isomethyleugenol has been researched along with Cancer of Lung in 261 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (13.03) | 18.7374 |
| 1990's | 36 (13.79) | 18.2507 |
| 2000's | 31 (11.88) | 29.6817 |
| 2010's | 80 (30.65) | 24.3611 |
| 2020's | 80 (30.65) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, SG; Gao, YB; Guo, L; Guo, W; He, J; Huai, QL; Song, P; Sun, SJ; Xue, XM; Ying, JM | 1 |
| Gao, S; He, J; Luo, Y; Sun, N; Tan, F; Wang, L; Wu, P; Xue, L; Xue, Q; Yang, Z; Zeng, H; Zeng, Q; Zhang, C; Zhang, G; Zhang, Z; Zheng, B | 1 |
| Chen, L; Li, Z; Lin, Y; Piao, S; Tang, X; Wang, X; Wang, Y; Yin, H; Zhang, H | 1 |
| Chen, J; Gong, J | 1 |
| Guo, M; Li, Z; Ming, L; Wan, J; Wang, Y; Yang, Z; Zhao, Z; Zhou, F | 1 |
| Fu, G; Jiang, M; Qu, J; Wang, L; Wei, Z; Zhang, X | 1 |
| Fu, Y; Gontcharov, AA; Jin, X; Li, C; Li, Y; Lin, D; Liu, X; Liu, Y; Lv, J; Wan, X; Wang, Q; Wu, X; Yang, H; Yang, X | 1 |
| Chen, N; Chen, S; Chen, Z; Han, L; Ma, Y; Nie, H; Shen, L; Xie, G; Yang, J; Zheng, Y; Zhou, B | 1 |
| Diao, H; Hao, N; Koropatnick, J; Liu, Q; Maleki Vareki, S; Min, J; Min, W; Raphael, J; Sang, Y; Wang, Z; Xiong, J; Xu, D; Zhang, Y; Zheng, X | 1 |
| Hu, Y; Jiang, F; Liu, X; Wang, M; Wu, C | 1 |
| Chen, J; Jiang, Y; Shen, Z; Shi, J; Tang, Y; Wang, J; Wang, T; Wu, A; Zhang, A; Zhou, H; Zhou, T; Zhu, J | 1 |
| Huang, T; Ye, W | 1 |
| Chen, YN; Liang, JK; Liu, J; Nie, GJ; Sui, Y; Yao, WS; Zhan, SF; Zou, AM | 1 |
| Gao, H; Li, D; Li, L; Lv, H; Tian, K; Wang, D; Wang, Z | 1 |
| Cen, HY; Chen, ZJ; Fu, JJ; Huang, JH; Lei, XP; Li, SP; Liang, L; Qin, AP; Qin, YY; Shen, A; Tan, L; Xu, WY; Yu, XY; Zhang, LM; Zhang, Y | 1 |
| Dong, C; Fu, Z; Li, D; Song, Y | 1 |
| Carvalho, Â; Constâncio, V; Fernandes, M; Guimarães-Teixeira, C; Henrique, R; Jerónimo, C; Macedo-Silva, C; Monteiro, FJ | 1 |
| Hao, F | 1 |
| Cui, J; Du, X; Ke, J; Ma, B; Yang, X; Yu, L | 1 |
| Ahmad, T; Benitez, AM; Brickner, JR; Casanova, AG; Chuffart, F; Couté, Y; Hainaut, P; Hausmann, S; Jansen, PWTC; Lukinović, V; Mazur, PK; Mosammaparast, N; Oyeniran, C; Reynoird, N; Rodell, R; Roth, GS; Tardif, M; Tsao, N; Vayr, J; Vermeulen, M | 1 |
| Chen, W; Li, F; Li, S; Li, Y; Lu, X; Zheng, D | 1 |
| Liu, H; Ma, J; Mao, Y; Zhang, L | 1 |
| Gao, C; Li, H; Liu, C; Liu, L; Ma, W; Sun, C; Zhang, Q; Zhuang, J | 1 |
| Lou, K; Xu, X; Xu, Y; Zhang, Y; Zheng, B | 1 |
| Guo, MY; He, JQ; Qiu, FS; Yu, CH; Zhong, YS | 1 |
| Gao, L; Ma, Z; Shi, S; Tian, Q; Wu, T; Xu, K; Xu, S; Yang, S; Yin, X; Zhang, X | 1 |
| Ishimura, A; Suphakhong, K; Suzuki, T; Takatsuka, R; Takino, T; Terashima, M; Wanna-Udom, S | 1 |
| Abudurufu, M; Cai, HY; Chen, TF; Ke, ZF; Lei, YY; Luo, HH; Shan, SC; Yang, HS; Zhu, Y; Zou, JY | 1 |
| Deng, M; Li, X; Li, Y; Lu, Y; Peng, Y; Ye, C | 1 |
| Li, L; Xu, L; Yan, C; Zhou, L | 1 |
| Gong, C; Li, W; Li, YY; Ma, Y; Tang, LW; Wu, J | 1 |
| Song, X; Wang, K; Wang, S; Xie, L; Zhang, Y | 1 |
| Guo, L; Li, M; Liang, S; Peng, J; Wang, Q; Wang, Y; Wen, Y | 1 |
| Li, JC; Liu, YS; Su, WJ; Sun, Q; Yang, LQ; Zeng, QC; Zhang, K | 1 |
| Guo, Z; Wang, X; Yan, F | 1 |
| Cao, Z; Dai, Y; Hei, TK; Li, B; Nie, J; Pei, H; Tang, J; Yu, Y; Zhang, Y; Zhou, G | 1 |
| Guo, Z; Huang, Y; Lai, S; Li, T; Lin, C; Wang, Y; Weng, S; Zhang, X | 1 |
| Diao, MN; Zhang, XJ; Zhang, YF | 1 |
| Chen, Y; Chu, Q; Hu, F; Hu, J; Huang, C; Jia, K; Jiang, T; Lan, J; Li, Y; Liu, A; Luo, X; Lv, P; Ren, S; Song, D; Sun, L; Wang, G; Wang, J; Wu, Q; Zheng, X; Zou, C | 1 |
| Chen, Y; Fang, H; Guo, Y; Huang, C; Jia, C; Li, T; Liu, A; Lu, C; Lv, Y; Mo, K; Mou, Y; Song, K; Song, Q; Song, X; Song, Y; Sun, P; Sun, Q; Tian, R; Wang, K; Wei, S; Yang, D; Yu, G; Yu, X; Yu, Y; Zhang, H; Zhou, J | 1 |
| Chen, R; Hua, X; Huang, C; Li, P; Li, T; Li, X; Tian, Z; Zhou, C; Zhu, J | 1 |
| Shen, Y; Shi, Z; Sun, D; Xu, Y; Zhang, H; Zhang, S; Zhang, X | 1 |
| An, C; Bae, JS; Jeong, BH; Jeong, MS; Joo, J; Joo, TW; Kim, H; Kim, HH; Kim, HK; Kim, K; Kim, Y; Kwon, HJ; Lee, H; Lee, K; Lee, KJ; Lee, MS; Lee, S; Lim, Y; Min, NY; Park, D; Shin, SH; Um, SW; Yun, SY | 1 |
| Cai, W; Chen, W; Xu, B; Zhang, J | 1 |
| Chiang, CY; Fan, S; Guo, W; Li, S; Sun, Y; Xiao, T; Zeng, J; Zhang, M; Zheng, D; Zheng, H; Zheng, Z; Zhong, C | 1 |
| Liang, C; She, B; Wang, Y; Wei, F; Zhong, Q | 1 |
| Chen, J; Chen, Y; Lin, L; Xu, F; Zhang, H | 1 |
| Hou, T; Li, M; Li, Y; Li, Z; Liu, C; Liu, X; Lu, X; Mao, Z; Tang, M; Wang, H; Wen, H; Yang, Q; Yang, Y; Zhao, Y; Zhu, Q; Zhu, WG | 1 |
| Kim, CH; Kim, H; Kim, HR; Kim, SY; Lee, TG | 1 |
| Chen, L; Hu, Z; Huang, Y; Jin, Y; Li, H; Mao, Y; Zheng, Q; Zhuang, Z | 1 |
| Chen, X; Jiao, Z; Liang, H; Liao, Z; Liu, Y; Qu, S; Rong, W; Sun, X; Wang, J; Wang, T; Wei, Y; Zen, K; Zhang, CY; Zhao, Q | 1 |
| Chellamuthu, A; Gray, SG | 1 |
| Kaur, P; Pandey, N; Pradhan, S; Rajam, MV; Srivastava, T; Tyagi, G | 1 |
| Huang, W; Li, P; Qiu, X | 1 |
| Chellappan, DR; Dharmalingam, D; Nagarajan, D; Ponnachipudhur Chinnaswamy, P; Ramadas, N; Raviraj, R; Selvakumar, I; Sunnaghatta Nagaraja, S | 1 |
| Bosgana, P; Bravou, V; Dimitrakopoulos, FI; Kalophonos, C; Kourea, E; Logotheti, S; Nikou, S; Sampsonas, F; Tzelepi, V; Zolota, V | 1 |
| Cao, Y; Chen, L; Cheng, Y; Lai, W; Liu, N; Liu, S; Liu, Y; Mao, C; Ouyang, L; Shi, Y; Tao, Y; Wang, H; Wang, M; Wang, X; Wang, Z; Xiao, D; Yang, R; Zhou, H | 1 |
| Bouvet, M; Endo, I; Hamada, K; Han, Q; Hoffman, RM; Inubushi, S; Kumamoto, T; Matsuyama, R; Miyake, K; Nishino, H; Sugisawa, N; Yamamoto, J | 1 |
| Cao, C; Liang, M; Song, S; Wang, L; Wu, F | 1 |
| Arber, N; Chorostowska-Wynimko, J; Eisenberg, VH; Gaga, M; Goldhaber, A; Haas, I; Horváth, I; Izbicki, G; Jansen, M; Levy Faber, D; Liang, H; Moalem, R; Panagoulias, V; Raviv, Y; Ronen, O; Rudzinski, P; Shitrit, D; Stav, D; Tammemagi, MC; Zhou, Q | 1 |
| Chen, C; Fan, Y; Li, X; Pan, H; Zhou, Q | 1 |
| Xie, Y; Zhao, W | 1 |
| Seliger, B; Subbarayan, K; Ulagappan, K; Wickenhauser, C | 1 |
| Amistadi, MK; Gandolfi, AJ; Hernandez-Gonzalez, S; Lantz, RC; Michel-Ramirez, G; Olivas-Calderón, E; Recio-Vega, R | 1 |
| Bian, H; Chen, R; Chen, X; Chen, ZN; Geng, JJ; Huang, W; Li, H; Lin, P; Nan, G; Ni, YF; Sun, XX; Wang, K; Wu, J; Zhang, T; Zhang, W; Zhu, P; Zhu, YM | 1 |
| Angulo-Ibanez, M; Azhibek, D; Chua, KF; Czaban, I; Fang, B; Fischle, W; Flores, NM; Gozani, O; Hausmann, S; Jaremko, M; Jaremko, Ł; Kharchenko, V; Lofgren, SM; Lu, X; Mazur, PK; Minna, JD; Roth, JA; Sengupta, D; Shao, NY; Vicent, S; Wistuba, II; Yuan, G | 1 |
| Villanueva, MT | 1 |
| Durán, M; Faull, I; Laes, JF; Lastra, E; Rodrigo, AB; Sánchez-Escribano, R | 1 |
| Seton-Rogers, S | 1 |
| An, J; Di, W; Du, J; Guo, J; Hu, B; Jin, D; Kong, L; Pan, L; Su, G; Wang, X; Wu, Y; Yang, L | 1 |
| Ding, X; Li, D; Peng, Y; Wang, X; Wang, Y; Wu, Y; Yang, A; Yang, P; Yin, H; Yu, Y; Zhang, J; Zhang, R; Zhang, X | 1 |
| Chen, B; Chen, P; Dai, C; Guo, H; He, Y; Jia, K; Jiang, M; Li, W; Liu, Y; Qi, H; Tang, X; Wang, H; Wang, L; Wu, S; Ye, J; Zhao, S | 1 |
| Dank, M; Forika, G; Kiss, E; Krenacs, T; Mohacsi, R; Nemeth, Z | 1 |
| Chen, E; Li, M; Liu, J; Wu, J; Xu, E; Yang, Q; Zhang, C; Zhou, J | 1 |
| Cai, C; Feng, XH; Gu, S; Shen, L; Yang, B; Yu, Y; Yuan, B; Zhang, H; Zhu, Y | 1 |
| Khan, RIN; Malla, WA | 1 |
| Akkın, S; Bilensoy, E; Erdoğar, N; Varan, G | 1 |
| Bai, H; Li, S; Liu, L; Ma, Z; Qu, Y; Wang, C; Wang, J; Xue, P; Zhang, X | 1 |
| Chen, X; Li, N; Li, W; Liu, Y; Zhou, T | 1 |
| Huang, Z; Shi, J; Shi, M; Wang, J; Zhang, H; Zheng, M; Zhou, H; Zhou, Y | 1 |
| Liu, H; Lv, T; Shi, X; Song, Y; Wu, Y; Zhu, Q | 1 |
| Deng, X; Dohmae, N; Hamamoto, R; Nakamura, Y; Park, JH; Suzuki, T; Ueda, K; Vougiouklakis, T; Wang, R; Yoshioka, Y | 1 |
| Akbay, EA; Bardeesy, N; Bass, AJ; Chen, T; Chen, Z; Diehl, JA; Dranoff, G; Fillmore Brainson, C; Garcia-de-Alba, C; Gupta, M; Hammerman, PS; Herter-Sprie, GS; Ji, H; Kim, CF; Koyama, S; Kwiatkowski, DJ; Li, S; Lu, G; Marsh, BP; Palakurthi, S; Paschini, M; Redig, AJ; Rustgi, AK; Saur, D; Sharpless, NE; Sholl, LM; Tuminello, SJ; Wang, X; Watanabe, H; Wong, KK; Xu, C; Zhang, H; Zhang, X; Zheng, M | 1 |
