liu, Y; Maciejewski, JP; Misiak, D; Müller-Tidow, C; Oellerich, T; Pabst, C; Pauli, C; Przychodzen, B; Regev, A; Rohde, C; Sauvageau, G; Schwartz, S; Seliger, B; Serve, H; Slany, R; Taketo, MM; Zhou, F | 1 |
| Ding, H; Duan, W; Jiang, H; Luo, C; Mao, R; Shao, J; Shi, Z; Sun, D; Zhang, C; Zhang, Y; Zhu, K | 1 |
| Brickner, JH; Sump, B | 1 |
| Aichinger, M; Bennett, KL; César-Razquin, A; Ebner, J; Eder, T; Grebien, F; Győrffy, B; Jude, J; Lu, B; Muhar, M; Müller, AC; Roth, M; Schmöllerl, J; Skucha, A; Stukalov, A; Superti-Furga, G; Vakoc, CR; Valent, P; Vittori, S; Zuber, J | 1 |
| Das, P; Ge, K; Ishii, M; Kaushik, S; Kikuta, J; Lin, K; Lu, Y; Nussenzweig, A; Santos, MA; Van, HT; Veazey, KJ | 1 |
| Alp, E; Konac, E; Menevse, S; Yilmaz, A | 1 |
| Bauer, R; Bernaskova, M; Huefner, A; Kretschmer, N; Schuehly, W; Weis, R | 1 |
| Hu, C; Jin, J; Li, K; Mei, C; Ren, Z; Tong, H; Vera, JC; Zhuang, Z | 1 |
| Abdallah, I; Buttolph, T; Carlson, S; Fandy, TE; Glass, KC; Hassan, HE | 1 |
| Armstrong, SA; Chen, CW | 1 |
| Cleary, ML; Duque-Afonso, J; Goode, DL; Iwasaki, M; Kuo, HP; Schneidawind, D; Wei, MC; Weng, Z; Wong, SH; Zhu, L | 1 |
| Guo, H; Guo, Q; Hou, S; Li, J; Liu, T; Wang, H | 1 |
| Kong, G; Lee, JY | 1 |
| Abdel-Wahab, O; Adusumilli, PS; Armstrong, SA; Béguelin, W; Blum, G; Campbell, JE; Chramiec, A; Chung, YR; de Stanchina, E; Doud, EH; Durham, B; Hricik, T; Keilhack, H; Kelleher, NL; Keller, MD; Khodos, I; Knutson, SK; Koche, R; Konstantinoff, K; Krivtsov, AV; LaFave, LM; Levine, RL; Luo, M; Melnick, A; Micol, JB; Ouerfelli, O; Papalexi, E; Shi, X; Spitzer, B; Teater, M; Thomas, PM | 1 |
| van Leeuwen, F; Vlaming, H | 1 |
| Chen, F; Dong, S; Feng, Z; Liu, W; Mo, Q; Redell, M; Song, Y; Wei, L; Wu, F; Yao, Y; Zhou, C | 1 |
| Buechele, C; Cleary, ML; Duque-Afonso, J; Gozani, O; Hansen, L; Huang, M; Ikenouye, L; Klein, BJ; Kutateladze, TG; Li, Q; Majeti, R; Martin, GM; Onishi, M; Schneidawind, D; Shen, J; Wong, SH; Zhu, F; Zhu, L | 1 |
| Chang, LS; Chen, YJ; Liu, WH | 1 |
| Balbach, ST; Orkin, SH | 1 |
| Ernst, P; Yang, W | 1 |
| Cattaneo, F; Nucifora, G | 1 |
| Pal, S; Sif, S; Wang, L | 1 |
| Suzuki, R | 1 |
| Armstrong, SA; Neff, T | 1 |
| Bo, J; Dou, LP; Jing, Y; Li, HH; Sun, JF; Wang, QS; Wang, SH; Yu, L; Zhao, Y | 1 |
| Bohlander, SK; Buske, C; Chen, Y; Deshpande, AJ; Kakadia, PM; Li, YQ; Lin, YH; Xu, GL; Zhang, KL; Zhang, Y | 1 |
| Fu, WL; Yao, J; Zhang, XB; Zhang, XL | 1 |
| Cosgrove, MS; Dharmarajan, V; Patel, A; Vought, VE | 1 |
| Blessington, P; Ernst, P; Feather, D; Hua, X; Koretzky, GA; Liu, Z; Thiel, AT; Wu, X; Yan, J; Zhang, H; Zou, T | 1 |
| Cosgrove, MS; Patel, A | 1 |
| Slany, RK | 1 |
| Brown, EJ; Cheng, EH; Hsieh, JJ; Kumar, R; Liu, H; Pandita, TK; Takeda, S; Westergard, TD | 1 |
| Arrey, TN; Baltruschat, S; Benedikt, A; Bursen, A; Dingermann, T; Karas, M; Marschalek, R; Meyer, B; Müller, AM; Scholz, B; Varagnolo, L | 1 |
| Huang, YQ; Ma, XD; Xiao, LY; Zou, Y | 1 |
| Dong, J; He, F; Ji, H; Kaberlein, JJ; Luo, RT; Mattison, R; Mi, S; Prabhakar, S; Thirman, MJ; Wang, QF; Wu, G; Wu, J | 1 |
| Armstrong, SA; Bernt, KM | 1 |
| Ma, XD; Zhao, T | 1 |
| Armstrong, SA; Khattab, MH; Kluk, MJ; Neff, T; Orkin, SH; Sinha, AU; Stein, L; Xie, H; Zhu, N | 1 |
| Idaghdour, Y; Marquez, VE; Momparler, LF; Momparler, RL | 1 |
| Altucci, L; Castellano, S; Costi, R; Dell'Aversana, C; Di Maro, S; Di Santo, R; Lepore, I; Mai, A; Novellino, E; Sbardella, G; Tardugno, M; Tomassi, S; Valente, S | 1 |
| Han, HD; Huang, YQ; Ma, XD; Zou, Y | 1 |
| Hahn, Y; Kim, JY; Seo, SB; Son, HJ | 1 |
| Lehner, B; Schuster-Böckler, B | 1 |
| Luciani, L; Nimer, SD; Vu, LP | 1 |
| Cui, ZC; Ma, KL; Tang, NM; Zhang, XB | 1 |
| Diana, F; Giancotti, V; Manfioletti, G; Rustighi, A; Sgarra, R | 1 |
| Bayar, E; Cortes, J; Faderl, S; Garcia-Manero, G; Giles, FJ; Issa, JP; Kantarjian, HM; Lyons, J; Mannari, R; Rosenfeld, CS; Thomas, D | 1 |
| Oka, T; Ouchida, M | 1 |
| Chim, CS; Kwong, YL; Wong, AS | 1 |
| Futscher, BW; Holtan, N; Isett, RB; List, AF; Merchant, NC; Miller, SJ; Munoz-Rodriguez, JL; Narro, ML; Nouzova, M; Oshiro, MM | 1 |
| Broome, JD; Ding, Y; Li, Z | 1 |
| Shilatifard, A; Tenney, K | 1 |
| Coffield, VM; Feng, Q; Jiang, Q; Li, Y; Lin, Y; Okada, Y; Su, L; Xu, G; Zhang, Y | 1 |
| Dan, K; Inokuchi, K; Nakayama, K | 1 |
| Brown, EJ; Chen, YX; Hess, JL; Hua, X; Keeshan, K; Pear, WS; Silva, A; Tubbs, AT; Wang, H; Yan, J | 1 |
