isomethyleugenol has been researched along with Carcinoma, Non-Small Cell Lung in 86 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 6 (6.98) | 18.2507 |
2000's | 13 (15.12) | 29.6817 |
2010's | 36 (41.86) | 24.3611 |
2020's | 31 (36.05) | 2.80 |
Authors | Studies |
---|---|
Chen, L; Li, Z; Lin, Y; Piao, S; Tang, X; Wang, X; Wang, Y; Yin, H; Zhang, H | 1 |
Chen, J; Gong, J | 1 |
Guo, M; Li, Z; Ming, L; Wan, J; Wang, Y; Yang, Z; Zhao, Z; Zhou, F | 1 |
Fu, G; Jiang, M; Qu, J; Wang, L; Wei, Z; Zhang, X | 1 |
Fu, Y; Gontcharov, AA; Jin, X; Li, C; Li, Y; Lin, D; Liu, X; Liu, Y; Lv, J; Wan, X; Wang, Q; Wu, X; Yang, H; Yang, X | 1 |
Chen, J; Jiang, Y; Shen, Z; Shi, J; Tang, Y; Wang, J; Wang, T; Wu, A; Zhang, A; Zhou, H; Zhou, T; Zhu, J | 1 |
Gao, H; Li, D; Li, L; Lv, H; Tian, K; Wang, D; Wang, Z | 1 |
Cen, HY; Chen, ZJ; Fu, JJ; Huang, JH; Lei, XP; Li, SP; Liang, L; Qin, AP; Qin, YY; Shen, A; Tan, L; Xu, WY; Yu, XY; Zhang, LM; Zhang, Y | 1 |
Dong, C; Fu, Z; Li, D; Song, Y | 1 |
Hao, F | 1 |
Liu, H; Ma, J; Mao, Y; Zhang, L | 1 |
Guo, MY; He, JQ; Qiu, FS; Yu, CH; Zhong, YS | 1 |
Gao, L; Ma, Z; Shi, S; Tian, Q; Wu, T; Xu, K; Xu, S; Yang, S; Yin, X; Zhang, X | 1 |
Deng, M; Li, X; Li, Y; Lu, Y; Peng, Y; Ye, C | 1 |
Song, X; Wang, K; Wang, S; Xie, L; Zhang, Y | 1 |
Cao, Z; Dai, Y; Hei, TK; Li, B; Nie, J; Pei, H; Tang, J; Yu, Y; Zhang, Y; Zhou, G | 1 |
Chen, Y; Chu, Q; Hu, F; Hu, J; Huang, C; Jia, K; Jiang, T; Lan, J; Li, Y; Liu, A; Luo, X; Lv, P; Ren, S; Song, D; Sun, L; Wang, G; Wang, J; Wu, Q; Zheng, X; Zou, C | 1 |
Shen, Y; Shi, Z; Sun, D; Xu, Y; Zhang, H; Zhang, S; Zhang, X | 1 |
Chiang, CY; Fan, S; Guo, W; Li, S; Sun, Y; Xiao, T; Zeng, J; Zhang, M; Zheng, D; Zheng, H; Zheng, Z; Zhong, C | 1 |
Chen, J; Chen, Y; Lin, L; Xu, F; Zhang, H | 1 |
Kim, CH; Kim, H; Kim, HR; Kim, SY; Lee, TG | 1 |
Chen, X; Jiao, Z; Liang, H; Liao, Z; Liu, Y; Qu, S; Rong, W; Sun, X; Wang, J; Wang, T; Wei, Y; Zen, K; Zhang, CY; Zhao, Q | 1 |
Kaur, P; Pandey, N; Pradhan, S; Rajam, MV; Srivastava, T; Tyagi, G | 1 |
Cao, C; Liang, M; Song, S; Wang, L; Wu, F | 1 |
Arber, N; Chorostowska-Wynimko, J; Eisenberg, VH; Gaga, M; Goldhaber, A; Haas, I; Horváth, I; Izbicki, G; Jansen, M; Levy Faber, D; Liang, H; Moalem, R; Panagoulias, V; Raviv, Y; Ronen, O; Rudzinski, P; Shitrit, D; Stav, D; Tammemagi, MC; Zhou, Q | 1 |
Chen, C; Fan, Y; Li, X; Pan, H; Zhou, Q | 1 |
Bian, H; Chen, R; Chen, X; Chen, ZN; Geng, JJ; Huang, W; Li, H; Lin, P; Nan, G; Ni, YF; Sun, XX; Wang, K; Wu, J; Zhang, T; Zhang, W; Zhu, P; Zhu, YM | 1 |
Villanueva, MT | 1 |
Seton-Rogers, S | 1 |
Akkın, S; Bilensoy, E; Erdoğar, N; Varan, G | 1 |
Chen, X; Li, N; Li, W; Liu, Y; Zhou, T | 1 |
Liu, H; Lv, T; Shi, X; Song, Y; Wu, Y; Zhu, Q | 1 |