| Bayo, J; Behrens, C; Bhanu, NV; Coombes, K; Dalvi, MP; Garcia, BA; Gazdar, AF; Girard, L; Heymach, JV; Kalhor, N; Kittler, R; Kollipara, RK; Martinez, ED; Minna, JD; Mino, B; Park, H; Parra, ER; Pataer, A; Rodriguez-Canales, J; Suraokar, M; Swisher, SG; Timmons, BC; Villalobos, P; Wang, L; Wistuba, II; Xie, Y; Yenerall, P; Zhong, R; Zhou, Y | 1 |
| Cheng, A; Garbett, NC; Merchant, ML; Petkowski, JJ; Schaner Tooley, CE; Shields, KM; Tooley, JG; Wilkey, DW | 1 |
| Chang, E; Chang, YJ; Chen, L; Chen, YJ; Chiu, H; Chou, SW; Huang, SF; Huang, WC; Jang, TH; Kung, HJ; Lin, MC; Shieh, TY; Shih, CH; Wang, LH; Wang, WC; Yang, MH | 1 |
| Chang, CC; Chang, J; Chang, YC; Chang, YF; Cheng, CC; Ho, AS; Huang, L; Huang, SC; Lim, KH; Lin, HC; Wu, CW | 1 |
| Evanno, E; Fouchaq, B; Godet, J; Gombert, JM; Guilhot, J; Milin, S; Piccirilli, N; Roche, J | 1 |
| Bernardo, MM; He, R; Kidder, BL; Padilla-Nash, HM; Ried, T; Sheng, S; Wangsa, D; Zhao, K | 1 |
| Bennett, J; Bushell, M; Chernova, T; Dinsdale, D; Donaldson, K; Dudek, KM; Galavotti, S; Greaves, P; Grosso, S; Le Quesne, J; MacFarlane, M; Murphy, FA; Nakas, A; Poland, CA; Powley, IR; Schinwald, A; Sun, XM; Willis, AE; Zacarias-Cabeza, J | 1 |
| Clark, NR; Comb, M; Cook, W; Foltz, L; Gaiser, J; Grimes, M; Hall, B; Hornbeck, P; Lachmann, A; Levy, T; Ma'ayan, A; Rikova, K; Smirnova, E; Wheeler, T; Zhang, B | 1 |
| Chen, J; Chen, L; Fang, H; Fang, L; Ge, X; Han, D; Jiao, C; Jin, J; Jin, X; Li, C; Li, Y; Liao, G; Liao, L; Liu, M; Liu, Z; Peng, X; Qin, HL; Teng, H; Wang, P; Wang, X; Wang, Y; Wei, Q; Weng, L; Yang, Y; Zhang, S; Zhao, B; Zhou, D; Zhou, J | 1 |
| De Leyn, P; De Ruysscher, D; Decaluwé, H; Dooms, C; Janssens, W; Lambrecht, M; Lambrechts, D; Moisse, M; Nackaerts, K; Peeters, S; Reynders, K; Vansteenkiste, J; Wauters, E | 1 |
| Li, P; Liu, C; Liu, H; Ma, Y; Yu, T | 1 |
| Betz, BL; Brown, NA; Cascalho, M; Cooke, A; Davis, A; El Kadi, N; Hassan, KA; Kalemkerian, GP; Korkaya, H; Vadnala, V; Wang, L | 1 |
| Chen Bojiang, BJ; Li Lei, L; Yang Lan, L | 1 |
| Cai, Z; Chen, TY; Gao, Y; Han, F; Hou, Z; Hsu, CC; Hu, J; Jin, G; Lan, J; Lee, MG; Li, H; Lin, HK; Long, J; Sun, L; Wang, G; Wang, YH; Xu, C; Yang, SC; Zhang, W | 1 |
| Bijukumar, DR; Chastain, PD; Duan, L; Maki, CG; Mathew, MT; Perez, RE | 1 |
| Cong, P; Hou, H; Jiang, Y; Xu, Y; Yu, X; Zhou, Y | 1 |
| Guo, D; Li, X; Mao, W; Xu, H | 1 |
| Dai, M; Hu, Y; Kong, W; Wu, H; Wu, J; Yu, B; Yu, X; Zhang, H; Zheng, Y | 1 |
| Gao, LM; Li, Y; Shi, SS; Tian, Q; Wang, P; Wu, T; Xu, SF; Yin, XB; Zhang, L; Zhao, J; Zheng, L; Zheng, Y | 1 |
| Chang, J; Liu, Y; Sun, J; Wang, H; Wang, M; Wang, W; Xiong, J; Ye, D; Yu, H; Yu, T; Zhao, C; Zhou, H | 1 |
| Jin, YT; Xu, PW | 1 |
| Kim, KC; Lee, JK | 1 |
| Cai, Y; Tan, M; Wu, J | 1 |
| Chang, Q; Chen, B; Chen, F; Lu, Y; Ma, D; Thakur, C; Yi, Z; Yu, M | 1 |
| Abrams, JS; Conley, BA; Freidlin, B; Korn, EL; McShane, LM; Polley, MY | 1 |
| Alam, H; Cascone, T; Chan, CH; Chung, J; Dhar, SS; Erez, B; Giri, D; Giri, U; Heymach, JV; Hung, MC; Kim, JH; Lee, MG; Li, N; Lin, HK; Multani, AS; Saigal, B; Wagner, KW; Wei, Y; Wu, X; Ye, Y | 1 |
| Acevedo, J; Cortés, S; Ferreccio, C; Kalman, D; Liaw, J; Melak, D; Parra, R; Pérez, L; Smith, AH; Steinmaus, C; Yuan, Y | 1 |
| Berry, A; Donn, R; Farrow, SN; Hanley, N; Jangani, M; Matthews, L; Poolman, TM; Ray, DW; Whetton, AD; Williamson, AJ; Yang, N | 1 |
| He, L; Kan, M; Liu, F; Liu, Y; Niu, X; Tao, L; Zhan, L; Zhang, D; Zhang, Z; Zhou, D; Zhou, Y | 1 |
| Gu, J; Hildebrandt, MA; Huang, M; Tan, W; Wu, X | 1 |
| Barbash, O; Butte, AJ; Dhanak, D; Garcia, BA; Gozani, O; Huddleston, M; Jansen, PW; Khatri, P; Kruger, RG; Liu, S; Mazur, PK; Reynoird, N; Sage, J; Tummino, PJ; Van Aller, GS; Vermeulen, M; Wilkinson, AW | 1 |
| De, W; Han, L; Kong, R; Liu, XH; Shu, YQ; Sun, M; Wang, KM; Wang, ZX; Xia, R; Yang, JS; Yin, DD; You, LH; Zhang, EB | 1 |
| Chen, Z; Li, Z; Lu, S; Niu, X; Shen, S; Tang, N; Xu, L; Xu, Y; Ye, X | 1 |
| Helke, KL; Kistner-Griffin, E; Krupenko, NI; Krupenko, SA; Oleinik, NV | 1 |
| Bodine, DM; Crawford, NP; Dworkin, AM; Gildea, D; Lee, M; Lichtenberg, J; Patel, SJ; Trivedi, NS | 1 |
| Gupta, KP; Pandey, M; Sahay, S; Sultana, S; Tiwari, P; Upadhyay, DS | 1 |
| Chen, JM; Chiu, SC; Chou, HY; Hsia, JY; Huang, HM; Huang, JY; Juan, CC; Lee, YC; Su, LJ; Wei, TY; Yu, CT | 1 |
| Colón-Bolea, P; Crespo, P | 1 |
| Chou, KH; Hsu, C; Huang, WF; Huang, YL; Lin, IH; Lin, LI; Lin, YH; Lin, YM; Lu, JW; Ou, DL; Shen, CK; Tzeng, TY; Wang, WP; Wu, PC; Yang, JY | 1 |
| Hamamoto, R; Jenuwein, T; Nakakido, M; Nakamura, Y; Piao, L; Sone, K; Ueda, K | 1 |
| Liu, Q; Liu, Y; Lu, X; Luo, F; Qin, Y; Shi, L; Wang, B; Xiang, Q; Xu, W; Xu, Y | 1 |
| Guo, H; Hong, X; Shi, G; Wang, B; Wang, Z | 1 |
| Battaglia-Hsu, SF; Brochin, L; Casse, JM; Gauchotte, G; Gueant, JL; Lacomme, S; Luc, A; Paris, C; Vignaud, JM; Vigouroux, C | 1 |
| Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
| Cavicchioli, F; Comino, A; Crook, T; Haley, V; Lackner, M; Lo Nigro, C; Mauri, F; Merlano, M; O'Leary, K; Schmid, P; Shia, A; Walter, K; Wischnewsky, MB | 1 |
| Bryan, JN; Herrera, CL; Kim, DY; Kumar, SR | 1 |
| Dosaka-Akita, H; Kikuchi, J; Kinoshita, I; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
| Ding, J; Gao, D; Li, Y; Qu, R; Tong, L; Xiao, Q; Xie, H; Yan, Q; Zhang, W | 1 |
| Chen, H; Gupta, V; Lorton, B; Shechter, D | 1 |
| Harris, CC; Robles, AI | 1 |
| Fennell, D; Habib, T; Jithesh, PV; Manente, AG; Moro, L; Nilsson, S; Pinton, G; Tavian, D; Zonca, S | 1 |
| Barrero, MJ; Brooks, HB; Campbell, RM; García-Carpizo, V; Graña, O; Han, B; Pisano, DG; Ruiz-Llorente, S; Sarmentero, J; Serrano, M | 1 |
| Chen, J; Dong, Y; Li, Y; Liu, C; Liu, H; Zhang, H | 1 |
| Botuyan, MV; Bruns, CJ; Cui, G; Klein, BJ; Kutateladze, TG; Lin, K; Lu, Y; Mer, G; Shi, X; Wang, X; Yuan, C; Zhao, Y | 1 |
| Geng, P; Huang, B; Li, Y; Li, Z; Lin, C; Liu, DX; Liu, X; Liu, Y; Lu, J; Tan, J; Wang, G; Yan, X; Zhang, N; Zhang, Y | 1 |
| Brocato, J; Costa, M; Jordan, A; Kluz, T; Laulicht-Glick, F; Sun, H; Wu, F; Zhang, X | 1 |
| Hwang, D; Kim, TY; Park, HR; Shin, KS; Suh, HJ; Yu, KW | 1 |
| Brambilla, C; Brambilla, E; Eymin, B; Gazzeri, S; Lantuejoul, S; Moro-Sibilot, D; Van Den Broeck, A | 1 |
| Belinsky, SA; Tessema, M | 1 |
| Kimura, T; Matsuura, N; Sugitachi, A; Yamamoto, K | 1 |
| Chia, D; Goodglick, L; Horvath, S; Kurdistani, SK; Mah, V; McBrian, MA; Seligson, DB; Tze, S; Wang, Q; Yu, H | 1 |
| Arita, A; Costa, M; Li, Q; Sun, H; Zhou, X | 1 |
| Beezhold, K; Castranova, V; Chang, Q; Chen, F; Lu, Y; Rojanasakul, Y; Shi, X; Zhang, Y; Zhao, H | 1 |
| Aozasa, K; Ikeda, J; Inoue, M; Morii, E; Oda, T; Okumura, M; Qiu, Y; Tian, T | 1 |
| Cheng, AL; Kuo, KT; Kuo, LT; Lee, WC; Lin, CH; Lin, YT; Lu, YS; Tasi, JC; Tseng, HM; Tseng, SH; Tu, YK; Wu, PF; Wu, RM; Yang, CH | 1 |
| Brambilla, E | 1 |
| Nakata, A; Oghiso, Y; Poncy, JL; Shimada, Y; Yamada, Y; Yoshida, MA | 1 |
| Horiguchi, K; Iijima, H; Imai, H; Iwasaki, Y; Mori, M; Sunaga, N; Tomizawa, Y; Yamada, M; Yanagitani, N | 1 |
| Jones, DR; Liu, Y; Nagji, AS; Stelow, EB; Stukenborg, GJ | 1 |
| Devine, SE; Iskow, RC; McCabe, MT; Mills, RE; Neuwald, AF; Pittard, WS; Torene, S; Van Meir, EG; Vertino, PM | 1 |
| Bertran-Alamillo, J; Cardenal, F; Cobo, M; Garrido, P; Isla, D; Lianes, P; Manegold, C; Massuti, B; Molina, MA; Moran, T; Ramirez, JL; Rosell, R; Salazar, F; Sanchez, JJ; Sanchez, JM; Sanchez-Ronco, M; Stahel, R; Taron, M; Trigo, JM | 1 |
| Dong, S; Li, Y; Liu, H; Ma, L; Xu, N; Yan, H; Zhang, P; Zhou, Q | 1 |
| Belinsky, SA; Bernauer, AM; Burki, EA; Costello, JF; Crowell, RE; Do, KC; Flores, KG; Gilliland, FD; Hong, C; Leng, S; Picchi, MA; Prados, MD; Stidley, CA; Tellez, CS; Tessema, M; Willink, RP; Yingling, CM | 1 |
| Cao, H; Deng, Z; Hu, C; Lv, H; Pan, G; Wen, J; Zhou, J | 1 |
| Chinnasamy, N; Hong, JA; Liu, F; Marquez, VE; Morgan, RA; Rao, M; Schrump, DS; Xi, S; Zhang, M; Zhang, Y | 1 |