| Angelucci, E; Attarbaschi, A; Biondi, A; Brady, HJ; Burmeister, T; Delabesse, E; den Boer, ML; Dingermann, T; Eckert, C; Ennas, MG; Greil, J; Griesinger, F; Haas, OA; Jakob, S; Jansen, MW; Kempski, H; Klingebiel, T; Koehl, U; Macintyre, E; Marschalek, R; Meyer, C; Niggli, FK; Nigro, LL; Pieters, R; Schäfer, BW; Schneider, B; Schnittger, S; Schoch, C; Schrappe, M; Stanulla, M; Strehl, S; Szczepański, T; Trka, J; van Dongen, JJ; Zuna, J; Zur Stadt, U | 1 |
| Aozasa, K; Hasegawa, JI; Ikeda, JI; Kim, YK; Kimura, H; Miyoshi, Y; Morii, E; Nishida, T; Noguchi, S; Takakuwa, T; Tomita, Y | 1 |
| Chen, CY; Chen, YC; Chou, WC; Huang, SY; Ko, BS; Shen, MC; Tang, JL; Tien, HF; Tsay, W; Wang, CH; Wu, SJ; Yao, M; Yeh, YC | 1 |
| Bitoun, E; Davies, KE; Oliver, PL | 1 |
| Armstrong, SA; Krivtsov, AV | 1 |
| Baek, HJ; Choe, NW; Eom, GH; Kee, HJ; Kim, JY; Kim, SM; Kook, H; Seo, SB | 1 |
| Clarke, MF; Mann, DL; Murray, C; Reitz, MS | 1 |
| Morita, Y; Siraganian, RP | 1 |
| Bouchard, J; Momparler, RL; Onetto, N; Rivard, GE | 1 |
| Amelotti, F; Barbieri, R; Bernardi, F; del Senno, L; Gambari, R | 1 |
| Amelotti, F; Barbieri, R; Bernardi, F; Conconi, F; del Senno, L; Gambari, R; Piva, R; Viola, L | 1 |
| Clarke, MF; Eiden, M; Mann, DL; Reitz, MS; Trainor, CD | 1 |
| Clarke, MF; Gallo, RC; Mann, DL; Reitz, MS; Trainor, CD | 1 |
| Cline, MJ; deKernion, JB; Slamon, DJ; Verma, IM | 1 |
| Agris, PF; Goldman, L; Horton, E; Playl, T; Rodi, C; Setzer, D; Woolverton, D | 1 |
| Dudley, PA; Kloog, Y; Markey, SP; Rivnay, B; Zatz, M | 1 |
| Kornacka, L; Malec, J; Sawecka, J | 1 |
| Avramis, VI; Kees, UR | 1 |
| de Kant, E; Huhn, D; Neubauer, A; Ritter, M | 1 |
| Lee, ST; Litz, CE; McGlennen, RC | 1 |
| Holmes, EH; Hu, J; Macher, BA; Stults, CL | 1 |
| Drexler, HG; Gignac, SM; Hu, ZB; Kreutz, M; Ludwig, WD; Ma, W; Rainey, FA; Uphoff, CC | 1 |
| Borisch, B; Fey, MF; Liechti-Gallati, S; Nagel, S; Oestreicher, M; Schneider, V; Theilkäs, L; Tobler, A; von Rohr, A; Ziemiecki, A | 1 |
| D'Adamo, F; Diverio, D; Lo Coco, F; Pelicci, PG; Saglio, G | 1 |
| Baylin, SB; Herman, JG; Jen, J; Merlo, A | 1 |
| Baylin, SB; Civin, CI; Collector, MI; Davidson, NE; Issa, JP; Kaufmann, SH; Sharkis, SJ; Zehnbauer, BA | 1 |
| Baens, M; Corveleyn, A; Hagemeijer, A; Hoornaert, I; Marynen, P; Wlodarska, I | 1 |
| Eriksson, S; Jacobsson, U; Johansson, NG; Kazimierczuk, Z; Kierdaszuk, B; Krawiec, K; Munch-Petersen, B; Shugar, D | 1 |
| Huang, DP; Lee, JC; Ng, MH; Wong, IH | 1 |
| Chen, C; Chen, W; Nallusamy, S; Novetsky, AD; Wang, JC | 1 |
| Heller-Schöch, G; Schöch, G | 1 |
| Levine, L; Stolbach, L; Waalkes, TP | 1 |
| Smirnova, IA | 1 |
| Koeffler, HP; Lübbert, M; Miller, CW | 1 |
| Huang, AT; Liu, YH; Panella, TJ; Teng, CT | 1 |
| Momparler, LF; Momparler, RL; Onetto-Pothier, N | 1 |
| Baruchel, A; Sigaux, F | 1 |
| Hanish, J; McClelland, M; Rebelsky, M; Westbrook, C | 1 |
| Boyd, Y; Hodges, E; Howell, WM; Smith, JL | 1 |
| Doerfler, W; Kochanek, S; Radbruch, A; Renz, D; Tesch, H | 1 |
| Achten, S; Behn-Krappa, A; Diehl, V; Doerfler, W; Hölker, I; Jücker, M; Schmitz, B; Sprengel, J; Tesch, H | 1 |
| Gyger, M; Momparler, RL; Rivard, GE | 1 |
| Chen, E; Ginder, GD; Karr, RW | 1 |
| Avramis, VI; Mecum, RA; Powell, WC | 2 |
| Hoshino, H; Kitamura, T; Miwa, M; Shimotohno, K; Shimoyama, M; Sugimura, T; Takaku, F; Takano, M | 1 |
| Browett, PJ; Norton, JD | 1 |
| Browett, PJ; Hoffbrand, AV; Norton, JD | 1 |
| Boggs, BA; Chinault, AC; McCredie, KB; Spitzer, G; Stass, SA; Yoffe, G | 1 |
| Ikawa, Y; Izawa, H; Ogawa, Y; Onuma, M; Sagata, N; Tsuzuku-Kawamura, J | 1 |
| Alhonen-Hongisto, L; Alitalo, K; Jänne, J; Jänne, OA; Laine, R; Leinonen, P; Sinervirta, R; Winqvist, R | 1 |
| Bianchi, MS; Bianchi, NO; de la Chapelle, A; Knuutila, S; Peltomäki, P | 1 |
| Boehm, TL; Drahovsky, D; Pfeifer, GP; Steigerwald, S | 1 |
| Baylin, SB; Burke, PJ; de Bustros, A; Fearon, ER; Nelkin, BD; Sharkis, SJ; Staal, SP; Vogelstein, B | 1 |
| Bubenshchikova, SN; Burtseva, NN; Gimadutdinov, OA; Vaniushin, BF | 1 |
| Valencia, R | 1 |
| Malec, J | 1 |
| Kornacka, L; Malec, J; Wojnarowska, M | 1 |
| Fedorov, NA | 1 |
| Datta, B; Datta, RK | 1 |
| Andreoli, A; Mauri, C; Torelli, GM; Torelli, UL | 1 |
| Gallo, RC | 2 |
| Broom, AD; Rizkalla, BH; Robins, RK | 1 |
| Bodey, GP; Brodovsky, HS; Freireich, EJ; Isassi, AA; Samuels, ML | 1 |
16 review(s) available for isomethyleugenol and Leucocythaemia
| Article | Year |
|---|---|
Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis.