Deng, X; Dohmae, N; Hamamoto, R; Nakamura, Y; Park, JH; Suzuki, T; Ueda, K; Vougiouklakis, T; Wang, R; Yoshioka, Y | 1 |
Bayo, J; Behrens, C; Bhanu, NV; Coombes, K; Dalvi, MP; Garcia, BA; Gazdar, AF; Girard, L; Heymach, JV; Kalhor, N; Kittler, R; Kollipara, RK; Martinez, ED; Minna, JD; Mino, B; Park, H; Parra, ER; Pataer, A; Rodriguez-Canales, J; Suraokar, M; Swisher, SG; Timmons, BC; Villalobos, P; Wang, L; Wistuba, II; Xie, Y; Yenerall, P; Zhong, R; Zhou, Y | 1 |
Clark, NR; Comb, M; Cook, W; Foltz, L; Gaiser, J; Grimes, M; Hall, B; Hornbeck, P; Lachmann, A; Levy, T; Ma'ayan, A; Rikova, K; Smirnova, E; Wheeler, T; Zhang, B | 1 |
De Leyn, P; De Ruysscher, D; Decaluwé, H; Dooms, C; Janssens, W; Lambrecht, M; Lambrechts, D; Moisse, M; Nackaerts, K; Peeters, S; Reynders, K; Vansteenkiste, J; Wauters, E | 1 |
Chen, G; Gan, BL; He, RQ; Hu, XH; Wei, DM; Zhang, Y | 1 |
Li, P; Liu, C; Liu, H; Ma, Y; Yu, T | 1 |
Chen Bojiang, BJ; Li Lei, L; Yang Lan, L | 1 |
Cai, Z; Chen, TY; Gao, Y; Han, F; Hou, Z; Hsu, CC; Hu, J; Jin, G; Lan, J; Lee, MG; Li, H; Lin, HK; Long, J; Sun, L; Wang, G; Wang, YH; Xu, C; Yang, SC; Zhang, W | 1 |
Bijukumar, DR; Chastain, PD; Duan, L; Maki, CG; Mathew, MT; Perez, RE | 1 |
Cong, P; Hou, H; Jiang, Y; Xu, Y; Yu, X; Zhou, Y | 1 |
Dai, M; Hu, Y; Kong, W; Wu, H; Wu, J; Yu, B; Yu, X; Zhang, H; Zheng, Y | 1 |
Chang, J; Liu, Y; Sun, J; Wang, H; Wang, M; Wang, W; Xiong, J; Ye, D; Yu, H; Yu, T; Zhao, C; Zhou, H | 1 |
Cai, Y; Tan, M; Wu, J | 1 |
Abrams, JS; Conley, BA; Freidlin, B; Korn, EL; McShane, LM; Polley, MY | 1 |
Alam, H; Cascone, T; Chan, CH; Chung, J; Dhar, SS; Erez, B; Giri, D; Giri, U; Heymach, JV; Hung, MC; Kim, JH; Lee, MG; Li, N; Lin, HK; Multani, AS; Saigal, B; Wagner, KW; Wei, Y; Wu, X; Ye, Y | 1 |
Gu, J; Hildebrandt, MA; Huang, M; Tan, W; Wu, X | 1 |
De, W; Han, L; Kong, R; Liu, XH; Shu, YQ; Sun, M; Wang, KM; Wang, ZX; Xia, R; Yang, JS; Yin, DD; You, LH; Zhang, EB | 1 |
Chen, Z; Li, Z; Lu, S; Niu, X; Shen, S; Tang, N; Xu, L; Xu, Y; Ye, X | 1 |
Guo, H; Hong, X; Shi, G; Wang, B; Wang, Z | 1 |
Battaglia-Hsu, SF; Brochin, L; Casse, JM; Gauchotte, G; Gueant, JL; Lacomme, S; Luc, A; Paris, C; Vignaud, JM; Vigouroux, C | 1 |
Cavicchioli, F; Comino, A; Crook, T; Haley, V; Lackner, M; Lo Nigro, C; Mauri, F; Merlano, M; O'Leary, K; Schmid, P; Shia, A; Walter, K; Wischnewsky, MB | 1 |
Gu, H; Jia, X; Lee, KA; Levy, T; Ren, JM; Rikova, K; Silva, JC; Stokes, MP; Yang, V | 1 |
Dosaka-Akita, H; Kikuchi, J; Kinoshita, I; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
Ding, J; Gao, D; Li, Y; Qu, R; Tong, L; Xiao, Q; Xie, H; Yan, Q; Zhang, W | 1 |
Cheng, SY; Fu, L; Gao, D; Wu, H; Zhang, L; Zhao, Y | 1 |
Harris, CC; Robles, AI | 1 |
Brambilla, C; Brambilla, E; Eymin, B; Gazzeri, S; Lantuejoul, S; Moro-Sibilot, D; Van Den Broeck, A | 1 |