| Dekhuijzen, PNR; Janssen, JP; Knuiman, GJ; Prinsen, CFM; Thunnissen, FBJM; van der Drift, MA | 1 |
| Cherdyntseva, NV; Dobrodeev, AIu; Laktionov, PP; Litviakov, NV; Ponomareva, AA; Rykova, EIu; Skvortsova, TE; Tuzikov, SA; Vlasov, VV; Zav'ialov, AA | 1 |
| Cho, HS; Daigo, Y; Field, HI; Hamamoto, R; Hayami, S; Ikawa, N; Kelly, JD; Maehara, Y; Maejima, K; Masuda, K; Nakamura, Y; Neal, DE; Ponder, BA; Toyokawa, G; Tsunoda, T; Yamane, Y | 1 |
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| Chai, HB; Chávez, D; Cordell, GA; Díaz, F; Fairchild, CR; Farnsworth, NR; Kardono, LB; Kinghorn, AD; Lee, D; Mi, Q; Pezzuto, JM; Riswan, S; Tan, GT; Wild, R | 1 |
| Brambilla, E; Gazdar, AF; Minna, JD; Padar, A; Sathyanarayana, UG; Takahashi, T; Toyooka, S | 1 |
| Clarke, S; Frankel, A; Gutmann, DH; Herschman, HR; Jiang, W; Miranda, TB; Newsham, IF; Robb, VA; Roemer, ME; Singh, V | 1 |
| Kelsey, KT; Kraunz, KS; Liu, M; Nelson, HH; Wiencke, JK | 1 |
| Baylin, SB; Chen, WY; Gu, W; Luo, J; Wang, DH; Yen, RC | 1 |
| Baudler, M; Beck, JF; Benimetskaya, L; Gekeler, V; Gimmnich, P; Gonser, B; Grebe, C; Hanauer, G; Hofmann, HP; Leja, A; Maier, T; Pieles, U; Römmele, M; Sanders, K; Stein, CA; Wagner, T | 1 |
| Chen, H; Costa, M; Davidson, TL; Shinkai, Y; Yan, Y | 1 |
| Anami, Y; Fukai, S; Iijima, T; Ishiyama, T; Kano, J; Noguchi, M; Okubo, C; Shu, Y; Sun, W; Tanaka, R | 1 |
| Pulukuri, SM; Rao, JS | 1 |
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| Barlési, F; Gallegos-Ruiz, MI; Giaccone, G; Kruyt, FA; Lefesvre, P; Loundou, A; Rodriguez, JA; Span, SW | 1 |
| Barlési, F; Gallegos-Ruiz, MI; Giaccone, G; Kruyt, FA; Lefesvre, P; Rodriguez, JA; Span, SW | 1 |
| Chen, H; Costa, M; Ellen, TP; Sun, H; Zhou, X | 1 |
| Cheah, MS; Hoffman, RM; Wallace, CD | 1 |
| Feinberg, AP; Vogelstein, B | 2 |
| Erb, N; Heller-Schöch, G; Lorenz, H; Müller, J; Schöch, G; Winkler, K | 1 |
| Carr, BI; Reilly, JG; Riggs, A; Smith, SS; Winberg, C | 1 |
| Borek, E | 1 |
| Chou, MW; Juliana, MM; Lu, AY; MacDonald, JS; Wislocki, PG; Yang, SK | 1 |
| Gerard, GF; Green, M; Loewenstein, PM | 1 |
| Briggs, RS; Day, IN; Ganderton, RH | 1 |
| Chen, W; Coxon, AB; Kaye, FJ; Khleif, SN; Otterson, GA | 1 |
| Baylin, SB; Biel, MA; Cavenee, WK; el Deiry, W; Issa, JP; Kuerbitz, SJ; Nelkin, BD; Wales, MM | 1 |
| Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
| Kondo, M; Osada, H; Suzuki, H; Takagi, K; Takahashi, T; Ueda, R | 1 |
| Buys, CH; Franke, M; Kok, K; Terpstra, P; Van den Berg, A; Veldhuis, PM | 1 |
| Barra, Y; Bergeron, P; Botto, F; Cau, P; De Meo, M; el Khyari, S; Henric, A; Seree, E | 1 |
| Astaldi Ricotti, GC; Baas, F; Borst, P; de Haas, M; de Nooij, J; Eijdems, EW; Kamst, E; Timmerman, AJ; Van der Schans, GP | 1 |
| Gradia, S; Hecht, SS; Peterson, LA; Ronai, ZA | 1 |
| Chen, WF; Ho, CT; Hong, JY; Shi, ST; Smith, TJ; Wang, ZY; Yang, CS | 1 |
| Horáková, I; Novotná, H; Vachtenheim, J | 1 |
| Lackie, PM; Papay, J; Roth, J; Scheidegger, EP | 1 |
| Carmella, SG; Foiles, PG; Hecht, SS; Murphy, SE; Peterson, LA | 1 |
| Adam-Rodwell, G; Morse, MA; Stoner, GD | 1 |
| Baylin, SB; Harris, CC; Spillare, EA; Vertino, PM | 1 |
| Edwards, CD; Ewen, ME; Mao, L; Merlo, A; Park, JE; Rollins, BJ; Shapiro, GI; Sidransky, D | 1 |
| Cillo, C; Dutrillaux, B; Flagiello, D; Malfoy, B; Poupon, MF | 1 |
| Kondo, M; Nagatake, M; Nishio, M; Osada, H; Shimokata, K; Takahashi, T; Uchida, K | 1 |
| Baylin, SB; Herman, JG; Jen, J; Merlo, A | 1 |
| Baylin, SB; Belinsky, SA; Issa, JP; Nikula, KJ | 1 |
| Bittman, R; Marino-Albernas, JR; Mayhew, E; Peters, A | 1 |
| Belinsky, SA; Kennedy, CH; Middleton, SK; Swafford, DS; Tesfaigzi, J | 1 |
| Biggs, ML; Ferreccio, C; Haque, R; Hopenhayn-Rich, C; Moore, L; Smith, A | 1 |
| Field, JK; Gorgoulis, VG; Halazonetis, TD; Kittas, C; Kotsinas, A; Kyroudi, A; Liloglou, T; Rassidakis, A; Veslemes, M; Zacharatos, P | 1 |
| Ahrendt, SA; Chow, JT; Decker, PA; Eisenberger, CF; Esteller, M; Herman, JG; Jen, J; Sidransky, D; Wu, L; Xu, LH; Yang, SC | 1 |
| Abrahamsen, N; Hougaard, S; Moses, HL; Nørgaard, P; Skovgaard Poulsen, H; Spang-Thomsen, M | 1 |
| Huang, L; Li, S; Whitmore, M | 1 |
| Bryant, D; Fong, KM; Fukuyama, Y; Gazdar, AF; Heda, S; Maitra, A; Minna, JD; Rathi, A; Sacchi, N; Thunnissen, F; Virmani, AK; Zöchbauer-Müller, S | 1 |
| Hong, WK; Kemp, BL; Khuri, FR; Lee, JJ; Liu, D; Mao, L; Tang, X | 1 |
| Mulshine, JL; Tockman, MS | 1 |
| Frébourg, T; Lamy, A; Métayer, J; Sesboüé, R; Thiberville, L | 1 |
| Su, C; Wang, D; Ye, Y | 1 |
| Chen, G; He, J; Liu, T | 1 |
| Forgacs, E; Minna, JD; Oláh, E; Zöchbauer-Müller, S | 1 |
| Arifi, AA; Lee, TW; Lo, DY; Mok, T; Ng, CS; Wan, S; Yim, AP; Zhang, J | 1 |
| Erickson, J; Kupper, R; Nagel, D; Toth, B | 1 |
| Baylin, SB; Latif, F; Lerman, MI; Makos, M; Nelkin, BD; Zbar, B | 1 |
| Evans, L; Gehrke, CW; Kuo, K; Madsen, R; Mitchell, EP; Schultz, P; Yarbro, JW | 1 |
| Biswas, DK; Brown, KL; Fei, YB | 1 |
| Hecht, SS; Peterson, LA | 1 |
| Gamou, S; Shimizu, N; Shimosato, Y | 1 |
| Kliasheva, RI | 1 |
| Chung, FL; Hecht, SS; Morse, MA | 1 |
| Amin, SG; Chung, FL; LaGreca, SD; Morse, MA | 1 |
| Anderson, MW; Belinsky, SA; Foley, JF; Maronpot, RR; White, CM | 1 |
| Kourides, IA; Whitfield, GK | 1 |
| Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL | 1 |
| Everett, CA; Hart, IR; Ormerod, EJ | 1 |
| Sekiya, T; Shiraishi, M | 1 |
| Akedo, H; Horai, T; Inoue, H; Mukai, M; Nishikawa, S; Ohigashi, H; Shinkai, K; Takeda, Y | 1 |
| Nyce, J | 1 |
| Baylin, SB; de Bustros, A; Ehrlich, G; Nelkin, BD; Poiesz, B; Silverman, A | 1 |
| Gamou, S; Merlino, GT; Shimizu, N; Shimosato, Y | 1 |
| Amin, SG; Chung, FL; Conran, PB; Hecht, SS; Mandal, S; Morse, MA; Stoner, GD; Wang, CX | 1 |
| Battey, J; Sausville, EA; Seifter, EJ | 1 |
| Baylin, SB; de Bustros, A; Höppener, JW; Lips, CJ; Nelkin, BD; Steenbergh, PH | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Wang, CX | 1 |
| Bates, SE; Benfield, JR; Derrick, M; Hammond, WG; Ohnuki, Y; Shively, J; Smith, SS; Teplitz, RL; Wain, JC | 1 |
| Hindmarsh, JT; McCurdy, RF | 1 |
| Jeltsch, W; Kleihues, P; Lijinsky, W; Schmerold, I; von Hofe, E | 1 |
| Castonguay, A; Hecht, SS; Rivenson, A; Trushin, N | 1 |
| Castonguay, A; d'Argy, R; Sperber, G; Tjälve, H; Trushin, N | 1 |
| Althoff, J; Cardesa, A; Mohr, U; Pour, P | 1 |
| Kaye, AM; Leboy, PS | 1 |
| Buu-Hoï, NP; Jacquignon, P; Lacassagne, A; Mangane, M; Stora, C; Zajdela, F | 1 |
| Bentvelzen, PA; den Engelse, L; Emmelot, P | 1 |
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18 review(s) available for isomethyleugenol and Cancer of Lung
| Article | Year |
|---|---|
Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics.
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Microbiota; RNA | 2022 |
Emerging role of N6-methyladenosine RNA methylation in lung diseases.
Topics: Adenosine; Asthma; Humans; Lung Diseases; Lung Neoplasms; Methylation; RNA; RNA, Messenger | 2022 |
RNA Epigenetics in Chronic Lung Diseases.
Topics: Adenosine; Epigenesis, Genetic; Humans; Lung Neoplasms; Methylation; RNA | 2022 |
The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy.
Topics: Humans; Lung Neoplasms; Methylation; Prognosis; Quality of Life; RNA | 2023 |
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Topics: 5-Methylcytosine; Animals; Breast Neoplasms; Colorectal Neoplasms; Female; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; Phylogeny; RNA, Messenger | 2020 |
[A Literature Review on the Role of TBX5 in Expression and Progression of Lung Cancer: Current Perspectives].
Topics: Animals; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; T-Box Domain Proteins | 2020 |
[Research Advances of m⁶A RNA Methylation in Non-small Cell Lung Cancer].
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Molecular Targeted Therapy; RNA, Messenger | 2020 |
m
Topics: Adenosine; Humans; Lung Neoplasms; Methylation; RNA; RNA, Long Noncoding; RNA, Messenger | 2021 |
[Research progress of circulating tumor DNA methylation in non-small cell lung cancer].