Topics: Histones; Homeodomain Proteins; Leukemia; Methylation; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion; Translocation, Genetic | 2017 |
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Drug Delivery Systems; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein | 2015 |
The upstreams and downstreams of H3K79 methylation by DOT1L.
Topics: Animals; Cell Cycle; Enzyme Activation; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Methyltransferases; Protein Processing, Post-Translational; Ubiquitination | 2016 |
SET/MLL family proteins in hematopoiesis and leukemia.
Topics: Animals; DNA-Binding Proteins; Hematopoiesis; Histone Chaperones; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Myeloid-Lymphoid Leukemia Protein; Protein Interaction Maps; Transcription Factors | 2017 |
[Future perspectives of research and clinical studies for NK-cell malignancy in Asia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asia; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Aberrations; DNA-Binding Proteins; Drug Design; Herpesvirus 4, Human; Humans; Killer Cells, Natural; Leukemia; Lymphoma; Methylation; Nuclear Proteins; Point Mutation; Proto-Oncogene Proteins c-kit; Tumor Protein p73; Tumor Suppressor Proteins | 2008 |
Chromatin maps, histone modifications and leukemia.
Topics: Acetylation; Chromatin; Histones; Humans; Leukemia; Methylation; Ubiquitination | 2009 |
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Forecasting; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Ligands; Lysine; Methylation; Models, Biological; Models, Molecular; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship | 2010 |
[Epigenetic regulation of histone H3 lysine 9 methylation in leukemia].
Topics: Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia; Lysine; Methylation | 2012 |
Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.
Topics: Animals; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans; Leukemia; Methylation; Phosphorylation; Protein Interaction Domains and Motifs; Protein Methyltransferases | 2013 |
[Recent progress in the protein-tyrosine phosphatase SHP1 gene: the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias].
Topics: Gene Expression Regulation, Enzymologic; Gene Silencing; Hematopoietic Stem Cells; Humans; Leukemia; Loss of Heterozygosity; Lymphoma; Methylation; Promoter Regions, Genetic; Protein Tyrosine Phosphatases | 2003 |
A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin.
Topics: Adult; Animals; Child; Chromatin; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogenes; Transcription Factors; Transcription, Genetic | 2005 |
MLL translocations, histone modifications and leukaemia stem-cell development.
Topics: Adult; Animals; Cell Division; Cell Transformation, Neoplastic; Child; Chromatin; Epigenesis, Genetic; Gene Expression Regulation; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant; Leukemia; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Prognosis; Protein Methyltransferases; Protein Processing, Post-Translational | 2007 |
[Control of cellular division by vitamin B 12 and folates].
Topics: Anemia, Macrocytic; Anemia, Pernicious; Animals; Cell Division; Euglena gracilis; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Methylation; Nucleic Acids; Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
[Molecular aspects of leukemogenesis].
Topics: Cell Differentiation; Cell Transformation, Neoplastic; DNA; DNA Nucleotidyltransferases; DNA, Neoplasm; Genetic Code; Humans; Leukemia; Methylation; Retroviridae; Simian virus 40 | 1972 |
[Methylation of nucleic acids under normal conditions and in leukemia. Literature survey and personal data].
Topics: Animals; Cricetinae; DNA; DNA Nucleotidyltransferases; DNA-Directed RNA Polymerases; DNA, Neoplasm; Humans; Leukemia; Lymphocytes; Methylation; Mice; Neoplasms, Experimental; Nucleic Acid Conformation; Rats; RNA; RNA, Neoplasm; RNA, Ribosomal | 1973 |
Role of the methylated nucleic acids in carcinogenesis.
Topics: Animals; DNA, Neoplasm; Humans; Leukemia; Leukemia, Experimental; Methylation; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acids; RNA, Neoplasm; Species Specificity; Transferases | 1969 |
3 trial(s) available for isomethyleugenol and Leucocythaemia
| Article | Year |
|---|---|
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.
Topics: Animals; Chromatin; Chromosomal Instability; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Methyltransferases; Mice; Oncogene Proteins, Fusion; Transcription Factors; Tumor Cells, Cultured | 2009 |
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Cell Cycle Proteins; Cell Differentiation; Child; Child, Preschool; Cohort Studies; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Female; Gene Silencing; Hematologic Neoplasms; Humans; Karyotyping; Leukemia; Male; Methylation; Middle Aged; Myeloproliferative Disorders; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2004 |
Clinical trial on 5-aza-2'-deoxycytidine in patients with acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Azacitidine; Cell Cycle; Cell Differentiation; Child; Clinical Trials as Topic; Decitabine; DNA, Neoplasm; Drug Evaluation; Humans; Leukemia; Methylation; Research Design | 1985 |
111 other study(ies) available for isomethyleugenol and Leucocythaemia
| Article | Year |
|---|---|
Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein.
Topics: Cytostatic Agents; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Molecular Structure | 2021 |
DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation.
