isomethyleugenol has been researched along with Cell Transformation, Neoplastic in 344 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 112 (32.56) | 18.7374 |
1990's | 46 (13.37) | 18.2507 |
2000's | 49 (14.24) | 29.6817 |
2010's | 106 (30.81) | 24.3611 |
2020's | 31 (9.01) | 2.80 |
Authors | Studies |
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Hu, W; Jiang, J; Li, J; Liu, G; Liu, K; Liu, Q; Lou, Y; Yang, L; Yang, M; Zhang, Y; Zhao, P; Zhao, Z | 1 |
Chen, Y; Qi, Y; Wang, B; Wang, D; Wang, Q; Xiong, F | 1 |
Fan, X; Pan, H; Wang, H; Yang, F; Zhang, H; Zhang, X | 1 |
Chen, W; He, Z; Hong, Z; Ji, K; Li, S; Liu, M; Peng, X; Song, M; Xu, Y; Yang, C; Yu, J; Zhang, Q; Zhou, J; Zhu, Q; Zuo, Q | 1 |
Feng, Y; He, A; Jia, Y; Jin, H; Kong, G; Li, Z; Liu, R; Shen, Y; Shi, L; Yang, D; Yang, Y; Yu, X; Zhang, L; Zhang, P; Zhang, X | 1 |
Aziz, N; Cho, JY; Hur, H; Kang, JS; Kim, E; Kim, HG; Kim, JH; Kim, KH; Lee, J; Manavalan, B; Parameswaran, N; Rahmawati, L; Yoo, BC | 1 |
Hong, D; Hu, F; Huang, C; Huang, H; Jin, H; Jin, R; Li, H; Liu, D; Ren, G; Sun, W; Wu, S; Zhang, X; Zhao, L | 1 |
Gu, R; Janknecht, R; Kim, TD; Oh, S; Shin, S; Song, H; Sui, Y | 1 |
Deng, X; He, YH; Hu, GS; Huang, HH; Huang, Y; Li, MY; Li, WJ; Lin, YA; Liu, W; Xie, BL; Yang, JJ; Zhang, BD; Zou, YQ | 1 |
Chen, K; Chen, Z; Huang, C; Xiang, W; Zeng, J; Zhang, Y | 1 |
Devi, NS; Kaluz, S; Olson, JJ; Van Meir, EG; Yu, B; Zhang, H; Zhang, Z; Zhu, D | 1 |
Chen, J; Cui, J; Fallon, MB; Gao, Y; Guha, S; Quan, M; Xie, D; Xie, K | 1 |
Chen, J; Chen, S; Fan, S; Fang, X; Fang, Y; Liu, G; Ma, J; Shen, P; Shen, S; Wang, S; Wu, H; Wu, Y; Xie, Z; Yang, Y | 1 |
Chai, P; Fan, X; Ge, S; Jia, R; Sun, B; Wang, S; Xu, Y; Yang, Y; Yang, YG | 1 |
Bai, R; Chen, Z; Gao, X; Han, B; Liu, K; Sheng, J; Wei, S; Xiang, J; Xu, Z; Yan, S | 1 |
Abe, S; Kadonosono, T; Matsumura, M; Nakamura, H; Sato, S; Ueda, H; Ueno, T | 1 |
Chen, Q; Ji, C; Lin, K; Miao, L; Xu, A; Yang, J; Yang, L; Yu, Y; Zhang, X | 1 |
Chen, C; Geng, W; Guo, H; Wang, Q; Wang, S; Wang, Z; Xu, K | 1 |
Feng, W; Gao, J; Hou, Y; Huang, W; Liu, W; Qiu, R; Su, D; Teng, X; Wang, Y; Yang, Y; Yi, X; Yu, H; Zhang, K; Zhang, T | 1 |
Chen, D; Chen, J; Cheng, M; Gao, F; He, Q; Huang, Z; Li, Q; Liang, J; Liu, L; Peng, L; Ren, H; Wang, A; Wu, Y; Zhao, L | 1 |
Demers, I; Henfling, MER; Hoogduin, KJ; Hopman, ANH; Looijenga, LHJ; Moshi, JM; Ramaekers, FCS; Stoop, H; Ummelen, M; van Engeland, M; Wouters, KAD | 1 |
Du, W; Duan, R; Guo, W | 1 |
Guo, Y; He, X; Stha, A; Sun, Y; Wang, M; Wu, X; Xu, C; Zhang, W | 1 |
Dong, W; Li, Q; Liu, P; Ma, Z; Zuo, Y | 1 |
Chen, Y; Cheng, T; Cheng, X; Chu, Y; Guan, J; Guo, H; Li, M; Shi, D; Shi, J; Wang, B; Wang, X; Xue, C; Yuan, W | 1 |
He, Z; Li, Z; Zhang, C; Zhou, S; Zhu, Y | 1 |
Huang, ZM; Ji, ZG; Wang, H | 1 |
Dere, R; Young, NL | 1 |
Chai, P; Gu, X; He, F; Jia, R; Shi, H; Wang, S; Xu, X; Yang, J; Yu, J; Zhuang, A | 1 |
Liu, F; Su, X | 1 |
Chen, E; Li, M; Liu, J; Wu, J; Xu, E; Yang, Q; Zhang, C; Zhou, J | 1 |
He, Y; Hu, Y; Liu, W; Su, Y; Xiao, B | 1 |
Barbosa, K; Bohlander, SK; Cox, KL; Deshpande, A; Deshpande, AJ; Khanal, S; Klein, BJ; Kutateladze, TG; Poirier, MG; Shi, X; Sinha, A; Tong, Q; Wen, H; Xuan, F; Zandian, M; Zhang, P; Zhang, Y | 1 |
Arai, T; Chijimatsu, R; Doki, Y; Eguchi, H; Hirotsu, T; Ishii, H; Kitagawa, T; Ofusa, K; Takeda, Y; Vecchione, A; Yabumoto, M | 1 |
Bai, J; Chen, H; He, A; Wang, X | 1 |
Dixit, D; Rich, JN; Xie, Q; Zhao, JC | 1 |
Kong, M; Lowman, XH; Tran, TQ | 1 |
Dohmae, N; Hamamoto, R; Matsuo, Y; Nakamura, Y; Suzuki, T; Tsurita, G; Watanabe, T; Yoshioka, Y | 1 |
Bartenhagen, C; Bäumer, N; Berdel, WE; Cui, C; Dugas, M; Farouq, D; Garcia-Cuellar, MP; Gerloff, D; Göllner, S; Hébert, J; Hüttelmaier, S; Klein, HU; Köhn, M; Liu, Y; Maciejewski, JP; Misiak, D; Müller-Tidow, C; Oellerich, T; Pabst, C; Pauli, C; Przychodzen, B; Regev, A; Rohde, C; Sauvageau, G; Schwartz, S; Seliger, B; Serve, H; Slany, R; Taketo, MM; Zhou, F | 1 |
Adams, DJ; Basheer, F; Bashford-Rogers, R; Burrows, N; Chan, WI; Clipson, A; Du, MQ; Erdem, A; Fitzgibbon, J; Foerster, S; Gallipoli, P; Giotopoulos, G; Hodson, D; Horton, SJ; Huntly, BJP; Laurenti, E; Maxwell, P; Okosun, J; Osaki, H; Petrunkina Harrison, A; Rashid, M; Sasca, D; Sheppard, O; Smith, KG; Sustic, T; Sybirna, A; Vohra, S; Wright, P; Yiangou, L; Yun, H; Zhao, W | 1 |
Anandi, L; Ashiq, KA; Bodakuntla, S; Chakravarty, V; Lahiri, M | 1 |
Allahverdi, A; Chung, HH; Cukuroglu, E; Geifman-Shochat, S; Göke, J; Lin, VCL; Madhusudhan, MS; Nordenskiöld, L; Su, IH; Tan, KP; Venkatesan, N; Wong, JF; Yau, YH | 1 |
Liu, Y; Tu, W; Xie, C; Zhou, X | 1 |
Kaneko, S; Li, X | 1 |
Chen, J; Chen, L; Fang, H; Fang, L; Ge, X; Han, D; Jiao, C; Jin, J; Jin, X; Li, C; Li, Y; Liao, G; Liao, L; Liu, M; Liu, Z; Peng, X; Qin, HL; Teng, H; Wang, P; Wang, X; Wang, Y; Wei, Q; Weng, L; Yang, Y; Zhang, S; Zhao, B; Zhou, D; Zhou, J | 1 |
He, C; Li, Z; Liu, H; Luan, S; Luo, J | 1 |
Banerjee, HN; Kahan, W; Kumar, V; Verma, M | 1 |
Armstrong, SA; Cai, S; Dou, Y; Dressler, GR; Ge, K; Hess, JL; Jang, Y; Koche, R; Levine, RL; Mao, F; Miao, H; Phuc Khoa, LT; Sun, Y; Witkin, M; Xu, J; Zhou, B; Zou, Z | 1 |
Kidder, BL; Xhabija, B | 1 |
Furuya, K; Ikura, M; Ikura, T | 1 |
Bassik, MC; Caporicci, M; Carlson, SM; Elias, JE; Francis, JW; Fuentes, ME; Gozani, O; Hausmann, S; Hulea, L; Kim, MP; Li, A; Liu, S; Lofgren, SM; Lu, J; Maitra, A; Mazur, PK; Nguyen, ND; Pillai, R; Porco, JA; Song, J; Tandoc, K; Topisirovic, I; Van Rechem, C; Wang, H; Wistuba, II | 1 |
Allis, CD; Bagert, JD; Feng, L; Gao, J; Kundra, R; Lemiesz, AE; Muir, TW; Nacev, BA; Schultz, N; Soshnev, AA | 1 |
Chen, J; Lin, N; Lu, Y; Xu, M; Xu, R; Yao, Z; Yuan, L; Zhou, S; Zou, X | 1 |
Beck, DB; Dooley, SJ; Fondevila, D; Kane-Goldsmith, N; Krüger, M; Marazuela-Duque, A; Martínez-Redondo, P; Muñoz, P; Rabanal, RM; Serrano, L; Tischfield, JA; Tong, Q; Vaquero, A; Vazquez, BN; Voigt, P | 1 |
Biller, SA; Brennan, CW; Campos, C; Chan, TA; Chen, Y; Clark, O; Graeber, TG; Grommes, C; Kernytsky, A; Komisopoulou, E; Kunii, K; Liu, W; Mellinghoff, IK; Miller, A; Oldrini, B; Palaskas, N; Pedraza, A; Popovici-Muller, J; Rohle, D; Rosenblum, MK; Schalm, S; Silverman, L; Su, SM; Tsoi, J; Turcan, S; Wang, F; Yang, H; Yen, KE | 1 |
Cho, EJ; Choi, A; Han, JW; Jang, H; Jo, CH; Kim, ST; Kim, YN; Lee, HY; Lee, J; Lim, J; Park, J; Song, TY; Song, Y; Yang, JH; Yang, YJ; Youn, HD | 1 |
Davie, JR; Guppy, BJ; McManus, KJ; Sawchuk, L; Thompson, LL | 1 |
Behrens, A; Chakraborty, A; Davies, CC; Diefenbacher, ME; Skehel, M | 1 |
Abdel-Wahab, O; Béguelin, W; Bunting, KL; Cerchietti, L; Chung, YR; Creasy, CL; Elemento, O; Ezponda, T; Gascoyne, RD; Jiang, Y; Kelleher, N; Kruger, RG; Levine, RL; Licht, JD; Liu, Y; Martinez-Garcia, E; McCabe, MT; McHugh, CF; Melnick, AM; Ott, HM; Popovic, R; Rosen, M; Scott, DW; Shaknovich, R; Shen, H; Teater, M; Van Aller, GS; Verma, SK; Wang, L; Wong, KK; Yang, SN; Zhang, H; Zheng, Y | 1 |
Chang, N; Joo, KM; Kim, E; Kim, H; Kim, M; Lee, C; Lee, J; Nakano, I; Nam, DH; Oh, YT; Rheey, J; Rich, JN; Shin, J; Shin, Y; Woo, DH | 1 |
Singh, KP; Treas, J; Tyagi, T | 1 |
Barnett, GH; Barnholtz-Sloan, JS; Capella, D; Chen, Y; Chiocca, EA; Cohen, ML; Devine, K; Elder, JB; Guan, X; Kerstetter, A; McPherson, C; Ostrom, QT; Selman, W; Sloan, AE; Vengoechea, J; Warnick, RE; Wolinsky, Y | 1 |
Albaret, MA; Belin, S; Bourdon, JC; Bouvet, P; Catez, F; Cong, R; Diaz, JJ; Ghayad, SE; Hacot, S; Jordan, L; Marcel, V; Mertani, HC; Morel, AP; Prats, AC; Puisieux, A; Saurin, JC; Solano-Gonzàlez, E; Tafer, Y; Therizols, G; Thompson, A; Vendrell, JA | 1 |
Kojima, C; Tokar, EJ; Waalkes, MP | 1 |
Hendzel, MJ; Young, LC | 1 |
Chen, D; Hu, L; Lin, G; Liu, L; Lu, G; Ouyang, Q; Sun, Y; Xie, P; Yuan, D; Zeng, S | 1 |
Bryll, A; Dyson, NJ; Manning, AL; Nicolay, B; Yazinski, SA; Zou, L | 1 |
Käser-Pébernard, S; Müller, F; Wicky, C | 1 |
Aparicio, SA; Berg, T; Bilenky, M; Chang, H; Cheng, SW; Gascoyne, RD; Hirst, M; Humphries, RK; Lai, CK; Lai, D; Lee, S; Lim, E; Marra, MA; Morin, GB; Morin, RD; Mungall, AJ; Oellerich, T; Rosten, P; Salmi, A; Schoeler, N; Serve, H; Thoene, S; Umlandt, P; Wee, T; Yap, D; Yue, L | 1 |
Barbash, O; Butte, AJ; Dhanak, D; Garcia, BA; Gozani, O; Huddleston, M; Jansen, PW; Khatri, P; Kruger, RG; Liu, S; Mazur, PK; Reynoird, N; Sage, J; Tummino, PJ; Van Aller, GS; Vermeulen, M; Wilkinson, AW | 1 |
Hamamoto, R; Nakakido, M; Nakamura, Y; Toyokawa, G; Ueda, K | 1 |
Li, J; Li, Y; Meng, X; Ouyang, Q; Wang, J; Xing, L; Xue, L; Yan, X; Zhang, X | 1 |
Kuang, D; Liu, J; Liu, T; Wu, Y; You, L; Zheng, Y | 1 |
Chen, JM; Chiu, SC; Chou, HY; Hsia, JY; Huang, HM; Huang, JY; Juan, CC; Lee, YC; Su, LJ; Wei, TY; Yu, CT | 1 |
Bearss, J; Gajiwala, S; Janat-Amsbury, M; Sharma, S; Sorna, V; Theisen, ER | 1 |
Liu, Q; Liu, Y; Lu, X; Luo, F; Qin, Y; Shi, L; Wang, B; Xiang, Q; Xu, W; Xu, Y | 1 |
Chitnis, N; Diehl, JA; Kita, Y; Klein-Szanto, AJ; Li, Y; Li, Z; Nakagawa, H; Natsugoe, S; Rustgi, AK; Wasik, M; Yang, Y | 1 |
Hamamoto, R; Nakamura, Y; Saloura, V | 1 |
Cai, Q; Chen, X; Dong, W; Gu, P; He, W; Huang, J; Lin, T; Wang, B; Xie, W; Xie, Y; Zhong, G | 1 |
Filatov, MV; Kovalev, RA; Semenova, EV; Shtam, TA; Volnitskiĭ, AV | 1 |
Benetti, R; Blasco, MA; Buemi, V; Dinami, R; Jordi, F; Petti, E; Schoeftner, S | 1 |
Armstrong, SA; Chen, CW | 1 |
Cleary, ML; Duque-Afonso, J; Goode, DL; Iwasaki, M; Kuo, HP; Schneidawind, D; Wei, MC; Weng, Z; Wong, SH; Zhu, L | 1 |
Liu, XJ; Wang, DY; Zhu, HG; Zhu, R; Zou, LP | 1 |
Ariyan, CE; Berger, MF; Borsu, L; Busam, KJ; Button, J; Cao, Z; Chen, Y; Chi, P; Fagin, JA; Gao, D; Hollmann, TJ; Hu, W; Ladanyi, M; Lailler, N; Landa, I; Lee, W; Merghoub, T; Murali, R; Murphy, DA; Obenauf, AC; Postow, MA; Ran, L; Sboner, A; Schwartz, GK; Scott, SN; Shah, RH; Shukla, S; Wang, L; Wiesner, T; Wong, EW; Zhang, QF; Zheng, D | 1 |
Kitanaka, C; Kurachi, H; Kuramoto, K; Nagase, S; Ohta, T; Okada, M; Sakaki, H; Seino, M; Seino, S; Suzuki, S; Takeda, H; Watarai, H | 1 |
Hof, F; Milosevich, N | 1 |
Capper, D; Franco, P; Grauvogel, J; Heiland, DH; Hirsch, M; Masalha, W; Schrimpf, D; Staszewski, O; Urbach, H; Weyerbrock, A | 1 |
Lei, PJ; Li, L; Li, YM; Wang, HY; Wei, G; Wu, M; Ye, M; Zhang, X; Zhao, J; Zhao, QY; Zheng, JY | 1 |
Antignano, F; Arrowsmith, CH; Braam, MJS; Brown, PJ; Freeman, SA; Gold, MR; Hughes, MR; McNagny, KM; Oudhoff, MJ; Owen, DR; Rattray, DG; Refaeli, I; Rossi, FMV; Sato, T; Snyder, K; Tatlock, JH; Wang, J; Wong, D; Zaph, C | 1 |
Buechele, C; Cleary, ML; Duque-Afonso, J; Gozani, O; Hansen, L; Huang, M; Ikenouye, L; Klein, BJ; Kutateladze, TG; Li, Q; Majeti, R; Martin, GM; Onishi, M; Schneidawind, D; Shen, J; Wong, SH; Zhu, F; Zhu, L | 1 |
Andricovich, J; Kai, Y; Tzatsos, A | 1 |
Ankri, S; Ehrenhofer-Murray, A; Helm, M; Jeltsch, A; Jurkowski, TP; Lyko, F; Nellen, W; Reuter, G; Schaefer, M | 1 |
Allis, CD; Josefowicz, SZ; Soshnev, AA | 1 |
Kluiver, J; Kok, K; Li, J; Osinga, J; Seelen, MA; Sijmons, RH; van den Berg, A; van Werkhoven, MB; Westers, H | 1 |
Aleksic, J; Bandiera, R; Blanco, S; Cortés-Garrido, R; Dietmann, S; Frye, M; Gkatza, N; Hussain, S; Lombard, P; Popis, M; Sajini, A; Tanna, H | 1 |
Hino, S; Kohrogi, K; Nakao, M | 1 |
Bjerkvig, R; Johannessen, TA; Mukherjee, J; Ohba, S; Pieper, RO; Ronen, SM; Viswanath, P | 1 |
Carlson, SM; Gozani, O | 1 |
Shilatifard, A; Sze, CC | 1 |
Rau, T | 1 |
Cackowski, FC; Decker, AM; Franceschi, RT; Jung, Y; Lee, E; Li, Y; Pienta, KJ; Taichman, RS; Wang, J; Yumoto, K | 1 |
Aburatani, H; Aihara, H; Cheung, E; Doiguchi, M; Hayashi, T; Higashi, M; Ikura, T; Imamura, Y; Inoue, S; Ito, T; Kato, M; Kodama, Y; Koseki, H; Mizusaki, H; Nakagawa, T; Nakayama, T; Oki, M; Takayama, KI; Takeshima, Y; Yoneda, M | 1 |
Fang, D; Gan, H; Wang, H; Zhang, Z; Zhou, H | 1 |
Bohnenberger, H; Chen, NM; Dyck, ML; Ellenrieder, V; Forster, T; Gaedcke, J; Grade, M; Griesmann, H; Hessmann, E; Johnsen, SA; Kitz, J; Koenig, AO; Lubeseder-Martellato, C; Neesse, A; Reuter-Jessen, K; Schildhaus, HU; Siveke, J; Steuber, B; Ströbel, P; Tsai, WC; Winter, T; Zhang, JS | 1 |
Pal, S; Sif, S; Wang, L | 1 |
Barretina, J; Chang, B; Elledge, SJ; Howley, PM; Liu, J; Macia, E; Mulligan, P; Ottinger, M; Pavlova, N; Shi, Y; Shi, YJ; Westbrook, TF | 1 |
Binda, O; Champagne, KS; Chang, HY; Gozani, O; Hung, T; Johnson, K; Kuo, AJ; Kutateladze, TG; Simon, MD | 1 |
Arita, A; Costa, M; Li, Q; Sun, H; Zhou, X | 1 |