Albericio, F; Bayó-Puxan, N; Marcucci, E; Prats-Alfonso, E; Tulla-Puche, J | 1 |
Horiguchi, K; Iijima, H; Imai, H; Iwasaki, Y; Mori, M; Sunaga, N; Tomizawa, Y; Yamada, M; Yanagitani, N | 1 |
Jones, DR; Liu, Y; Nagji, AS; Stelow, EB; Stukenborg, GJ | 1 |
Bertran-Alamillo, J; Cardenal, F; Cobo, M; Garrido, P; Isla, D; Lianes, P; Manegold, C; Massuti, B; Molina, MA; Moran, T; Ramirez, JL; Rosell, R; Salazar, F; Sanchez, JJ; Sanchez, JM; Sanchez-Ronco, M; Stahel, R; Taron, M; Trigo, JM | 1 |
Cao, H; Deng, Z; Hu, C; Lv, H; Pan, G; Wen, J; Zhou, J | 1 |
Cherdyntseva, NV; Dobrodeev, AIu; Laktionov, PP; Litviakov, NV; Ponomareva, AA; Rykova, EIu; Skvortsova, TE; Tuzikov, SA; Vlasov, VV; Zav'ialov, AA | 1 |
Cho, HS; Daigo, Y; Field, HI; Hamamoto, R; Hayami, S; Iwai, Y; Kelly, JD; Maehara, Y; Masuda, K; Nakamura, Y; Neal, DE; Ponder, BA; Takawa, M; Toyokawa, G; Tsuchiya, E; Tsunoda, T; Yamane, Y; Yoshimatsu, M | 1 |
Jang, SJ; Kim, DK; Kim, YS; Park, SI; Song, JS | 1 |
Chen, S; Ge, JF; Hou, JY; Jiang, D; Zhao, J; Zheng, SY | 1 |
Dosaka-Akita, H; Kikuchi, E; Kikuchi, J; Kinoshita, I; Marquez, VE; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
Brabender, J; Danenberg, KD; Danenberg, PV; Groshen, S; Hölscher, AH; Lord, RV; Metzger, R; Park, J; Salonga, D; Schneider, PM; Schneider, S; Takebe, N; Tsao-Wei, DD; Usadel, H | 1 |
Brambilla, E; Gazdar, AF; Minna, JD; Padar, A; Sathyanarayana, UG; Takahashi, T; Toyooka, S | 1 |
Clarke, S; Frankel, A; Gutmann, DH; Herschman, HR; Jiang, W; Miranda, TB; Newsham, IF; Robb, VA; Roemer, ME; Singh, V | 1 |
Kelsey, KT; Kraunz, KS; Liu, M; Nelson, HH; Wiencke, JK | 1 |
Barlési, F; Gallegos-Ruiz, MI; Giaccone, G; Kruyt, FA; Lefesvre, P; Loundou, A; Rodriguez, JA; Span, SW | 1 |
Barlési, F; Gallegos-Ruiz, MI; Giaccone, G; Kruyt, FA; Lefesvre, P; Rodriguez, JA; Span, SW | 1 |
Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
Astaldi Ricotti, GC; Baas, F; Borst, P; de Haas, M; de Nooij, J; Eijdems, EW; Kamst, E; Timmerman, AJ; Van der Schans, GP | 1 |
Horáková, I; Novotná, H; Vachtenheim, J | 1 |
Edwards, CD; Ewen, ME; Mao, L; Merlo, A; Park, JE; Rollins, BJ; Shapiro, GI; Sidransky, D | 1 |
Field, JK; Gorgoulis, VG; Halazonetis, TD; Kittas, C; Kotsinas, A; Kyroudi, A; Liloglou, T; Rassidakis, A; Veslemes, M; Zacharatos, P | 1 |
Ahrendt, SA; Chow, JT; Decker, PA; Eisenberger, CF; Esteller, M; Herman, JG; Jen, J; Sidransky, D; Wu, L; Xu, LH; Yang, SC | 1 |
Bryant, D; Fong, KM; Fukuyama, Y; Gazdar, AF; Heda, S; Maitra, A; Minna, JD; Rathi, A; Sacchi, N; Thunnissen, F; Virmani, AK; Zöchbauer-Müller, S | 1 |
Hong, WK; Kemp, BL; Khuri, FR; Lee, JJ; Liu, D; Mao, L; Tang, X | 1 |
Frébourg, T; Lamy, A; Métayer, J; Sesboüé, R; Thiberville, L | 1 |