Topics: Acylation; Cell Line; Cell Proliferation; Glucose; Hexosamines; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Mutagenesis, Site-Directed; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid-Lymphoid Leukemia Protein; N-Acetylglucosaminyltransferases; Protein Stability; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases; Ubiquitination | 2021 |
DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding.
Topics: Cell Line, Tumor; Cell Proliferation; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Male; Methylation; Models, Molecular; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Protein Binding; Ubiquitin; Ubiquitination | 2022 |
New readers and writers of RNA modifications unique to leukemia stem cells.
Topics: Humans; Leukemia; Methylation; Methyltransferases; RNA; RNA-Binding Proteins; Stem Cells | 2023 |
Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration.
Topics: Animals; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Methylation; Myeloid-Lymphoid Leukemia Protein; Protein Multimerization; Protein Structure, Quaternary; Temperature | 2023 |
Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia.
Topics: Animals; Apoptosis; Cell Survival; Core Binding Factor Alpha 2 Subunit; Family; Female; Genetic Predisposition to Disease; Genotype; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation, Missense; Myelodysplastic Syndromes; Pedigree; Protein Processing, Post-Translational | 2020 |
BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.
Topics: Animals; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Chromatin Immunoprecipitation; Gene Expression Regulation; Gene Silencing; HEK293 Cells; HeLa Cells; Histone Code; Histones; Humans; Jurkat Cells; Leukemia; Methylation; Mice; Mice, Transgenic; Neoplasm Transplantation; Protein Processing, Post-Translational; Proteins; Transplantation, Heterologous | 2020 |
METTLing with RNA methylation in leukaemia.
Topics: Humans; Leukemia; Methylation; RNA | 2021 |
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia.
Topics: Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid-Lymphoid Leukemia Protein; STAT5 Transcription Factor; Tumor Suppressor Proteins | 2021 |
The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3).
Topics: Benzene; Benzoquinones; Cell Line; Cysteine; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Primary Cell Culture; Zinc Fingers | 2021 |
AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.
Topics: Animals; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Co-Repressor Proteins; Core Binding Factor Alpha 2 Subunit; DEAD-box RNA Helicases; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; HEK293 Cells; HL-60 Cells; Humans; K562 Cells; Leukemia; Methylation; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Phenotype; Protein Interaction Maps; Proto-Oncogene Proteins c-myc; Repressor Proteins; Ribonucleoproteins; RNA, Ribosomal; RNA, Small Nucleolar; RUNX1 Translocation Partner 1 Protein; Signal Transduction; Time Factors; Transcription Factors; U937 Cells | 2017 |
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.
Topics: Acetanilides; Antineoplastic Agents; Benzimidazoles; Cell Line; Cell Line, Tumor; Cell Proliferation; Databases, Chemical; Drug Screening Assays, Antitumor; Humans; Kinetics; Leukemia; Lymphoma; Methylation; Models, Molecular; Molecular Docking Simulation; Protein Binding; Protein-Arginine N-Methyltransferases; snRNP Core Proteins; Structure-Activity Relationship | 2017 |
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Topics: Amino Acid Motifs; Cell Differentiation; Cell Line, Tumor; DNA Damage; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methylation; Methyltransferases; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Oncogene Proteins, Fusion; Protein Binding | 2018 |
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Topics: Animals; Bone and Bones; Bone Marrow; Bone Marrow Cells; Carrier Proteins; Cell Differentiation; DNA-Binding Proteins; Epigenesis, Genetic; Hematopoiesis; Hematopoietic Stem Cells; Histones; Leukemia; Methylation; Mice; Nuclear Proteins; Osteoclasts; Osteogenesis; PPAR gamma; Stem Cell Niche | 2018 |
The DNA methyl transferase inhibitor, 5'-aza-2-deoxycitidine, enhances the apoptotic effect of Mevastatin in human leukemia HL-60 cells.
Topics: Apoptosis; Azacitidine; Caspases; Decitabine; DNA Modification Methylases; DNA Replication; Drug Synergism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; L-Lactate Dehydrogenase; Leukemia; Lovastatin; Methylation; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Glioblastoma; HCT116 Cells; Humans; Inhibitory Concentration 50; Leukemia; Lignans; Methylation; Microwaves | 2014 |
Sequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Nucleus; Cell Proliferation; Decitabine; Down-Regulation; Drug Synergism; Humans; Idarubicin; In Situ Nick-End Labeling; Leukemia; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Wnt Proteins | 2014 |
Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biotransformation; Cell Line, Tumor; Curcumin; DNA Methylation; Dose-Response Relationship, Drug; Drug Stability; Epigenesis, Genetic; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Leukemic; Histones; Humans; Leukemia; Methylation; Microsomes, Liver; Promoter Regions, Genetic; Time Factors | 2015 |
The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin Receptor Common gamma Subunit; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous | 2015 |
Quantitative analysis of histone H3 and H4 post-translational modifications in doxorubicin-resistant leukemia cells.
Topics: Acetylation; Antibiotics, Antineoplastic; Cell Line, Tumor; Chromatography, Liquid; Doxorubicin; Drug Resistance, Neoplasm; Histones; Humans; Leukemia; Mass Spectrometry; Methylation; Protein Processing, Post-Translational | 2016 |
DOT1L: a new therapeutic target for aggressive breast cancer.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Epithelial-Mesenchymal Transition; Female; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Methyltransferases; Mice; Neoplastic Stem Cells; Transcriptional Activation | 2015 |
Loss of BAP1 function leads to EZH2-dependent transformation.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; HEK293 Cells; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoprecipitation; Leukemia; Mesothelioma; Methylation; Mice; Polycomb Repressive Complex 2; Real-Time Polymerase Chain Reaction; Repressor Proteins; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2015 |
Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Child; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; MCF-7 Cells; Methylation; Methyltransferases; Mice, Inbred NOD; Mice, SCID; Molecular Structure; Monoamine Oxidase Inhibitors; Myeloid-Lymphoid Leukemia Protein; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Xenograft Model Antitumor Assays | 2016 |
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; F-Box Proteins; Female; Gene Expression Regulation, Leukemic; Heterografts; High-Throughput Nucleotide Sequencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2016 |
Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells.
Topics: ADAM17 Protein; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Transcription Factors; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Leukemia; Methylation; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sp1 Transcription Factor; src-Family Kinases; U937 Cells | 2017 |
An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation.
Topics: DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Transcription Factors; Translocation, Genetic | 2016 |
EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression.
