isomethyleugenol has been researched along with Brain Neoplasms in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (4.84) | 18.7374 |
| 1990's | 10 (5.38) | 18.2507 |
| 2000's | 21 (11.29) | 29.6817 |
| 2010's | 82 (44.09) | 24.3611 |
| 2020's | 64 (34.41) | 2.80 |
| Authors | Studies |
|---|---|
| Brandner, S; Cheng, HY; Dawson, S; Faulkner, CL; Higgins, JPT; Jefferies, S; Kelly, C; Kurian, KM; McAleenan, A; Schmidt, L; Spiga, F; Wragg, C | 1 |
| Li, H; Li, X; Lu, J | 1 |
| Fujii, T; Ichimura, K; Kawauchi, D; Kobayashi, T; Kondo, A; Nakano, T; Narita, Y; Sasaki, N; Satomi, K; Takahashi, M; Tomiyama, A; Uchida, E; Wada, K; Yamamuro, S; Yoshino, A | 1 |
| Chen, G; Huang, H; Luo, S; Tang, G; Wang, FF | 1 |
| Hölzl, D; Kral, M; Kraus, TFJ; Ladisich, B; Machegger, L; Pöppe, J; Schlicker, HU; Schwartz, C; Sotlar, K; Spendel, M; Zellinger, B | 1 |
| French, PJ; Golfinopoulos, V; Gorlia, T; Tesileanu, CMS; van den Bent, MJ | 1 |
| Cheng, X; Gao, Y; Han, Z; Jin, H; Li, P; Liang, W; Lin, S; Liu, Z; Luan, Z; Qian, R | 1 |
| McDonald, KL; Noor, H; Whittaker, S | 1 |
| Cao, D; Huang, W; Su, Y; Xing, Z; Yang, X; Zhou, X | 1 |
| Chu, Q; Lou, Y; Lv, P; Mao, M; Wang, LJ | 1 |
| Abdullaev, Z; Aldape, K; Crawford, JR; Elster, JD; Kalawi, AZ; Khanna, PC; Levy, ML; Malicki, DM; Paul, MR; Pratt, DW; Quezado, M | 1 |
| Dong, W; Liu, L; Liu, X; Ruan, X; Shao, L; Wang, D; Wang, P; Xue, Y; Yang, C; Zhang, M | 1 |
| André, N; Basset, L; Boddaert, N; Chotard, G; Chrétien, F; Figarella-Branger, D; Girard, N; Hasty, L; Hostein, I; Jecko, V; le Loarer, F; Listrat, A; Machet, MC; Métais, A; Nicaise, Y; Rousseau, A; Scavarda, D; Tallegas, M; Tauziède-Espariat, A; Testud, B; Uro-Coste, E; Varlet, P | 1 |
| Ebrahimi, A; Herrlinger, U; Kaluza, L; Pietsch, T; Waha, A | 1 |
| Booth, TC; Salihoğlu, AK | 1 |
| Liu, M; Liu, Q; Liu, R; Sun, G; Xu, B; Zhao, K | 1 |
| Birkl-Toeglhofer, AM; Brawanski, KR; Freyschlag, CF; Haybaeck, J; Hoeftberger, R; Manzl, C; Sprung, S; Ströbel, T; Thomé, C | 1 |
| Arakawa, Y; Fukuoka, K; Hirato, J; Honda, S; Ichimura, K; Itabashi, T; Koh, K; Kurihara, J; Matsushita, Y; Mori, M; Nakazawa, A; Nobusawa, S; Tanami, Y | 1 |
| Cao, D; Hu, C; Lin, Y; Su, Y; Wang, X; Xing, Z; Yang, X | 1 |
| Achawal, S; Barry, A; Beltran-Alvarez, P; Deepak, S; Feugere, L; Green, V; Greenman, J; Hosni, I; Iles, A; Moursi, A; Rajaraman, C; Samuel, SF; Scott, IS; Sennett, CJ; Stead, LF; Wade, MA; Wollenberg Valero, KC | 1 |
| Bruce, JN; Canoll, PD; Cheng, SK; Grinband, J; Iwamoto, FM; Kachnic, LA; Kinslow, CJ; Kumar, P; McKhann, GM; Mercurio, A; Rae, AI; Siegelin, MD; Sisti, MB; Taparra, K; Upadhyayula, PS; Wang, TJC; Yu, JB | 1 |
| Angelini, C; Caccese, M; Cavallin, F; Cerretti, G; Chioffi, F; d'Avella, D; De Bonis, P; De Rossi, A; Giunco, S; Lombardi, G; Morello, M; Padovan, M; Puppa, AD; Rizzo, B; Zagonel, V | 1 |
| Alafandi, A; Gorlia, T; Klein, S; Nabors, L; Rizopoulos, D; Smits, M; Stupp, R; Tonn, JC; van der Voort, SR; van Garderen, KA; Weller, M | 1 |
| Harter, PN; Herms, J; Katzendobler, S; Niedermeyer, S; Niyazi, M; Stoecklein, VM; Thon, N; Tonn, JC; Trumm, C; Weller, J | 1 |
| Ferrer, VP; Machado, GC | 1 |
| Bruce, JN; Canoll, PD; Cheng, SK; Gill, BJA; Grinband, J; Horowitz, DP; Iwamoto, FM; Kachnic, LA; Kinslow, CJ; Kumar, P; McKhann, GM; Neugut, AI; Rae, AI; Siegelin, MD; Sisti, MB; Taparra, K; Wang, TJC; Yu, JB | 1 |
| Alasmawi, H; Ridzuan, M; Saeed, N; Sobirov, I; Yaqub, M | 1 |
| Chen, J; Chen, X; Chen, Y; Cheng, Z; Duan, H; Huang, Y; Li, K; Li, Q; Li, Y; Lin, X; Liu, J; Lu, Y; Pan, G; Qin, Z; Shen, X; Shu, M; Wang, F; Wang, G; Wang, X; Xing, F; Yang, S; Zeng, Y; Zhang, H; Zhang, Y | 1 |