Forgacs, E; Minna, JD; Oláh, E; Zöchbauer-Müller, S | 1 |
Arifi, AA; Lee, TW; Lo, DY; Mok, T; Ng, CS; Wan, S; Yim, AP; Zhang, J | 1 |
4 review(s) available for isomethyleugenol and Carcinoma, Non-Small Cell Lung
Article | Year |
---|---|
Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics.
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Microbiota; RNA | 2022 |
[Research Advances of m⁶A RNA Methylation in Non-small Cell Lung Cancer].
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Molecular Targeted Therapy; RNA, Messenger | 2020 |
[Research progress of circulating tumor DNA methylation in non-small cell lung cancer].
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Circulating Tumor DNA; DNA; DNA Methylation; Humans; Lung Neoplasms; Methylation; Neoplastic Cells, Circulating | 2018 |
Molecular genetic abnormalities in the pathogenesis of human lung cancer.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chromosome Aberrations; Disease Susceptibility; Genes, Tumor Suppressor; Growth Substances; Humans; Lung Neoplasms; Methylation; Molecular Biology; Neoplasm Proteins; Oncogenes; Promoter Regions, Genetic; Stem Cells; Tobacco Smoke Pollution | 2001 |
82 other study(ies) available for isomethyleugenol and Carcinoma, Non-Small Cell Lung
Article | Year |
---|---|
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; MicroRNAs; Receptor, Transforming Growth Factor-beta Type I; RNA Stability; RNA, Long Noncoding; Smad2 Protein; Smad3 Protein | 2023 |
CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA, Complementary | 2021 |
Expression and prognostic significance of m6A-related genes in TP53-mutant non-small-cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Computational Biology; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mutation; Prognosis; Tumor Suppressor Protein p53 | 2022 |
Survival-associated N
Topics: Adenine; Adenosine; Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Databases, Genetic; Female; Gene Expression; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; Principal Component Analysis; Prognosis; RNA, Messenger; ROC Curve; Survival Rate; Time Factors | 2021 |
Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Basidiomycota; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Fungal Polysaccharides; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Molecular Weight; Spectroscopy, Fourier Transform Infrared | 2022 |
Integrative Analysis of m6A RNA Methylation Regulators and the Tumor Immune Microenvironment in Non-Small-Cell Lung Cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; RNA; Tumor Microenvironment | 2022 |
Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA, Circular; Tensins | 2022 |
Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9.