Topics: Animals; Binding Sites; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; MDS1 and EVI1 Complex Locus Protein; Methylation; Methyltransferases; Mice; Protein Binding; Protein Methyltransferases; Proto-Oncogenes; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2008 |
Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Methylation; MicroRNAs; Protein Binding; Protein Biosynthesis; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic | 2008 |
[Investigation on MS-PCR as a method for detecting minimal residual disease in acute leukemia].
Topics: HL-60 Cells; Humans; Inhibitor of Differentiation Proteins; Leukemia; Methylation; Neoplasm, Residual; Polymerase Chain Reaction | 2009 |
Methylation status of oestrogen receptor alpha-A: a predictor of prognosis in leukaemias.
Topics: Adult; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Female; Humans; Leukemia; Male; Methylation; Prognosis | 2010 |
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Topics: DNA-Binding Proteins; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Lysine; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Retinol-Binding Proteins, Cellular; Transcription Factors | 2009 |
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
Topics: Alleles; Animals; Gene Expression Regulation, Leukemic; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Proto-Oncogene Proteins; Translocation, Genetic | 2010 |
When speed matters: leukemogenic transformation by MLL fusion proteins.
Topics: Animals; Cell Transformation, Neoplastic; Drosophila melanogaster; Histones; Humans; Leukemia; Methylation; Models, Biological; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Signal Transduction | 2010 |
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
Topics: Alleles; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromatin; DNA Damage; DNA Replication; Genes, Dominant; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Mice; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; S Phase; S-Phase Kinase-Associated Proteins; Signal Transduction; Translocation, Genetic | 2010 |
The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
Topics: Chromatography, Gel; DNA-Binding Proteins; Enzyme Activation; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Oncogene Proteins, Fusion; Phosphorylation; Positive Transcriptional Elongation Factor B; Transcriptional Elongation Factors | 2011 |
[Study on aberration in histone methylation and acetylation in acute leukemia].
Topics: Acetylation; DNA Methylation; Histones; Humans; Leukemia; Methylation; Protein Processing, Post-Translational | 2010 |
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
Topics: Animals; Cell Line, Tumor; Gene Expression Regulation, Leukemic; Genetic Loci; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Oncogene Proteins, Fusion; Protein Binding; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Up-Regulation | 2011 |
A role for DOT1L in MLL-rearranged leukemias.
Topics: Chromatin Immunoprecipitation; Epigenesis, Genetic; Gene Rearrangement; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Methyltransferases; Myeloid-Lymphoid Leukemia Protein; Transcription Factors | 2011 |
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
Topics: Animals; Cell Proliferation; Chromatin Immunoprecipitation; Cytoprotection; Disease Progression; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Silencing; Genes, Neoplasm; Genetic Loci; Genome; Histone-Lysine N-Methyltransferase; Histones; Leukemia; Methylation; Mice; Mice, Inbred C57BL; Oncogene Proteins, Fusion; Phenotype; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Precancerous Conditions; Proto-Oncogene Proteins c-myc; Repressor Proteins | 2012 |
Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; DNA Methylation; Drug Synergism; Gene Expression Regulation, Leukemic; Histone Deacetylase Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; HL-60 Cells; Humans; Leukemia; Methylation; Mice; Tumor Cells, Cultured | 2012 |
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.
Topics: Cell Cycle; Cell Death; Cell Differentiation; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Granulocytes; Histocompatibility Antigens; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Polycomb Repressive Complex 2; Substrate Specificity | 2012 |
[The effects of JARID1B siRNA on proliferation and apoptosis in HL-60 cell].
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Gene Expression Regulation, Leukemic; Gene Targeting; Histones; HL-60 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Leukemia; Methylation; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering | 2012 |
Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia.
Topics: Adaptor Proteins, Signal Transducing; Cell Differentiation; Chromobox Protein Homolog 5; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; HL-60 Cells; Humans; Janus Kinase 2; K562 Cells; Leukemia; LIM Domain Proteins; Methylation; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Transcription, Genetic; Tretinoin; YY1 Transcription Factor | 2012 |
Chromatin organization is a major influence on regional mutation rates in human cancer cells.
Topics: Animals; CpG Islands; Epigenesis, Genetic; Euchromatin; Genome, Human; Heterochromatin; Histones; Humans; Leukemia; Lung Neoplasms; Male; Melanoma; Methylation; Mutagenesis; Mutation Rate; Neoplasms; Pan troglodytes; Polymorphism, Single Nucleotide; Principal Component Analysis; Prostatic Neoplasms; Small Cell Lung Carcinoma | 2012 |
Effects of ganglioside GM3 on phospholipid turnover of human leukemic J6-2 cells.
Topics: Autoradiography; Cytidine Diphosphate Choline; G(M3) Ganglioside; Humans; Leukemia; Methylation; Phospholipids; Tumor Cells, Cultured | 2002 |
Increase of HMGA1a protein methylation is a distinctive characteristic of leukaemic cells induced to undergo apoptosis.
Topics: Apoptosis; Chromatin; Chromatography, High Pressure Liquid; HMGA1a Protein; Humans; Leukemia; Methylation; Phosphorylation; Protein Structure, Tertiary; Serine; Time Factors; U937 Cells | 2003 |
Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Carrier Proteins; Case-Control Studies; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; Leukemia; Male; Methylation; Middle Aged; Prognosis; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Repressor Proteins; Signal Transduction; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators | 2004 |
Epigenomic changes during leukemia cell differentiation: analysis of histone acetylation and cytosine methylation using CpG island microarrays.
Topics: Acetylation; Cell Differentiation; Chromatin; CpG Islands; Cytosine; Databases, Genetic; DNA; Gene Library; Histones; Humans; Immunoprecipitation; In Situ Hybridization; Keratolytic Agents; Leukemia; Methylation; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Sulfites; Tretinoin | 2004 |
Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines.
Topics: Acetylation; Animals; Asparagine; Aspartate-Ammonia Ligase; Cell Division; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Coculture Techniques; Enzyme Induction; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Leukemia; Macrophages; Methylation; Mice; Promoter Regions, Genetic | 2005 |
hDOT1L links histone methylation to leukemogenesis.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Proto-Oncogenes; Recombinant Fusion Proteins; RNA, Small Interfering; Saccharomyces cerevisiae; Stem Cells; Transcription Factors; Up-Regulation | 2005 |
Hypermethylation of the putative tumor-suppressor genes DCC, p51/63 and O6-methylguanine-DNA methyltransferase (MGMT) and loss of their expressions in cell lines of hematological malignancies.