Allis, CD; Casadio, F; Dormann, HL; Li, H; Luo, JL; Patel, DJ; Song, J; Wang, GG; Wang, Z | 1 |
Akagi, K; Ishimura, A; Kimura, H; Sugano, S; Suzuki, T; Suzuki, Y; Terashima, M | 1 |
Armstrong, SA; Feng, Z; Krivtsov, AV | 1 |
Cowling, VH | 1 |
Anglim, PP; Caballería, J; Embade, N; Fernández-Ramos, D; Finnell, RH; Gorospe, M; Laird-Offringa, IA; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-Lopez, N; Mato, JM; Varela-Rey, M; Vázquez-Chantada, M; Wagner, C; Woodhoo, A | 1 |
Issa, JP | 1 |
Slany, RK | 1 |
Kai, M; Suzuki, H; Toyota, M | 1 |
Cho, YJ; Koellhoffer, EC; Lemieux, ME; McKenna, ES; Orkin, SH; Pomeroy, SL; Roberts, CW; Shen, X; Wang, X; Wilson, BG | 1 |
Achille, NJ; Chang, MJ; Chou, CW; Hemenway, CS; Reisenauer, MR; Wu, H; Zeleznik-Le, NJ; Zhang, W | 1 |
Ohno, M; Okamura, K; Tsutsui, T | 1 |
Kimura, H; Okada, M; Oneyama, C; Suzuki, K; Tajima, S | 1 |
Cabarcas, SM; Crea, F; Danesi, R; Farrar, WL; Hurt, EM; Marquez, VE; Mathews, LA; Sun, L | 1 |
Füllgrabe, J; Joseph, B; Kavanagh, E | 1 |
Arnoldo, L; Brady, L; Cravello, L; Giancotti, V; Manfioletti, G; Maurizio, E; Sgarra, R; Spolaore, B | 1 |
Armstrong, SA; Bernt, KM; Bullinger, L; Daigle, A; Faber, J; Feng, Z; Krivtsov, AV; Kung, AL; Pollock, RM; Punt, N; Richon, VM; Sinha, AU; Vempati, S; Zhu, N | 1 |
Chakraborty, J; Ghosh, A; Ghosh, S; Maiti, GP; Mukherjee, N; Mukherjee, S; Panda, CK; Roy, A; Roychoudhury, S | 1 |
Chen, K; Cheung, P; Garcia, BA; Gozani, O; Kioi, M; Kuo, AJ; Lauring, J; Li, W; Park, BH; Shi, X; Xi, Y; Zee, BM | 1 |
Chiou, YY; Fu, SL; Lin, CH; Lin, WJ | 1 |
Carr, SM; Cho, EC; Coutts, AS; Kerr, DJ; Kessler, B; Khan, O; Konietzny, R; Liu, G; Lu, YC; McGouran, J; Moehlenbrink, J; Munro, S; Stimson, L; Thangue, NB; Zheng, S | 1 |
Demidem, A; Israel, M; Morvan, D; Schwartz, L; Steyaert, JM | 1 |
Akasu, T; Atomi, Y; Cho, HS; Dohmae, N; Field, HI; Hamamoto, R; Hayami, S; Iwai, Y; Kobayashi, T; Kogure, M; Maejima, K; Masuda, A; Nakamura, Y; Ohnuma, S; Ponder, BA; Sugiyama, M; Takawa, M; Toyokawa, G; Tsunoda, T; Ueda, K; Yamane, Y | 1 |
Adamopoulos, C; Gargalionis, AN; Papavassiliou, AG; Piperi, C | 1 |
Alenda, C; Guarinos, C; Jover, R; Payá, A; Rodríguez-Soler, M; Sánchez-Fortún, C | 1 |
Al-Sohaily, S; Biankin, A; Kohonen-Corish, M; Leong, R; Warusavitarne, J | 1 |
Amstislavskiy, V; Ast, V; Avci, M; Bartholomae, CC; Bender, S; Benes, V; Betts, MJ; Brors, B; Cho, YJ; Cin, H; Clifford, SC; Coco, S; Collins, VP; Ebinger, M; Eils, J; Eils, R; Felsberg, J; Frühwald, MC; Graf, N; Hans, V; Hasselblatt, M; Herold-Mende, C; Hovestadt, V; Hutter, B; Hutter, S; Jabado, N; Jäger, N; Jones, DT; Kabbe, R; Kim, YJ; Kool, M; Korbel, JO; Korshunov, A; Koster, J; Kulozik, AE; Lasitschka, B; Lawerenz, C; Lehrach, H; Lichter, P; Maass, E; McCabe, MG; Meyerson, M; Milde, T; Monoranu, C; Northcott, PA; Pfaff, E; Pfister, SM; Pleier, S; Pomeroy, SL; Pugh, TJ; Raeder, B; Rausch, T; Reifenberger, G; Remke, M; Roggendorf, W; Rössler, J; Russell, RB; Rutkowski, S; Ryzhova, M; Scheurlen, W; Schmidt, M; Schuhmann, MU; Schüller, U; Shih, D; Sieber, L; Sturm, D; Stütz, AM; Sultan, M; Taylor, MD; Tonini, GP; Tzaridis, T; Unterberg, A; van Sluis, P; Volckmann, R; von Bueren, AO; von Deimling, A; von Kalle, C; Wang, Q; Warnatz, HJ; Weber, UD; Weischenfeldt, J; Wiemann, S; Williamson, D; Witt, H; Witt, O; Wittmann, A; Wolf, S; Yaspo, ML; Zapatka, M; Zichner, T | 1 |
Abdel-Wahab, O; Adli, M; Aifantis, I; Bernstein, BE; Carroll, M; Chung, YR; Gao, J; Hricik, T; Jaffe, JD; Koche, R; LaFave, LM; Levine, RL; Melnick, A; Nimer, SD; Pandey, S; Park, CY; Patel, JP; Perna, F; Shih, AH; Taylor, JE; Zhao, X | 1 |
Jackson, JB; Pallas, DC | 1 |
Peng, X; Qiang, B; Tan, X; Wang, S; Yang, B; Yin, B; Yuan, J | 1 |
Chen, Z; Dou, Y; Viboolsittiseri, SS; Wang, JH; Yan, CT | 1 |
Avila, MA; Berasain, C; Corrales, FJ; Elizalde, M; Garcia-Irigoyen, O; Latasa, MU; Nicou, A; Perugorría, MJ; Prieto, J; Recio, JA; Salis, F; Urtasun, R | 1 |
Bian, YQ; Chen, F; Dang, J; Dong, GY; Gao, S; Kjems, J; Liu, Q; Sun, JY; Wang, QT; Wang, XW | 1 |
Arai, Y; Ariga, T; Furukawa, S; Haruta, M; Ichikawa, M; Kajii, T; Kaneko, Y | 1 |
Gong, Y; Hu, H; Ji, Q; Jiang, B; Li, X; Liu, Q; Liu, R; Shang, Y; Shao, C; Wang, Y; Yang, Y; Yuan, J; Zhao, W; Zou, Y | 1 |
Gozani, O; Hammell, M; Joshua-Tor, L; Kuo, A; McCombie, WR; Mills, AA; Paul, S; Schalch, T; Vogel, H | 1 |
Drobná, Z; Jaspers, I; Lin, S; Stýblo, M; Thomas, DJ | 1 |
Di Mario, A; Guidi, F; Hohaus, S; Leone, G; Pagano, L; Scardocci, A; Voso, MT; Zini, G | 1 |
Kaina, B | 1 |
Fujimura, T; Fujita, M; Horie-Inoue, K; Inoue, S; Kitamura, T; Kumagai, J; Ouchi, Y; Sasano, H; Suzuki, T; Takahashi, S; Urano, T | 1 |
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Farraye, FA; Mack, C; O'Brien, MJ; Posnik, O; Yang, S | 1 |
Coffield, VM; Feng, Q; Jiang, Q; Li, Y; Lin, Y; Okada, Y; Su, L; Xu, G; Zhang, Y | 1 |
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Cha, TL; Chen, CT; Hung, MC; Otte, AP; Ping, B; Wu, Y; Xia, W; Yang, CC; Zhou, BP | 1 |
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Agnese, V; Augello, C; Bazan, V; Bruno, L; Calò, V; Cammareri, P; Cascio, S; Corsale, S; Gargano, G; Gerbino, A; Gregorio, V; Gullo, A; Macaluso, M; Morello, V; Passantino, R; Rinaldi, G; Russo, A; Surmacz, E; Tomasino, RM | 1 |
Fodor, BD; Jenuwein, T; Kohlmaier, A; Kubicek, S; Lachner, M; Linderson, Y; Martens, JH; O'Sullivan, RJ; Perez-Burgos, L; Peters, AH; Schotta, G; Sengupta, R; Yonezawa, M | 1 |
Golebiowski, F; Karaczyn, AA; Kasprzak, KS | 1 |
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Chiffer, RC; Leuba, SH; Rodriguez-Collazo, P; Smith, CL; Snyder, SK; Zlatanova, J | 1 |
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Abraham, JM; Agarwal, R; Beer, DG; Cheng, Y; David, S; Hamilton, JP; Ito, T; Jin, Z; Kan, T; Mantzur, C; Meltzer, SJ; Mori, Y; Olaru, A; Paun, B; Sato, F; Wang, S; Yang, J | 1 |
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MacLeod, AR; Rouleau, J; Szyf, M | 1 |
Doerfler, W; Heller, H; Kämmer, C; Wilgenbus, P | 1 |
Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Li, JW | 1 |
Jaenisch, R; Laird, PW | 1 |
Kwan, WK; Qiu, R; Schimmer, BP; Tsao, J | 1 |
Kadam, S; McAlpine, JB | 1 |
Coetzee, GA; Eversole-Cire, P; Gonzales, FA; Hustad, CM; Jones, PA; Rideout, WM; Spruck, CH | 1 |
Klock, G; List, HJ; Patzel, V; Rühl, G; Schopen, A; Stollwerk, J; Zeidler, U | 1 |
Colburn, NH; Oberley, LW; Sun, Y | 1 |
Bassett, DE; Baylin, SB; Herman, J; Issa, JP; Nelkin, BD; Wu, J | 1 |
Baylin, SB; Harris, CC; Spillare, EA; Vertino, PM | 1 |
Baylin, SB; de Bustros, A; Herman, JG; Lee, RY; Mabry, M; Nelkin, BD; Wilson, G; Wu, J; Yen, RW | 1 |
Beart, RW; Jones, PA; Nguyen, TT; Schmutte, C; Yang, AS | 1 |
Brent, TP; Harris, LC; Howell, SR; Remack, JS; Venable, CC; von Wronski, MA | 1 |
Baylin, SB; Belinsky, SA; Issa, JP; Nikula, KJ | 1 |
Heby, O | 1 |
Ge, X; Kamada, N; Tanaka, K | 1 |
Chaves, P; Costa Mira, F; Cravo, M; Fidalgo, P; Glória, L; Nobre-Leitão, C; Pinto, R | 1 |
Aquilina, G; Bignami, M | 1 |
Ira, G | 1 |
Gu, H; Kim, S; Lee, HW; Lim, IK; Paik, WK; Park, GH; Park, SH | 1 |
Jin, M; Jung, HJ; Kim, CG; Kim, H; Kim, NG; Park, C; Park, JH; Piao, Z; Shin, EC | 1 |
Berchem, G; Dicato, M; Duhem, C; Ries, F | 1 |
Shou, J; Wu, D; Zhang, Y | 1 |
Bosserhoff, AK; Buettner, R; de Herreros, AG; Domínguez, D; Poser, I; Varnai, A | 1 |
Freedman, AN; Ishibe, N | 1 |
Badawi, AF; Cavalieri, EL; Higginbotham, S; Kumar, S; Rogan, EG; Todorovic, R | 1 |
Chakraborty, S; Nucifora, G; Senyuk, V | 1 |
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Hawkins, NJ; Ward, RL | 1 |
Klochendler-Yeivin, A; Yaniv, M | 1 |
Asp, J; Benassi, MS; Brantsing, C; Gamberi, G; Gobbi, GA; Magagnoli, G; Molendini, L; Pazzaglia, L; Picci, P; Ragazzini, P; Sangiorgi, L | 1 |
Chen, C; Chen, W; Nallusamy, S; Novetsky, AD; Wang, JC | 1 |
Cuendet, M; Fong, HH; Hawthorne, ME; Kardono, LB; Kinghorn, AD; Mehta, RG; Pezzuto, JM; Riswan, S; Su, BN | 1 |
Browne, MJ; Burdon, RH | 1 |
Lawrence, F; Pierré, A; Richou, M; Robert-Géro, M; Vigier, P | 1 |
Kobliakov, VA | 1 |
Holliday, R | 1 |
Azizov, IuM; Burtseva, NN; Demidkina, NP; Vaniushin, BF | 1 |
Smirnova, IA | 1 |
Hancock, RL | 1 |
Hirose, S; Kato, M; Kodama, S; Okada, S; Ono, T; Sasaki, MS; Tawa, R; Uehara, Y; Yasuzawa, K | 1 |
Jones, PA; Rideout, WM; Shen, JC; Spruck, CH; Tsai, YC | 1 |
Chieco-Bianchi, L; Forino, M; Majone, F; Saggioro, D; Turchetto, L | 1 |
Buss, JE; Cox, AD; Der, CJ; Graham, SM; Hisaka, MM; Kato, K | 1 |
Fujitani, Y; Horio, K; Iwamoto, A; Kawabata, M; Lee, G; Odawara, T; Sudo, K; Yoshikura, H | 1 |
Guernsey, DL; Thomas, JE | 1 |
Bassin, RH; Rimoldi, D; Samid, D; Srikantan, V; Wilson, VL | 1 |
Lawe, D; Prendergast, GC; Ziff, EB | 1 |
DiMaria, P; Duerre, JA; Kim, S; Paik, WK | 1 |
Beenken, SW; Karsenty, G; Lozano, G; Raycroft, L | 1 |
Prendergast, GC; Ziff, EB | 1 |
Smith, SS | 1 |
Ferluga, J | 1 |
Adany, R; Iozzo, RV | 1 |
Barrett, JC; Ebert, R; Pechan, R; Reiss, E; Röllich, G; Schiffmann, D; Wiseman, RW | 1 |
Hiraizumi, S; Kobata, A; Kochibe, N; Shiroki, K; Takasaki, S | 1 |
Coetzee, GA; Gonzales, FA; Jones, PA; Marziasz, CM; Rideout, WM; Tapscott, SJ; Wolkowicz, MJ | 1 |
Gattoni-Celli, S; Hsiao, WL; Weinstein, IB | 2 |
Suk, WA | 1 |
Jones, PA | 1 |
de Haan, JB; Gevers, W; Parker, MI | 1 |
Nettesheim, P; Walker, C | 1 |
Bongarzone, I; Borrello, MG; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA | 1 |
Bloemers, HP; Roebroek, AJ; van de Ven, WJ | 1 |
Kuratomi, Y; Kuwano, M; Masumi, S; Ono, M; Yasutake, C | 1 |
Biedler, JL; Melera, PW; Michitsch, RW | 1 |
Bongarzone, I; Borrello, MG; Cattadori, MR; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA; Traversari, C | 1 |
Szpirer, C; Vanhamme, L | 1 |
Cecchini, E; Citti, L; Durante, M; Geri, C; Natali, L; Nuti Ronchi, V; Parenti, R | 1 |
Cole, MD; Mango, SE; Schuler, GD; Steele, ME | 1 |
Austin, SJ; Beeman, DK; Lasley, JA; Mass, MJ; Schorschinsky, NS | 1 |
Lee, RM; Ouellette, AJ; Weitzman, SA | 1 |
He, ZX; Wu, GL; Xue, JY | 1 |
Archer, MC; Brown, K; Hirani-Hojatti, S; Kovnat, A; Milligan, JR | 1 |
Avvedimento, VE; Berlingieri, MT; Di Fiore, PP; Di Lauro, R; Fusco, A; Musti, AM | 1 |
Hamburger, J; Kotler, M; Moskowitz, H; Relevy, H; Roguel, N | 1 |
Burnett, TS; Gallimore, PH | 1 |
Beato, M | 1 |
Dobrzanski, P; Doerfler, W; Knebel, D; Knust-Kron, B; Langner, KD; Weyer, U | 1 |
Boss, GR; Erbe, RW; Levitt, LJ | 1 |
Cochran, BH; Hayes, TE; Kitchen, AM | 1 |
Breznik, T; Butel, JS; Cohen, JC; Gama-Sosa, MA; Medina, D | 1 |
Kurian, P; Milo, GE; Ribovich, ML | 1 |
Chriqui-Zeira, E; Kedar, E; Mann, V; Razin, A; Szyf, M | 1 |
Atchison, ML; Kelley, DE; Perry, RP; Pollok, BA | 1 |
del Senno, L; Hanau, S; Mollica, G; Pansini, FS; Piva, R; Rimondi, AP | 1 |
Marsilio, E; Smith, BD | 1 |
Spandidos, DA | 1 |
Baylin, SB; Burke, PJ; de Bustros, A; Fearon, ER; Nelkin, BD; Sharkis, SJ; Staal, SP; Vogelstein, B | 1 |
Fidler, IJ; Frost, P | 1 |
Munholland, JM; Nazar, RN | 1 |
Day, RS; DiPaolo, JA; Doniger, J | 1 |
Khodosova, IA | 1 |
D'Ambrosio, SM; Wani, AA; Wani, G | 1 |
Hopkins, RC | 1 |
Chorváth, B; Duraj, J; Sedlák, J | 1 |
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D'Ambrosio, SM; Kamat, PL; Kumari, HL; Milo, GE; Witiak, DT | 1 |
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Ivankovic, S; Schmähl, D; Zeller, WJ | 1 |
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Dubbs, DR; Kit, S; Nakajima, K | 1 |
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Shearer, RW; Smuckler, EA | 1 |
Culp, LA; Kolodny, GM; Rosenthal, LJ | 1 |
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Klagsbrun, M | 1 |
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Gantt, RR | 2 |
Macgillivray, AJ; Paul, J; Threlfall, G | 1 |
Borek, E; Kerr, SJ | 1 |
Hartenstein, R; Rabes, HM; Ringelmann, W | 1 |
Benoit, A; Chauveau, J | 1 |
Bertram, JS; Heidelberger, C; Peterson, AR | 1 |
Evans, VJ; Gantt, R | 1 |
Blair, DG; Dell'Orco, RT; Morgan, JF | 1 |
Magee, PN | 1 |
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Hacker, B; Maag, TA; Mandel, LR | 1 |
Pillinger, DJ; Wilkinson, R | 1 |
Chaney, SQ; Halpern, BC; Halpern, RM; Smith, RA | 1 |
Gallo, RC | 2 |
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67 review(s) available for isomethyleugenol and Cell Transformation, Neoplastic
Article | Year |
---|---|
Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.