Topics: Adenocarcinoma of Lung; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Methylation; Mice; MicroRNAs | 2022 |
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit-induced long intergenic non-protein coding RNA 1833 N6-methyladenosine methylation promotes the non-small cell lung cancer progression via regulating heterogeneous nuclear ribon
Topics: Adenosine; Animals; Carcinoma, Non-Small-Cell Lung; Catalytic Domain; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; RNA, Long Noncoding | 2022 |
Entanglement of Methylation Changes and cGAS-STING Signaling in Non-Small-Cell Lung Cancer.
Topics: Carcinoma, Non-Small-Cell Lung; DNA; Humans; Lung Neoplasms; Mechanotransduction, Cellular; Methylation; Nucleotidyltransferases; Tumor Microenvironment | 2023 |
LRTCLS: low-rank tensor completion with Laplacian smoothing regularization for unveiling the post-transcriptional machinery of N6-methylation (m6A)-mediated diseases.
Topics: Adenosine; Alternative Splicing; Carcinoma, Non-Small-Cell Lung; COVID-19; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA-Binding Proteins; RNA, Circular | 2022 |
Serum-derived extracellular vesicles promote the growth and metastasis of non-small cell lung cancer by delivering the m6A methylation regulator HNRNPC through the regulation of DLGAP5.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Extracellular Vesicles; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Lung Neoplasms; Methylation; Mice; Mice, Nude; Neoplasm Proteins; RNA, Messenger | 2023 |
Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m
Topics: Animals; Apoptosis; Cancer-Associated Fibroblasts; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type X; Culture Media, Conditioned; Fibroblasts; Lung; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Nude; Oxidative Stress; RNA, Messenger; Sincalide | 2022 |
SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer.
Topics: Autophagy; Base Sequence; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; RNA, Ribosomal, 28S; RNA, Small Nucleolar; Stearoyl-CoA Desaturase | 2023 |
The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Methylation; Mitochondria; RNA, Long Noncoding | 2023 |
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance.
Topics: B7-H1 Antigen; Biomarkers; Carcinoma, Non-Small-Cell Lung; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation | 2023 |
SETD1A-mediated H3K4me3 methylation upregulates lncRNA HOXC-AS3 and the binding of HOXC-AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; E1A-Associated p300 Protein; Ferroptosis; Humans; Lung Neoplasms; Methylation; RNA, Long Noncoding | 2023 |
Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Guanine Nucleotide Exchange Factors; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras) | 2023 |
Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma.
Topics: Adenosine; Aged; AlkB Homolog 5, RNA Demethylase; Antineoplastic Agents, Immunological; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Methylation; Methyltransferases; Middle Aged; Prognosis; RNA-Binding Proteins; RNA-Seq; T Follicular Helper Cells; Transcriptome | 2020 |
Radiation Induces Autophagy
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epigenesis, Genetic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Microtubule-Associated Proteins; RNA, Small Interfering | 2020 |
3'-Terminal 2'-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.
Topics: Apoptosis Regulatory Proteins; Argonaute Proteins; Carcinoma, Non-Small-Cell Lung; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Methyltransferases; MicroRNAs; RNA-Binding Proteins | 2020 |
Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cisplatin; Disulfides; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; MAP Kinase Signaling System; Methylation; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Sulfinic Acids | 2020 |
LncRNA SNHG10 is downregulated in non-small cell lung cancer and predicts poor survival.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Down-Regulation; Humans; Linear Models; Lung Neoplasms; Methylation; MicroRNAs; RNA, Long Noncoding; Tumor Cells, Cultured | 2020 |
Validation of Lung EpiCheck, a novel methylation-based blood assay, for the detection of lung cancer in European and Chinese high-risk individuals.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; China; Early Detection of Cancer; Humans; Lung; Lung Neoplasms; Methylation; Prospective Studies | 2021 |
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Topics: Animals; Basigin; Carcinoma, Non-Small-Cell Lung; Cell Line; Humans; Lactic Acid; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Oligopeptides | 2021 |
Squamous cell lung cancer changes driver.