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Circulating Tumor DNA; DNA; DNA Methylation; Humans; Lung Neoplasms; Methylation; Neoplastic Cells, Circulating | 2018 |
Clinicopathological Significance and Diagnostic Value of DLEC1 Hypermethylation in Lung Cancer: A Meta-analysis.
Topics: Adenocarcinoma; Age Factors; Biomarkers, Tumor; Carcinoma, Squamous Cell; Databases, Bibliographic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Lymphatic Metastasis; Methylation; Neoplasm Staging; Odds Ratio; Predictive Value of Tests; Risk; ROC Curve; Sensitivity and Specificity; Tumor Suppressor Proteins | 2019 |
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
Topics: Acetylation; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Lung Neoplasms; Methylation; Pulmonary Disease, Chronic Obstructive; RNA, Untranslated | 2013 |
Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins p21(ras); Signal Transduction | 2014 |
[Epigenetic modifications in lung cancer].
Topics: Acetylation; Chromatin; Chromatin Assembly and Disassembly; CpG Islands; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Genes, Tumor Suppressor; Histones; Humans; Lung Neoplasms; Methylation; Neoplasm Proteins; Protein Processing, Post-Translational | 2009 |
Biomarkers of ambient air pollution and lung cancer: a systematic review.
Topics: Air Pollution; Biomarkers; DNA Adducts; Environmental Exposure; Humans; Lung Neoplasms; Methylation; Micronuclei, Chromosome-Defective; Oxidative Stress; Pyrenes | 2012 |
Impact of smoking status on the biological behavior of lung cancer.
Topics: Acid Anhydride Hydrolases; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Biomarkers; Disease Progression; Health Behavior; Health Status; Humans; Hypoxia-Inducible Factor 1; Japan; Loss of Heterozygosity; Lung Neoplasms; Methylation; Neoplasm Proteins; Nicotiana; Prognosis; Risk Factors; Smoking | 2007 |
The early detection of occult lung cancer.
Topics: Gene Deletion; Gene Expression Regulation; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Genetic Markers; Humans; Immunologic Tests; Loss of Heterozygosity; Lung Neoplasms; Mass Screening; Methylation; Microsatellite Repeats; Mutation; Polymerase Chain Reaction; Prospective Studies; Radiography, Thoracic; Sputum; Time Factors; Tomography, X-Ray Computed | 2000 |
Molecular genetic abnormalities in the pathogenesis of human lung cancer.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Chromosome Aberrations; Disease Susceptibility; Genes, Tumor Suppressor; Growth Substances; Humans; Lung Neoplasms; Methylation; Molecular Biology; Neoplasm Proteins; Oncogenes; Promoter Regions, Genetic; Stem Cells; Tobacco Smoke Pollution | 2001 |
Clinical and environmental aspects of arsenic toxicity.
Topics: Abnormalities, Drug-Induced; Adsorption; Animals; Arsenic; Arsenic Poisoning; Chemical Phenomena; Chemical Precipitation; Chemistry; Ecology; Environment; Environmental Pollutants; Female; Gases; Humans; Inactivation, Metabolic; Intestinal Absorption; Lung; Lung Neoplasms; Maternal-Fetal Exchange; Methylation; Oxidation-Reduction; Plants; Pregnancy; Skin; Skin Neoplasms; Tissue Distribution | 1986 |
243 other study(ies) available for isomethyleugenol and Cancer of Lung
| Article | Year |
|---|---|
Development and validation of m6A RNA methylation regulators-based signature in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Humans; Lung Neoplasms; Methylation; Prognosis; RNA | 2021 |
The landscape of m
Topics: Adenosine; Biomarkers, Tumor; Computational Biology; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Lung Neoplasms; Methylation; Prognosis; RNA; Signal Transduction; Small Cell Lung Carcinoma | 2021 |
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; MicroRNAs; Receptor, Transforming Growth Factor-beta Type I; RNA Stability; RNA, Long Noncoding; Smad2 Protein; Smad3 Protein | 2023 |
CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA, Complementary | 2021 |
Expression and prognostic significance of m6A-related genes in TP53-mutant non-small-cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Computational Biology; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mutation; Prognosis; Tumor Suppressor Protein p53 | 2022 |
Survival-associated N
Topics: Adenine; Adenosine; Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Databases, Genetic; Female; Gene Expression; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; Principal Component Analysis; Prognosis; RNA, Messenger; ROC Curve; Survival Rate; Time Factors | 2021 |
Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Basidiomycota; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Fungal Polysaccharides; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Molecular Weight; Spectroscopy, Fourier Transform Infrared | 2022 |
PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1
Topics: Animals; Carcinogenesis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Chromatin Immunoprecipitation; Colonic Neoplasms; Hematopoiesis; Lectins, C-Type; Lung Neoplasms; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Positive Regulatory Domain I-Binding Factor 1; Protein-Arginine N-Methyltransferases; Receptors, Immunologic; RNA-Seq; Signal Transduction; Single-Cell Analysis | 2022 |
TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer.
Topics: Animals; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Demethylation; DNA-Binding Proteins; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Demethylases; Histones; Lung Neoplasms; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2021 |
Methylation Pattern Mediated by m
Topics: Adenocarcinoma of Lung; Humans; Lung Neoplasms; Methylation; Neoplasm Invasiveness; Prognosis; Transfection; Tumor Microenvironment | 2022 |
Integrative Analysis of m6A RNA Methylation Regulators and the Tumor Immune Microenvironment in Non-Small-Cell Lung Cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; RNA; Tumor Microenvironment | 2022 |
Correlation analysis of m6A-modified regulators with immune microenvironment infiltrating cells in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Adenosine; Humans; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Methylation; RNA; RNA Processing, Post-Transcriptional; Tumor Microenvironment | 2022 |
Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Endoribonucleases; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Homologous Recombination; Humans; Lung Neoplasms; Membrane Proteins; Methylation; Mitochondrial Membrane Transport Proteins; Prognosis; Protein Serine-Threonine Kinases; Proteinase Inhibitory Proteins, Secretory; Tumor Suppressor Proteins | 2022 |
Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA, Circular; Tensins | 2022 |
Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9.
Topics: Adenocarcinoma of Lung; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Methylation; Mice; MicroRNAs | 2022 |
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit-induced long intergenic non-protein coding RNA 1833 N6-methyladenosine methylation promotes the non-small cell lung cancer progression via regulating heterogeneous nuclear ribon
Topics: Adenosine; Animals; Carcinoma, Non-Small-Cell Lung; Catalytic Domain; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; RNA, Long Noncoding | 2022 |
One sample fits all: a microfluidic-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer.
Topics: Cell-Free Nucleic Acids; Humans; Lung Neoplasms; Methylation; Microfluidics; Neoplastic Cells, Circulating | 2022 |
Entanglement of Methylation Changes and cGAS-STING Signaling in Non-Small-Cell Lung Cancer.
Topics: Carcinoma, Non-Small-Cell Lung; DNA; Humans; Lung Neoplasms; Mechanotransduction, Cellular; Methylation; Nucleotidyltransferases; Tumor Microenvironment | 2023 |
[Comprehensive Analysis of the Relationship between m6A Methylation Patterns and Immune Microenvironment in Lung Adenocarcinoma].
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenosine; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Tumor Microenvironment | 2022 |
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
Topics: Alkylation; Cell Line, Tumor; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Phosphorylation; Protein Processing, Post-Translational; Small Cell Lung Carcinoma | 2022 |
Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression.
Topics: Animals; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Nude; MicroRNAs; RNA-Binding Proteins; Sincalide; Suppressor of Cytokine Signaling Proteins | 2022 |
LRTCLS: low-rank tensor completion with Laplacian smoothing regularization for unveiling the post-transcriptional machinery of N6-methylation (m6A)-mediated diseases.
Topics: Adenosine; Alternative Splicing; Carcinoma, Non-Small-Cell Lung; COVID-19; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA-Binding Proteins; RNA, Circular | 2022 |
Comprehensive Analysis of Gene Signatures of m6ARNA Methylation Regulators in Lung Adenocarcinoma and Development of a Risk Scoring System.
Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Humans; Lung Neoplasms; Methylation; Prognosis; Risk Factors | 2022 |
Methylation patterns of Lys9 and Lys27 on histone H3 correlate with patient outcome and tumor progression in lung cancer.
Topics: Adenocarcinoma of Lung; DNA Methylation; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Prognosis; Retrospective Studies | 2022 |
Serum-derived extracellular vesicles promote the growth and metastasis of non-small cell lung cancer by delivering the m6A methylation regulator HNRNPC through the regulation of DLGAP5.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Extracellular Vesicles; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Lung Neoplasms; Methylation; Mice; Mice, Nude; Neoplasm Proteins; RNA, Messenger | 2023 |
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Topics: Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Methylation; Methyltransferases; RNA, Messenger; Transcription Factor AP-1; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factors | 2022 |
Methylation of N6 adenosine-related long noncoding RNA: effects on prognosis and treatment in 'driver-gene-negative' lung adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Humans; Lung; Lung Neoplasms; Methylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; Tumor Microenvironment | 2023 |
Cancer-Associated Fibroblasts Hinder Lung Squamous Cell Carcinoma Oxidative Stress-Induced Apoptosis via METTL3 Mediated m
Topics: Animals; Apoptosis; Cancer-Associated Fibroblasts; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type X; Culture Media, Conditioned; Fibroblasts; Lung; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Nude; Oxidative Stress; RNA, Messenger; Sincalide | 2022 |
AKBA inhibits radiotherapy resistance in lung cancer by inhibiting maspin methylation and regulating the AKT/FOXO1/p21 axis.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Forkhead Box Protein O1; Humans; Lung Neoplasms; Methylation; Proto-Oncogene Proteins c-akt; Triterpenes | 2023 |
SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer.
Topics: Autophagy; Base Sequence; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; RNA, Ribosomal, 28S; RNA, Small Nucleolar; Stearoyl-CoA Desaturase | 2023 |
Ligand-independent EphA2 contributes to chemoresistance in small-cell lung cancer by enhancing PRMT1-mediated SOX2 methylation.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Erythropoietin; Humans; Ligands; Lung Neoplasms; Methylation; Protein-Arginine N-Methyltransferases; Repressor Proteins; Small Cell Lung Carcinoma; SOXB1 Transcription Factors | 2023 |
Analysis of m
Topics: Adenocarcinoma of Lung; Humans; Lung Neoplasms; Methylation; Protein Processing, Post-Translational; Tumor Microenvironment | 2022 |
The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m
Topics: Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Methylation; Mitochondria; RNA, Long Noncoding | 2023 |
METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation.
Topics: Adenosine; Animals; Carcinoma, Pancreatic Ductal; DEAD-box RNA Helicases; Gemcitabine; Humans; Lung Neoplasms; Methylation; Methyltransferases; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2023 |
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance.
Topics: B7-H1 Antigen; Biomarkers; Carcinoma, Non-Small-Cell Lung; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation | 2023 |
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Topics: Adenocarcinoma of Lung; Ecosystem; Endothelial Cells; Humans; Lung Neoplasms; Methylation; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; RNA-Binding Proteins; Tumor Microenvironment | 2023 |
ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation.
Topics: Animals; Epithelial Cells; Humans; Lung Neoplasms; Mammals; Methylation; Mice; MicroRNAs; Promoter Regions, Genetic; Proteolysis; Up-Regulation | 2023 |
SETD1A-mediated H3K4me3 methylation upregulates lncRNA HOXC-AS3 and the binding of HOXC-AS3 to EP300 and increases EP300 stability to suppress the ferroptosis of NSCLC cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; E1A-Associated p300 Protein; Ferroptosis; Humans; Lung Neoplasms; Methylation; RNA, Long Noncoding | 2023 |
Advances in methylation analysis of liquid biopsy in early cancer detection of colorectal and lung cancer.
Topics: Cell-Free Nucleic Acids; Colorectal Neoplasms; Gastrointestinal Agents; Humans; Liquid Biopsy; Lung Neoplasms; Methylation | 2023 |
Exploring the methylation status of CFTR and PKIA genes as potential biomarkers for lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Biomarkers; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Lung Neoplasms; Male; Methylation | 2023 |
Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Guanine Nucleotide Exchange Factors; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras) | 2023 |
Combined Methylation of
Topics: Biomarkers, Tumor; DNA; Homeodomain Proteins; Humans; Lung Neoplasms; Methylation; Pleural Effusion; Pleural Effusion, Malignant | 2023 |
Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma.
Topics: Adenosine; Aged; AlkB Homolog 5, RNA Demethylase; Antineoplastic Agents, Immunological; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Methylation; Methyltransferases; Middle Aged; Prognosis; RNA-Binding Proteins; RNA-Seq; T Follicular Helper Cells; Transcriptome | 2020 |
CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis.