Topics: Adenosine; Cell Physiological Phenomena; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Glycolipids; Humans; Methylation; Methyltransferases; Models, Biological; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Biosynthesis; Radiation Tolerance; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Neoplasm | 2020 |
EZH2: a novel target for cancer treatment.
Topics: Adenosine; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Histone Code; Histones; Humans; Methylation; Morpholines; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship; Transcriptional Activation; Tumor Microenvironment | 2020 |
Mechanistic insights into KDM4A driven genomic instability.
Topics: Animals; Cell Transformation, Neoplastic; Genomic Instability; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2021 |
Effects of m6A modifications on signaling pathways in human cancer (Review).
Topics: Adenosine; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; Signal Transduction | 2021 |
Impact of One-Carbon Metabolism-Driving Epitranscriptome as a Therapeutic Target for Gastrointestinal Cancer.
Topics: Animals; Carbon; Cell Transformation, Neoplastic; Folic Acid; Gastrointestinal Neoplasms; Humans; Methylation; Mitochondria; Reactive Oxygen Species; RNA | 2021 |
MicroRNA: an important regulator in acute myeloid leukemia.
Topics: Animals; Cell Transformation, Neoplastic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Methylation; MicroRNAs; RNA Processing, Post-Transcriptional | 2017 |
Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer.
Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Metabolic Networks and Pathways; Methylation; Neoplasms | 2017 |
Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.
Topics: Adenosine; Animals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger | 2018 |
KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Neoplasms; Nuclear Proteins; Repressor Proteins; Stem Cells | 2019 |
Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis.
Topics: Animals; Cell Transformation, Neoplastic; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasm Proteins | 2019 |
Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Repair; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genomic Instability; Histone Demethylases; Histones; Humans; Interphase; Methylation; Mitosis; Neoplasms; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Transcriptome; Ubiquitination | 2013 |
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Drosophila melanogaster; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Isoenzymes; Methylation; Mice; Mice, Transgenic; Neoplasms; Signal Transduction | 2013 |
Critical roles of non-histone protein lysine methylation in human tumorigenesis.
Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Retinoblastoma Protein; STAT3 Transcription Factor; Tumor Suppressor Protein p53 | 2015 |
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Drug Delivery Systems; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein | 2015 |
Chemical Inhibitors of Epigenetic Methyllysine Reader Proteins.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Drug Delivery Systems; Epigenesis, Genetic; Humans; Methylation; Protein Processing, Post-Translational | 2016 |
Lysine-specific histone demethylases in normal and malignant hematopoiesis.
Topics: Animals; Cell Transformation, Neoplastic; Gene Expression Regulation; Hematologic Neoplasms; Hematopoiesis; Histone Demethylases; Histones; Humans; Methylation; Signal Transduction | 2016 |
Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.
Topics: Animals; Binding Sites; Catalysis; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; Humans; Methylation; Nucleic Acids; Phylogeny; Protein Binding; Retroelements; Structure-Activity Relationship; Substrate Specificity | 2017 |
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Models, Molecular; Mutation; Neoplasms; Nucleic Acid Conformation; Oncogenes; Phosphorylation; Protein Binding; Protein Conformation; Structure-Activity Relationship; Transcription, Genetic | 2016 |
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.
Topics: Animals; Cell Transformation, Neoplastic; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histone Demethylases; Histones; Humans; Methylation; Neoplasms; Phenotype | 2016 |
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.
Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; DNA Damage; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2016 |
MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer.
Topics: Animals; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Neoplasms; Protein Processing, Post-Translational | 2016 |
[Pathogenetic aspects in precursor lesions of gastrointestinal tumors].
Topics: Adenomatous Polyposis Coli Protein; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Progression; DNA Mismatch Repair; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Humans; In Situ Hybridization, Fluorescence; Methylation; Phenotype; Precancerous Conditions; Promoter Regions, Genetic | 2016 |
Epigenetic changes in the myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia, Myeloid; Methylation; Myelodysplastic Syndromes; Neoplasms; Protein Processing, Post-Translational | 2010 |
[Disease and epigenome analysis].
Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genomics; Histones; Humans; Life Style; Mental Disorders; Methylation; Neoplasms; Neoplastic Stem Cells | 2010 |
Histone onco-modifications.
Topics: Acetylation; Cell Transformation, Neoplastic; Chromatin; DNA Repair; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Methylation; Neoplasms; Oncogene Proteins; Protein Processing, Post-Translational | 2011 |
Histone modifications as a pathogenic mechanism of colorectal tumorigenesis.
Topics: Acetylation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Histones; Humans; Methylation; Models, Biological; Protein Processing, Post-Translational | 2012 |
Serrated polyposis syndrome: molecular, pathological and clinical aspects.
Topics: Cell Transformation, Neoplastic; Colorectal Neoplasms; CpG Islands; Humans; Intestinal Polyposis; Methylation; Proto-Oncogene Proteins B-raf | 2012 |
Molecular pathways in colorectal cancer.
Topics: Adenomatous Polyposis Coli; Cell Transformation, Neoplastic; Chromosomal Instability; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; CpG Islands; Hamartoma Syndrome, Multiple; Humans; Methylation; Microsatellite Instability; Peutz-Jeghers Syndrome | 2012 |
The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update.
Topics: Animals; Arsenic; Biotransformation; Cell Line; Cell Transformation, Neoplastic; Humans; Mammals; Methylation; Methyltransferases; Transcription, Genetic | 2002 |
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Apoptosis; Base Pair Mismatch; Cell Cycle; Cell Transformation, Neoplastic; Chromosome Aberrations; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Guanosine; Humans; Methylation; Mice; Models, Genetic; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Recombination, Genetic; Sister Chromatid Exchange | 2004 |
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
Topics: Acetylation; Amino Acid Sequence; Apoptosis; Cell Transformation, Neoplastic; Chromatin; High Mobility Group Proteins; Methylation; Molecular Sequence Data; Neoplasms; Protein Conformation; Sequence Homology, Amino Acid | 2004 |
The role of histone modifications in epigenetic transitions during normal and perturbed development.
Topics: Animals; Cell Differentiation; Cell Lineage; Cell Transformation, Neoplastic; Chromatin; Embryonic Development; Epigenesis, Genetic; Histones; Humans; Methylation; Protein Structure, Tertiary | 2006 |
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.
Topics: Acetylation; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Neoplasms; Prognosis; Protein Processing, Post-Translational; Tumor Suppressor Proteins | 2007 |
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.
Topics: Animals; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Mammals; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; Nucleosomes; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Repressor Proteins; Retinoblastoma-Binding Protein 2; Saccharomyces cerevisiae Proteins; Substrate Specificity; Tumor Suppressor Proteins | 2007 |
Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?
Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chemoprevention; Flavones; Flavonoids; Humans; Methylation; Neoplasms | 2007 |
MLL translocations, histone modifications and leukaemia stem-cell development.
Topics: Adult; Animals; Cell Division; Cell Transformation, Neoplastic; Child; Chromatin; Epigenesis, Genetic; Gene Expression Regulation; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant; Leukemia; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Prognosis; Protein Methyltransferases; Protein Processing, Post-Translational | 2007 |
Genetic analyses of the role of RCE1 in RAS membrane association and transformation.
Topics: Animals; Cardiomyopathy, Dilated; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Fibroblasts; Genes, ras; Hematopoiesis; Humans; Liver; Methylation; Mice; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myeloproliferative Disorders; Protein Processing, Post-Translational; ras Proteins; Transfection | 2008 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
[Methylation of eukaryote DNA. II. Biological significance].
Topics: Animals; Base Sequence; Cell Differentiation; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Chromosome Aberrations; Cricetinae; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA Restriction Enzymes; DNA-Directed RNA Polymerases; Gene Expression Regulation; Genes, Regulator; Histones; Methylation; Organoids; Transcription, Genetic | 1981 |
DNA methylation--a regulatory signal in eukaryotic gene expression.
Topics: 5-Methylcytosine; Adenoviridae; Animals; Bacteriophages; Base Sequence; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Gene Expression Regulation; Genes, Viral; Herpesviridae; Insect Viruses; Methylation; Polyomavirus; Retroviridae; Simian virus 40 | 1981 |
5-Methylcytosine depletion during tumour development: an extension of the miscoding concept.
Topics: 5-Methylcytosine; Alkylation; Amino Acid Metabolism, Inborn Errors; Animals; Carcinogens; Cell Transformation, Neoplastic; Choline Deficiency; Cytosine; DNA; DNA Repair; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Models, Genetic; Neoplasms; Oncogenes; Rats; Tyrosine; Vitamin B 6 Deficiency | 1983 |
Chemical-viral interactions in cell transformation.
Topics: Animals; Carcinogens; Cell Adhesion; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cocarcinogenesis; DNA, Neoplasm; Epidermal Growth Factor; Humans; Methylation; Phenotype | 1983 |
Generation of phenotypic diversity and progression in metastatic tumor cells.
Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Clone Cells; DNA; Humans; Methylation; Mutation; Neoplasm Metastasis; Neoplasms; Phenotype | 1984 |
The use of cloned gene probes to study differentiation in teratocarcinomas.
Topics: Animals; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; DNA; Enhancer Elements, Genetic; Gene Expression Regulation; Genes; Genetic Techniques; Genetics; Methylation; Mice; Neoplasm Proteins; Teratoma; Transcription, Genetic; Viral Proteins | 1984 |
Isozyme alterations, gene regulation and the neoplastic transformation.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Fetal Proteins; Gene Expression Regulation; Glycolysis; Hormones; Isoenzymes; Liver Neoplasms, Experimental; Methylation; Oncogenes; Rats | 1983 |
Alterations in DNA methylation may play a variety of roles in carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mutation | 1995 |
DNA methylation and cancer.
Topics: Animals; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA, Neoplasm; Gene Expression; Humans; Methylation; Mutation; Neoplasms | 1994 |
DNA methylation and polyamines in embryonic development and cancer.
Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; Embryonic and Fetal Development; Female; Gene Expression Regulation, Developmental; Humans; Male; Methylation; Mice; Mutagenesis; Neoplasms; Nucleic Acid Conformation; Oogenesis; Polyamines; Replication Origin; Spermatogenesis; Transcription, Genetic | 1995 |
Genetic instability and methylation tolerance in colon cancer.