Topics: Carcinoma, Non-Small-Cell Lung; Epithelial Cells; Histones; Humans; Lung Neoplasms; Methylation | 2021 |
A driver gene hiding in plain sight.
Topics: Carcinoma, Non-Small-Cell Lung; Epithelial Cells; Histones; Humans; Lung Neoplasms; Methylation | 2021 |
Erlotinib complexation with randomly methylated
Topics: A549 Cells; Animals; Antineoplastic Agents; beta-Cyclodextrins; Caco-2 Cells; Calorimetry, Differential Scanning; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Liberation; Erlotinib Hydrochloride; Humans; Intestinal Absorption; Lung Neoplasms; Methylation; Mice; Microscopy, Electron, Scanning; Solubility; Treatment Outcome | 2021 |
Gene Characteristics and Prognostic Values of m
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinoma, Non-Small-Cell Lung; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Prognosis; RNA; RNA Helicases | 2021 |
Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.
Topics: Acetylation; Aged; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Databases, Genetic; Down-Regulation; Female; Gene Expression Profiling; Homeodomain Proteins; Humans; Lung Neoplasms; Male; Methylation; Mice, Inbred BALB C; Mice, Nude; Middle Aged; RNA, Long Noncoding | 2017 |
Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
Topics: Anaplastic Lymphoma Kinase; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Oncogene Proteins, Fusion; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction | 2017 |
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzazepines; Bridged-Ring Compounds; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydrazones; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation; Mice; Neoadjuvant Therapy; Pyrimidines; Taxoids; Transcription, Genetic | 2017 |
Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks.
Topics: Acetylation; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lung Neoplasms; Methylation; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Proteomics; Signal Transduction; Small Cell Lung Carcinoma; Tumor Cells, Cultured | 2018 |
RNA-sequencing in non-small cell lung cancer shows gene downregulation of therapeutic targets in tumor tissue compared to non-malignant lung tissue.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Male; Methylation; Molecular Targeted Therapy; RNA, Neoplasm; Vascular Endothelial Growth Factor A | 2018 |
Downregulation of HOXA3 in lung adenocarcinoma and its relevant molecular mechanism analysed by RT-qPCR, TCGA and in silico analysis.
Topics: Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Computational Biology; Disease Progression; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Lung; Male; Methylation; MicroRNAs; Middle Aged; Real-Time Polymerase Chain Reaction; Young Adult | 2018 |
Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression.
Topics: A549 Cells; Animals; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; CpG Islands; Disease Progression; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Nude; MicroRNAs; Middle Aged; Repressor Proteins; Xenograft Model Antitumor Assays | 2018 |
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
Topics: A549 Cells; Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; NIH 3T3 Cells; Protein Methyltransferases; Proto-Oncogene Proteins c-akt; Transplantation, Heterologous; Ubiquitination | 2019 |
JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Checkpoint Kinase 1; Cisplatin; Drug Resistance, Neoplasm; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation | 2019 |
Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin.
Topics: A549 Cells; Animals; Antigens, CD; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cisplatin; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Homeodomain Proteins; Humans; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Nerve Tissue Proteins; Promoter Regions, Genetic; Transcription, Genetic | 2019 |
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Topics: A549 Cells; Acetylation; Antigens, CD; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Snail Family Transcription Factors; Transforming Growth Factor beta1 | 2019 |
SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lung; Lung Neoplasms; Male; MAP Kinase Signaling System; Methylation; Methyltransferases; Middle Aged; Neoplasm Invasiveness; Pneumonectomy; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Survival Rate | 2019 |
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Non-Small-Cell Lung; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Methylation; MicroRNAs; Promoter Regions, Genetic; Repressor Proteins; Wnt Signaling Pathway | 2013 |
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins | 2013 |
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Dual Specificity Phosphatase 3; Epigenesis, Genetic; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Heterografts; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Male; MAP Kinase Signaling System; Methylation; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Prognosis; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA Interference; RNA, Messenger; RNA, Neoplasm | 2013 |
Epigenetic analysis of microRNA genes in tumors from surgically resected lung cancer patients and association with survival.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Female; Humans; Lung Neoplasms; Male; Methylation; MicroRNAs; Middle Aged; Polymerase Chain Reaction; Smoking; Survival Rate | 2015 |
P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression.