| Li, J; Liang, C; Liu, Q; Liu, Y; Xiao, Z; Yan, X; Zhang, Y | 1 |
| Chen, R; Chen, X; Gimple, RC; Jiang, T; Lin, P; Liu, L; Liu, Q; Liu, X; Liu, Z; Luo, J; Prager, BC; Rich, JN; Wang, D; Wu, E; Wu, Q; Wu, W; Xie, Q; Yu, J; Zhang, W; Zhang, Y; Zhao, W | 1 |
| Bahador, M; Bifulco, E; Bindesbøll, C; Brekke, J; Chekenya, M; Engelsen, A; Enger, PØ; Gjertsen, BT; Goplen, D; Gras Navarro, A; Lie, SA; Rahman, MA; Sarowar, S; Selheim, F; Simonsen, A; Waha, A | 1 |
| Bai, X; Chen, F; Fang, J; Hu, Z; Li, X; Lu, Z; Qian, X; Shi, Z; Xia, Y; Xu, D; You, Y; Zheng, Y; Zhou, Q | 1 |
| Li, F; Zhang, C; Zhang, G | 1 |
| Chen, W; Feng, F; Feng, S; Jiang, C; Kong, Z; Liu, S; Lyu, Y; Ma, W; Wang, R; Wang, Y; You, H; Zhang, Y; Zhao, D; Zhu, R | 1 |
| Ichimura, K; Igaki, H; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Takahashi, M | 1 |
| Chen, Y; Deng, Y; Lodhi, AF; Ma, H; Sun, C; Sun, F; Wang, H; Yan, L; Zhang, P | 1 |
| Carrato, A; Esteban, J; Gutiérrez, JA; Ley, L; Torres, J; Vaz Salgado, MA | 1 |
| Ahmadipour, Y; Gembruch, O; Jabbarli, R; Pierscianek, D; Sure, U | 1 |
| Ciafrè, SA; Galardi, S; Michienzi, A | 1 |
| Chen, H; Chen, W; Ge, J; Guo, L; Hou, G; Mao, Q; Yang, J; Zhang, X | 1 |
| Arita, H; Fukai, J; Kanematsu, D; Kanemura, Y; Kinoshita, M; Kodama, Y; Mano, M; Mori, K; Nakao, N; Nonaka, M; Okita, Y; Sakamoto, D; Shofuda, T; Tsuyuguchi, N; Uda, T; Uematsu, Y; Umehara, T; Yoshioka, E | 1 |
| Cao, X; Du, F; Gao, Y; Guo, Y; Li, PA; Lv, Y; Wang, F; Wang, S; Wu, Y; Yu, J | 1 |
| Hao, L; Li, M; Liu, L; Ma, L; Song, S; Wang, G; Wang, L; Yu, C; Zhang, Z | 1 |
| Alkam, D; Day, JD; De Loose, A; Ho, SM; Jenjaroenpun, P; Leung, YK; Nookaew, I; Rodriguez, A; Ussery, DW; Wongsurawat, T | 1 |
| Brinkmann, DH; Herman, MG; Hunt, CH; Kemp, BJ; Laack, NN; Lowe, V; Pafundi, DH; Qian, J | 1 |
| Alaggio, R; Alexandrescu, S; Lidov, HG; Ligon, KL; Meredith, DM; Novello, M; Vargas, SO | 1 |
| Li, W; Zhou, XJ | 1 |
| Chen, WJ; Han, H; He, XS; Kang, EM; Liu, WP; Lv, JN; Wang, GH; Wang, J; Yu, YB; Zhang, W; Zhang, X; Zhang, YL | 1 |
| Cheng, H; Dai, X; Hu, Y; Wang, H; Wang, J; Wu, B; Ye, L | 1 |
| Cai, H; Chen, F; Chen, Z; Hu, Y; Li, C; Ni, X; Wang, J; Xi, S; Yu, Y | 1 |
| Agnihotri, S; Bridge, T; Hawkins, C; Huang, A; Kim, B; Li, C; Milos, S; Pajovic, S; Patel, P; Phillips, L; Rakopoulos, P; Ryall, S; Sheth, J; Siddaway, R; Srikanthan, D; Yu, M | 1 |
| Bartom, E; Huang, TY; Morgan, M; Piunti, A; Qi, J; Saratsis, AM; Shilatifard, A | 1 |
| Chen, N; Gong, Q; Su, X; Sun, H; Tan, Q; Wan, X; Wang, W; Yang, X; Yue, Q; Zhang, S | 1 |
| Barry, A; Beltran-Alvarez, P; Greenman, J; Samuel, SF | 1 |
| van der Hoorn, A; van Dijken, BRJ | 1 |
| Banasavadi-Siddegowda, YK; Bryant, JP; Heiss, J | 1 |
| Caselli, M; Dührsen, L; Felce, JH; Fita, KD; Fuh, MM; Glatzel, M; Görgens, A; Heiland, DH; Jones, JC; Joosse, SA; Kaulich, K; Lamszus, K; Maire, CL; Miklosi, AG; Pantel, K; Pereno, V; Reifenberger, G; Reimer, R; Ricklefs, FL; Ricklefs, T; Sauvigny, T; Schlüter, H; Schüller, U; Stevic, I; Welsh, JA; Westphal, M | 1 |
| Guo, L; He, W; Hua, J; Li, X; Liao, S; Liu, X; Wang, W; Wu, Y; Xiao, X; Xu, Y; Zhou, J | 1 |
| Navarria, P; Pessina, F; Politi, LS; Simonelli, M | 1 |
| Anderson, SK; Brinkmann, D; Brown, P; Hunt, C; Kabat, B; Kaufmann, T; Kemp, B; Kizilbash, S; Laack, NN; Lowe, V; Pafundi, D; Ruff, M; Sarkaria, J; Seaberg, M; Uhm, J; Vogen, D; Wan Chan Tseung, HS; Yan, E; Zakhary, M; Zhang, Y | 1 |
| Horbinski, C; McCortney, K; Stupp, R | 1 |
| Kanekar, S; Zacharia, BE | 1 |