Topics: Cell Transformation, Neoplastic; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Damage; DNA Repair; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1996 |
[CpG islands--the only unmethylated fragments of DNA in the vertebrate genome].
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; CpG Islands; DNA; Eukaryotic Cells; Genetic Markers; Humans; Mammals; Methylation; Vertebrates | 1997 |
The biology of colorectal cancer.
Topics: Cell Cycle; Cell Transformation, Neoplastic; Colorectal Neoplasms; Gene Expression; Genes, Tumor Suppressor; Humans; Intestinal Mucosa; Methylation; Mutation; Oncogenes | 2000 |
Understanding the interaction between environmental exposures and molecular events in colorectal carcinogenesis.
Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma; Cell Cycle Proteins; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Dietary Fiber; Environmental Exposure; Enzyme Inhibitors; Folic Acid; Genes, APC; Genes, bcl-2; Genes, DCC; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Humans; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Microtubule-Associated Proteins; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Smoking; Tumor Suppressor Proteins | 2001 |
Genetic lesions and perturbation of chromatin architecture: a road to cell transformation.
Topics: Acetylation; Amino Acid Motifs; Animals; Cell Transformation, Neoplastic; Chromatin; Chromosome Aberrations; CREB-Binding Protein; Dimerization; Gene Expression Regulation; Gene Targeting; Histones; Humans; Leukemia, Promyelocytic, Acute; Macromolecular Substances; Methylation; Mice; Models, Genetic; Multigene Family; Neoplasm Proteins; Nuclear Proteins; Nuclear Receptor Coactivator 2; Nucleosomes; Oncogene Proteins, Fusion; Phosphorylation; Protein Processing, Post-Translational; Receptors, Retinoic Acid; Trans-Activators; Transcription Factors; Transcription, Genetic; Translocation, Genetic | 2001 |
Chromatin modifiers and tumor suppression.
Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; Chromosomal Proteins, Non-Histone; DNA Methylation; DNA-Binding Proteins; Genes, Tumor Suppressor; Heterochromatin; Histones; Humans; Methylation; Nuclear Proteins; Nucleosomes; Phosphorylation; Signal Transduction; SMARCB1 Protein; Trans-Activators; Transcription Factors | 2001 |
[Transformations of polycyclic aromatic hydrocarbons in the cell].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Carcinogens, Environmental; Cell Transformation, Neoplastic; DNA; Drug Interactions; Endoplasmic Reticulum; Enzyme Activation; Epoxy Compounds; Free Radicals; Humans; Methylation; Microsomes; Oxidation-Reduction; Phenols; Polycyclic Compounds | 1977 |
Methylation, mutation and cancer.
Topics: 5-Methylcytosine; Animals; Cell Transformation, Neoplastic; Cytosine; Deamination; DNA; DNA, Neoplasm; Female; Genes, p53; Genetic Diseases, Inborn; Humans; Male; Methylation; Mutation; Neoplasms; Neoplasms, Experimental; Vertebrates | 1992 |
Current status of protein methylation in carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Esterification; Histones; Humans; Methylation; Methyltransferases; Neoplasms; Nuclear Proteins; Proteins | 1991 |
DNA methylation in eukaryotic chromosome stability.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomes; DNA; Humans; Methylation | 1991 |
Potential role of anti-oncogenes in aging.
Topics: Aging; Cell Survival; Cell Transformation, Neoplastic; DNA; DNA Tumor Viruses; Humans; Methylation; Oncogene Proteins; Oncogenes; Phenotype | 1990 |
Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromosomes; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Genes, Viral; Humans; Methylation; Phenotype; Species Specificity | 1985 |
A unified theory for the development of cancer.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Genes, Recessive; Humans; Methylation; Mutation; Neoplasms; Oncogenes; Retroviridae; Transduction, Genetic; Translocation, Genetic | 1986 |
[Role of enzymatic DNA methylation in cell differentiation and carcinogenesis].
Topics: Animals; Base Composition; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cytosine; DNA; DNA, Neoplasm; Gene Expression Regulation; Methylation; Methyltransferases; Neoplasms, Experimental; Transcription, Genetic | 1985 |
[Molecular aspects of leukemogenesis].
Topics: Cell Differentiation; Cell Transformation, Neoplastic; DNA; DNA Nucleotidyltransferases; DNA, Neoplasm; Genetic Code; Humans; Leukemia; Methylation; Retroviridae; Simian virus 40 | 1972 |
Protein modification, metabolic controls, and their significance in transformation in eukaryotic cells.
Topics: Acetylation; Adenosine Triphosphate; Animals; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Contact Inhibition; Cyclic AMP; DNA Replication; Glycoproteins; Inclusion Bodies; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms; Nucleoproteins; Oxidative Phosphorylation; Transcription, Genetic | 1974 |
Transcriptional regulation in eukaryotic cells.
Topics: Acetates; Cell Differentiation; Cell Nucleus; Cell Transformation, Neoplastic; Chromatin; Chromosomes; Coliphages; DNA; Genes, Regulator; Genetic Code; Heterochromatin; Histones; Methylation; Molecular Biology; Nucleic Acid Hybridization; Nucleoproteins; Peptide Chain Initiation, Translational; Phosphoproteins; RNA; RNA Nucleotidyltransferases; Templates, Genetic | 1972 |
The tRNA methyltransferases.
Topics: Animals; Bacteriophages; Base Sequence; Binding Sites; Biological Evolution; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Escherichia coli; Genetics, Microbial; Methylation; Methyltransferases; Mice; Mutation; Nucleic Acid Conformation; Organ Specificity; Rats; RNA, Transfer; S-Adenosylmethionine; Virus Replication; Viruses | 1972 |
The possible role of nucleic acid methylases in the induction of cancer.
Topics: Alkylating Agents; Alkylation; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethionine; Methylation; Methyltransferases; Neoplasms; Nucleic Acids; RNA, Neoplasm; RNA, Transfer; Transferases | 1971 |
277 other study(ies) available for isomethyleugenol and Cell Transformation, Neoplastic
Article | Year |
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TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation.
Topics: Arginine; Bone Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Osteosarcoma; Protein-Arginine N-Methyltransferases; Repressor Proteins; STAT3 Transcription Factor | 2022 |
The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.
Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Cholangiocarcinoma; Histone Demethylases; Histones; Humans; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Methylation | 2022 |
Chromosomal instability-associated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Chromosomal Instability; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; RNA, Long Noncoding; Uveal Neoplasms | 2022 |
The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer.
Topics: Breast Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Female; Humans; Methylation; Methyltransferases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors | 2023 |
PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6.
Topics: Carcinogenesis; Cell Cycle Proteins; Cell Transformation, Neoplastic; Humans; Methylation; Multiple Myeloma; NADH Dehydrogenase; Oxidative Phosphorylation; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA Splicing Factors | 2023 |
Protection of c-Fos from autophagic degradation by PRMT1-mediated methylation fosters gastric tumorigenesis.
Topics: Arginine; Carcinogenesis; Cell Transformation, Neoplastic; Humans; Methylation; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-fos; Repressor Proteins; Stomach Neoplasms; Transcription Factor AP-1 | 2023 |
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter.
Topics: Animals; Cell Transformation, Neoplastic; Colorectal Neoplasms; Humans; Methylation; Mice; Mice, Nude; RNA; Sp1 Transcription Factor; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2023 |
SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Histone Demethylases; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Matrix Metalloproteinase 1; Methylation; Prostatic Neoplasms | 2023 |
Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis.
Topics: Alternative Splicing; Breast Neoplasms; Cell Transformation, Neoplastic; Exons; Female; Humans; Methylation; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA; Serine-Arginine Splicing Factors | 2023 |
Ubiquitous expressed transcript promotes tumorigenesis by acting as a positive modulator of the polycomb repressive complex 2 in clear cell renal cell carcinoma.
Topics: Aged; Carcinoma, Renal Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Kidney Neoplasms; Male; Methylation; Middle Aged; Molecular Chaperones; Mutation; Neoplasm Proteins; Polycomb Repressive Complex 2; Prognosis; Protein Binding; Survival Analysis; Transcription Factors | 2019 |
EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.
Topics: Angiogenic Proteins; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Medulloblastoma; Methylation; Peptide Fragments; Receptors, G-Protein-Coupled; Sialoglycoproteins; Tumor Suppressor Protein p53 | 2020 |
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Histones; Humans; Methylation; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Monocarboxylic Acid Transporters; Pancreatic Neoplasms; Pyruvic Acid; Retinoblastoma-Binding Protein 2; Signal Transduction; Transcription, Genetic | 2020 |
CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling.
Topics: 3' Untranslated Regions; Animals; ATPases Associated with Diverse Cellular Activities; beta Catenin; Bone Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Disease Progression; DNA Helicases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Lymphoid Enhancer-Binding Factor 1; Methylation; Mice; MicroRNAs; Myosins; Neoplasm Metastasis; Osteosarcoma; Promoter Regions, Genetic; Protein Binding; RNA Interference; RNA, Circular; Wnt Signaling Pathway | 2019 |
m
Topics: Adenosine; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Eye Neoplasms; Gene Expression Profiling; Humans; Melanoma; Methylation; Mitochondrial Proteins; Prognosis; RNA Processing, Post-Transcriptional; RNA, Messenger | 2019 |
YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness.
Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Intestines; Methylation; Mice; Wnt Signaling Pathway | 2020 |
Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction.
Topics: Animals; Binding Sites; Biocatalysis; Cell Line, Tumor; Cell Transformation, Neoplastic; Click Chemistry; Electron Transport; Horseradish Peroxidase; Humans; Luminol; Male; Methylation; Mice; Models, Molecular; Protein Conformation; Proteins; Tyrosine | 2020 |
Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Bile Duct Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cholangiocarcinoma; Disease Models, Animal; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Heterografts; Histones; Humans; Male; Methylation; Mice; RNA Interference; RNA, Long Noncoding; RNA, Small Interfering; Tumor Suppressor Proteins | 2020 |
PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis.
Topics: Breast Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Female; Humans; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Polycomb Repressive Complex 2 | 2020 |
METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m
Topics: Adenosine; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Mice; Mouth Neoplasms; Protein Binding; RNA, Messenger | 2020 |
Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix.
Topics: Cell Proliferation; Cell Transformation, Neoplastic; Cervix Uteri; CpG Islands; Epithelial Cells; Female; Humans; In Situ Hybridization; In Situ Hybridization, Fluorescence; Metaplasia; Methylation; Papillomaviridae; Papillomavirus Infections; Promoter Regions, Genetic; SOXB1 Transcription Factors; SOXF Transcription Factors; Squamous Intraepithelial Lesions of the Cervix; Stem Cells | 2020 |
Expression and methylation of Dickkopf-1 in the pathogenesis and malignant transformation of oral submucous fibrosis.
Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Humans; Methylation; Mouth Neoplasms; Oral Submucous Fibrosis | 2020 |
METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP.
Topics: Adenosine; Aged; Carcinogenesis; Carcinoma, Endometrioid; Carcinoma, Ovarian Epithelial; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; China; Female; Gene Expression; Gene Expression Profiling; HeLa Cells; Humans; Methylation; Methyltransferases; Middle Aged; RNA Splicing Factors; RNA, Messenger; Transcriptome | 2020 |
SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cells; Histones; Humans; Leukemia, Myeloid, Acute; Lysine; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Repressor Proteins; Transcription, Genetic | 2020 |
Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway.
Topics: Cell Communication; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Epithelial-Mesenchymal Transition; Exosomes; Gene Expression Profiling; Gene Expression Regulation; Humans; Methylation; MicroRNAs; Oral Submucous Fibrosis; Prognosis; Proto-Oncogene Proteins c-akt; RNA, Long Noncoding; Signal Transduction | 2021 |
CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells.
Topics: Animals; Arsenites; Aurora Kinase B; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D2; Enhancer of Zeste Homolog 2 Protein; Enzyme Activation; Female; Heterografts; HSP70 Heat-Shock Proteins; Humans; Methylation; Mice; MicroRNAs; RNA, Circular; Up-Regulation; Urinary Bladder Neoplasms | 2021 |
m
Topics: Adenosine; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Calcium; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Ion Channels; Melanoma; Methylation; RNA; RNA Interference; Uveal Neoplasms | 2021 |
A genome-wide screen for differentially methylated long noncoding RNAs identified that lncAC007255.8 is regulated by promoter DNA methylation in Beas-2B cells malignantly transformed by NNK.
Topics: Bronchi; Butanones; Cell Line; Cell Transformation, Neoplastic; DNA; DNA (Cytosine-5-)-Methyltransferase 1; Epithelial Cells; Gene Expression Regulation; Genome-Wide Association Study; Humans; Lung Neoplasms; Methylation; Nitrosamines; Promoter Regions, Genetic; Respiratory Mucosa; RNA, Long Noncoding; Up-Regulation | 2021 |
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Neoplasm Invasiveness; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-myc; Ribosomal Proteins | 2021 |
The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
Topics: Acute Disease; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Chromatin; HEK293 Cells; Histones; Humans; Leukemia, Myeloid, Acute; Methylation; Mice; Models, Molecular; Monomeric Clathrin Assembly Proteins; Nucleosomes; Protein Conformation; Transcription Factors; Translocation, Genetic | 2021 |
Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Glioblastoma; Humans; Methylation; RNA, Messenger | 2017 |
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Methylation; Microsatellite Repeats; Phosphorylation; Polymorphism, Genetic; Protein Binding; Protein Multimerization; Receptor, ErbB-2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering | 2017 |
AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.
Topics: Animals; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Co-Repressor Proteins; Core Binding Factor Alpha 2 Subunit; DEAD-box RNA Helicases; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; HEK293 Cells; HL-60 Cells; Humans; K562 Cells; Leukemia; Methylation; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Phenotype; Protein Interaction Maps; Proto-Oncogene Proteins c-myc; Repressor Proteins; Ribonucleoproteins; RNA, Ribosomal; RNA, Small Nucleolar; RUNX1 Translocation Partner 1 Protein; Signal Transduction; Time Factors; Transcription Factors; U937 Cells | 2017 |
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Topics: Acetylation; Animals; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Cells, Cultured; CREB-Binding Protein; DNA Damage; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Histones; Lymphangiogenesis; Lymphoid Progenitor Cells; Lymphoma; Lymphopoiesis; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neoplastic Stem Cells; Phenotype; Signal Transduction; Time Factors; Transcription, Genetic; Tumor Suppressor Protein p53 | 2017 |
DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage.
Topics: Alkylating Agents; Benzaldehydes; Cell Line, Tumor; Cell Transformation, Neoplastic; Comet Assay; DNA-Activated Protein Kinase; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Golgi Apparatus; Humans; Mammary Glands, Human; Methylation; Methylnitrosourea; Protein Kinase Inhibitors | 2017 |
EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Janus Kinase 2; Jurkat Cells; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Mutagenesis, Site-Directed; Neoplasms; Nuclear Localization Signals; Proto-Oncogene Proteins c-vav; Recombinant Proteins; STAT3 Transcription Factor; Talin; Xenograft Model Antitumor Assays | 2018 |
Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells.
Topics: Arsenites; Blotting, Western; Bronchi; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Down-Regulation; Histone Demethylases; Histone Methyltransferases; Histones; Humans; Methylation; Respiratory Mucosa | 2018 |
X chromosome protects against bladder cancer in females via a
Topics: Animals; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, X-Linked; Genetic Predisposition to Disease; Gonadal Steroid Hormones; Histone Demethylases; Methylation; Mice; Mice, Knockout; Mutation; Prognosis; Sex Chromosomes; Sex Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Urinary Bladder Neoplasms; X Chromosome | 2018 |
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Topics: A549 Cells; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Signal Transduction; Transcription Factors; Tumor Burden; YAP-Signaling Proteins | 2018 |
Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Incidence; Male; Methylation; MicroRNAs; Neoplasms; Population Groups; Prevalence; Risk Factors | 2018 |
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Enhancer Elements, Genetic; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Methylation; Promoter Regions, Genetic | 2018 |
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Topics: Adult; Aged; Animals; Carcinogenesis; Cell Line; Cell Transformation, Neoplastic; Female; HEK293 Cells; Heterografts; Humans; Lysine; Male; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pancreatic Neoplasms; Peptide Elongation Factor 1; Protein Biosynthesis; Protein Processing, Post-Translational; Proteomics; Signal Transduction | 2019 |
The expanding landscape of 'oncohistone' mutations in human cancers.