Topics: Animals; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Multivariate Analysis; Neoplasm Staging; Polycomb Repressive Complex 2; Response Elements; Risk Factors; RNA, Long Noncoding; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Tumor Burden; Tumor Suppressor Protein p53 | 2014 |
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Histones; Humans; Lung Neoplasms; Lysine; Male; Methylation; Middle Aged; NF-E2-Related Factor 2; Polycomb Repressive Complex 2; Survival Analysis | 2014 |
Clinicopathological significance and potential drug target of T-cadherin in NSCLC.
Topics: Antineoplastic Agents; Cadherins; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Molecular Targeted Therapy | 2015 |
Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; ELAV-Like Protein 1; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lung Neoplasms; Male; Methylation; Middle Aged; Minichromosome Maintenance Complex Component 6; Neoplasm Staging; Prognosis; Protein Transport | 2015 |
Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer.
Topics: Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Progression; Down-Regulation; Endoglin; Gene Silencing; Genes, Tumor Suppressor; Genome-Wide Association Study; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein Array Analysis; Receptors, Cell Surface; Sequence Analysis, DNA | 2015 |
Quantitative Profiling of Post-translational Modifications by Immunoaffinity Enrichment and LC-MS/MS in Cancer Serum without Immunodepletion.
Topics: Acetylation; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatography, Liquid; Female; Humans; Leukemia, Myeloid, Acute; Methylation; Neoplasm Proteins; Protein Processing, Post-Translational; Proteomics; Tandem Mass Spectrometry | 2016 |
Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.
Topics: Acetylation; Adenosine; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mutation; Phosphorylation; Polycomb Repressive Complex 2; Signal Transduction; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Lung Neoplasms; Methylation; Molecular Docking Simulation; Point Mutation; Protein Kinase Inhibitors; Pyrimidines | 2016 |
Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals.
Topics: Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; DNA; Hedgehog Proteins; Histone-Lysine N-Methyltransferase; Humans; Kruppel-Like Transcription Factors; Methylation; Mice; Neoplasm Metastasis; Nerve Tissue Proteins; Protein Binding; Protein Processing, Post-Translational; Protein Stability; Signal Transduction; Zinc Finger Protein Gli3 | 2016 |
Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Cytokines; Early Detection of Cancer; Gene Expression; Humans; Lung Neoplasms; Mass Screening; Metabolomics; Methylation; MicroRNAs; Neoplasm Recurrence, Local; Neoplasm Staging; Precision Medicine; Smoking; Survival Rate; Tomography, X-Ray Computed | 2017 |
Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Precancerous Conditions; Prognosis; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
NMe amide as a synthetic surrogate for the thioester moiety in thiocoraline.
Topics: Amides; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Colon; Depsipeptides; Drug Stability; Esters; Humans; Hydrogen Bonding; Male; Methylation; Protein Conformation; Sulfides | 2009 |
Epigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromosomes, Human, Pair 3; Epigenesis, Genetic; ErbB Receptors; Female; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Methylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Small Cell Lung Carcinoma; Thyroid Hormone Receptors beta | 2010 |
BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathological stage in non-small cell lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; CpG Islands; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; Transcription, Genetic | 2010 |
First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Mutation; Neoplasm Proteins; Neoplasm Staging; Poly-ADP-Ribose Binding Proteins; Protein Kinase Inhibitors; Quinazolines; Survival Analysis; Ubiquitin-Protein Ligases | 2011 |
The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma.