Topics: Acetylation; Animals; Cell Line, Tumor; Chromatin Immunoprecipitation; Colorectal Neoplasms; Disease Progression; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Peptide Fragments; Plasmids; Protein Processing, Post-Translational; Sialoglycoproteins; Signal Transduction; Ubiquitin-Protein Ligases | 2020 |
Radiation Induces Autophagy
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epigenesis, Genetic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Microtubule-Associated Proteins; RNA, Small Interfering | 2020 |
Diagnostic, progressive and prognostic performance of m
Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Methyltransferases; RNA | 2020 |
3'-Terminal 2'-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.
Topics: Apoptosis Regulatory Proteins; Argonaute Proteins; Carcinoma, Non-Small-Cell Lung; Exoribonucleases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Methyltransferases; MicroRNAs; RNA-Binding Proteins | 2020 |
Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cisplatin; Disulfides; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; MAP Kinase Signaling System; Methylation; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Sulfinic Acids | 2020 |
Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT:
Topics: A549 Cells; Animals; Antigens, CD; Benzaldehydes; Cadherins; Epithelial-Mesenchymal Transition; Female; Histones; Humans; Lung; Lung Neoplasms; Methylation; Oxidative Stress; Promoter Regions, Genetic; Rats; Rats, Wistar | 2020 |
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; DNA-Binding Proteins; Female; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Prognosis | 2021 |
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties.
Topics: Animals; Cell Line, Tumor; DNA Helicases; Female; Humans; Lung Neoplasms; Methylation; Mice; Mice, Nude; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation | 2020 |
Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells.
Topics: Carbon-Sulfur Lyases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Fibroblasts; Histones; Humans; Lung Neoplasms; Methionine; Methylation; Recombinant Proteins | 2020 |
LncRNA SNHG10 is downregulated in non-small cell lung cancer and predicts poor survival.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Down-Regulation; Humans; Linear Models; Lung Neoplasms; Methylation; MicroRNAs; RNA, Long Noncoding; Tumor Cells, Cultured | 2020 |
Validation of Lung EpiCheck, a novel methylation-based blood assay, for the detection of lung cancer in European and Chinese high-risk individuals.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; China; Early Detection of Cancer; Humans; Lung; Lung Neoplasms; Methylation; Prospective Studies | 2021 |
KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.
Topics: A549 Cells; Adenocarcinoma of Lung; Adenosine; Cell Movement; Cell Proliferation; Databases, Genetic; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Methylation; Middle Aged; Mucin-3; Neoplasm Invasiveness; Neoplasm Staging; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; Signal Transduction; Tumor Burden | 2021 |
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues.
Topics: Adenocarcinoma of Lung; Angiotensin-Converting Enzyme 2; COVID-19; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Methylation; Promoter Regions, Genetic; SARS-CoV-2; Serine Endopeptidases; Smoking; Up-Regulation | 2021 |
Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort.
Topics: Adult; Aged; Aged, 80 and over; Arsenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cohort Studies; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Female; Genotype; Humans; Lung Neoplasms; Male; Methylation; Methyltransferases; Mexico; Middle Aged; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Risk Factors; Surveys and Questionnaires; Young Adult | 2021 |
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Topics: Animals; Basigin; Carcinoma, Non-Small-Cell Lung; Cell Line; Humans; Lactic Acid; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Oligopeptides | 2021 |
Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
Topics: Animals; Biocatalysis; Carcinogenesis; Carcinoma, Squamous Cell; Female; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Male; Methylation; Mice; Models, Molecular; Mutation; Nuclear Proteins; Receptor, Fibroblast Growth Factor, Type 1; Xenograft Model Antitumor Assays | 2021 |
Squamous cell lung cancer changes driver.
Topics: Carcinoma, Non-Small-Cell Lung; Epithelial Cells; Histones; Humans; Lung Neoplasms; Methylation | 2021 |
ARID1A genomic alterations driving microsatellite instability through somatic MLH1 methylation with response to immunotherapy in metastatic lung adenocarcinoma: a case report.
Topics: Adenocarcinoma of Lung; CD8-Positive T-Lymphocytes; DNA-Binding Proteins; Female; Genomics; Humans; Immunotherapy; Lung Neoplasms; Methylation; Microsatellite Instability; Middle Aged; Mutation; MutL Protein Homolog 1; Transcription Factors | 2021 |
A driver gene hiding in plain sight.
Topics: Carcinoma, Non-Small-Cell Lung; Epithelial Cells; Histones; Humans; Lung Neoplasms; Methylation | 2021 |
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Topics: Drug Resistance; Humans; Lung Neoplasms; Methylation; Methyltransferases; MicroRNAs; RNA, Messenger | 2021 |
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Topics: Adenosine; Animals; Base Sequence; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Cellular Reprogramming; Cytokines; Gene Deletion; Gene Expression Regulation; Lung Neoplasms; Macrophages; Melanoma, Experimental; Methylation; Methyltransferases; Mice, Knockout; Myeloid Cells; Neoplasm Metastasis; NF-kappa B; Programmed Cell Death 1 Receptor; Repressor Proteins; RNA-Binding Proteins; RNA, Neoplasm; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2021 |
Aberrant methylation modifications reflect specific drug responses in small cell lung cancer.
Topics: Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA, Long Noncoding; Small Cell Lung Carcinoma | 2021 |
Methyl-Donors Can Induce Apoptosis and Attenuate Both the Akt and the Erk1/2 Mediated Proliferation Pathways in Breast and Lung Cancer Cell Lines.
Topics: Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Choline; Folic Acid; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; Methionine; Methylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Vitamin B 12 | 2021 |
A genome-wide screen for differentially methylated long noncoding RNAs identified that lncAC007255.8 is regulated by promoter DNA methylation in Beas-2B cells malignantly transformed by NNK.
Topics: Bronchi; Butanones; Cell Line; Cell Transformation, Neoplastic; DNA; DNA (Cytosine-5-)-Methyltransferase 1; Epithelial Cells; Gene Expression Regulation; Genome-Wide Association Study; Humans; Lung Neoplasms; Methylation; Nitrosamines; Promoter Regions, Genetic; Respiratory Mucosa; RNA, Long Noncoding; Up-Regulation | 2021 |
PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.
Topics: Arginine; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Methylation; Prognosis; Protein-Arginine N-Methyltransferases; Smad7 Protein; STAT3 Transcription Factor | 2021 |
Erlotinib complexation with randomly methylated
Topics: A549 Cells; Animals; Antineoplastic Agents; beta-Cyclodextrins; Caco-2 Cells; Calorimetry, Differential Scanning; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Liberation; Erlotinib Hydrochloride; Humans; Intestinal Absorption; Lung Neoplasms; Methylation; Mice; Microscopy, Electron, Scanning; Solubility; Treatment Outcome | 2021 |
Topics: Adenocarcinoma of Lung; Aged; Biomarkers, Tumor; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Immune Tolerance; Immunotherapy; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Membrane Glycoproteins; Methylation; Middle Aged; Oxidoreductases; Prognosis; Promoter Regions, Genetic; RNA-Seq; RNA, Messenger; Tumor Microenvironment | 2021 |
Gene Characteristics and Prognostic Values of m
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinoma, Non-Small-Cell Lung; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Prognosis; RNA; RNA Helicases | 2021 |
Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment.
Topics: Adenocarcinoma of Lung; Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Prognosis; RNA Processing, Post-Transcriptional; Survival Rate; Transcriptome; Tumor Microenvironment | 2021 |
Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.
Topics: Acetylation; Aged; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Databases, Genetic; Down-Regulation; Female; Gene Expression Profiling; Homeodomain Proteins; Humans; Lung Neoplasms; Male; Methylation; Mice, Inbred BALB C; Mice, Nude; Middle Aged; RNA, Long Noncoding | 2017 |
Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
Topics: Anaplastic Lymphoma Kinase; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Oncogene Proteins, Fusion; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction | 2017 |
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.
Topics: Adenocarcinoma; AMP-Activated Protein Kinases; Animals; Carcinoma, Squamous Cell; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Kaplan-Meier Estimate; Lung Neoplasms; Methylation; Mice, 129 Strain; Mice, Knockout; Polycomb Repressive Complex 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Tumor Cells, Cultured | 2017 |
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzazepines; Bridged-Ring Compounds; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydrazones; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation; Mice; Neoadjuvant Therapy; Pyrimidines; Taxoids; Transcription, Genetic | 2017 |
Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Topics: A549 Cells; Amino Acid Substitution; Biocatalysis; Catalytic Domain; Cell Cycle Proteins; Crystallography, X-Ray; Endometrial Neoplasms; Female; Gene Expression; Guanine Nucleotide Exchange Factors; HCT116 Cells; HEK293 Cells; Histidine; Humans; Isoenzymes; Kinetics; Lung Neoplasms; Male; Methylation; Methyltransferases; Models, Molecular; Mutation; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Fusion Proteins; Substrate Specificity | 2017 |
EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL1; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Male; Methylation; Mice; Molecular Targeted Therapy; Mouth Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; STAT1 Transcription Factor; Up-Regulation; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2017 |
YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells.
Topics: Afatinib; Antineoplastic Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Imidazoles; Lung Neoplasms; Methylation; Naphthoquinones; Octamer Transcription Factor-3; Phosphorylation; Quinazolines; RNA, Messenger | 2017 |
Tri-methylation of H3K79 is decreased in TGF-β1-induced epithelial-to-mesenchymal transition in lung cancer.
Topics: A549 Cells; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Regulatory Networks; Histone Deacetylase Inhibitors; Histones; Humans; Lung Neoplasms; Methylation; Transforming Growth Factor beta | 2017 |
SMYD5 Controls Heterochromatin and Chromosome Integrity during Embryonic Stem Cell Differentiation.
Topics: A549 Cells; Animals; Base Sequence; Cell Differentiation; Cell Line, Tumor; Chromosomes; Colonic Neoplasms; DNA Copy Number Variations; Embryonic Stem Cells; Epigenesis, Genetic; HCT116 Cells; Heterochromatin; Histone Code; Histones; Humans; Lung Neoplasms; MCF-7 Cells; Methylation; Methyltransferases; Mice; RNA Interference; RNA, Small Interfering; Sequence Analysis, DNA; Xenograft Model Antitumor Assays | 2017 |
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
Topics: Aged; Animals; Asbestos; Carcinogenesis; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p19; Female; Humans; Lung Neoplasms; Male; Mesothelioma; Mesothelioma, Malignant; Methylation; Mice; Mice, Inbred C57BL; Middle Aged; Nanotubes, Carbon | 2017 |
Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks.
Topics: Acetylation; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lung Neoplasms; Methylation; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational; Proteomics; Signal Transduction; Small Cell Lung Carcinoma; Tumor Cells, Cultured | 2018 |
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Topics: A549 Cells; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Signal Transduction; Transcription Factors; Tumor Burden; YAP-Signaling Proteins | 2018 |
RNA-sequencing in non-small cell lung cancer shows gene downregulation of therapeutic targets in tumor tissue compared to non-malignant lung tissue.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Male; Methylation; Molecular Targeted Therapy; RNA, Neoplasm; Vascular Endothelial Growth Factor A | 2018 |
Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression.
Topics: A549 Cells; Animals; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; CpG Islands; Disease Progression; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Nude; MicroRNAs; Middle Aged; Repressor Proteins; Xenograft Model Antitumor Assays | 2018 |
The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer.
Topics: 5-Methylcytosine; Aged; Cell Line, Tumor; Cytidine Deaminase; Deamination; Disease Progression; ErbB Receptors; Female; Humans; Hydrolysis; Lung Neoplasms; Male; Mass Spectrometry; Methylation; Middle Aged; Mutation; NF-kappa B; Polymerase Chain Reaction; Protein-Tyrosine Kinases | 2018 |
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
Topics: A549 Cells; Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; NIH 3T3 Cells; Protein Methyltransferases; Proto-Oncogene Proteins c-akt; Transplantation, Heterologous; Ubiquitination | 2019 |
JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Checkpoint Kinase 1; Cisplatin; Drug Resistance, Neoplasm; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation | 2019 |
Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin.
Topics: A549 Cells; Animals; Antigens, CD; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cisplatin; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Homeodomain Proteins; Humans; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Nerve Tissue Proteins; Promoter Regions, Genetic; Transcription, Genetic | 2019 |
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Topics: A549 Cells; Acetylation; Antigens, CD; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Snail Family Transcription Factors; Transforming Growth Factor beta1 | 2019 |
Long non-coding RNA H19 is responsible for the progression of lung adenocarcinoma by mediating methylation-dependent repression of CDH1 promoter.
Topics: A549 Cells; Adenocarcinoma of Lung; Adult; Aged; Animals; Antigens, CD; Apoptosis; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Small Interfering; Young Adult | 2019 |
SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lung; Lung Neoplasms; Male; MAP Kinase Signaling System; Methylation; Methyltransferases; Middle Aged; Neoplasm Invasiveness; Pneumonectomy; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Survival Rate | 2019 |
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Death; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein Methyltransferases | 2013 |
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Non-Small-Cell Lung; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Methylation; MicroRNAs; Promoter Regions, Genetic; Repressor Proteins; Wnt Signaling Pathway | 2013 |
Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Cell Line, Tumor; Dioxygenases; Down-Regulation; Heterochromatin; Histone Demethylases; Histones; Humans; Lung Neoplasms; Methylation; Nuclear Proteins; RNA, Long Noncoding; RNA, Small Interfering; Survival Analysis; Transcription, Genetic; Transfection | 2013 |
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins | 2013 |
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Dual Specificity Phosphatase 3; Epigenesis, Genetic; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Heterografts; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Male; MAP Kinase Signaling System; Methylation; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Prognosis; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA Interference; RNA, Messenger; RNA, Neoplasm | 2013 |
Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile.