| Kleszcz, R; Krajka-Kuźniak, V; Kruhlenia, N; Majchrzak-Celińska, A; Misiorek, JO; Przybyl, L; Rolle, K | 1 |
| Oudenaarden, C; Pietras, K; Sjölund, J | 1 |
| Jiang, X; Qiu, Y; Wang, M; Wang, X; Wu, Z; Yu, H; Zheng, J; Zhou, Z | 1 |
| Alirezaei, Z; Amouheidari, A; Ghahremani, F; Kefayat, A | 1 |
| Chen, SH; Cui, WY; Lv, QL; Shen, XL; Tan, ZL; Wang, LC; Zhang, Z | 1 |
| Chlamydas, S; Gargalionis, AN; Gazouli, M; Kalamatianos, T; Kanakoglou, DS; Katifelis, H; Klonou, A; Korkolopoulou, P; Mitsios, A; Papavassiliou, AG; Papavassiliou, KA; Piperi, C; Sgouros, S; Stranjalis, G; Themistocleous, MS | 1 |
| Bronsema, A; Guerreiro, H; Kresbach, C; Rutkowski, S; Schüller, U; Winkler, B | 1 |
| Akagi, Y; Hata, N; Hatae, R; Hideki, M; Hiwatashi, A; Iihara, K; Iwaki, T; Kuga, D; Mizoguchi, M; Sangatsuda, Y; Suzuki, SO; Togao, O; Yamashita, K; Yoshimoto, K | 1 |
| Back, M; Brazier, D; Cook, R; Gzell, C; Harris, G; Jayamanne, D; Kastelan, M; Khasraw, M; Louw, S; Parkinson, J; Schembri, G; Wheeler, H | 1 |
| Cai, J; Dinislam, M; Duan, C; Gao, F; Gao, W; Han, B; Jiang, C; Kang, C; Lin, L; Meng, X; Wang, R; Wu, P | 1 |
| Deng, J; Jiao, X; Li, J; Qiu, D; Sun, Z; Wan, X; Xia, Z; Yang, R | 1 |
| Bender, B; Bier, G; Brendle, C; Castaneda Vega, S; Ernemann, U; Hempel, JM; Klose, U; Schittenhelm, J; Skardelly, M; Tabatabai, G | 1 |
| Battenhouse, AM; Cowperthwaite, MC; Hall, AW; Iyer, VR; Morris, AR; Shivram, H; Shpak, M | 1 |
| Arnold, EP; Haile, S; Hulleman, E; Kadapakkam, M; Labanieh, L; Mackall, CL; Majzner, RG; Monje, M; Mount, CW; Rietberg, SP; Sundaresh, S; Vogel, H; Woo, PJ | 1 |
| Li, W; Shi, J; Shi, L; Shi, X; Wen, H | 1 |
| Han, P; Lee, A; Malakhov, N; Schreiber, D; Sheth, N; Wang, A | 1 |
| Choi, SH; Chun, SJ; Kim, IH; Kim, JW; Kim, TM; Lee, ST; Park, CK; Park, SH | 1 |
| Ai, C; Dong, F; Gao, W; Huo, D; Kang, C; Kong, Y; Li, Q; Li, W; Liu, W; Liu, X; Sun, X; Wang, W; Wang, X; Wu, X; Yang, C; Zhou, Y | 1 |
| Abril, L; Archila, P; Arrieta, O; Balaña, C; Behaine, J; Bermúdez, S; Cardona, AF; Carranza, H; Cifuentes, H; Feo, O; González, D; Hakim, F; Jacobo, J; Jiménez, E; Mantilla, MI; Marquez, JC; Mejía, JA; Ortiz, LD; Otero, J; Penagos, P; Pineda, D; Pino, LE; Ramón, JF; Ricaurte, L; Rodríguez, J; Rojas, L; Rosell, R; Ruiz-Patiño, A; Useche, N; Vargas, C; Wills, B; Zatarain-Barrón, ZL | 1 |
| Cantero, D; de Velasco, G; Hernández-Laín, A; Hilario, A; Manneh Kopp, RA; Pérez Núñez, A; Ramos, A; Ruano, Y; Sánchez-Gómez, P; Sepúlveda-Sánchez, JM; Toldos, O | 1 |
| Boldt, HB; Dahlrot, RH; Hansen, S; Hjelmborg, JB; Kreutzfeldt, MS; Kristensen, BW; Larsen, P | 1 |
| Cai, J; Cao, L; Chen, Z; Gu, J; Guo, C; Li, C; Liang, J; Lin, Y; Liu, X; Liu, Y; Lu, B; Lu, W; Mai, J; Ou-Yang, Y; Qiu, P; Sai, K; Sheng, L; Su, X; Sun, H; Sun, S; Tan, Y; Wang, J; Xing, F; Xue, D; Yan, G; Yang, X; Yin, W; Zhu, W; Zhu, Z | 1 |
| Chen, W; Chen, Y; Deng, X; Lian, M; Long, H; Qian, D; Shi, P; Wang, H; Wang, K; Xiao, D | 1 |
| Delaney, K; Pankowski, A; Steiner, FA; Strobino, M; Wenda, JM | 1 |
| Bhargava, S; Bi, J; Brown, JM; Cang, H; Dong, Z; Gimple, RC; Gromovsky, AD; Huan, T; Jiang, L; Kidwell, RL; Kim, LJY; Lee, D; Lv, D; Mack, SC; Mischel, PS; Prager, BC; Rich, JN; Sloan, AE; Sun, T; Wang, X; Wolf, M; Wu, Q; Xie, Q; Ye, Q; Zhang, G; Zhao, L; Zhu, Z | 1 |
| Dong, X; Donohoo, KB; Mechref, Y; Peng, W; Tang, H; Yu, CY; Zhou, S | 1 |
| Albrecht, S; Bognar, L; Busche, S; Faury, D; Fleming, A; Fontebasso, AM; Garami, M; Gerges, N; Hadjadj, D; Hauser, P; Jabado, N; Jones, DT; Khuong-Quang, DA; Klekner, A; Kool, M; Korshunov, A; Lepage, P; Liberski, PP; Liu, XY; Majewski, J; Montpetit, A; Pfister, SM; Schwartzentruber, J; Staffa, A; Sturm, D; Witt, H; Zadeh, G; Zakrzewska, M; Zakrzewski, K | 1 |