Topics: Cell Transformation, Neoplastic; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Nucleosomes; Protein Domains; Protein Processing, Post-Translational | 2019 |
Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.
Topics: Adult; Animals; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Disease Models, Animal; Female; Gallbladder Neoplasms; Gene Expression Regulation, Neoplastic; Heterografts; Histones; Humans; Male; Methylation; Mice; Middle Aged; Models, Biological; Prognosis; RNA Interference; RNA, Long Noncoding; Young Adult | 2019 |
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.
Topics: Acetylation; Amino Acid Sequence; Animals; Cell Cycle; Cell Transformation, Neoplastic; Chromatin; DNA Damage; Gene Knockout Techniques; Genomic Instability; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; M Phase Cell Cycle Checkpoints; Methylation; Mice; Mice, Knockout; Mitosis; Protein Binding; Sirtuin 2 | 2013 |
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Topics: Animals; Benzeneacetamides; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glutarates; Histones; Imidazoles; Isocitrate Dehydrogenase; Methylation; Mice; Mice, SCID; Mutant Proteins; Protein Multimerization; RNA Interference; Xenograft Model Antitumor Assays | 2013 |
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Fibroblasts; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Methyltransferases; Mice; Mutation; Protein Transport; Proto-Oncogene Proteins; Repressor Proteins; Signal Transduction | 2013 |
Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.
Topics: Animals; Arginine; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Dimerization; HEK293 Cells; Humans; Methylation; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-jun; Rabbits; Repressor Proteins; Signal Transduction; Trans-Activators; Transcription Factor AP-1; Transcriptional Activation; Ubiquitin-Protein Ligases | 2013 |
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Gene Deletion; Gene Expression Regulation, Neoplastic; Germinal Center; Histones; Methylation; Mice; Mutation; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2 | 2013 |
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
Topics: Animals; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Glioblastoma; Humans; Methylation; Mice; Phosphorylation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; Transplantation, Heterologous; Tumor Cells, Cultured | 2013 |
Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1.
Topics: Adaptor Proteins, Signal Transducing; Arsenic; Cell Cycle; Cell Enlargement; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Estrogens; Gene Expression; Gene Silencing; Humans; Male; Methylation; MutL Protein Homolog 1; Nuclear Proteins; Prostate | 2013 |
Methylation markers of malignant potential in meningiomas.
Topics: Biomarkers, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Methylation; Middle Aged | 2013 |
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Peptide Chain Initiation, Translational; Prognosis; Protein Binding; Protein Biosynthesis; RNA, Ribosomal; Tumor Suppressor Protein p53 | 2013 |
Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic.
Topics: Adaptation, Physiological; Animals; Arsenic Poisoning; Arsenicals; Cell Line; Cell Transformation, Neoplastic; DNA Damage; Humans; Liver; Male; Methylation; Multidrug Resistance-Associated Protein 2; Oxidation-Reduction; Prostate; PTEN Phosphohydrolase; Rats; Toxicity Tests, Chronic | 2014 |
Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells.
Topics: Animals; Biomarkers; Blastocyst; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Embryonic Stem Cells; Genomic Instability; Histones; Humans; Methylation; Mice; Neoplasm Transplantation; Protein Processing, Post-Translational; Telomerase; Telomere; Telomere Homeostasis; Teratoma; Wnt Signaling Pathway | 2014 |
Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Centromere; Chromosomal Instability; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Cohesins; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Methylation; Retinoblastoma Protein; RNA, Small Interfering; S Phase; Signal Transduction | 2014 |
LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cellular Reprogramming; Chromatin; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation; Germ Cells; Histones; Male; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Mutation; Neoplasms, Germ Cell and Embryonal; Neurons; Oxidoreductases, N-Demethylating; Protein Binding; Stem Cells | 2014 |
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Topics: Animals; B-Lymphocytes; Blotting, Western; Bone Marrow Cells; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Histones; Humans; Kaplan-Meier Estimate; Lymphoma; Lymphoma, B-Cell; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-myc; Spleen | 2014 |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Protein Phosphatase 2; Proto-Oncogene Proteins A-raf; Signal Transduction | 2014 |
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.
Topics: Amino Acid Sequence; Cell Proliferation; Cell Transformation, Neoplastic; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; HSP90 Heat-Shock Proteins; Humans; Methylation; Molecular Sequence Data; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Processing, Post-Translational | 2014 |
Different roles for p16(INK) (4a) -Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach.
Topics: Adenocarcinoma; Aged; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Humans; Male; Methylation; Middle Aged; Retinoblastoma Protein; Signal Transduction; Stomach; Stomach Neoplasms | 2014 |
Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells.
Topics: Animals; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Heterografts; Histones; Humans; Kidney Neoplasms; Methylation; Mice; RNA, Long Noncoding; RNA, Small Interfering; Tumor Burden | 2014 |
Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
Topics: Adaptor Proteins, Signal Transducing; Androgens; Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Estrogen Receptor alpha; Estrogens; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Signal Transduction; Up-Regulation | 2014 |
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Endometrial Neoplasms; Female; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasm Grading; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract.
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; MicroRNAs; Mitogen-Activated Protein Kinase 7; Smoking | 2016 |
PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Animals; Apoptosis; Arginine; Cell Transformation, Neoplastic; Cluster Analysis; Cyclin D1; Cyclin-Dependent Kinase 4; Enzyme Activation; Gene Expression Profiling; Humans; Leukemia, T-Cell; Lymphoma; Lymphoma, T-Cell; Methylation; Mice; Mutation; Oncogenes; Phosphorylation; Protein-Arginine N-Methyltransferases; Tumor Suppressor Protein p53 | 2015 |
Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Case-Control Studies; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Cell Transformation, Neoplastic; Cisplatin; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Lymphatic Metastasis; Male; Methylation; Middle Aged; Neoplasm Grading; Neoplasm Staging; Tumor Burden; Urinary Bladder Neoplasms | 2015 |
[Aberrant expression of sox2 gene in malignant gliomas].
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Methylation; Primary Cell Culture; Protein Processing, Post-Translational; SOXB1 Transcription Factors; Tumor Microenvironment | 2014 |
Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Epidermis; Female; Histones; Humans; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mutation; ras Proteins; Repressor Proteins; Skin Neoplasms; Telomere; Telomere Homeostasis; Telomere Shortening | 2015 |
The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin Receptor Common gamma Subunit; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous | 2015 |
Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Genes, p16; Hepatitis B virus; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Promoter Regions, Genetic; Trans-Activators; Viral Regulatory and Accessory Proteins | 2015 |
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Topics: Alleles; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Introns; Isoenzymes; Lysine; Methylation; Mice; Molecular Sequence Data; Molecular Weight; Neoplasms; NIH 3T3 Cells; Oncogenes; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; RNA Polymerase II; RNA, Messenger; Signal Transduction; Transcription Initiation, Genetic | 2015 |
GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells; Ovarian Neoplasms; Xenograft Model Antitumor Assays | 2015 |
Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis.
Topics: Adult; Autoantigens; Brain Neoplasms; Cell Transformation, Neoplastic; Cluster Analysis; DNA Copy Number Variations; DNA Mutational Analysis; Genome, Human; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Neoplasms, Neuroepithelial; Proteasome Endopeptidase Complex | 2016 |
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; MCF-7 Cells; Methylation; Mice; Mice, Nude | 2016 |
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Axin Protein; beta Catenin; Caco-2 Cells; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Intestinal Neoplasms; Intestines; MCF-7 Cells; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Protein Methyltransferases; RNA Interference; RNA, Small Interfering; Wnt Proteins; Wnt Signaling Pathway; YAP-Signaling Proteins | 2016 |
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; F-Box Proteins; Female; Gene Expression Regulation, Leukemic; Heterografts; High-Throughput Nucleotide Sequencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2016 |
Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma.
Topics: beta-Galactosidase; Carcinoma, Renal Cell; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; E2F1 Transcription Factor; Epithelial Cells; Genes, Tumor Suppressor; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney Neoplasms; Kidney Tubules; Methylation; RNA Interference; RNA, Small Interfering | 2016 |
Stem cell function and stress response are controlled by protein synthesis.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cytosine; Female; Fluorouracil; Hair Follicle; Humans; Male; Methylation; Methyltransferases; Mice; Neoplastic Stem Cells; Protein Biosynthesis; Regeneration; RNA, Transfer; Skin Neoplasms; Stem Cells; Stress, Physiological | 2016 |
Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis.
Topics: Astrocytes; Benzeneacetamides; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Glioma; Glutarates; Histones; Humans; Imidazoles; Isocitrate Dehydrogenase; Methylation; Mutation | 2016 |
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epithelial-Mesenchymal Transition; Gene Silencing; Histones; Homeodomain Proteins; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; Methylation; Mice; Neoplasm Metastasis; Neoplastic Stem Cells; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Kinase C-alpha; Repressor Proteins; RNA Interference; Spheroids, Cellular; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zinc Finger E-box Binding Homeobox 2 | 2016 |
Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin; Cyclin D1; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Neoplastic; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Mice; Oligopeptides; Phosphorylation; Protamine Kinase; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Threonine; Ubiquitination | 2016 |
Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.
Topics: Amino Acid Substitution; Cell Line, Transformed; Cell Transformation, Neoplastic; Chondrocytes; Chromatin; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mutation; Protein Processing, Post-Translational; Signal Transduction | 2017 |
Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.
Topics: Acinar Cells; Animals; Carcinoma, Pancreatic Ductal; Cell Plasticity; Cell Proliferation; Cell Transdifferentiation; Cell Transformation, Neoplastic; Ceruletide; Cyclin-Dependent Kinase Inhibitor p16; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Gene Silencing; Histones; Humans; Methylation; Mice; NFATC Transcription Factors; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Regeneration; Signal Transduction; Transcription, Genetic | 2017 |
Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Methylation; MicroRNAs; Protein Binding; Protein Biosynthesis; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic | 2008 |
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Topics: Cell Transformation, Neoplastic; Co-Repressor Proteins; DNA-Binding Proteins; Down-Regulation; Epithelial Cells; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydro-Lyases; Lysine; Methylation; Multiprotein Complexes; Nerve Tissue Proteins; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Protein Binding; Protein Methyltransferases; Proteins; Proto-Oncogene Mas; Receptor, trkC; Repressor Proteins; RNA Interference; Transcription, Genetic | 2008 |
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.
Topics: Acetylation; Binding Sites; Cell Line, Tumor; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Crystallography, X-Ray; Histones; Humans; Methylation; Models, Molecular; Peptides; Protein Conformation; Substrate Specificity; Tumor Suppressor Proteins | 2009 |
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Topics: Arsenites; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromates; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Nickel; Potassium Compounds; Protein Processing, Post-Translational; Sodium Compounds; Time Factors | 2009 |
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
Topics: Amino Acid Motifs; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genes, Homeobox; Hematologic Neoplasms; Hematopoiesis; Hematopoietic Stem Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Magnetic Resonance Spectroscopy; Methylation; Mice; Models, Molecular; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion; Protein Binding; Protein Conformation; Retinoblastoma-Binding Protein 2; Transcription, Genetic; Tumor Suppressor Proteins | 2009 |
Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Deacetylases; Histones; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2 | 2009 |
Transformation from committed progenitor to leukemia stem cells.
Topics: Animals; Cell Transformation, Neoplastic; Hematopoietic Stem Cells; Histones; Humans; Leukemia, Myeloid, Acute; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells | 2009 |
Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cyclin D1; Humans; Kinetics; Mammary Glands, Human; Methylation; Methyltransferases; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; ras Proteins; RNA Caps; Up-Regulation | 2010 |
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Binding Sites; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; ELAV Proteins; ELAV-Like Protein 1; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Glycine N-Methyltransferase; Half-Life; Hepatocytes; Heterogeneous Nuclear Ribonucleoprotein D0; Heterogeneous-Nuclear Ribonucleoprotein D; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; RNA Interference; RNA Processing, Post-Transcriptional; RNA Stability; RNA-Binding Proteins; RNA, Messenger; S-Adenosylmethionine; Signal Transduction; Transfection | 2010 |
When speed matters: leukemogenic transformation by MLL fusion proteins.
Topics: Animals; Cell Transformation, Neoplastic; Drosophila melanogaster; Histones; Humans; Leukemia; Methylation; Models, Biological; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Signal Transduction | 2010 |
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
Topics: Animals; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Cyclin-Dependent Kinase Inhibitor p16; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibroblasts; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Models, Genetic; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins; SMARCB1 Protein; Stem Cells; T-Lymphocytes; Transcription, Genetic; Up-Regulation | 2010 |
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Leukemia, Experimental; Lysine; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein | 2010 |
Possible involvement of loss of imprinting in immortalization of human fibroblasts.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; DNA Methylation; Female; Fibroblasts; Gene Expression Profiling; Genomic Imprinting; Histones; Humans; Male; Methylation; Methyltransferases; Polymorphism, Genetic; Promoter Regions, Genetic; Transcription, Genetic | 2011 |
Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neoplastic; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histones; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Methylation; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Tumor Suppressor Proteins | 2011 |
Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Survival; Cell Transformation, Neoplastic; Disease Progression; Gene Expression Regulation, Neoplastic; Histones; Humans; Male; Methylation; Mice; Mice, SCID; Neoplastic Stem Cells; Polycomb-Group Proteins; Prostatic Neoplasms; Repressor Proteins; RNA, Messenger; Spheroids, Cellular; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
Conformational role for the C-terminal tail of the intrinsically disordered high mobility group A (HMGA) chromatin factors.
Topics: Amino Acid Sequence; Cell Transformation, Neoplastic; Chromatin; HMGA Proteins; Humans; Methylation; Molecular Sequence Data; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteomics; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Static Electricity | 2011 |
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Topics: Animals; Apoptosis; Cell Cycle; Cell Differentiation; Cell Transformation, Neoplastic; Gene Rearrangement; Genetic Loci; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Methyltransferases; Mice; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Protein Processing, Post-Translational | 2011 |
Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 9; Confidence Intervals; DNA, Viral; Fanconi Anemia Complementation Group C Protein; Female; Gene Expression; Head and Neck Neoplasms; Homeodomain Proteins; Human papillomavirus 16; Human papillomavirus 18; Humans; Male; Methylation; Middle Aged; Odds Ratio; Patched Receptors; Patched-1 Receptor; Promoter Regions, Genetic; Receptors, Cell Surface; RNA, Messenger; Sequence Deletion; Xeroderma Pigmentosum Group A Protein; Young Adult | 2012 |
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Mice, SCID; Multiple Myeloma; Recombinant Proteins; Repressor Proteins; Signal Transduction; Transcription, Genetic; Translocation, Genetic; Xenograft Model Antitumor Assays | 2011 |
Proteomics analysis of in vitro protein methylation during Src-induced transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Humans; Methylation; Protein Processing, Post-Translational; Proteins; Proteome; Proteomics; Rats; src-Family Kinases | 2012 |
Arginine methylation controls growth regulation by E2F-1.
Topics: Apoptosis; Arginine; Cell Line, Tumor; Cell Transformation, Neoplastic; E2F1 Transcription Factor; Gene Expression Regulation; Humans; Methylation; Protein Methyltransferases; Protein Stability; Protein-Arginine N-Methyltransferases | 2012 |
Normal human melanocytes exposed to chronic insulin and glucose supplementation undergo oncogenic changes and methyl group metabolism cellular redistribution.
Topics: Blotting, Western; Cell Cycle; Cell Fractionation; Cell Transformation, Neoplastic; Child; Child, Preschool; Culture Media; DNA; Dose-Response Relationship, Drug; Glucose; Glycolysis; Humans; Hypoglycemic Agents; Insulin; Isotope Labeling; Karyotyping; Magnetic Resonance Spectroscopy; Male; Melanocytes; Methylation; Precancerous Conditions; Protein Phosphatase 2; Pyruvate Kinase; Signal Transduction; Stem Cells | 2012 |
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
Topics: Aged; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Damage; DNA Replication; Female; Histone-Lysine N-Methyltransferase; Humans; Lysine; Male; Methylation; Middle Aged; Proliferating Cell Nuclear Antigen; Real-Time Polymerase Chain Reaction; RNA, Small Interfering | 2012 |
Dissecting the genomic complexity underlying medulloblastoma.