Topics: Cell Line, Tumor; DNA Methylation; DNA-Binding Proteins; Gene Expression; Genes, DCC; Genes, Tumor Suppressor; Humans; Leukemia; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Phosphoproteins; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins | 2005 |
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Topics: Animals; Blotting, Western; Cell Line, Transformed; Cell Proliferation; Chromatin Immunoprecipitation; DNA; DNA Methylation; DNA-Binding Proteins; Exons; Flow Cytometry; Gene Expression Regulation; Genotype; Hematopoiesis; Histones; Homeodomain Proteins; Homozygote; Leukemia; Lysine; Methylation; Mice; Mice, Knockout; Mice, Transgenic; Models, Genetic; Models, Statistical; Myeloid Cells; Proto-Oncogene Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Time Factors; Transgenes | 2006 |
The MLL recombinome of acute leukemias.
Topics: Acute Disease; Adult; Child; Chromosome Aberrations; Chromosome Mapping; DNA; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Methylation; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Translocation, Genetic | 2006 |
Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells.
Topics: Adenocarcinoma; Antigens, CD; Antigens, Neoplasm; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; CpG Islands; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Ki-67 Antigen; Leukemia; Lymphoma; Methylation; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2006 |
Clinical implications of SOCS1 methylation in myelodysplastic syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chromosome Aberrations; Disease Progression; Female; Genes, ras; Humans; Karyotyping; Leukemia; Male; Methylation; Middle Aged; Mutation; Myelodysplastic Syndromes; Polymerase Chain Reaction; Prognosis; Risk Factors; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2006 |
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
Topics: Animals; Cell Line; Chromatin Assembly and Disassembly; DNA Polymerase II; Down-Regulation; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methylation; Methyltransferases; Mice; Models, Biological; Multiprotein Complexes; Nuclear Proteins; Phosphorylation; Phosphotransferases; Positive Transcriptional Elongation Factor B; Proteasome Endopeptidase Complex; RNA Polymerase II; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2007 |
Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
Topics: Acetylation; Acute Disease; Adult; Amino Acid Sequence; Cell Line, Tumor; Female; Gene Expression Regulation, Leukemic; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Male; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Structure, Tertiary; Repressor Proteins; RNA, Small Interfering; Sequence Alignment; Sequence Homology, Amino Acid | 2008 |
Differential methylation of class I histocompatibility antigen genes in T-cell lines derived from two different types of T-cell malignancies.
Topics: Acute Disease; Cell Line; Deltaretrovirus; DNA, Neoplasm; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leukemia; Lymphoma; Methylation; RNA, Messenger; T-Lymphocytes | 1984 |
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
5-aza-2'-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation.
Topics: Azacitidine; Cell Line; Decitabine; DNA, Neoplasm; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methylation | 1984 |
Epsilon-globin gene is undermethylated in K-562 cells: increased expression after treatment of the cells with 5-azacytidine.
Topics: Azacitidine; Cell Line; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; DNA, Recombinant; Gene Expression Regulation; Globins; Humans; Leukemia; Methylation; Nucleic Acid Hybridization; RNA, Messenger | 1984 |
Human leukemic K562 cells: differential effects of 5-azacytidine on DNA methylation of epsilon-, gamma-globin and 7SL RNA genes.
Topics: Azacitidine; Base Sequence; Cell Line; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Electrophoresis, Cellulose Acetate; Globins; Humans; Leukemia; Methylation; RNA | 1984 |
DNA methylation and expression of HLA-DR alpha.
Topics: Adult; Antigens, Surface; B-Lymphocytes; Cell Line; Cell Transformation, Viral; DNA, Neoplasm; Genes, MHC Class II; Herpesvirus 4, Human; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Leukemia; Lymphoma; Methylation; Nucleic Acid Hybridization; T-Lymphocytes | 1984 |
Methylation of human T-cell leukemia virus proviral DNA and viral RNA expression in short- and long-term cultures of infected cells.
Topics: Cells, Cultured; Deltaretrovirus; DNA, Viral; Humans; Kinetics; Leukemia; Methylation; Molecular Weight; Nucleic Acid Hybridization; RNA, Viral; T-Lymphocytes | 1984 |
Expression of cellular oncogenes in human malignancies.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Female; Gastrointestinal Neoplasms; Gene Amplification; Genes, Viral; Genital Neoplasms, Female; Humans; Kidney Neoplasms; Leukemia; Lymphoma; Methylation; Mutation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; RNA, Messenger; RNA, Neoplasm; Sarcoma; Transcription, Genetic; Translocation, Genetic | 1984 |
Processing of tRNA is accomplished by a high-molecular-weight enzyme complex.
Topics: Amino Acyl-tRNA Synthetases; Animals; Cell Line; Humans; Kinetics; Leukemia; Leukemia, Experimental; Methylation; Mice; Molecular Weight; Multienzyme Complexes; Nucleosides; RNA Processing, Post-Transcriptional; RNA, Transfer; Transcription, Genetic; tRNA Methyltransferases | 1983 |
Nonpolar lipid methylation-identification of nonpolar methylated products synthesized by rat basophilic leukemia cells, retina and parotid.
Topics: Animals; Basophils; Cell Line; Leukemia; Lipid Metabolism; Methionine; Methylation; Methyltransferases; Parotid Gland; Rats; Retina; Ubiquinone | 1982 |
Intragenomic distribution of 5-methylcytosine in various forms of human and murine leukemic cells.
Topics: 5-Methylcytosine; Animals; Chromatin; Cytosine; Deoxyribonucleases; DNA, Neoplasm; Humans; Leukemia; Leukemia L5178; Leukocytes; Lymphocytes; Magnesium; Methylation; Mice; Phytohemagglutinins; Transcription, Genetic | 1980 |
Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; DNA; Humans; Leukemia; Methylation; Tumor Cells, Cultured | 1995 |
Detection of DNA methylation in the calcitonin gene in human leukemias using differential polymerase chain reaction.
Topics: Base Sequence; Calcitonin; DNA, Neoplasm; Gene Amplification; Humans; Leukemia; Methylation; Molecular Sequence Data; Polymerase Chain Reaction; Reference Values; Tumor Cells, Cultured | 1995 |
Clonal determination by the fragile X (FMR1) and phosphoglycerate kinase (PGK) genes in hematological malignancies.
Topics: Base Sequence; Female; Fragile X Mental Retardation Protein; Humans; Leukemia; Methylation; Molecular Sequence Data; Nerve Tissue Proteins; Phosphoglycerate Kinase; Polymerase Chain Reaction; RNA-Binding Proteins; X Chromosome | 1994 |
Structural characterization of intermediates in the biosynthetic pathway of neolacto glycosphingolipids: differential expression in human leukaemia cells.