| Allis, CD; Banaszynski, LA; Becher, OJ; Cordero, F; Garcia, BA; Koletsky, MS; Lewis, PW; Lin, S; Muir, TW; Müller, MM | 1 |
| Chen, W; Chen, Y; Hu, F; Shao, H; Zhang, Y; Zhou, Y | 1 |
| Collins, VP; Harris, FP; Jefferies, SJ; Price, SJ; Watts, C | 1 |
| Attar, R; Biray Avci, C; Caglar, HO; Dalbasti, T; Gunduz, C; Haydaroglu, A; Kitapcioglu, G; Oktar, N; Yurtsever, A | 1 |
| Byun, HS; Choi, SW; Hong, JH; Huang, SM; Hur, GM; Jeon, J; Kim, JM; Kim, SH; Lee, JH; Lee, Y; Li, Y; Liu, ZG; Lu, T; Park, J; Park, KA; Ro, H; Shen, HM; Sohn, KC; Stark, GR; Zhang, T | 1 |
| Adamopoulos, C; Dalagiorgou, G; Gargalionis, A; Lea, RW; Papavassiliou, AG; Papavassiliou, KA; Piperi, C; Spyropoulou, A | 1 |
| Arita, H; Fukushima, S; Ichimura, K; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Shibui, S; Takami, H; Yoshida, A | 1 |
| Bender, S; Castel, D; Chen, S; Cho, YJ; Collins, VP; Ebinger, M; Grill, J; Gronych, J; Helin, K; Hovestadt, V; Højfeldt, JW; Jabado, N; Johann, PD; Jones, C; Jones, DT; Kool, M; Korshunov, A; Lichter, P; Lindroth, AM; Meyer, J; Milde, T; Monje, M; Monoranu, CM; Northcott, PA; Pfister, SM; Plass, C; Ponnuswami, A; Puget, S; Radlwimmer, B; Ryzhova, M; Schubert, S; Schuhmann, M; Seker-Cin, H; Stark, S; Sturm, D; Tang, Y; Truffaux, N; von Deimling, A; Wang, W; Witt, O; Zapatka, M | 1 |
| Chamberlain, MC | 1 |
| Bond, F; Bridges, LR; Burke, E; Crocker, M; Elderfield, K; Grobler, M; Taylor, R | 1 |
| Balañà, C; Capdevila, L; Carrato, C; Cros, S; Cuadra, JL; Etxaniz, O; Hostalot, C; Massuet, A; Ramirez, JL; Romeo, M; Sanz, C; Villà, S | 1 |
| Bähr, O; Braczynski, AK; Dunst, M; Eibach, S; Harter, PN; Hattingen, E; Mittelbronn, M; Plate, KH; Rieger, J; Seifert, V; Steinbach, JP; Weise, LM | 1 |
| Feng, D; Hu, Q; Li, H; Ma, H; Su, Y; Tao, H; Wang, X; Zhang, C | 1 |
| Chapet, S; Lévy, S; Mazeron, JJ | 1 |
| Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C | 1 |
| He, W; Liu, R; Yang, SH; Yuan, F | 1 |
| Berghoff, AS; Hainfellner, JA; Marosi, C; Preusser, M | 1 |
| Filatov, MV; Kovalev, RA; Semenova, EV; Shtam, TA; Volnitskiĭ, AV | 1 |
| Cloughesy, TF; Ha, W; Hitchins, MP; Lai, A; McDonald, KL; Nguyen, HN; Nowak, AK; Rapkins, RW; Wang, F | 1 |
| Cui, DX; Ding, MH; Fu, HL; Gao, J; Hu, GH; Jiang, L; Jin, WL; Lin, XB; Liu, ZY; Ma, Y; Qiu, GZ; Shi, YF; Wang, Z; Zhang, CL | 1 |
| Benecke, R; Grossmann, A; Hildebrandt, G; Kirschstein, T; Piek, J; Rösche, J | 1 |
| Auclair-Perrossier, J; Blanché, H; Bodo, S; Bourdeaut, F; Brems, H; Brugières, L; Buhard, O; Buisine, MP; Cabaret, O; Caron, O; Chalastanis, A; Cohen-Haguenauer, O; Colas, C; Collura, A; Coulet, F; Duval, A; Entz-Werle, N; Fedhila, F; Fléjou, JF; Frébourg, T; Gauthier-Villars, M; Gerdes, AM; Goldberg, Y; Grandjouan, S; Guilloux, A; Hamelin, R; Ilencikova, D; Kinzel, M; Knappe, UJ; Lafitte, P; Lavoine, N; Leclerc, J; Leis, A; Lejeune, S; Malka, D; Mathieu-Dramard, M; Mortemousque, I; Muleris, M; Parfait, B; Ruiz-Ponte, C; Sheridan, E; Soubrier, F; Svrcek, M; Tinat, J; Vasen, H; Verloes, A; Vidaud, D; Wafaa, B; Wang, Q; Wimmer, K | 1 |
| Cui, H; Matthiesen, R; Mu, Y; Su, X; Sun, W; Xi, YG; Yu, L | 1 |
| Mohile, NA | 1 |
| Capper, D; Franco, P; Grauvogel, J; Heiland, DH; Hirsch, M; Masalha, W; Schrimpf, D; Staszewski, O; Urbach, H; Weyerbrock, A | 1 |
| Alyami, W; Bouhlel, A; Li, A; McConathy, J; Rich, K; Yuan, L | 1 |