Topics: Aging; Amino Acid Sequence; beta Catenin; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Child; Chromatin; Chromosomes, Human; DEAD-box RNA Helicases; DNA Helicases; DNA-Binding Proteins; Genome, Human; Genomics; Hedgehog Proteins; High-Throughput Nucleotide Sequencing; Histone Demethylases; Humans; Medulloblastoma; Methylation; Mutation; Mutation Rate; Neoplasm Proteins; Nuclear Proteins; Oncogene Proteins, Fusion; Patched Receptors; Patched-1 Receptor; Phosphoprotein Phosphatases; Polyploidy; Receptors, Cell Surface; Sequence Analysis, RNA; Signal Transduction; T-Box Domain Proteins; Transcription Factors; Wnt Proteins | 2012 |
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Hematopoietic System; Histones; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Methylation; Mice; Mutation; Myeloid Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; ras Proteins; Repressor Proteins; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin Thiolesterase; Up-Regulation | 2012 |
Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner.
Topics: Antigens, Polyomavirus Transforming; Carboxylic Ester Hydrolases; Cell Line; Cell Proliferation; Cell Size; Cell Survival; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation; Humans; Methylation; Protein Multimerization; Protein O-Methyltransferase; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; RNA Interference; Signal Transduction | 2012 |
The role of protein arginine-methyltransferase 1 in gliomagenesis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Glioma; Histones; Humans; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA Interference; RNA, Small Interfering; Transplantation, Heterologous; Up-Regulation | 2012 |
The role of a newly identified SET domain-containing protein, SETD3, in oncogenesis.
Topics: Animals; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cloning, Molecular; DNA End-Joining Repair; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lymphoma, B-Cell; Methylation; Mice; Tumor Suppressor Protein p53 | 2013 |
Epidermal growth factor receptor signaling in hepatocellular carcinoma: inflammatory activation and a new intracellular regulatory mechanism.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Transformation, Neoplastic; EGF Family of Proteins; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Hepatocytes; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Liver; Liver Neoplasms; MAP Kinase Signaling System; Methylation; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma.
Topics: Adult; Age Factors; Alcohol Drinking; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Connective Tissue; Cyclin-Dependent Kinase Inhibitor p16; Epithelium; Female; Genes, p16; Humans; Lichen Planus, Oral; Male; Methylation; MicroRNAs; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Polymerase Chain Reaction; Precancerous Conditions; Promoter Regions, Genetic; Risk Factors; Sex Factors; Time Factors | 2013 |
Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor.
Topics: Adolescent; Cell Transformation, Neoplastic; Child; Child, Preschool; Chromosome Aberrations; Core Binding Factor Alpha 3 Subunit; DNA Methylation; Epigenesis, Genetic; Female; Genomic Imprinting; Histones; Humans; Infant; Infant, Newborn; Male; Meiosis; Methylation; Mutation; Neoplasms, Germ Cell and Embryonal; Polymorphism, Single Nucleotide; snRNP Core Proteins; Uniparental Disomy | 2013 |
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Cullin Proteins; Cyclin-Dependent Kinase Inhibitor p16; DNA-Binding Proteins; Esophageal Neoplasms; Female; Histones; Humans; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Polycomb Repressive Complex 2; PTEN Phosphohydrolase; Transcription, Genetic; Transplantation, Heterologous; Ubiquitin-Protein Ligases; Ubiquitination; Up-Regulation | 2012 |
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; DNA Helicases; Genetic Loci; Genome; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Neuroblastoma; Peptides; Protein Binding; Structure-Activity Relationship | 2013 |
Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes.
Topics: Aged; Apoptosis; Apoptosis Regulatory Proteins; Bone Marrow Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Death-Associated Protein Kinases; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Male; Methylation; Middle Aged; Myelodysplastic Syndromes; Polymerase Chain Reaction | 2004 |
14-3-3sigma is down-regulated in human prostate cancer.
Topics: 14-3-3 Proteins; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Cell Line, Tumor; Cell Transformation, Neoplastic; Cysteine Endopeptidases; Down-Regulation; Exonucleases; Exoribonucleases; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Membrane Glycoproteins; Methylation; Multienzyme Complexes; Neoplasm Proteins; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Isoforms; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2004 |
Significance of beta-catenin and pRB pathway components in malignant ovarian germ cell tumours: INK4A promoter CpG island methylation is associated with cell proliferation.
Topics: Adolescent; Adult; beta Catenin; Cell Cycle Proteins; Cell Transformation, Neoplastic; Child; Child, Preschool; CpG Islands; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Cytoskeletal Proteins; DNA, Neoplasm; Female; Genes, p16; Germinoma; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Methylation; Mutation; Neoplasm Proteins; Ovarian Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Trans-Activators | 2004 |
Increased hTR expression during transition from adenoma to carcinoma is not associated with promoter methylation.
Topics: Adenocarcinoma; Adenoma; Base Sequence; Biopsy, Needle; Case-Control Studies; Cell Transformation, Neoplastic; Colonic Neoplasms; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; In Situ Hybridization; Male; Methylation; Molecular Sequence Data; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA; Sampling Studies; Sensitivity and Specificity; Telomerase | 2004 |
BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status.
Topics: Adenoma; Aged; Cell Transformation, Neoplastic; Colonic Polyps; Colorectal Neoplasms; CpG Islands; Female; Humans; Male; Methylation; Middle Aged; Mutation; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins | 2004 |
hDOT1L links histone methylation to leukemogenesis.
Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Proto-Oncogenes; Recombinant Fusion Proteins; RNA, Small Interfering; Saccharomyces cerevisiae; Stem Cells; Transcription Factors; Up-Regulation | 2005 |
Oncogene-induced senescence as an initial barrier in lymphoma development.
Topics: ADP-Ribosylation Factors; Animals; Apoptosis; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cellular Senescence; Chromosomal Instability; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, ras; Heterochromatin; Lymphoma; Methylation; Methyltransferases; Mice; Mice, Transgenic; Precancerous Conditions; Repressor Proteins; Transgenes; Tumor Suppressor Protein p53 | 2005 |
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Topics: Bone Morphogenetic Protein 3; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation; Genes, ras; Growth Differentiation Factor 10; Humans; Lung Neoplasms; Methylation; Mutation; Polymerase Chain Reaction; ras Proteins; Signal Transduction; Tumor Cells, Cultured | 2005 |
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; COS Cells; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Morpholines; Phosphorylation; Polycomb Repressive Complex 2; Protein Binding; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Transcription Factors | 2005 |
Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis.
Topics: Aged; Alleles; Cell Transformation, Neoplastic; Clone Cells; Cluster Analysis; Disease Progression; Epigenesis, Genetic; Humans; Male; Methylation; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms | 2006 |
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
Topics: Adenoma; Base Sequence; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; Epigenesis, Genetic; Genotype; Humans; Methylation; Mutation; Proto-Oncogene Proteins p21(ras); Tumor Suppressor Protein p53 | 2006 |
Ni(II) affects ubiquitination of core histones H2B and H2A.
Topics: Cell Line; Cell Transformation, Neoplastic; Histones; Humans; Lung; Methylation; Nickel; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2006 |
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Histones; Methylation; Rats | 2007 |
Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; CpG Islands; Epithelial Cells; Humans; Intestinal Mucosa; Methylation; Microsatellite Instability; Models, Biological; Mutation; MutL Protein Homolog 1; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf | 2007 |
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Topics: Acetylation; Acute Disease; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Methylation; Mice; Mice, Knockout; Molecular Sequence Data; Mutation; Myeloid Progenitor Cells; Nuclear Pore Complex Proteins; Nuclear Proteins; Oncogene Proteins, Fusion; Spectrophotometry, Atomic; Transcriptional Activation; Translocation, Genetic | 2007 |
Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression.
Topics: Animals; Blotting, Western; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogens; Female; Gene Expression Regulation; Histones; Mammary Neoplasms, Experimental; Methylation; MicroRNAs; Rats | 2007 |
Protein arginine-methyltransferase-dependent oncogenesis.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Arginine; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation; HeLa Cells; Histones; Homeodomain Proteins; Humans; Immunoprecipitation; Methylation; Mutation; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Transfection | 2007 |
cAMP signaling induces rapid loss of histone H3 phosphorylation in mammary adenocarcinoma-derived cell lines.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, cdc; Histones; Humans; Mammary Neoplasms, Animal; Methylation; Mice; Phosphorylation; Regulatory Elements, Transcriptional; Signal Transduction | 2008 |
Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer.
Topics: Biomarkers; Biomarkers, Tumor; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Methylation; Esophageal Neoplasms; Humans; Methylation; Prognosis; Promoter Regions, Genetic; Risk; RNA; Sensitivity and Specificity; Tachykinins | 2007 |
Carcinogenesis and the hypothesis of phylogenetic reversion.
Topics: Animals; Cell Transformation, Neoplastic; Chemoprevention; CpG Islands; Gene Silencing; Humans; Karyometry; Methylation; Neoplasms; Phylogeny | 2007 |
Id1 delays senescence of primary human melanocytes.
Topics: Cell Division; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Foreskin; Humans; In Situ Hybridization, Fluorescence; Infant, Newborn; Inhibitor of Differentiation Protein 1; Male; Melanocytes; Methylation; Promoter Regions, Genetic; Telomere | 2008 |
Inhibition of polyoma gene expression in transformed mouse cells by hypermethylation.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Methylation; Mice; Mice, Inbred Strains; Mutation; Nucleic Acid Hybridization; Plasmids; Polyomavirus | 1984 |
Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells.
Topics: 5-Methylcytosine; Animals; Avian Sarcoma Viruses; Azacitidine; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cytosine; DNA Restriction Enzymes; DNA, Viral; Methylation; Rats; Transcription, Genetic | 1984 |
Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine.
Topics: Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; DNA; Kidney; Methylation; Mutagenicity Tests; Mutagens; Mutation | 1984 |
Moloney murine leukemia virus-induced tumors: recombinant proviruses in active chromatin regions.
Topics: AKR murine leukemia virus; Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Chromatin; Deoxyribonuclease I; Deoxyribonucleases; DNA Restriction Enzymes; DNA, Recombinant; Endonucleases; Leukemia, Experimental; Methylation; Mice; Mice, Inbred BALB C; Moloney murine leukemia virus | 1982 |
DNA methylation levels in normal and chemically-transformed mouse 3T3 cells.
Topics: 5-Methylcytosine; Animals; Base Composition; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Cytosine; DNA; Methylation; Methylcholanthrene; Mice | 1982 |
Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; DNA Restriction Enzymes; Genes; Genes, Viral; Methylation; Mice; Moloney murine leukemia virus; Muridae; Rats; Sarcoma Viruses, Murine; Transcription, Genetic | 1982 |
Chromatin structure interferes with excision of abnormal bases from DNA.
Topics: Cell Line; Cell Transformation, Neoplastic; Chromatin; DNA; DNA Glycosylases; DNA Repair; Female; Herpesvirus 4, Human; Humans; Kinetics; Lymphocytes; Methylation; N-Glycosyl Hydrolases; Nucleosomes; Uracil | 1982 |
Can DNA methylation regulate gene expression?
Topics: 5-Methylcytosine; Adenoviruses, Human; Animals; Cell Line; Cell Transformation, Neoplastic; Cytosine; DNA; DNA Restriction Enzymes; DNA, Viral; Female; Genes; Humans; Methylation; Oocytes; Operon; Transcription, Genetic; Xenopus | 1983 |
Regulation of viral and cellular oncogene expression by cytosine methylation.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cloning, Molecular; Cytosine; DNA, Viral; Gene Expression Regulation; Genes, Viral; Methylation; Mink; Oncogenes; Rats; Recombination, Genetic; Retroviridae; Sarcoma Viruses, Feline; Transfection | 1983 |
DNA methylation and gene activity: the adenovirus system as a model.
Topics: Adenoviridae; Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Humans; Methylation; Operon | 1983 |
Organization of polyoma virus DNA in mouse tumor cell lines.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromosome Deletion; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Methylation; Mice; Polyomavirus; Recombination, Genetic; Repetitive Sequences, Nucleic Acid | 1984 |
The chromosomal integration site determines the tissue-specific methylation of mouse mammary tumour virus proviral genes.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Chromosome Mapping; Chromosomes; DNA Restriction Enzymes; Genes, Viral; Liver; Mammary Tumor Virus, Mouse; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Simian virus 40; Species Specificity | 1984 |
Structural changes of carbohydrate chains of human thyroglobulin accompanying malignant transformations of thyroid glands.
Topics: Carbohydrate Conformation; Carcinoma, Papillary; Cell Transformation, Neoplastic; Chromatography, DEAE-Cellulose; Chromatography, Gel; Humans; Magnetic Resonance Spectroscopy; Methylation; Oligosaccharides; Thyroglobulin; Thyroid Gland; Thyroid Neoplasms | 1984 |
DNA sequences involved in the rearrangement and expression of the murine c-myc gene.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; DNA; DNA, Neoplasm; Humans; Kidney; Liver; Methylation; Mice; Mice, Inbred BALB C; Oncogenes; Plasmacytoma; Species Specificity; Transcription, Genetic; Translocation, Genetic | 1984 |
Methylating and ethylating carcinogens have different requirements for poly(ADP-ribose) synthesis during malignant transformation.
Topics: Alkylating Agents; Animals; Benzamides; Carcinogens; Cell Transformation, Neoplastic; DNA Repair; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose | 1984 |
Expression of cellular oncogenes in human malignancies.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Female; Gastrointestinal Neoplasms; Gene Amplification; Genes, Viral; Genital Neoplasms, Female; Humans; Kidney Neoplasms; Leukemia; Lymphoma; Methylation; Mutation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; RNA, Messenger; RNA, Neoplasm; Sarcoma; Transcription, Genetic; Translocation, Genetic | 1984 |
Effect of DNA methylation on gene expression.
Topics: Adenine Phosphoribosyltransferase; Adenoviridae; Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Genes; Globins; Humans; L Cells; Macromolecular Substances; Methylation; Teratoma | 1983 |
Retroviruses and embryogenesis: de novo methylation activity involved in gene expression.
Topics: Animals; Blastocyst; Cell Line; Cell Transformation, Neoplastic; DNA, Viral; Embryo Implantation; Embryo, Mammalian; Female; Genes, Viral; Methylation; Mice; Moloney murine leukemia virus; Pregnancy; Transfection | 1983 |
Alteration of enzymatic methylation of DNA cytosines by chemical carcinogens: a mechanism involved in the initiation of carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Humans; Methylation; Methyltransferases; Oncogenes | 1983 |
Significance of S-adenosylmethionine pools in the hypomethylation of ribosomal RNA during the propagation of tissue culture cells and oncogenesis.
Topics: Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Child; Fibroblasts; HeLa Cells; Humans; Kidney; Kinetics; Liver; Liver Regeneration; Male; Methylation; Osteosarcoma; Rats; Rats, Inbred Strains; RNA, Ribosomal; S-Adenosylhomocysteine; S-Adenosylmethionine | 1983 |
Activation of dormant genes in specialized cells.
Topics: Animals; Anura; Cell Differentiation; Cell Fusion; Cell Transformation, Neoplastic; Chickens; Chromatin; DNA; Drosophila; Embryo, Mammalian; Embryo, Nonmammalian; Extremities; Gene Expression Regulation; Humans; Hybrid Cells; Iris; Methylation; Mice; Nuclear Transfer Techniques; Phenotype; Rats; Xenopus | 1984 |
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship | 1984 |
Early changes in phosphatidylcholine metabolism in human acute promyelocytic leukemia cells stimulated to differentiate by phorbol ester.
Topics: Cell Transformation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Methylation; Phorbol Esters; Phorbols; Phosphatidylcholines; Phospholipids; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
Topics: Cell Line; Cell Transformation, Neoplastic; Cross-Linking Reagents; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylation; Mutation; Nitrosourea Compounds; Peptide Hydrolases | 1980 |
Cycle-dependent removal of certain methylated bases from DNA of 10T1/2 cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Base Composition; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Replication; Interphase; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Time Factors | 1981 |
Alkylation of DNA and tissue specificity in nitrosamine carcinogenesis.
Topics: Alkylation; Animals; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Dimethylnitrosamine; DNA; DNA Repair; Liver; Liver Neoplasms; Mesocricetus; Methylation; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Rats; Structure-Activity Relationship | 1981 |
Increased DT-diaphorase activity in transformed and tumorigenic pancreatic acinar cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; In Vitro Techniques; Methylation; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1995 |
Methylation and p16: suppressing the suppressor.
Topics: 5-Methylcytosine; Carrier Proteins; Cell Transformation, Neoplastic; Cocarcinogenesis; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; DNA; Gene Expression Regulation; Genes, Tumor Suppressor; Genomic Imprinting; Humans; Methylation; Models, Genetic; Neoplasms | 1995 |
DNA methylation is not involved in the structural alterations of ornithine decarboxylase or total chromatin of c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Cell Cycle; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatin; DNA; Genes, ras; Methylation; Mice; Nucleotide Mapping; Ornithine Decarboxylase; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid | 1995 |
Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin.