Topics: Aged; Arsenic; Case-Control Studies; Chile; Drinking Water; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Odds Ratio; Risk Factors; Surveys and Questionnaires; Urinary Bladder Neoplasms; Water Pollutants | 2014 |
The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
Topics: B-Lymphocytes; Bronchi; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chromatin Assembly and Disassembly; Epithelium; Gene Expression Regulation, Neoplastic; Glucocorticoids; Histones; Humans; Inflammation; Interferon-gamma; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Receptors, Glucocorticoid; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Ubiquitination | 2014 |
Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition.
Topics: Cell Line, Tumor; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Methylation; Mixed Function Oxygenases; Neoplasm Invasiveness; Proto-Oncogene Proteins; RNA, Neoplasm; Time Factors; Transforming Growth Factor beta | 2014 |
Epigenetic analysis of microRNA genes in tumors from surgically resected lung cancer patients and association with survival.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Female; Humans; Lung Neoplasms; Male; Methylation; MicroRNAs; Middle Aged; Polymerase Chain Reaction; Smoking; Survival Rate | 2015 |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Protein Phosphatase 2; Proto-Oncogene Proteins A-raf; Signal Transduction | 2014 |
P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression.
Topics: Animals; Binding Sites; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Multivariate Analysis; Neoplasm Staging; Polycomb Repressive Complex 2; Response Elements; Risk Factors; RNA, Long Noncoding; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Tumor Burden; Tumor Suppressor Protein p53 | 2014 |
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Histones; Humans; Lung Neoplasms; Lysine; Male; Methylation; Middle Aged; NF-E2-Related Factor 2; Polycomb Repressive Complex 2; Survival Analysis | 2014 |
Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.
Topics: Adenocarcinoma; Administration, Oral; Animals; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Survival; Cofilin 1; Dietary Supplements; Endoplasmic Reticulum; Epithelial-Mesenchymal Transition; Folic Acid; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Methylation; Mice, SCID; Neoplasm Transplantation; p21-Activated Kinases; Phosphorylation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Transport; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Signal Transduction | 2014 |
Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation.
Topics: Animals; Apoptosis Regulatory Proteins; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Histones; Humans; Lung Neoplasms; Methylation; Mice; Neoplasms, Experimental; Repressor Proteins; Transcription, Genetic; Tripartite Motif-Containing Protein 28 | 2014 |
Involvement of EZH2, SUV39H1, G9a and associated molecules in pathogenesis of urethane induced mouse lung tumors: potential targets for cancer control.
Topics: Animals; Enhancer of Zeste Homolog 2 Protein; Female; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; MicroRNAs; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; Urethane | 2014 |
Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
Topics: Adaptor Proteins, Signal Transducing; Androgens; Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Estrogen Receptor alpha; Estrogens; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Signal Transduction; Up-Regulation | 2014 |
H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis.
Topics: Animals; Annexin A2; Cell Line, Tumor; Epigenesis, Genetic; Gene Silencing; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Methylation; Neoplasm Metastasis; Promoter Regions, Genetic; Protein Methyltransferases; Signal Transduction; Smad2 Protein; Smad3 Protein; Xenograft Model Antitumor Assays; Zebrafish | 2014 |
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.
Topics: Animals; Cell Separation; Chlorocebus aethiops; Chromatin; COS Cells; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Fibroblasts; Flow Cytometry; Gamma Rays; Gene Expression Regulation; Genes, Dominant; HeLa Cells; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Lysine; Methylation; Mice; Mutation; Phosphorylation; RNA, Small Interfering; Tissue Array Analysis | 2014 |
Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract.
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; MicroRNAs; Mitogen-Activated Protein Kinase 7; Smoking | 2016 |
Clinicopathological significance and potential drug target of T-cadherin in NSCLC.
Topics: Antineoplastic Agents; Cadherins; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Molecular Targeted Therapy | 2015 |
Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; ELAV-Like Protein 1; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lung Neoplasms; Male; Methylation; Middle Aged; Minichromosome Maintenance Complex Component 6; Neoplasm Staging; Prognosis; Protein Transport | 2015 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |
Identification of Endoglin as an epigenetically regulated tumour-suppressor gene in lung cancer.
Topics: Antigens, CD; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Progression; Down-Regulation; Endoglin; Gene Silencing; Genes, Tumor Suppressor; Genome-Wide Association Study; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein Array Analysis; Receptors, Cell Surface; Sequence Analysis, DNA | 2015 |
Peroxisome proliferator activated receptor γ protein expression is asymmetrically distributed in primary lung tumor and metastatic to lung osteosarcoma samples and does not correlate with gene methylation.
Topics: Animals; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Male; Methylation; Osteosarcoma; PPAR gamma | 2015 |
Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.
Topics: Acetylation; Adenosine; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mutation; Phosphorylation; Polycomb Repressive Complex 2; Signal Transduction; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Lung Neoplasms; Methylation; Molecular Docking Simulation; Point Mutation; Protein Kinase Inhibitors; Pyrimidines | 2016 |
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.
Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenocarcinoma of Lung; Arginine; Breast Neoplasms; Carcinoma, Squamous Cell; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; MCF-7 Cells; Methylation; Neoplasm Invasiveness; Neoplasms; Prognosis; Protein-Arginine N-Methyltransferases; Sequence Analysis, RNA; Transcription, Genetic; Transforming Growth Factor beta | 2017 |
Integration of multiple "OMIC" biomarkers: A precision medicine strategy for lung cancer.
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Cytokines; Early Detection of Cancer; Gene Expression; Humans; Lung Neoplasms; Mass Screening; Metabolomics; Methylation; MicroRNAs; Neoplasm Recurrence, Local; Neoplasm Staging; Precision Medicine; Smoking; Survival Rate; Tomography, X-Ray Computed | 2017 |
KDM6B histone demethylase is an epigenetic regulator of estrogen receptor β expression in human pleural mesothelioma.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line, Tumor; Epigenesis, Genetic; Estrogen Receptor beta; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Methylation; Protein Processing, Post-Translational | 2016 |
NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.
Topics: Animals; Azepines; Benzamides; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Diphenylamine; Enhancer Elements, Genetic; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression; Gene Knockdown Techniques; Genes, ras; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Methylation; Mice; Mice, Nude; Nuclear Proteins; Repressor Proteins; Transcription Factors; Transcription, Genetic; Triazoles; Xenograft Model Antitumor Assays | 2016 |
[Methylation Status of the SOCS3 Gene Promoter in H2228 Cells and
EML4-ALK-positive Lung Cancer Tissues].
Topics: Cell Line, Tumor; Cell Proliferation; DNA Methylation; Humans; Lung Neoplasms; Methylation; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Suppressor of Cytokine Signaling 3 Protein | 2016 |
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Topics: Acetylation; Amino Acid Sequence; Antigens, Neoplasm; Aspartic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glutamic Acid; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Models, Biological; Models, Molecular; Mutation; Protein Binding; Protein Domains; Transcription Factors; Tumor Suppressor Protein p53 | 2016 |
Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression.
Topics: Animals; Breast Neoplasms; Female; Gene Deletion; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MCF-7 Cells; Methylation; Mice; Mice, Nude; Mutation; Neoplasms, Experimental; Protein-Arginine N-Methyltransferases | 2017 |
Tungsten exposure causes a selective loss of histone demethylase protein.
Topics: Adenocarcinoma; Animals; Bronchi; Cells, Cultured; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Male; Methylation; Mice; Proteolysis; Retinoblastoma-Binding Protein 2; Tungsten | 2017 |
Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells.
Topics: Animals; Antineoplastic Agents; Female; Glycosylation; Killer Cells, Natural; Lung Neoplasms; Macrophage Activation; Melanoma, Experimental; Methylation; Mice; Neoplasm Metastasis; Pectins; Plant Leaves; Polygalacturonase; Tea | 2017 |
Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Precancerous Conditions; Prognosis; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Mining the epigenome for methylated genes in lung cancer.
Topics: Chromosomes, Human, Pair 6; Epigenesis, Genetic; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic | 2008 |
Anti-angiogenic and anti-metastatic effects of beta-1,3-D-glucan purified from Hanabiratake, Sparassis crispa.
Topics: Agaricales; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; beta-Glucans; Capillaries; Cell Line; Cell Movement; Cell Proliferation; Female; Humans; Lung Neoplasms; Melanoma, Experimental; Methylation; Mice; Mice, Inbred ICR; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Proteoglycans; Structure-Activity Relationship; Vascular Endothelial Growth Factor A | 2009 |
Global levels of histone modifications predict prognosis in different cancers.
Topics: Acetylation; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Cohort Studies; Female; Histones; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Lung Neoplasms; Male; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Processing, Post-Translational; Repetitive Sequences, Nucleic Acid; Tissue Array Analysis | 2009 |
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Topics: Arsenites; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromates; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Nickel; Potassium Compounds; Protein Processing, Post-Translational; Sodium Compounds; Time Factors | 2009 |
Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.
Topics: Amino Acid Sequence; Chromatin Immunoprecipitation; Dioxygenases; F-Box Proteins; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Lysine; Methylation; Molecular Sequence Data; Nuclear Proteins; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Interaction Domains and Motifs; RNA Polymerase I; RNA, Ribosomal; RNA, Small Interfering; Sequence Alignment | 2009 |
Tumorigenic role of orphan nuclear receptor NR0B1 in lung adenocarcinoma.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Line, Tumor; DAX-1 Orphan Nuclear Receptor; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lymphatic Metastasis; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; Prognosis; Promoter Regions, Genetic; Recurrence; Transcription, Genetic | 2009 |
O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2010 |
Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat.
Topics: Adenocarcinoma; Animals; Cell Line; Cell Line, Tumor; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, p16; Karyotyping; Lung Neoplasms; Methylation; Mice; Mice, Nude; Polymerase Chain Reaction; Rats; Rats, Wistar; Respiratory Mucosa | 2010 |
Epigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromosomes, Human, Pair 3; Epigenesis, Genetic; ErbB Receptors; Female; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Methylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Small Cell Lung Carcinoma; Thyroid Hormone Receptors beta | 2010 |
BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathological stage in non-small cell lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; CpG Islands; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; Transcription, Genetic | 2010 |
Natural mutagenesis of human genomes by endogenous retrotransposons.
Topics: Alu Elements; Brain Neoplasms; Genome, Human; Humans; Long Interspersed Nucleotide Elements; Lung Neoplasms; Methylation; Mutagenesis; Sequence Analysis, DNA | 2010 |
First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Mutation; Neoplasm Proteins; Neoplasm Staging; Poly-ADP-Ribose Binding Proteins; Protein Kinase Inhibitors; Quinazolines; Survival Analysis; Ubiquitin-Protein Ligases | 2011 |
The relationship between methylation of the Syk gene in the promoter region and the genesis of lung cancer.
Topics: Carcinoma, Large Cell; Carcinoma, Small Cell; Cell Line, Tumor; DNA Methylation; DNA Primers; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA; Syk Kinase | 2010 |
The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Antineoplastic Agents, Alkylating; beta-Galactosidase; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genetic Association Studies; Haplotypes; Humans; Linkage Disequilibrium; Luciferases; Lung Neoplasms; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Precancerous Conditions; Promoter Regions, Genetic; Smoking; Sputum; Temozolomide; Transcription, Genetic; Tumor Suppressor Proteins | 2011 |
The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma.
Topics: ADAM Proteins; Adult; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Methylation; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2011 |
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer.
Topics: Antigens, Neoplasm; Cell Line, Tumor; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Profiling; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Lysine; Melanoma-Specific Antigens; Membrane Proteins; Methylation; Neoplasm Proteins | 2011 |
Diagnosing peripheral lung cancer: the additional value of the Ras-association domain family 1A gene methylation and Kirsten rat sarcoma 2 viral oncogene homolog mutation analyses in washings in nondiagnostic bronchoscopy.
Topics: Adult; Aged; Aged, 80 and over; Bronchoscopy; DNA Mutational Analysis; DNA, Neoplasm; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Mutation; Polymerase Chain Reaction; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Reproducibility of Results; Time Factors; Tumor Suppressor Proteins | 2012 |
[Assay of methylated gene RARbeta2 in circulating DNA of blood from patients with lung cancer as a potential prognostic marker].