| Chen, S; De Marco, V; Gamblin, SJ; Haire, LF; Justin, N; Martin, SR; Reinberg, D; Tarricone, C; Underwood, E; Walker, PA; Wilson, JR; Zhang, Y | 1 |
| Luo, D; Luo, K; Wen, H | 1 |
| Cui, HJ; Huang, MY; Liu, W; Xuan, F | 1 |
| Bjerkvig, R; Johannessen, TA; Mukherjee, J; Ohba, S; Pieper, RO; Ronen, SM; Viswanath, P | 1 |
| Choi, SH; Heo, DS; Jung, HW; Kim, DG; Kim, IH; Kim, SK; Kim, TM; Lee, SH; Lee, ST; Park, CK | 1 |
| Drummond, KJ; Kaye, AH; Paldor, I; Pearce, FC | 1 |
| Ando, N; Dong, X; Kobayashi, D; Maehara, T; Sumita, K; Tamura, K | 1 |
| Iqbal, U; Jack Li, YC; Lin, MC | 1 |
| Berger, MS; Lin, C; Lin, CA; Phillips, JJ; Rhodes, CT | 1 |
| Cui, Q; He, C; Huang, Y; Li, L; Lu, Z; Qu, Q; Riggs, AD; Shi, H; Shi, Y; Sun, G; Yang, CG; Ye, P | 1 |
| Del Maestro, R; Guiot, MC; Kavan, P; Lambert, C; Leblanc, R; Muanza, T; Panet-Raymond, V; Roberge, D; Shakibnia, L; Shenouda, G; Souhami, L | 1 |
| Bian, X; Chen, K; Dunlop, NM; Gao, Y; Gong, W; Howard, OM; Huang, J; Wang, JM | 1 |
| Chen, T; Gao, J; Gong, Y; Guo, X; Hu, G; Liu, J; Liu, W; Peng, X; Qiang, B; Yin, B; Yuan, J; Zhao, J | 1 |
| Cerdán, S; López-Larrubia, P; Rodrigues, TB | 1 |
| Addeo, R; Caraglia, M; De Santi, MS; Del Prete, S | 1 |
| Ballman, KA; Carlson, BL; Decker, PA; Giannini, C; Grogan, PT; James, CD; Kitange, GJ; Mladek, AC; Sarkaria, JN; Schroeder, MA; Wu, W | 1 |
| Cheng, AL; Kuo, KT; Kuo, LT; Lee, WC; Lin, CH; Lin, YT; Lu, YS; Tasi, JC; Tseng, HM; Tseng, SH; Tu, YK; Wu, PF; Wu, RM; Yang, CH | 1 |
| Berger, H; Felsberg, J; Hartmann, C; Heese, O; Krex, D; Loeffler, M; Nikkhah, G; Pietsch, T; Reifenberger, G; Schackert, G; Schramm, J; Simon, M; Steinbach, JP; Tonn, JC; von Deimling, A; Weller, M; Westphal, M; Wiestler, O | 1 |
| Bilbao, JM; Del Maestro, RF; Fazl, M; Guiot, MC; Oh, J; Perry, JR; Tsao, MN | 1 |
| Carapella, CM; Carosi, M; Cognetti, F; Fabi, A; Giannarelli, D; Maschio, M; Metro, G; Mirri, MA; Pace, A; Pellegrini, D; Pompili, A; Russillo, M; Vidiri, A | 1 |
| Agarwal, N; Ahluwalia, MS; Barnett, GH; Brewer, CJ; Elson, P; Peereboom, DM; Shepard, DR; Stevens, GH; Suh, JH; Toms, SA; Vogelbaum, MA; Weil, RJ | 1 |
| Blechschmidt, C; Czabanka, M; Koch, A; Misch, M; Plotkin, M; Stockhammer, F; Tuettenberg, J; Vajkoczy, P | 1 |
| Devine, SE; Iskow, RC; McCabe, MT; Mills, RE; Neuwald, AF; Pittard, WS; Torene, S; Van Meir, EG; Vertino, PM | 1 |
| Catapano, G; D'Urso, OF; D'Urso, PI; Gianfreda, CD; Marsigliante, S; Montinaro, A; Muscella, A; Storelli, C | 1 |
| Hartmann, C; Korshunov, A; von Deimling, A | 1 |
| Furuyama, N; Hamada, J; Hayashi, Y; Kamide, T; Nakada, M; Nakada, S; Sawada-Kitamura, S; Suzuki, T; Tanaka, S; Yano, S | 1 |
| Fukushima, T; Katayama, Y; Nagase, H; Ohta, T; Shinojima, Y; Terui, T; Watanabe, T; Yachi, K; Yoshino, A | 2 |
| Amano, T; Araki, Y; Iwaki, T; Mizoguchi, M; Nakamizo, A; Sasaki, T; Shono, T; Suzuki, SO; Yoshimoto, K | 1 |
| Agnihotri, S; Guha, A; Munoz, D; Wolf, A | 1 |
| Hirose, Y; Kanai, R; Louis, DN; Martuza, RL; Rabkin, SD; Sgubin, D; Wakimoto, H; Yip, S; Zaupa, CM | 1 |
| Chatzisotiriou, A; Eleftheraki, AG; Fountzilas, G; Iliadis, G; Kotoula, V; Lambaki, S; Misailidou, D; Selviaridis, P; Televantou, D | 1 |
| Ewelt, C; Felsberg, J; Jakobs, O; Martus, P; Meinel, T; Reifenberger, G; Stummer, W | 1 |
| Jha, P; Joshi, N; Julka, PK; Kale, SS; Mahapatra, AK; Mallick, S; Purkait, S; Sarkar, C; Sharma, MC; Sharma, V; Singh, G; Singh, M; Suri, V | 1 |
| Batchelor, TT; Louis, DN; Sorensen, AG | 1 |
| Geng, J; Luo, H; Pu, Y; Wu, X; Xu, W; Yang, Z; Zhou, Z | 1 |
| Hamada, J; Hayashi, Y; Kato, Y; Nakada, M; Ooi, A; Sabit, H; Sato, H; Suzuki, S; Watanabe, T; Yoshikawa, A | 1 |