Topics: Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; DNA; DNA Damage; DNA, Satellite; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Lymphocytes; Methylation; Nucleic Acid Denaturation | 1993 |
Regulation of DNA methylation by the Ras signaling pathway.
Topics: Adrenal Cortex Neoplasms; Animals; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; DNA, Complementary; DNA, Neoplasm; Genes, ras; GTPase-Activating Proteins; Humans; Methylation; Methyltransferases; Mice; Oncogene Protein p65(gag-jun); Promoter Regions, Genetic; Proteins; ras GTPase-Activating Proteins; ras Proteins; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured | 1995 |
Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments.
Topics: Adenoviridae; Animals; Bacteriophage lambda; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Clone Cells; Cricetinae; DNA; DNA Probes; DNA, Viral; In Situ Hybridization, Fluorescence; Mesocricetus; Methylation; Plasmids; Transcription, Genetic; Transfection; Virus Integration | 1995 |
Polylysine domain of K-ras 4B protein is crucial for malignant transformation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Compartmentation; Cell Membrane; Cell Transformation, Neoplastic; In Vitro Techniques; Lysine; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Rats; Structure-Activity Relationship | 1994 |
Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.
Topics: Adenylyl Cyclases; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Blotting, Southern; Cell Transformation, Neoplastic; Drug Resistance; Genes; Isoproterenol; Methylation; Mice; Mutation; Receptors, Adrenergic, beta; Receptors, Corticotropin; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. III. Biological properties and mechanism of action.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antifungal Agents; Cell Transformation, Neoplastic; Genes, ras; Mating Factor; Methylation; Mice; Oncogene Protein p21(ras); Peptides; Piperidones; Protein Biosynthesis; Protein O-Methyltransferase; Signal Transduction; Transferases | 1994 |
Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation.
Topics: 5-Methylcytosine; Animals; Base Sequence; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cytosine; DNA Primers; DNA Replication; Enhancer Elements, Genetic; Gene Expression Regulation; Heterochromatin; Humans; Methylation; Mice; Molecular Sequence Data; MyoD Protein; Promoter Regions, Genetic; Restriction Mapping | 1994 |
Methylation sensitivity of the enhancer from the human papillomavirus type 16.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; DNA, Viral; Enhancer Elements, Genetic; Genes, Viral; HeLa Cells; Humans; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Papillomaviridae; Regulatory Sequences, Nucleic Acid; Transcription Factors; Transcription, Genetic; Transfection | 1994 |
Depression of catalase gene expression after immortalization and transformation of mouse liver cells.
Topics: Animals; Catalase; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Liver; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Transcription, Genetic | 1993 |
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dexamethasone; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Primers; Gene Expression; Kinetics; Mammary Tumor Virus, Mouse; Methylation; Mice; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Promoter Regions, Genetic; Transfection | 1993 |
Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.
Topics: Base Sequence; Bronchi; Calcitonin; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Cytosine; DNA; Epithelium; Guanine; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Tumor Cells, Cultured | 1993 |
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Death; Cell Survival; Cell Transformation, Neoplastic; Cytosine; DNA; DNA-Cytosine Methylases; Gene Expression; Gene Expression Regulation, Enzymologic; Methylation; Mice; Molecular Sequence Data; Transfection | 1996 |
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Topics: Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Complementary; DNA, Neoplasm; Escherichia coli; Humans; Intestinal Mucosa; Methylation; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Thymidine; Uracil-DNA Glycosidase | 1996 |
Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts.
Topics: Antigens, Polyomavirus Transforming; Blotting, Western; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Fibroblasts; Humans; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Simian virus 40 | 1996 |
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA-Cytosine Methylases; Gene Expression; Hyperplasia; Lung; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Species Specificity | 1996 |
Different methylation patterns of the M-BCR gene in myeloblastic and lymphoblastic crisis of chronic myelocytic leukemia.
Topics: Blast Crisis; Cell Transformation, Neoplastic; Gene Rearrangement; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methylation; Oncogene Proteins; Oncogenes; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcr | 1996 |
Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Chronic Disease; DNA, Neoplasm; Female; Gastritis; Gastritis, Atrophic; Humans; Male; Methylation; Middle Aged; Precancerous Conditions; Stomach Neoplasms | 1996 |
Identification of highly methylated arginine residues in an endogenous 20-kDa polypeptide in cancer cells.
Topics: Animals; Cell Extracts; Cell Transformation, Neoplastic; HeLa Cells; Humans; Methylation; Neoplasm Proteins; Protein-Arginine N-Methyltransferases; Tritium; Tumor Cells, Cultured | 1999 |
p16 is a major inactivation target in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; DNA, Neoplasm; Gene Deletion; Genes, p16; Humans; Liver Neoplasms; Methylation; Promoter Regions, Genetic; Proteins; RNA; Transcription Factors; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2000 |
Molecular alteration of alpha-induced transformed Syrian hamster embryo cells.
Topics: Alpha Particles; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Genes, myc; Genes, p53; Genes, ras; In Vitro Techniques; Mesocricetus; Methylation; Plutonium; Point Mutation | 1997 |
Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail.
Topics: Blotting, Western; Cadherins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Humans; Melanoma; Methylation; Oligonucleotides, Antisense; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Transcription Factor AP-2; Transcription Factors; Transfection; Tumor Cells, Cultured; Up-Regulation | 2001 |
Imbalance of estrogen homeostasis in kidney and liver of hamsters treated with estradiol: implications for estrogen-induced initiation of renal tumors.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; DNA Adducts; Estradiol; Estrogens; Estrogens, Catechol; Homeostasis; Kidney; Kidney Neoplasms; Liver; Male; Mesocricetus; Methylation; Oxidoreductases; Quinones | 2001 |
Origin of colorectal cancers in hyperplastic polyps and serrated adenomas: another truism bites the dust.
Topics: Adaptor Proteins, Signal Transducing; Adenoma; Carrier Proteins; Case-Control Studies; Cell Transformation, Neoplastic; Colonic Polyps; Colorectal Neoplasms; DNA, Neoplasm; Humans; Hyperplasia; Methylation; Microsatellite Repeats; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Odds Ratio | 2001 |
Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas.
Topics: Adaptor Proteins, Signal Transducing; Adenoma; Aged; Carrier Proteins; Case-Control Studies; Cell Transformation, Neoplastic; Colonic Polyps; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Hyperplasia; Immunohistochemistry; Male; Methylation; Microsatellite Repeats; Middle Aged; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic | 2001 |
Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma.
Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Cell Transformation, Neoplastic; Child; Cyclin-Dependent Kinase Inhibitor p16; DNA, Neoplasm; Exons; Female; Fungal Proteins; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunohistochemistry; Male; Methylation; Middle Aged; Osteosarcoma; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Serine Endopeptidases; Transcription, Genetic; Tumor Suppressor Protein p53 | 2001 |
Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation.
Topics: Blotting, Southern; Cell Cycle Proteins; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Genes, p16; Genes, Tumor Suppressor; Humans; Leukemia; Methylation; Polymerase Chain Reaction; Precancerous Conditions; Primary Myelofibrosis; Tumor Suppressor Proteins | 2002 |
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylation; Animals; Benzofurans; Breast; Catechin; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indonesia; Isoenzymes; Membrane Proteins; Methylation; Mice; Mice, Inbred BALB C; Molecular Structure; Moraceae; Nuclear Magnetic Resonance, Biomolecular; Organ Culture Techniques; Plant Bark; Plant Extracts; Plant Shoots; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Stilbenes | 2002 |
The sequence specificity of vertebrate DNA methylation.
Topics: Animals; Base Sequence; Biological Evolution; Cell Fractionation; Cell Line; Cell Transformation, Neoplastic; Cytosine; Deoxyribonucleotides; DNA; HeLa Cells; L Cells; Methionine; Methylation; Polyomavirus; Species Specificity; Vertebrates | 1977 |
Decreased rate of S-adenosyl-L-homocysteine metabolism: an early event related to transformation in cells infected with Rous sarcoma virus.
Topics: Adenosine; Adenosine Deaminase; Amino Acid Oxidoreductases; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Homocysteine; Hydrolases; Methylation; Neoplasm Proteins; Proteins; S-Adenosylhomocysteine; Tumor Virus Infections | 1977 |
A new theory of carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Repair; Genes; Humans; Methylation; Methyltransferases; Mutagens; Mutation; Neoplasms; Phenotype; Probability | 1979 |
[Changes in the specificity of DNA methylation in cattle blood lymphocytes under chronic lymphoid leukemia].
Topics: Animals; Cattle; Cattle Diseases; Cell Transformation, Neoplastic; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Leukemia, Lymphoid; Lymphocytes; Methylation; Transcription, Genetic | 1978 |
Structural alterations of the ribosomal RNA genes in leukemic cells.
Topics: Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; DNA, Ribosomal; Female; Gene Amplification; Gene Rearrangement; Hematopoietic System; Leukemia; Leukemia, Erythroblastic, Acute; Male; Methylation; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Rats; Rats, Wistar; Rauscher Virus; RNA, Neoplasm; RNA, Ribosomal; Tumor Virus Infections | 1992 |
Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXVII. Intermediate generalizations (Part B).
Topics: alpha-Fetoproteins; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; DNA; Fetal Proteins; Gene Expression; Liver; Methylation; Mice; Models, Biological | 1992 |
Changes of DNA methylation in protooncogenes in the process of radiation-induced transformation of mouse m5S/1M cells in vitro.
Topics: Animals; Blotting, Southern; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; Methylation; Mice; Proto-Oncogenes | 1992 |
Studies on the mechanisms of HTLV-I leukemogenesis.
Topics: Cell Transformation, Neoplastic; DNA Damage; Genes, pX; HTLV-I Infections; Humans; Leukemia, T-Cell; Methylation; Micronucleus Tests; Plasmids; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1992 |
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Compartmentation; Cell Membrane; Cell Transformation, Neoplastic; Endopeptidases; Farnesol; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras) | 1992 |
Epigenetic control of tumor cell morphology.
Topics: Actins; Animals; Avian Sarcoma Viruses; Blotting, Southern; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cytoskeletal Proteins; DNA, Neoplasm; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; Rats; Restriction Mapping; Sarcoma, Avian; Transplantation, Heterologous; Vinculin | 1991 |
Altered oncogenes in UV-transformed C3H 10T1/2 mouse cells: identification of mutated H-ras allele(s).
Topics: Alleles; Animals; Blotting, Northern; Blotting, Southern; Cell Line, Transformed; Cell Transformation, Neoplastic; Genes, ras; In Vitro Techniques; Methylation; Mice; Mutation; Ultraviolet Rays | 1991 |
Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Differentiation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Decitabine; DNA; Genes, ras; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger | 1991 |
Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blood; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA-Binding Proteins; Gene Expression Regulation; Genes, myc; Genes, ras; Leucine Zippers; Methylation; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myc; Transfection | 1991 |
An intron binding protein is required for transformation ability of p53.
Topics: Animals; Base Sequence; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; DNA-Binding Proteins; Gene Expression; Genes, p53; Guanidine; Guanidines; Introns; Methylation; Mice; Molecular Sequence Data; Mutation; Regulatory Sequences, Nucleic Acid | 1991 |
Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Transformation, Neoplastic; Cloning, Molecular; DNA; DNA-Binding Proteins; Genes, ras; Leucine Zippers; Macromolecular Substances; Methylation; Molecular Sequence Data; Mutagenesis; Oligonucleotide Probes; Protein Conformation; Proto-Oncogene Proteins c-myc; Rabbits; Rats; Recombinant Fusion Proteins | 1991 |
Altered methylation of versican proteoglycan gene in human colon carcinoma.
Topics: Blotting, Southern; Cell Transformation, Neoplastic; Chondroitin Sulfate Proteoglycans; Colon; Colonic Neoplasms; DNA; DNA, Neoplasm; Humans; Inflammation; Lectins, C-Type; Methylation; Muscle, Smooth; Reference Values; Restriction Mapping; Versicans | 1990 |
Activation of cellular oncogenes by chemical carcinogens in Syrian hamster embryo fibroblasts.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; DNA; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Mesocricetus; Methylation; Mutation; Proto-Oncogenes | 1990 |
Transfection with fragments of the adenovirus 12 gene induces tumorigenicity-associated alteration of N-linked sugar chains in rat cells.
Topics: Adenoviridae; Animals; Carbohydrate Conformation; Carbohydrate Sequence; Cell Line; Cell Transformation, Neoplastic; Chromatography, Affinity; Genes, Viral; Glycosylation; Methylation; Molecular Sequence Data; Oligosaccharides; Rats; RNA, Messenger; Transfection | 1990 |
De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.
Topics: Animals; Base Sequence; Blotting, Southern; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dinucleoside Phosphates; DNA; DNA Probes; Embryo, Mammalian; Methylation; Methylcholanthrene; Mice; Molecular Sequence Data; MyoD Protein; Nuclear Proteins; Oligonucleotide Probes; Phosphoproteins; Polymerase Chain Reaction; Restriction Mapping | 1990 |
Effects of 5-azacytidine on the progressive nature of cell transformation.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Methylation; Mice | 1985 |
Interaction between nontransforming retroviruses and chemicals in cells in vitro: association with progression to neoplastic phenotypes.
Topics: Animals; Azacitidine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; DNA; Methylation; Oncogenes; Phenotype; Rats; Rats, Inbred F344; Retroviridae | 1985 |
Effects of sodium butyrate on the synthesis and methylation of DNA in normal cells and their transformed counterparts.
Topics: Butyrates; Butyric Acid; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Methylation; Protein Biosynthesis; RNA | 1986 |
Effects of 5-azacytidine on expression of endogenous retrovirus-related sequences in C3H 10T1/2 cells.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA, Viral; Fibroblasts; Genes, Intracisternal A-Particle; Mammary Tumor Virus, Mouse; Methylation; Mice; Mice, Inbred C3H; Poly A; Repetitive Sequences, Nucleic Acid; Retroviridae; RNA; RNA, Messenger; RNA, Viral; Transcription, Genetic | 1986 |
In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Decitabine; DNA; Dose-Response Relationship, Drug; Epithelium; Male; Methylation; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Inbred F344; Time Factors; Trachea | 1986 |
DNA methylation affecting the transforming activity of the human Ha-ras oncogene.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Humans; Methylation; Mice; Oncogenes; Plasmids; Transfection | 1987 |
Reversion to the nontransformed phenotype of Abelson murine leukemia virus-transformed cells and their subsequent retransformation.
Topics: Abelson murine leukemia virus; Animals; Cell Line; Cell Transformation, Neoplastic; DNA Restriction Enzymes; DNA, Viral; Leukemia Virus, Murine; Lung; Methylation; Mink; Phenotype; RNA; RNA, Viral | 1986 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Metallothionein; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mutation; Proto-Oncogenes; Tetradecanoylphorbol Acetate | 1987 |
Modulation of N-myc expression, but not tumorigenicity, accompanies phenotypic conversion of neuroblastoma cells in prolonged culture.
Topics: Azacitidine; Cell Line; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Humans; Methylation; Neuroblastoma; Oncogenes; Phenotype; Time Factors; Tumor Cells, Cultured | 1988 |
Modulation of the human Harvey-ras oncogene expression by DNA methylation.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; DNA; Gene Expression Regulation; Genes, ras; Humans; Methylation; Mice; Restriction Mapping; Transfection | 1988 |
Spontaneous and 5-azacytidine-induced revertants of methionine-dependent tumor-derived and H-ras-1-transformed cells.
Topics: Animals; Azacitidine; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Culture Media; Ethyl Methanesulfonate; Homocysteine; Methionine; Methylation; Oncogenes; Tumor Cells, Cultured | 1989 |
5-azacytidine-induced tumorous transformation and DNA hypomethylation in Nicotiana tissue cultures.
Topics: 5-Methylcytosine; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Cytosine; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoresis, Agar Gel; Methylation; Plant Tumors; Thymidine; Time Factors | 1989 |
Germ line c-myc is not down-regulated by loss or exclusion of activating factors in myc-induced macrophage tumors.
Topics: Animals; Base Sequence; Bucladesine; Cell Transformation, Neoplastic; Chromatin; Colony-Stimulating Factors; Deoxyribonuclease I; DNA; Exons; Gene Expression Regulation; Humans; Macrophages; Methylation; Mice; Molecular Sequence Data; Oncogenes; RNA; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1989 |
Consistent oncogene methylation changes in epithelial cells chemically transformed in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Benzo(a)pyrene; Blotting, Southern; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Epithelial Cells; Epithelium; Genes, ras; Male; Methylation; Proto-Oncogenes; Rats; Rats, Inbred F344; Restriction Mapping; Tetradecanoylphorbol Acetate; Trachea | 1989 |
Alterations in c-abl gene methylation in cells transformed by phagocyte-generated oxidants.