Topics: ADAM Proteins; Adult; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Methylation; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2011 |
[Assay of methylated gene RARbeta2 in circulating DNA of blood from patients with lung cancer as a potential prognostic marker].
Topics: Adult; Carcinoma, Non-Small-Cell Lung; DNA, Neoplasm; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Receptors, Retinoic Acid; Risk Factors | 2011 |
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Topics: beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Hep G2 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tissue Array Analysis; Urinary Bladder Neoplasms; Wnt Signaling Pathway | 2011 |
Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Female; Histones; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Tissue Array Analysis | 2012 |
Clinical outcomes of downregulation of E-cadherin gene expression in non-small cell lung cancer.
Topics: Adult; Aged; Cadherins; Carcinoma, Non-Small-Cell Lung; CpG Islands; Down-Regulation; Exons; Female; Humans; Lung; Lung Neoplasms; Male; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms; Methylation; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; RNA Interference; Transcription Factors | 2012 |
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Multivariate Analysis; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; Sulfites; Time Factors; Treatment Outcome | 2003 |
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Topics: Azacitidine; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; Humans; Kalinin; Laminin; Lung Neoplasms; Lymphocytes; Methylation; Models, Genetic; Mouth Mucosa; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cloning, Molecular; Humans; Lung Neoplasms; Membrane Proteins; Methylation; Microfilament Proteins; Protein-Arginine N-Methyltransferases; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae; Tumor Suppressor Proteins | 2004 |
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Topics: Bone Morphogenetic Protein 3; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation; Genes, ras; Growth Differentiation Factor 10; Humans; Lung Neoplasms; Methylation; Mutation; Polymerase Chain Reaction; ras Proteins; Signal Transduction; Tumor Cells, Cultured | 2005 |
Global histone modifications predict prognosis of resected non small-cell lung cancer.
Topics: Acetylation; Aged; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Female; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Prognosis; Proportional Hazards Models; Protein Processing, Post-Translational; Survival Analysis | 2007 |
Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC.
Topics: Base Sequence; Carcinoma, Non-Small-Cell Lung; DNA Primers; Genotype; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Methylation; Minisatellite Repeats; Polymorphism, Genetic; Risk Factors | 2008 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Topics: Amsacrine; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Etoposide; Humans; Lung Neoplasms; Methylation; RNA, Messenger; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1995 |
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Topics: Alleles; Base Sequence; Binding Sites; Carcinoma, Non-Small-Cell Lung; Codon; DNA, Neoplasm; Gene Deletion; Genes, ras; Humans; Lung; Lung Neoplasms; Methylation; Molecular Sequence Data; Mutation; Repetitive Sequences, Nucleic Acid | 1994 |
Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.
Topics: Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Cycle; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Methylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; RNA, Neoplasm; Sequence Deletion; Tumor Cells, Cultured | 1995 |
Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chromosomes, Human, Pair 9; Cyclin-Dependent Kinase Inhibitor p16; Female; Gene Expression; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Microsatellite Repeats; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Polymorphism, Single-Stranded Conformational; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 1998 |
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.
Topics: Alleles; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Genes, ras; Humans; In Situ Hybridization; Lung Neoplasms; Methylation; Microsatellite Repeats; Mutation; Neoplasm Staging; Oncogenes; Polymerase Chain Reaction; Prospective Studies; Sensitivity and Specificity; Tumor Suppressor Protein p53 | 1999 |
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Gene Expression Regulation, Neoplastic; Humans; Loss of Heterozygosity; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Death-Associated Protein Kinases; DNA, Neoplasm; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Multivariate Analysis; Neoplasm Staging; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Retrospective Studies | 2000 |
Re: Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Topics: Antineoplastic Agents; Bronchoscopy; Carcinoma in Situ; Carcinoma, Non-Small-Cell Lung; Fluorescence; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Receptors, Retinoic Acid | 2001 |
Tumor p16M is a possible marker of advanced stage in non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; DNA, Neoplasm; Female; Genes, p16; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Staging; Pneumonectomy; Polymerase Chain Reaction; Prognosis; Prospective Studies | 2002 |