| Adamopoulos, C; Papavassiliou, AG; Piperi, C; Spyropoulou, A | 1 |
| Laird, PW; Marczinek, K; Nürnberg, P; Rohde, K; Szymas, J; Thiel, G; Uhlmann, K; Vogel, S; Zeller, C | 1 |
| Katayama, Y; Komine, C; Watanabe, T; Yokoyama, T; Yoshino, A | 1 |
| Baeza, N; Kleihues, P; Ohgaki, H; Weller, M; Yonekawa, Y | 1 |
| Itaba, N; Kamitani, H; Maegawa, S; Nanba, E; Oshimura, M; Otsuka, S; Tahimic, CG; Watanabe, T | 1 |
| Gao, Y; Guan, M; Liu, W; Lu, Y; Su, B; Xu, M | 1 |
| Desrosiers, RR; Lanthier, J; Lapointe, M; Moumdjian, R; Régina, A | 1 |
| du Plessis, DG; Dunn, JR; Gee, AL; Reed, JE; Reeves, P; Shaw, EJ; Walker, C; Warnke, P | 1 |
| Hu, J; Jiang, Y; Jiang, Z; Li, G; Li, X; Lu, D; Zhou, W | 1 |
| Auger, N; Benouaich-Amiel, A; Crinière, E; Delattre, JY; Everhard, S; Hoang-Xuan, K; Kaloshi, G; Laigle-Donadey, F; Lejeune, J; Mokhtari, K; Polivka, M; Sanson, M; Thillet, J | 1 |
| du Plessis, DG; Dunn, JR; Gee, AL; Moss, DJ; Reed, JE; Reeves, P; Sellar, GC; Shaw, EJ; Walker, C; Warnke, PC | 1 |
| Cankovic, M; Mikkelsen, T; Rosenblum, ML; Zarbo, RJ | 1 |
| Fukushima, T; Katayama, Y; Komine, C; Ogino, A; Ohta, T; Watanabe, T; Yachi, K; Yoshino, A | 1 |
| Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM | 1 |
| Doerfler, W | 1 |
| Augusti-Tocco, G; Bartolucci, S; Carpinelli, P; Granata, F; Rossi, M | 1 |
| Baylin, SB; Biel, MA; Cavenee, WK; el Deiry, W; Issa, JP; Kuerbitz, SJ; Nelkin, BD; Wales, MM | 1 |
| Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
| Berger, MS; Blank, A; Bobola, MS; Silber, JR | 1 |
| Christensen, B; Fiskerstrand, T; Refsum, H; Tysnes, OB; Ueland, PM | 1 |
| Baylin, SB; Brodeur, GM; Cavenee, WK; Chazin, VR; Makos, M; Nelkin, BD | 1 |
| Berger, MS; Cavenee, WK; Costello, JF; Huang, HS | 1 |
| Endo, S; Feng, X; Ichikawa, T; Koga, H; Kumanishi, T; Onda, K; Washiyama, K; Zhang, S | 1 |
| Bruner, JM; Fueyo, J; Gomez-Manzano, C; Kyritsis, AP; Levin, VA; Saito, Y; Yung, WK; Zhang, B; Zhang, W | 1 |
| Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH | 1 |
| Bortolotto, S; Bosone, I; Cavalla, P; Chiadò-Piat, L; Mauro, A; Schiffer, D | 1 |
| Mennel, HD; Zülch, KJ | 1 |
| Viale, GL | 2 |
| Karlsson, KA; Pascher, I; Samuelsson, BE | 1 |
| Kleihues, P; Margison, GP | 1 |
| Perria, L; Viale, GL | 1 |
| Grosso, G; Kroh, H; Viale, E; Viale, GL | 1 |
18 review(s) available for isomethyleugenol and Brain Neoplasms
| Article | Year |
|---|---|
MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Systematic Review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Glioma; Humans; Methylation; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2021 |
Diagnostic performance of radiomics using machine learning algorithms to predict MGMT promoter methylation status in glioma patients: a meta-analysis.
Topics: Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Machine Learning; Methylation; Tumor Suppressor Proteins | 2021 |
A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature.
Topics: Astrocytoma; Biology; Brain Neoplasms; Chromosomes, Human, Pair 1; DNA; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Oligodendroglioma | 2022 |
Insights into the Regulatory Role of m
Topics: Adenosine; Brain Neoplasms; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; RNA, Ribosomal, 28S | 2020 |
Arginine methylation: the promise of a 'silver bullet' for brain tumours?
Topics: Antineoplastic Agents; Arginine; Brain Neoplasms; Enzyme Inhibitors; Humans; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2021 |
Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies.