Topics: Adult; Carcinoma, Non-Small-Cell Lung; DNA, Neoplasm; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Receptors, Retinoic Acid; Risk Factors | 2011 |
The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation; Oligonucleotide Array Sequence Analysis; RNA Interference; RNA, Small Interfering; Transcription Factors; Transcription, Genetic; Urinary Bladder Neoplasms | 2012 |
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Topics: beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Hep G2 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Methylation; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tissue Array Analysis; Urinary Bladder Neoplasms; Wnt Signaling Pathway | 2011 |
Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Female; Histones; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Tissue Array Analysis | 2012 |
Structural analysis of a new cytotoxic demethylated analogue of neo-N-methylsansalvamide with a different peptide sequence produced by Fusarium solani isolated from potato.
Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Depsipeptides; Female; Fusarium; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Melanoma; Methylation; Molecular Structure; Ovarian Neoplasms; Peptides, Cyclic; Solanum tuberosum; Spectrometry, Mass, Electrospray Ionization; Uterine Neoplasms | 2012 |
Clinical outcomes of downregulation of E-cadherin gene expression in non-small cell lung cancer.
Topics: Adult; Aged; Cadherins; Carcinoma, Non-Small-Cell Lung; CpG Islands; Down-Regulation; Exons; Female; Humans; Lung; Lung Neoplasms; Male; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Chromatin organization is a major influence on regional mutation rates in human cancer cells.
Topics: Animals; CpG Islands; Epigenesis, Genetic; Euchromatin; Genome, Human; Heterochromatin; Histones; Humans; Leukemia; Lung Neoplasms; Male; Melanoma; Methylation; Mutagenesis; Mutation Rate; Neoplasms; Pan troglodytes; Polymorphism, Single Nucleotide; Principal Component Analysis; Prostatic Neoplasms; Small Cell Lung Carcinoma | 2012 |
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms; Methylation; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; RNA Interference; Transcription Factors | 2012 |
New terpenoids from the brown alga Stypopodium zonale.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Colonic Neoplasms; Humans; Inhibitory Concentration 50; Lung Neoplasms; Methylation; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phaeophyceae; Spain; Spectroscopy, Fourier Transform Infrared; Terpenes; Tumor Cells, Cultured | 2002 |
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Multivariate Analysis; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; Sulfites; Time Factors; Treatment Outcome | 2003 |
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.
Topics: Acylation; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Disease Models, Animal; Drug Screening Assays, Antitumor; Flavonoids; Humans; Indonesia; Inhibitory Concentration 50; Leukemia P388; Lung Neoplasms; Male; Methylation; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Prostatic Neoplasms; Tumor Cells, Cultured; Vitex | 2003 |
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Topics: Azacitidine; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; Humans; Kalinin; Laminin; Lung Neoplasms; Lymphocytes; Methylation; Models, Genetic; Mouth Mucosa; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cloning, Molecular; Humans; Lung Neoplasms; Membrane Proteins; Methylation; Microfilament Proteins; Protein-Arginine N-Methyltransferases; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae; Tumor Suppressor Proteins | 2004 |
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Topics: Bone Morphogenetic Protein 3; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation; Genes, ras; Growth Differentiation Factor 10; Humans; Lung Neoplasms; Methylation; Mutation; Polymerase Chain Reaction; ras Proteins; Signal Transduction; Tumor Cells, Cultured | 2005 |
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Topics: Adenocarcinoma; Aging; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; DNA Damage; Epigenesis, Genetic; Humans; Kruppel-Like Transcription Factors; Lung Neoplasms; Lymphoma; Methylation; Mice; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Sarcoma, Experimental; Sirtuin 1; Sirtuins; Soft Tissue Neoplasms; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation | 2005 |
G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; B-Lymphocytes; Carcinoma; Cell Line, Tumor; Cytosine; Female; Humans; Lung Neoplasms; Lymphocyte Activation; Methylation; Mice; Mice, Nude; Neoplasms; Oligodeoxyribonucleotides; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Thionucleotides; Xenograft Model Antitumor Assays | 2006 |
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Hypoxia; Cell Line, Tumor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Mice; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Protein Methyltransferases; Protein Processing, Post-Translational; Tetrahydrofolate Dehydrogenase; Transfection | 2006 |
The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma.
Topics: Adenocarcinoma; Biomarkers, Tumor; Cell Line, Tumor; Disease Progression; DNA, Neoplasm; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Staging; Nuclear Proteins; Prognosis; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis.
Topics: Animals; Coculture Techniques; Epigenesis, Genetic; Humans; Lung Neoplasms; Male; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Prostatic Neoplasms; RNA, Small Interfering; Urokinase-Type Plasminogen Activator | 2007 |
Global histone modifications predict prognosis of resected non small-cell lung cancer.
Topics: Acetylation; Aged; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Female; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Prognosis; Proportional Hazards Models; Protein Processing, Post-Translational; Survival Analysis | 2007 |
Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC.
Topics: Base Sequence; Carcinoma, Non-Small-Cell Lung; DNA Primers; Genotype; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Methylation; Minisatellite Repeats; Polymorphism, Genetic; Risk Factors | 2008 |
Arsenite alters global histone H3 methylation.
Topics: Arsenites; Blotting, Northern; Blotting, Western; Fluorescent Antibody Technique; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Methylation; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Methyltransferases; Sodium Compounds; Transcription, Genetic; Tumor Cells, Cultured | 2008 |
Hypomethylation of DNA in human cancer cells: a site-specific change in the c-myc oncogene.
Topics: Base Sequence; Cell Line; DNA Restriction Enzymes; DNA, Neoplasm; Glioma; Humans; Lung Neoplasms; Melanoma; Methylation; Neoplasms; Oncogenes | 1984 |
Hypomethylation distinguishes genes of some human cancers from their normal counterparts.
Topics: Aged; Base Sequence; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; Female; Genes; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasms | 1983 |
Hypomethylation of ras oncogenes in primary human cancers.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Colonic Neoplasms; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Humans; Lung Neoplasms; Methylation; Neoplasms; Nucleic Acid Hybridization; Oncogenes; Polymorphism, Genetic | 1983 |
Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.
Topics: Analysis of Variance; Autoanalysis; Breast Neoplasms; Female; Humans; Kidney Neoplasms; Longitudinal Studies; Lung Neoplasms; Lymphoma; Male; Methylation; Neoplasms; Prostatic Neoplasms; Ribonucleosides; RNA | 1983 |
The tumorigenicity of 5-azacytidine in the male Fischer rat.
Topics: Animals; Azacitidine; DNA; Kidney Neoplasms; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphatic Diseases; Male; Methylation; Neoplasms, Experimental; Rats; Rats, Inbred F344; Skin Neoplasms; Testicular Neoplasms | 1984 |
Toward a universal tumour marker.
Topics: Amino Acids; Asbestosis; Chorionic Gonadotropin; DNA, Neoplasm; Female; Humans; Hydatidiform Mole; Lung Neoplasms; Mesothelioma; Methylation; Neoplasm Proteins; Neoplasms; Nucleosides; Pregnancy; RNA, Neoplasm; RNA, Transfer; Uterine Neoplasms | 1984 |
Tumorigenicity of 7,12-dimethylbenz[a]anthracene, its hydroxymethylated derivatives and selected dihydrodiols in the newborn mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Animals, Newborn; Benz(a)Anthracenes; Carcinogens; Female; Hydroxylation; Liver Neoplasms; Lung Neoplasms; Methylation; Mice; Pregnancy | 1981 |
Characterization of a DNA polymerase activity in cultured human melanoma cells that copies poly(2'-O-methylcytidylate).
Topics: Cell Line; Deoxyguanine Nucleotides; DNA-Directed DNA Polymerase; Humans; Kinetics; Lung Neoplasms; Melanoma; Methylation; Molecular Weight; Oligodeoxyribonucleotides; Poly C; Polyribonucleotides; Templates, Genetic | 1980 |
Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma.
Topics: 5-Methylcytosine; Cytosine; DNA, Neoplasm; Electrophoresis, Agar Gel; Humans; Lung; Lung Neoplasms; Male; Methylation; Neoplasm Proteins; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Proteins; Restriction Mapping; Spermatozoa | 1995 |
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.
Topics: Azacitidine; Base Sequence; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Protein Kinase Inhibitors; Tumor Cells, Cultured | 1995 |
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Topics: Amino Acid Sequence; Brain Neoplasms; Breast Neoplasms; Cell Division; Chromosomes, Human, Pair 17; Colonic Neoplasms; CpG Islands; Female; Fibroblasts; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Growth Inhibitors; Humans; Kruppel-Like Transcription Factors; Lung Neoplasms; Methylation; Molecular Sequence Data; Organ Specificity; Recombinant Proteins; Sequence Alignment; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Zinc Fingers | 1995 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers.
Topics: Adult; Autoantigens; Base Sequence; Chromosomes, Human, Pair 11; DNA Primers; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Lung Neoplasms; Methylation; Molecular Sequence Data; Ribonucleoproteins, Small Nuclear; snRNP Core Proteins; Wilms Tumor | 1995 |
The genomic structure of the human UBE1L gene.
Topics: Base Sequence; Carcinoma, Small Cell; DNA Mutational Analysis; Exons; Gene Expression Regulation; Humans; Introns; Ligases; Lung Neoplasms; Methylation; Molecular Sequence Data; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases | 1995 |
Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors.
Topics: Base Sequence; Blotting, Western; Carcinoma, Squamous Cell; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; DNA; DNA Primers; DNA, Neoplasm; Gene Expression; Humans; Lung; Lung Neoplasms; Male; Methylation; Microsomes; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Polymerase Chain Reaction; RNA, Messenger; Smoking | 1994 |
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Topics: Amsacrine; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Etoposide; Humans; Lung Neoplasms; Methylation; RNA, Messenger; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1995 |
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents.
Topics: Adenine; Animals; Base Sequence; Carcinogens; Codon; Dimethylnitrosamine; DNA, Neoplasm; Female; Genes, ras; Guanine; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Point Mutation; Polymorphism, Restriction Fragment Length; Pyridines; Thymine | 1993 |
Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice.
Topics: Animals; Beverages; Carcinogens; Catechin; DNA; Female; Flavonoids; Lung; Lung Neoplasms; Methylation; Mice; Microsomes; Nitrosamines; Pyridines; Tea | 1994 |
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Topics: Alleles; Base Sequence; Binding Sites; Carcinoma, Non-Small-Cell Lung; Codon; DNA, Neoplasm; Gene Deletion; Genes, ras; Humans; Lung; Lung Neoplasms; Methylation; Molecular Sequence Data; Mutation; Repetitive Sequences, Nucleic Acid | 1994 |
In vitro and in vivo growth of clonal sublines of human small cell lung carcinoma is modulated by polysialic acid of the neural cell adhesion molecule.
Topics: Animals; Carcinoma, Small Cell; Cell Adhesion; Cell Adhesion Molecules, Neuronal; Cell Communication; Cell Division; DNA, Neoplasm; Humans; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Methylation; Mice; Mice, Nude; Sialic Acids; Tumor Cells, Cultured | 1994 |
Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans.
Topics: Animals; Biomarkers; Carcinogens; DNA; DNA Damage; Hemoglobins; Humans; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Smoking; Tobacco, Smokeless | 1993 |
Lung tumors in strain A mice: application for studies in cancer chemoprevention.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Disease Models, Animal; DNA; DNA Damage; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; Male; Methylation; Mice | 1993 |
Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.
Topics: Base Sequence; Bronchi; Calcitonin; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Cytosine; DNA; Epithelium; Guanine; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Tumor Cells, Cultured | 1993 |
Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.
Topics: Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Cycle; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Methylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; RNA, Neoplasm; Sequence Deletion; Tumor Cells, Cultured | 1995 |
Relationship between DNA methylation and gene expression of the HOXB gene cluster in small cell lung cancers.
Topics: Animals; Base Sequence; Carcinoma, Small Cell; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Humans; Lung Neoplasms; Methylation; Mice; Molecular Sequence Data; Multigene Family; Promoter Regions, Genetic | 1996 |
Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers.
Topics: Adenocarcinoma; Blotting, Southern; Carcinoma, Large Cell; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 18; DNA, Neoplasm; Exons; Genes, Retinoblastoma; Humans; Lung Neoplasms; Methylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Restriction Mapping | 1996 |
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
Topics: Adult; Breast Neoplasms; Carrier Proteins; Cell Cycle Proteins; Cell Line; Child; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 9; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Dinucleoside Phosphates; DNA; DNA, Neoplasm; Female; Genes, Tumor Suppressor; Glioma; Homozygote; Humans; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphocytes; Male; Methylation; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Reference Values; Restriction Mapping; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1996 |
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA Modification Methylases; DNA-Cytosine Methylases; Gene Expression; Hyperplasia; Lung; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Mice, Inbred C3H; Nitrosamines; Species Specificity | 1996 |
Synthesis and growth inhibitory properties of glycosides of 1-O-hexadecyl-2-O-methyl-sn-glycerol, analogs of the antitumor ether lipid ET-18-OCH3 (edelfosine).
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Survival; Female; Glycosides; Humans; Indicators and Reagents; Leukemia L1210; Leukemia P388; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methylation; Mice; Molecular Structure; Phospholipid Ethers; Tumor Cells, Cultured | 1996 |
Deletion and differential expression of p16INK4a in mouse lung tumors.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Chromosome Mapping; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclins; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Mutation; Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins | 1997 |
Arsenic-laced water in Chile.