Topics: Carbohydrate Sequence; Cell Differentiation; Galactosyltransferases; Glycosphingolipids; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Methylation; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1994 |
Characterization of the monocyte-specific esterase (MSE) gene.
Topics: Base Sequence; Blotting, Northern; Blotting, Southern; Carboxylic Ester Hydrolases; DNA, Neoplasm; Electrophoresis, Gel, Pulsed-Field; Gene Expression; Gene Expression Regulation, Leukemic; Gene Rearrangement; Humans; Isoelectric Focusing; Leukemia; Lymphoma; Methylation; Molecular Sequence Data; Monocytes; Point Mutation; Polymerase Chain Reaction; RNA, Messenger | 1994 |
Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aging; Base Sequence; Blotting, Southern; Child; Child, Preschool; Chronic Disease; Cloning, Molecular; DNA Primers; DNA Probes; Female; Hematopoiesis; Humans; Leukemia; Leukocytes; Lymphoma, Non-Hodgkin; Methylation; Middle Aged; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Genetic; Reference Values; Restriction Mapping; X Chromosome | 1994 |
Polyclonal hemopoiesis in leukemia patients following molecularly documented remission.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Female; Gene Rearrangement; Hematopoiesis; Humans; Leukemia; Methylation; Middle Aged; X Chromosome | 1994 |
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
Topics: Adult; Breast Neoplasms; Carrier Proteins; Cell Cycle Proteins; Cell Line; Child; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 9; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Dinucleoside Phosphates; DNA; DNA, Neoplasm; Female; Genes, Tumor Suppressor; Glioma; Homozygote; Humans; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphocytes; Male; Methylation; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Reference Values; Restriction Mapping; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1996 |
The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.
Topics: Adult; Animals; Biomarkers, Tumor; Child; Child, Preschool; Chromosomes, Human, Pair 6; CpG Islands; Humans; Infant; Infant, Newborn; Leukemia; Lymphoma; Methylation; Mice; Rats; Receptors, Estrogen; Tumor Cells, Cultured | 1996 |
A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p).
Topics: Cell Cycle Proteins; Chromosome Banding; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 12; CpG Islands; Cyclin-Dependent Kinase Inhibitor p27; DNA-Binding Proteins; DNA, Complementary; ETS Translocation Variant 6 Protein; Exons; Expressed Sequence Tags; Female; Humans; In Situ Hybridization, Fluorescence; Introns; Leukemia; Low Density Lipoprotein Receptor-Related Protein-6; Male; Methylation; Microsatellite Repeats; Microtubule-Associated Proteins; Physical Chromosome Mapping; Polymorphism, Genetic; Proto-Oncogene Proteins c-ets; Receptors, LDL; Repressor Proteins; Transcription Factors; Tumor Suppressor Proteins | 1999 |
Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues.
Topics: Antimetabolites, Antineoplastic; Deoxycytidine Kinase; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Methylation; Neoplasm Proteins; Nucleosides; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase | 1999 |
Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blotting, Southern; Cell Cycle Proteins; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Humans; Karyotyping; Leukemia; Leukemia, Myelomonocytic, Acute; Methylation; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Time Factors; Transcription Factors; Tumor Suppressor Proteins | 2000 |
Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation.
Topics: Blotting, Southern; Cell Cycle Proteins; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Genes, p16; Genes, Tumor Suppressor; Humans; Leukemia; Methylation; Polymerase Chain Reaction; Precancerous Conditions; Primary Myelofibrosis; Tumor Suppressor Proteins | 2002 |
[Molecular biology and clinical significance of the metabolism of normal and modified nucleobases (author's transl)].
Topics: Animals; Base Sequence; Cells, Cultured; Chemical Phenomena; Chemistry; DNA; Humans; Kidney Neoplasms; Leukemia; Leukemia, Experimental; Liver; Liver Regeneration; Methylation; Mice; Neoplasms, Experimental; Nucleosides; Rats; RNA; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; tRNA Methyltransferases | 1977 |
Serum levels of N2, N2-dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy.
Topics: Antibody Specificity; Breast Neoplasms; Guanosine; Humans; Leukemia; Methylation; Neoplasms; Pseudouridine; Radioimmunoassay; Uridine | 1975 |
Structural alterations of the ribosomal RNA genes in leukemic cells.
Topics: Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA, Ribosomal; Female; Gene Amplification; Gene Rearrangement; Hematopoietic System; Leukemia; Leukemia, Erythroblastic, Acute; Male; Methylation; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Rats; Rats, Wistar; Rauscher Virus; RNA, Neoplasm; RNA, Ribosomal; Tumor Virus Infections | 1992 |
Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation.
Topics: Base Sequence; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Line; Chromatin; Cloning, Molecular; DNA; DNA, Neoplasm; Genes; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Lymphoma; Methylation; Peroxidase; Restriction Mapping | 1991 |
Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer.
Topics: Amino Acid Sequence; Breast Neoplasms; Gene Library; Genes; Humans; Lactoferrin; Leukemia; Leukocytes; Methylation; Molecular Sequence Data; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length | 1991 |
Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype.
Topics: Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; DNA; Humans; Leukemia; Methylation; Phenotype; Tumor Cells, Cultured | 1990 |
Hypermethylation of the calcitonin gene and leukemia.
Topics: Acute Disease; Calcitonin; Genetic Markers; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methylation; Transformation, Genetic | 1991 |
Application of methylase-limited partial NotI cleavage for a long-range restriction map of the human ABL locus.
Topics: Base Sequence; Binding, Competitive; Chromosomes, Human, Pair 9; Deoxyribonucleases, Type II Site-Specific; DNA-Cytosine Methylases; DNA, Neoplasm; Electrophoresis, Agar Gel; Genes, abl; Genetic Markers; Humans; Leukemia; Methylation; Philadelphia Chromosome; Restriction Mapping; Substrate Specificity; Tumor Cells, Cultured | 1991 |
Variable X-chromosome DNA methylation patterns detected with probe M27 beta in a series of lymphoid and myeloid malignancies.
Topics: Antigens, Neoplasm; DNA Probes; DNA, Neoplasm; Dosage Compensation, Genetic; Female; Humans; Leukemia; Lymphoma, Non-Hodgkin; Methylation; Neoplastic Stem Cells; X Chromosome | 1991 |
DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias.
Topics: Adult; Aged; Cell Separation; DNA; DNA, Neoplasm; Female; Gene Expression Regulation; Genes; Humans; Leukemia; Leukocytes; Lymphoma; Lymphotoxin-alpha; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Restriction Mapping; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1991 |
Patterns of DNA methylation in selected human genes in different Hodgkin's lymphoma and leukemia cell lines and in normal human lymphocytes.