Topics: Arginine; Brain Neoplasms; Carcinogenesis; Humans; Methylation; Models, Biological; Protein-Arginine N-Methyltransferases | 2021 |
Imaging Findings of New Entities and Patterns in Brain Tumor: Isocitrate Dehydrogenase Mutant, Isocitrate Dehydrogenase Wild-Type, Codeletion, and MGMT Methylation.
Topics: Brain; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Methylation; Mutation; Tomography, X-Ray Computed; Tumor Suppressor Proteins | 2021 |
MGMT promoter methylation and glioblastoma prognosis: a systematic review and meta-analysis.
Topics: Brain Neoplasms; Disease-Free Survival; DNA Methylation; Genetic Heterogeneity; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic | 2013 |
[Management of gliomas].
Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Chemoradiotherapy; Chromosome Deletion; Chromosomes, Human, Pair 1; Clinical Trials as Topic; Combined Modality Therapy; Dacarbazine; Dose Fractionation, Radiation; Drug Resistance, Neoplasm; Glioma; Humans; Lomustine; Methylation; Multicenter Studies as Topic; Neoplasm Proteins; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Temozolomide; Treatment Outcome; Vincristine | 2014 |
Assessing MGMT methylation status and its current impact on treatment in glioblastoma.
Topics: Brain Neoplasms; DNA Modification Methylases; Glioblastoma; Humans; Methylation | 2015 |
How I treat glioblastoma in older patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Geriatric Assessment; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Quality of Life; Seizures; Standard of Care; Temozolomide; Tumor Suppressor Proteins | 2016 |
The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations.
Topics: Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Proto-Oncogene Proteins B-raf; Tumor Suppressor Proteins | 2011 |
Non-promoter hypermethylation of zygote arrest 1 (ZAR1) in human brain tumors.
Topics: Adenoma; Biomarkers, Tumor; Brain Neoplasms; Egg Proteins; Glioma; Humans; Methylation; Oligonucleotide Array Sequence Analysis; Oocytes; Pituitary Neoplasms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Zygote | 2011 |
Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation.
Topics: Brain Neoplasms; Chemoradiotherapy; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Fatal Outcome; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Medulla Oblongata; Methylation; Middle Aged; Mutation; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2013 |
Deregulated chromatin remodeling in the pathobiology of brain tumors.
Topics: Acetylation; Adenosine Triphosphate; Antineoplastic Agents; Brain Neoplasms; Chromatin Assembly and Disassembly; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioma; Histone Deacetylase Inhibitors; Histones; Humans; Macromolecular Substances; Methylation; Molecular Targeted Therapy; Neoplasm Proteins; Nucleosomes; Protein Processing, Post-Translational | 2013 |
Uptake, fixation, and expression of foreign DNA in mammalian cells: the organization of integrated adenovirus DNA sequences.
Topics: Adenoviridae; Animals; Attachment Sites, Microbiological; Base Sequence; Brain Neoplasms; Cell Line; Cell Transformation, Viral; Cricetinae; DNA Restriction Enzymes; DNA, Viral; Gene Amplification; Gene Expression Regulation; Humans; Methylation; Mice; Molecular Weight; Neoplasms, Experimental; Operon; Protein Biosynthesis; Rats; Recombination, Genetic; Tumor Virus Infections; Virus Replication | 1982 |
New aspects of brain tumor research.
Topics: Alkylation; Animals; Brain Neoplasms; DNA; Humans; Methylation; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds | 1977 |
The RNA-overmethylation in brain tumours. Data and hypothesis.
Topics: Animals; Brain Neoplasms; Cell Differentiation; Cytogenetics; Glioma; Humans; Methylation; Mutation; Ribosomes; RNA, Neoplasm; RNA, Transfer | 1969 |
4 trial(s) available for isomethyleugenol and Brain Neoplasms
| Article | Year |
|---|---|
Initial Results of a Phase 2 Trial of
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Cognition; Confidence Intervals; Dihydroxyphenylalanine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Positron-Emission Tomography; Progression-Free Survival; Prospective Studies; Quality of Life; Radiopharmaceuticals; Radiotherapy, Image-Guided; Temozolomide; Young Adult | 2021 |
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoadjuvant Therapy; Radiation-Sensitizing Agents; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2014 |
Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Deoxycytidine; DNA Modification Methylases; DNA Repair Enzymes; Female; Gemcitabine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Radiation-Sensitizing Agents; Tumor Suppressor Proteins | 2010 |
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
164 other study(ies) available for isomethyleugenol and Brain Neoplasms
| Article | Year |
|---|---|
Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Topics: Brain Neoplasms; Diffusion Magnetic Resonance Imaging; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Methylation; Mutation; Perfusion; Retrospective Studies; Tumor Suppressor Proteins | 2021 |
Lomustine and nimustine exert efficient antitumor effects against glioblastoma models with acquired temozolomide resistance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Histones; Humans; Injections, Intraperitoneal; Lomustine; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Nimustine; Salvage Therapy; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2021 |
MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas.
Topics: Algorithms; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Temozolomide; Tumor Suppressor Proteins | 2022 |
Prognostic Significance of mRNA Expression RBBP8 or Its Methylation in Gliomas.
Topics: Brain Neoplasms; Endodeoxyribonucleases; Glioma; Humans; Methylation; Prognosis; RNA, Messenger; Tumor Microenvironment | 2023 |
DLL3 expression and methylation are associated with lower-grade glioma immune microenvironment and prognosis.
Topics: Biomarkers, Tumor; Brain Neoplasms; Epigenesis, Genetic; Glioma; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Methylation; Prognosis; Tumor Microenvironment | 2022 |
Non-invasive prediction of p53 and Ki-67 labelling indices and O-6-methylguanine-DNA methyltransferase promoter methylation status in adult patients with isocitrate dehydrogenase wild-type glioblastomas using diffusion-weighted imaging and dynamic suscept
Topics: Adult; Brain Neoplasms; DNA; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Perfusion; Retrospective Studies; Tumor Suppressor Protein p53 | 2022 |
RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma.