Topics: Animals; Blotting, Southern; Cell Line; Cell Transformation, Neoplastic; DNA; Methylation; Mice; Mice, Inbred C3H; Neutrophils; Phagocytes; Polymorphism, Restriction Fragment Length; Proto-Oncogenes | 1989 |
[Studies on DNA methylation in transformed mouse liver cells].
Topics: Animals; Cell Transformation, Neoplastic; DNA Modification Methylases; Liver; Liver Neoplasms, Experimental; Male; Methylation; Mice | 1989 |
Activation of the c-Ha-ras-1 proto-oncogene by methylation in vitro with alpha-acetoxy-N-nitrosodimethylamine.
Topics: Animals; Blotting, Southern; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Dimethylnitrosamine; DNA; DNA Mutational Analysis; DNA-Directed DNA Polymerase; Gene Amplification; Gene Expression Regulation; Genes, ras; Humans; Male; Methylation; Mice; Mice, Inbred CBA; Oligonucleotide Probes; Plasmids; Proto-Oncogene Mas; Taq Polymerase; Transfection | 1989 |
The block of thyroglobulin synthesis, which occurs upon transformation of rat thyroid epithelial cells, is at the transcriptional level and it is associated with methylation of the 5' flanking region of the gene.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; DNA; Epithelium; Genes; Kirsten murine sarcoma virus; Methylation; Rats; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Thyroglobulin; Thyroid Gland; Transcription, Genetic | 1989 |
The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; DNA Restriction Enzymes; DNA, Viral; Embryo, Mammalian; Fibroblasts; Methylation; Proviruses; Rats; Rats, Inbred Strains | 1987 |
Introduction of cloned human papillomavirus 1a DNA into rat fibroblasts: integration, de novo methylation and absence of cellular morphological transformation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cloning, Molecular; DNA, Viral; Fibroblasts; Genes, Viral; Humans; Methylation; Papillomaviridae; Plasmids; Rats; Recombination, Genetic; Transfection | 1985 |
Modulation of gene expression through DNA-binding proteins: is there a regulatory code?
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; DNA-Binding Proteins; DNA, Viral; Gene Expression Regulation; Genes; Glucocorticoids; Mammary Tumor Virus, Mouse; Methylation; Mice; Nucleic Acid Conformation; Repetitive Sequences, Nucleic Acid; Transcription, Genetic | 1985 |
Site-specific promoter methylations and gene inactivation.
Topics: Adenoviruses, Human; Animals; Base Sequence; Cell Nucleus; Cell Transformation, Neoplastic; DNA; DNA Restriction Enzymes; DNA, Viral; Female; Genes; Histones; Humans; Methylation; Oocytes; Promoter Regions, Genetic; Xenopus | 1985 |
Decreased methylation rates of DNA in SV40-transformed human fibroblasts.
Topics: Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Fibroblasts; Gene Expression Regulation; Humans; Methionine; Methylation; S-Adenosylmethionine; Simian virus 40 | 1986 |
Inducible binding of a factor to the c-fos regulatory region.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA Restriction Enzymes; DNA-Binding Proteins; Genes, Regulator; Methylation; Mice; Mice, Inbred BALB C; Proto-Oncogenes; Transcription, Genetic; Transduction, Genetic | 1987 |
Mammary preneoplasia and tumorigenesis in the BALB/c mouse: structure and modification of mouse mammary tumor virus DNA sequences.
Topics: 5-Methylcytosine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cytosine; DNA Restriction Enzymes; DNA, Viral; Female; Genes, Viral; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Methylation; Mice; Mice, Inbred BALB C; Precancerous Conditions; Recombination, Genetic; Virus Replication | 1987 |
Specific BPDE I modification of replicating and parental DNA from early S phase human foreskin fibroblasts.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Adducts; DNA Replication; Fibroblasts; Humans; Interphase; Male; Methylation; Nucleotides | 1986 |
Characterization of a tumorigenic murine T-lymphoid-cell line spontaneously derived from an IL-2-dependent T-cell line.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Interleukin-2; Karyotyping; Methylation; Mice; Neoplasms, Experimental; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes, Cytotoxic | 1986 |
The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.
Topics: Abelson murine leukemia virus; Animals; B-Lymphocytes; Cell Line; Cell Transformation, Neoplastic; Enhancer Elements, Genetic; Genes, Immunoglobulin; Genes, Regulator; Immunoglobulin kappa-Chains; Immunoglobulin Light Chains; Methylation; Transcription, Genetic; Transfection | 1988 |
Hypomethylated state of estrogen receptor gene in endometrial carcinomas.
Topics: Adenocarcinoma; Cell Transformation, Neoplastic; DNA, Neoplasm; Endometrial Hyperplasia; Female; Humans; Methylation; Receptors, Estrogen; Uterine Neoplasms | 1988 |
Methylation of the alpha 2(I) collagen gene in chemically transformed rat liver epithelial cells.
Topics: Acetoxyacetylaminofluorene; Animals; Cell Line; Cell Transformation, Neoplastic; Collagen; DNA; Electrophoresis, Agar Gel; Epithelium; Genes; Liver; Methylation; Promoter Regions, Genetic; Rats; Transcription, Genetic; Tumor Cells, Cultured | 1988 |
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies.
Topics: Acute Disease; Calcitonin; Cell Differentiation; Cell Transformation, Neoplastic; Genes, Regulator; Humans; Leukemia; Lymphoma; Methylation | 1987 |
Biology of metastasis.
Topics: Animals; Cell Transformation, Neoplastic; DNA, Neoplasm; Humans; Methylation; Mutation; Neoplasm Metastasis; Phenotype | 1986 |
Methylation of ribosomal RNA as a possible factor in cell differentiation.
Topics: Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Methylation; Neoplasms; Protein Biosynthesis; RNA, Ribosomal | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Repair of DNA O-alkylation damage by various human organs.
Topics: Brain; Cell Transformation, Neoplastic; DNA Repair; Escherichia coli; Fetus; Humans; Intestinal Mucosa; Liver; Methylation; Organ Specificity | 1985 |
A molecular model relating to carcinogenesis.
Topics: Cell Transformation, Neoplastic; Cisplatin; Cytosine; DNA; DNA, Neoplasm; Methylation; Models, Molecular; Oncogenes | 1985 |
A simple technique for cell surface radioactive labeling of human and animal neoplastic cells: reductive methylation with formaldehyde and tritiated borohydride.
Topics: Animals; Borohydrides; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Electrophoresis; Formaldehyde; Humans; Isotope Labeling; Methylation; Neoplasm Proteins; Neoplasms; Rats; Tritium | 1985 |
Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts.
Topics: 5-Methylcytosine; Cell Transformation, Neoplastic; Cells, Cultured; Chorionic Gonadotropin; Cytosine; DNA Replication; Gene Expression Regulation; Genes; Humans; Methylation | 1985 |
A comparative study of dimethylhydrazine regioisomers and the methylazoxymethanol metabolite of 1,1- and 1,2-dimethylhydrazine in relation to transformation in human fibroblasts.
Topics: 1,2-Dimethylhydrazine; Azo Compounds; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Dimethylhydrazines; DNA; Fibroblasts; Humans; Methylation; Methylazoxymethanol Acetate; Methylhydrazines | 1985 |
Unmasking of proteins by in vitro methylation of rat liver RNA during azo dye carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Coloring Agents; Cytoplasm; Histocytochemistry; Liver; Liver Neoplasms; Methods; Methylation; Microscopy; Neoplasm Proteins; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Precancerous Conditions; Proteins; Rats; RNA; RNA, Neoplasm; Staining and Labeling; Temperature | 1971 |
[N-demethylation of the carcinogen dimethylnitrosamine by human embryonal tissue (author's transl)].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Dimethylamines; Embryo, Mammalian; Female; Formaldehyde; Gestational Age; Guinea Pigs; Humans; In Vitro Techniques; Liver; Maternal-Fetal Exchange; Methylation; Microsomes, Liver; Neoplasms; Nitrosamines; Pregnancy; Rats; Species Specificity; Subcellular Fractions | 1974 |
Effect of chloramphenicol and dextramycine on the toxicity of carcinogenic hydrocarbons.
Topics: Adrenal Cortex; Animals; Antineoplastic Agents; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chloramphenicol; Drug Interactions; Embryo, Mammalian; Fibroblasts; In Vitro Techniques; Male; Methylation; Poisoning; Rats; Stereoisomerism; Time Factors | 1974 |
Transfer RNA methylase activities of SV40-transformed cells and cells infected with animal viruses.
Topics: Animals; Cell Transformation, Neoplastic; Culture Techniques; DNA Viruses; Enzyme Induction; Haplorhini; Kidney; Methylation; Mice; RNA, Transfer; Simian virus 40; Simplexvirus; Thymidine Kinase; Transferases; Vaccinia virus | 1970 |
Transfer RNA methylase alterations in polyoma transformed rat embryo culture cells.
Topics: Acetates; Animals; Biological Assay; Cell Transformation, Neoplastic; Culture Techniques; Escherichia coli; Methylation; Polyomavirus; Quaternary Ammonium Compounds; Rats; RNA, Transfer; S-Adenosylmethionine; Transferases; Yeasts | 1971 |
Altered regulation of the transport of RNA from nucleus to cytoplasm in rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Fetus; Liver; Liver Neoplasms; Liver Regeneration; Male; Methylation; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Rats; RNA, Neoplasm | 1972 |
Secretion of RNA by normal and transformed cells.
Topics: Animals; Autoradiography; Carbon Isotopes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, Gel; Chromatography, Paper; Formates; Hydrolysis; In Vitro Techniques; Methionine; Methylation; Nucleotides; RNA; RNA, Neoplasm; RNA, Ribosomal; Simian virus 40; Thymidine; Trichloroacetic Acid; Tritium; Uridine | 1972 |
The contrast between the methylation of transfer ribonucleic acid in vivo and in vitro by normal and SV40 transformed 3T3 cells.
Topics: Animals; Carbon Isotopes; Cell Line; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Chromatography; Chromatography, DEAE-Cellulose; Clone Cells; Cytoplasm; Electrophoresis; Escherichia coli; Fibroblasts; Methylation; Mice; Mice, Inbred BALB C; Oligonucleotides; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Simian virus 40; Tritium | 1972 |
DNA methylation in normal and tumour virus-transformed cells in tissue culture. I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells).
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Transformation, Neoplastic; Chromatography, Paper; Clone Cells; Cricetinae; Cytidine; Cytosine; Deoxyuridine; DNA; Kidney; Methionine; Methylation; Polyomavirus; Thymidine; Time Factors; Tritium; Uridine | 1973 |
Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Chromatography, Thin Layer; Cricetinae; Cytosine; Deoxycytidine; DNA; DNA, Mitochondrial; Escherichia coli; Kidney; L Cells; Methionine; Methylation; Methyltransferases; Mice; Phosphorus Radioisotopes; Polyomavirus; Subcellular Fractions; Tritium | 1973 |
[Ethylation of guanine-N-7 in the nucleic acids of rat embryos and liver by ethylnitrosourea].
Topics: Alkylation; Animals; Carbon Isotopes; Carcinogens; Cell Transformation, Neoplastic; Chromatography, Ion Exchange; DNA; Embryo, Mammalian; Female; Guanine; Lethal Dose 50; Liver; Maternal-Fetal Exchange; Methylation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Pregnancy; Rats; RNA | 1971 |
Is aberrant nucleic acid methylation related to malignant transformation?
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Forecasting; Methylation; Methyltransferases; Mice; Models, Biological; Neoplasms; RNA, Neoplasm; RNA, Transfer | 1974 |
DNA synthesis in rat liver during early stages of azo dye-induced hepatocarcinogenesis.
Topics: Animals; Autoradiography; Cell Division; Cell Transformation, Neoplastic; DNA, Neoplasm; Liver; Liver Neoplasms; Male; Methylation; p-Dimethylaminoazobenzene; Rats; Thymidine; Tritium | 1972 |
[Binding to DNA and to hepatic proteins of 2 azo compounds with different carcinogenic properties].
Topics: Animals; Azo Compounds; Binding Sites; Carbon Isotopes; Cell Nucleus; Cell Transformation, Neoplastic; DNA; Liver; Male; Methylation; p-Dimethylaminoazobenzene; Protein Binding; Rats; Receptors, Drug | 1973 |
DNA damage and its repair in transformable mouse fibroblasts treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Carbon Radioisotopes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Choline; Coliphages; DNA; DNA Repair; DNA, Neoplasm; DNA, Single-Stranded; Dose-Response Relationship, Drug; Fibroblasts; Leucine; Lipids; Methylation; Mice; Mice, Inbred C3H; Molecular Weight; Nitrosoguanidines; Proteins; Time Factors; Tritium | 1974 |
Comparison of soluble RNA methylase capacity in paired neoplastic and nonneoplastic cell lines in vitro.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell-Free System; Escherichia coli; Methionine; Methylation; Mice; Neoplasms; RNA, Neoplasm; RNA, Transfer; Transferases | 1969 |
Comparative transfer RNA methylase capacity in mouse ascites tumors and in their derived tumorigenic and nontumorigenic cell cultures.
Topics: Adenocarcinoma; Animals; Ascites; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Culture Techniques; Escherichia coli; Female; Kidney; Liver; Lung; Lymphoma, Non-Hodgkin; Male; Methylation; Methylcholanthrene; Mice; Neoplasm Transplantation; Neoplasms, Experimental; RNA, Bacterial; RNA, Neoplasm; RNA, Transfer; Transferases | 1971 |
Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Chromatography; Female; Histidine; Leucine; Liver Diseases; Lysine; Methionine; Methylation; p-Dimethylaminoazobenzene; Phenylalanine; Precancerous Conditions; Rats; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine; Valine | 1970 |
Altered transfer RNA methylase patterns in Marek's disease tumors.
Topics: Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Cell-Free System; Chickens; Escherichia coli; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Lung; Methylation; Methyltransferases; Myocardium; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Poultry Diseases; RNA, Neoplasm; RNA, Transfer; Spleen; Transferases; Viruses, Unclassified | 1971 |
Initiation of malignant transformation and the significance of changes in transfer RNA methylase enzymes.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Female; Kidney; Kidney Neoplasms; Male; Methylation; Methyltransferases; Mice; Neoplasms; Ovarian Neoplasms; Ovary; Prostate; Prostatic Neoplasms; RNA, Transfer; Transferases | 1971 |
Reversal of malignant transformation by tumor DNA.
Topics: Animals; Carcinoma 256, Walker; Cell Transformation, Neoplastic; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Methylation; Rats; RNA, Transfer; Transferases | 1970 |
Transfer RNA and transfer RNA methylation in growing and "resting" adult and embryonic tissues and in various oncogenic systems.
Topics: Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cell-Free System; DNA; DNA, Neoplasm; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Lymphocytes; Methylation; Methyltransferases; Mice; Mitosis; Oncogenic Viruses; RNA, Transfer; Transferases | 1971 |
Transfer RNA's in human leukemia.
Topics: Amino Acid Sequence; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromatography; Humans; Leucine; Leukemia; Lymphocyte Activation; Lymphocytes; Methylation; RNA, Neoplasm; RNA, Transfer; Time Factors; Tyrosine | 1969 |
Comparison of methyl-labeled tRNA in a neoplastic cell line with a paired non-neoplastic control.
Topics: Animals; Carbon Isotopes; Cell Line; Cell Transformation, Neoplastic; Chemistry Techniques, Analytical; Chromatography; Culture Techniques; Embryo, Mammalian; Methionine; Methylation; Mice; Neoplasms, Experimental; RNA, Transfer; Tritium | 1970 |
In vitro transfer RNA methylation in paired neoplastic and nonneoplastic cell cultures.
Topics: Animals; Carbon Isotopes; Cell Differentiation; Cell Transformation, Neoplastic; Cell-Free System; Chromatography; Culture Techniques; Methylation; Mice; Neoplasms, Experimental; Nucleic Acids; Nucleotides; RNA, Neoplasm; RNA, Transfer; Transferases; Tritium | 1971 |
The regulation of transfer RNA methylation in normal and neoplastic mammary cells.
Topics: Animals; Carbon Isotopes; Cell Division; Cell Transformation, Neoplastic; Culture Techniques; Cycloheximide; Dactinomycin; DNA; Enzyme Induction; Insulin; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylation; Methyltransferases; Mice; Prolactin; Protein Biosynthesis; RNA; RNA, Neoplasm; RNA, Transfer; Suppression, Genetic; Time Factors; Transferases | 1971 |