Topics: Arsenic; Case-Control Studies; Chile; Humans; Lung Neoplasms; Methylation; Neoplasms; Risk Factors; Urinary Bladder Neoplasms; Water Pollutants, Chemical | 1998 |
Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chromosomes, Human, Pair 9; Cyclin-Dependent Kinase Inhibitor p16; Female; Gene Expression; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Microsatellite Repeats; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Polymorphism, Single-Stranded Conformational; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 1998 |
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.
Topics: Alleles; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Genes, ras; Humans; In Situ Hybridization; Lung Neoplasms; Methylation; Microsatellite Repeats; Mutation; Neoplasm Staging; Oncogenes; Polymerase Chain Reaction; Prospective Studies; Sensitivity and Specificity; Tumor Suppressor Protein p53 | 1999 |
Inactivation of the transforming growth factor beta type II receptor in human small cell lung cancer cell lines.
Topics: Blotting, Northern; Blotting, Southern; Carcinoma, Small Cell; Humans; Lung Neoplasms; Methylation; Mutagenesis; Polymorphism, Single-Stranded Conformational; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Tumor Cells, Cultured | 1999 |
LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth.
Topics: Animals; Cell Division; Cholesterol; Cytokines; Drug Combinations; Fatty Acids, Monounsaturated; Fibrosarcoma; Injections, Intravenous; Liposomes; Lung Neoplasms; Methylation; Mice; Mice, Inbred C57BL; Mice, SCID; Plasmids; Protamines; Quaternary Ammonium Compounds; Vaccines, DNA | 1999 |
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Gene Expression Regulation, Neoplastic; Humans; Loss of Heterozygosity; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2000 |
Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer.
Topics: Adenocarcinoma; Aged; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Death-Associated Protein Kinases; DNA, Neoplasm; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Multivariate Analysis; Neoplasm Staging; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Retrospective Studies | 2000 |
Re: Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Topics: Antineoplastic Agents; Bronchoscopy; Carcinoma in Situ; Carcinoma, Non-Small-Cell Lung; Fluorescence; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Receptors, Retinoic Acid | 2001 |
[Correlation between methylation on SmaI locus of the CDKN2/p16 gene CpG island and lung cancer].
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; CpG Islands; DNA Restriction Enzymes; Female; Gene Silencing; Genes, p16; Humans; Hybridization, Genetic; Lung Neoplasms; Male; Methylation; Middle Aged | 2000 |
[Status of methylation of promoter of mis-match repair gene hMLH1 in lung cancer].
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Carrier Proteins; Female; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Squamous Cell; Nuclear Proteins; Promoter Regions, Genetic | 2000 |
Tumor p16M is a possible marker of advanced stage in non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; DNA, Neoplasm; Female; Genes, p16; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Neoplasm Staging; Pneumonectomy; Polymerase Chain Reaction; Prognosis; Prospective Studies | 2002 |
Tumorigenicity of tetramethylhydrazine hydrochloride in Swiss mice.
Topics: Adenoma; Animals; Carcinogens; Female; Hemangioma; Hemangiosarcoma; Hydrazines; Kidney Neoplasms; Lung Neoplasms; Male; Methylation; Methylhydrazines; Mice; Monomethylhydrazine; Neoplasms, Experimental; Structure-Activity Relationship | 1976 |
Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.
Topics: Carcinoma; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Colonic Neoplasms; DNA; DNA Probes; Gene Expression Regulation; Heterozygote; Humans; Lung Neoplasms; Methylation; Polymorphism, Restriction Fragment Length; Tumor Cells, Cultured | 1992 |
Modified nucleosides in human serum.
Topics: Adult; Aged; Carcinoma; Chromatography, High Pressure Liquid; Female; Humans; Leukemia, Myelomonocytic, Acute; Lung Neoplasms; Male; Methylation; Middle Aged; Nucleosides; Reference Values | 1992 |
[Regulation of dimethylbenzanthracene-induced P1-450 gene expression in human lung tumor cells in culture].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; RNA, Messenger; Tumor Cells, Cultured | 1992 |
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.
Topics: Animals; Carcinogens; Dimethylnitrosamine; DNA; Female; Guanine; Hydroxylation; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1991 |
Regulation of the epidermal growth factor receptor gene expression in a morphological variant isolated from an epidermal growth factor receptor-deficient small cell lung carcinoma cell line.
Topics: Blotting, Northern; Blotting, Southern; Carcinoma, Small Cell; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lung Neoplasms; Methylation; Polymorphism, Restriction Fragment Length; Proto-Oncogenes; RNA, Messenger; Tumor Cells, Cultured | 1990 |
[DNA methylation in human lung tumors].
Topics: Chromatography, Thin Layer; Cytosine; DNA; DNA, Neoplasm; Electrophoresis, Agar Gel; Humans; In Vitro Techniques; Lung; Lung Neoplasms; Methylation; Molecular Weight | 1990 |
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Nose Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Thiocyanates | 1990 |
Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice.
Topics: Adenoma; Animals; Carcinogens; DNA; Female; In Vitro Techniques; Indoles; Liver; Lung; Lung Neoplasms; Methylation; Mice; Nitrosamines | 1990 |
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Guanine; Hyperplasia; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Metaplasia; Methylation; Microscopy, Electron; Nitrosamines; Nose Neoplasms; Olfactory Mucosa; Rats; Rats, Inbred F344 | 1990 |
Expression of chorionic gonadotropin alpha- and beta-genes in normal and neoplastic human tissues: relationship to deoxyribonucleic acid structure.
Topics: Cell Line; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Female; Glycoprotein Hormones, alpha Subunit; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Nucleic Acid Hybridization; Peptide Fragments; Placenta; Polymorphism, Genetic; Pregnancy; Trophoblastic Neoplasms | 1985 |
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1985 |
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation | 1986 |
Change in methylation status of DNA of remaining allele in human lung cancers with loss of heterozygosity on chromosomes 3p and 13q.
Topics: Alleles; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 3; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Probes; DNA, Neoplasm; Heterozygote; Humans; Lung Neoplasms; Methylation; Polymorphism, Restriction Fragment Length | 1989 |
Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Deoxyadenosines; Fibrosarcoma; Humans; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Melanoma, Experimental; Methylation; Neoplasm Invasiveness; Rats; Rats, Inbred Strains; Thionucleosides; Tumor Cells, Cultured | 1989 |
Drug-induced DNA hypermethylation and drug resistance in human tumors.
Topics: 5-Methylcytosine; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cytosine; DNA Replication; DNA, Neoplasm; Drug Resistance; Humans; Lung Neoplasms; Methylation; Rhabdomyosarcoma; Tumor Cells, Cultured; Tumor Stem Cell Assay; Zidovudine | 1989 |
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
Topics: Calcitonin; Cell Line; Cell Transformation, Viral; Chromosomes, Human, Pair 11; Colonic Neoplasms; Deltaretrovirus; DNA; Fibroblasts; Gene Expression Regulation; Humans; Lung Neoplasms; Lymphocytes; Methylation; Neoplasms; Suppression, Genetic; Teratoma; Tumor Cells, Cultured | 1988 |
Methylation status of epidermal growth factor receptor gene in lung carcinoma cells.
Topics: Adenocarcinoma; Blotting, Southern; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Deoxyribonuclease EcoRI; ErbB Receptors; Gene Expression Regulation; Humans; Lung Neoplasms; Methylation; Promoter Regions, Genetic | 1988 |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
Topics: Alkylation; Animals; Biological Assay; Diet; DNA; Isothiocyanates; Liver Neoplasms; Lung Neoplasms; Methylation; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Thiocyanates | 1989 |
Comparison of amplified and unamplified c-myc gene structure and expression in human small cell lung carcinoma cell lines.
Topics: Carcinoma, Small Cell; Cell Line; Chromatin; Deoxyribonuclease I; DNA, Neoplasm; Gene Amplification; Humans; Lung Neoplasms; Methylation; Oncogenes; RNA, Messenger | 1986 |
DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.
Topics: Calcitonin; Carcinoma; Carcinoma, Small Cell; Cell Line; Chromosome Mapping; DNA, Neoplasm; Dopa Decarboxylase; Humans; Lung Neoplasms; Lymphoma; Methylation; RNA, Messenger; Thyroid Neoplasms | 1986 |
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats.
Topics: Animals; Carcinogens; Diet; DNA; Glucosinolates; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Methyltransferases; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pancreatic Neoplasms; Rats; Rats, Inbred F344; Thioglycosides | 1988 |
Biochemical and cytogenetic studies of human lung cancers.
Topics: Animals; Cytosine; DNA, Neoplasm; Electrophoresis, Agar Gel; Female; Humans; Karyotyping; Lung Neoplasms; Male; Methylation; Mice; Mice, Nude; Molecular Weight; Neoplasm Staging; Neoplasm Transplantation; Prognosis | 1988 |
DNA methylation in rat tissues by a series of homologous aliphatic nitrosamines ranging from N-nitrosodimethylamine to N-nitrosomethyldodecylamine.
Topics: Animals; DNA; Esophagus; Kidney; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylation; Nitrosamines; Organ Specificity; Rats; Rats, Inbred F344; Structure-Activity Relationship; Urinary Bladder Neoplasms | 1987 |
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.
Topics: Animals; Dimethylnitrosamine; DNA, Neoplasm; Guanine; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasms, Experimental; Nicotiana; Nitrosamines; Nose Neoplasms; Plants, Toxic; Rats | 1986 |
Metabolism and tissue distribution of tobacco-specific N-nitrosamines in the marmoset monkey (Callithrix jacchus).
Topics: Animals; Autoradiography; Callithrix; Carbon Radioisotopes; Carcinogens; Computers; Densitometry; DNA; Lung Neoplasms; Male; Methylation; Nitrosamines; Species Specificity; Tissue Distribution | 1985 |
Comparative studies of neoplastic response to a single dose of nitroso compounds. 1. The effect of N-nitrosohexamethyleneimine in Syrian golden hamsters and Swiss mice.
Topics: Adenoma; Animals; Bronchial Neoplasms; Cricetinae; Cyclohexanes; Imines; Injections, Subcutaneous; Laryngeal Neoplasms; Lethal Dose 50; Lung Neoplasms; Methylation; Mice; Nitroso Compounds; Nose Neoplasms; Polyps; Respiratory Tract Neoplasms; Time Factors; Tracheal Neoplasms | 1972 |
Methylation of RNA by mouse organs and tumors: ionic stimulation in vitro.
Topics: Adenocarcinoma; Animals; Animals, Newborn; Brain; Dialysis; Electrophoresis; Escherichia coli; Kidney; Leukemia Virus, Murine; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Lung; Lung Neoplasms; Methylation; Mice; Neoplasm Transplantation; Neoplasms; Quaternary Ammonium Compounds; RNA, Bacterial; RNA, Transfer; Spleen; Splenic Neoplasms; Temperature; Transferases | 1968 |
[Carcinogenic properties of 5-oxo-5 H-benzo(e)isochromeno(4,3-b)indole and its derivatives and analogues: relations between structure and activity].
Topics: Adenoma; Animals; Chemical Phenomena; Chemistry; Connective Tissue; Female; Lactones; Liver; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Mice; Microscopy, Fluorescence; Rats; Sarcoma, Experimental | 1971 |
Studies on lung tumours. I. Methylation of deoxyribonucleic acid and tumour formation following administration of dimethylnitrosamine to mice.
Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; DNA, Neoplasm; Guanine Nucleotides; Kidney; Kinetics; Liver; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosamines; Species Specificity; Spleen; Time Factors | 1970 |
Tissue-dependent differences in DNA methylation products of mice treated with methyl-labelled methylnitrosourea.
Topics: Adenine; Adenoma; Animals; Bone Marrow; Carbon Isotopes; DNA, Neoplasm; Guanine; Kidney; Liver; Lung; Lung Neoplasms; Lymphoma; Methylation; Mice; Neoplasms, Experimental; Nitroso Compounds; Spleen; Thymus Gland; Thymus Neoplasms; Urea | 1971 |
[Results of a trial of a methylhydrazine in the treatment of epidermoid and anaplastic cancers of the lung].
Topics: Carcinoma, Squamous Cell; Hydrazines; Lung Neoplasms; Methylation | 1968 |
Carcinogenicity of 1-methyl-1-nitrosourea in newborn mice and rats.
Topics: Animals; Animals, Newborn; Carcinogens; Injections, Subcutaneous; Kidney Neoplasms; Leukemia, Experimental; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylation; Mice; Nitroso Compounds; Rats; Urea | 1968 |
Pulmonary and hepatic oncogenesis during treatment of male RF mice with dimethyl-nitrosamine.
Topics: Adenoma; Animals; Hemangioendothelioma; Hemangiosarcoma; Liver Neoplasms; Lung Neoplasms; Male; Methylation; Neoplasm Metastasis; Nitrosamines; Rats; Time Factors | 1968 |