Topics: Base Sequence; DNA; Genes, myc; Genes, ras; Genome, Human; Hodgkin Disease; Humans; Leukemia; Lymphocytes; Lymphotoxin-alpha; Methylation; Proto-Oncogenes; Tumor Cells, Cultured | 1991 |
Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.
Topics: Azacitidine; DNA, Neoplasm; Drug Synergism; Gene Expression Regulation; HLA Antigens; Humans; Interferon-gamma; Kinetics; Leukemia; Methylation; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1987 |
Cellular metabolism of 5,6-dihydro-5-azacytidine and its incorporation into DNA and RNA of human lymphoid cells CEM/O and CEM/dCk(-).
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line; DNA, Neoplasm; Humans; Leukemia; Lymphocytes; Methylation; Mutation; RNA, Neoplasm; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |
Cellular metabolism of 1-beta-D-arabinofuranosyl-5-azacytosine and incorporation into DNA and RNA of human lymphoid CEM/0 and CEM/dCk(-) cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methylation; RNA, Neoplasm; Stereoisomerism; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |
Methylation pattern of human T-cell leukemia virus in vivo and in vitro: pX and LTR regions are hypomethylated in vivo.
Topics: Adult; Aged; Antigens, Viral; Cell Line; Chromosome Mapping; Deltaretrovirus; Deoxyribonuclease HpaII; DNA Restriction Enzymes; DNA, Viral; Female; Genes; Genes, Viral; Humans; Leukemia; Male; Methylation; Middle Aged; Retroviridae Infections; T-Lymphocytes | 1985 |
Analysis of ras gene mutations and methylation state in human leukemias.
Topics: Blotting, Southern; DNA Probes; DNA, Neoplasm; Gene Amplification; Genes, ras; Humans; Leukemia; Methylation; Mutation; Myeloproliferative Disorders; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Restriction Mapping | 1989 |
Use of the X-chromosome linked hypoxanthine phosphoribosyl transferase gene as a marker of cell monoclonality in hemopoietic malignancies.
Topics: Clone Cells; DNA Restriction Enzymes; Female; Genes; Genetic Linkage; Genetic Markers; Hypoxanthine Phosphoribosyltransferase; Leukemia; Methylation; Polymorphism, Genetic; X Chromosome | 1988 |
Determination of clonality in acute nonlymphocytic leukemia by restriction fragment length polymorphism and methylation analysis.
Topics: Acute Disease; Adult; Child, Preschool; Clone Cells; DNA, Neoplasm; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methylation; Middle Aged; Polymorphism, Restriction Fragment Length | 1987 |
Methylation pattern of the bovine leukemia provirus genome in bovine leukemic cells.
Topics: Animals; Cattle; Cattle Diseases; DNA, Neoplasm; Genes, Viral; Leukemia; Leukemia Virus, Bovine; Methylation; Retroviridae | 1985 |
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.
Topics: Animals; Cells, Cultured; DNA; DNA Restriction Enzymes; Electrophoresis, Agar Gel; Gene Amplification; Humans; Leukemia; Methylation; Mice; Multiple Myeloma; Ornithine Decarboxylase; Polymorphism, Genetic; Species Specificity | 1987 |
The pattern of methylation in rearranged and germ-line human immunoglobulin constant mu genes.
Topics: B-Lymphocytes; DNA; DNA Restriction Enzymes; Fibroblasts; Gene Expression Regulation; Genetic Variation; Granulocytes; Humans; Immunoglobulin Constant Regions; Immunoglobulin mu-Chains; Immunoglobulins; Leukemia; Methylation; Nucleic Acid Hybridization; T-Lymphocytes | 1987 |
DNA methylation levels in acute human leukemia.
Topics: 5-Methylcytosine; Acute Disease; Cytosine; DNA, Neoplasm; Humans; Leukemia; Methylation | 1988 |
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies.
Topics: Acute Disease; Calcitonin; Cell Differentiation; Cell Transformation, Neoplastic; Genes, Regulator; Humans; Leukemia; Lymphoma; Methylation | 1987 |
[Determination of DNA methylase activity in animal tissue extracts].
Topics: Adsorption; Animals; Cattle; Cattle Diseases; DNA; DNA (Cytosine-5-)-Methyltransferases; Female; Hydrolysis; In Vitro Techniques; Leukemia; Lymphocytes; Male; Methods; Methylation; Methyltransferases; S-Adenosylmethionine; Spleen; Tissue Extracts; Tritium | 1985 |
Methylation of DNA in human normal and leukaemic white cells.
Topics: Chromatography, Paper; DNA; DNA, Neoplasm; Humans; Hydrolysis; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Methylation | 1974 |
Partial failure of methylation and cleavage of 45S RNA in the blast cells of acute leukaemia.
Topics: Acute Disease; Centrifugation, Density Gradient; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocytes; Methionine; Methylation; RNA; Tritium; Uridine | 1970 |
Transfer RNA and transfer RNA methylation in growing and "resting" adult and embryonic tissues and in various oncogenic systems.
Topics: Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cell-Free System; DNA; DNA, Neoplasm; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Lymphocytes; Methylation; Methyltransferases; Mice; Mitosis; Oncogenic Viruses; RNA, Transfer; Transferases | 1971 |
Transfer RNA's in human leukemia.
Topics: Amino Acid Sequence; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromatography; Humans; Leucine; Leukemia; Lymphocyte Activation; Lymphocytes; Methylation; RNA, Neoplasm; RNA, Transfer; Time Factors; Tyrosine | 1969 |
Purine nucleosides. XXVII. The synthesis of 1- and 7-methyl-8-oxoguanosine and related nucleosides. The use of the N-amino group as a selective blocking agent in nucleoside synthesis.
Topics: Chemical Phenomena; Chemistry, Physical; Deuterium; Dimethyl Sulfoxide; Fluoroacetates; Humans; Hydrogen-Ion Concentration; Leukemia; Magnetic Resonance Spectroscopy; Methods; Methylation; Nucleosides; Purines; Spectrophotometry; Temperature; Ultraviolet Rays | 1969 |
Studies of combination 6-mercaptopurine (NSC-755) and 6-methylmercaptopurine riboside (NSC-40774) in patients with acute leukemia and metastatic cancer.
Topics: Acute Disease; Adult; Aged; Female; Humans; Leukemia; Male; Mercaptopurine; Methylation; Middle Aged; Neoplasm Metastasis; Ribose | 1968 |