Topics: Brain Neoplasms; Gene Expression Regulation, Neoplastic; Glioma; Humans; Methylation; RNA; Tumor Microenvironment | 2022 |
The role of methylation profiling in histologically diagnosed neurocytoma: a case series.
Topics: Brain Neoplasms; Child; Female; Humans; Ki-67 Antigen; Magnetic Resonance Imaging; Male; Methylation; Neurocytoma; Synaptophysin | 2022 |
CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Topics: Animals; Astrocytes; Brain Neoplasms; Endothelial Cells; Epigenesis, Genetic; Glioma; Humans; Methylation; Methyltransferases; Mice; MicroRNAs; Microvessels; Permeability; RNA Splicing Factors; RNA-Binding Proteins; Serine-Arginine Splicing Factors; Zonula Occludens-1 Protein | 2022 |
Clinicopathological and molecular characterization of three cases classified by DNA-methylation profiling as "Glioneuronal Tumors, NOS, Subtype A".
Topics: Brain Neoplasms; Central Nervous System Neoplasms; DNA; DNA Methylation; Humans; Methylation; Neoplasms, Neuroepithelial | 2022 |
Methylation class oligosarcoma may encompass IDH-wildtype gliomas.
Topics: Brain Neoplasms; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mutation | 2023 |
Editorial for "Apparent Diffusion Coefficient as Imaging Biomarker for Identifying IDH Mutation, 1p19q Codeletion, and MGMT Promoter Methylation Status in Patients With Glioma".
Topics: Biomarkers; Brain Neoplasms; Diffusion Magnetic Resonance Imaging; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Tumor Suppressor Proteins | 2023 |
MR Imaging, MGMT Promoter Methylation Features and Prognostic Analysis of Subventricular Zone Contacting IDH Wild-type Glioblastoma.
Topics: Adult; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Lateral Ventricles; Magnetic Resonance Imaging; Methylation; Prognosis; Retrospective Studies; Tumor Suppressor Proteins | 2023 |
Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Progression-Free Survival; Temozolomide; Tumor Suppressor Proteins | 2023 |
An infantile pineal embryonal tumor showing pathological features of a CNS ganglioneuroblastoma and the methylation profiling of an atypical teratoid/rhabdoid tumor and SMARCA4 mutation.
Topics: Brain Neoplasms; Central Nervous System Neoplasms; DNA Helicases; Ganglioneuroblastoma; Humans; Methylation; Mutation; Neoplasms, Germ Cell and Embryonal; Nuclear Proteins; Rhabdoid Tumor; SMARCB1 Protein; Teratoma; Transcription Factors | 2023 |
Prediction of Ki-67 labeling index, ATRX mutation, and MGMT promoter methylation status in IDH-mutant astrocytoma by morphological MRI, SWI, DWI, and DSC-PWI.
Topics: Astrocytoma; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Methylation; Mutation; Retrospective Studies; Tumor Suppressor Proteins; X-linked Nuclear Protein | 2023 |
Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.
Topics: Arginine; Brain Neoplasms; Humans; Methylation; Perfusion; Protein Processing, Post-Translational; Quality of Life | 2023 |
Association of MGMT Promoter Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Male; Methylation; Prognosis; Prospective Studies; Tumor Suppressor Proteins | 2023 |
Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients.
Topics: Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Prognosis; Prospective Studies; Retrospective Studies; Telomerase; Telomere; Tumor Suppressor Proteins | 2023 |
Association of pre-radiotherapy tumour burden and overall survival in newly diagnosed glioblastoma adjusted for MGMT promoter methylation status.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Retrospective Studies; Tumor Burden; Tumor Suppressor Proteins | 2023 |
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status.
Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Tumor Suppressor Proteins | 2023 |
MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients.
Topics: Adult; Brain Neoplasms; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mucins; Mutation; Prognosis; Retrospective Studies | 2023 |
MGMT Promoter Methylation Predicts Overall Survival after Chemotherapy for 1p/19q-Codeleted Gliomas.
Topics: Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Prognosis; Tumor Suppressor Proteins | 2023 |
MGMT promoter methylation status prediction using MRI scans? An extensive experimental evaluation of deep learning models.
Topics: Aged; Brain Neoplasms; Deep Learning; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Imaging; Methylation; Reproducibility of Results; Tumor Suppressor Proteins | 2023 |
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Topics: Animals; Brain Neoplasms; Female; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mice; Mutation; Oncolytic Virotherapy; Oncolytic Viruses | 2023 |
Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma.
Topics: Brain Neoplasms; Glioma; Humans; Methylation; Prognosis; rap GTP-Binding Proteins; RNA; Tumor Microenvironment | 2023 |
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation.
Topics: Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Methylation; Neoplastic Stem Cells; Ribonucleoproteins, Small Nucleolar; RNA, Long Noncoding | 2023 |
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
Topics: Animals; Antineoplastic Agents; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Drug Administration Schedule; Drug Resistance, Neoplasm; Glioblastoma; High-Throughput Nucleotide Sequencing; Humans; Kaplan-Meier Estimate; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Transcription Factor RelA | 2019 |
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Organelle Biogenesis; Oxygen; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Processing, Post-Translational; Reactive Oxygen Species; Signal Transduction; Tumor Burden; Tumor Hypoxia; Tumor Microenvironment | 2019 |
m6A RNA Methylation Controls Proliferation of Human Glioma Cells by Influencing Cell Apoptosis.
Topics: Adenosine; Apoptosis; Brain Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Glioma; Humans; Methylation; Methyltransferases | 2019 |
Fusion Radiomics Features from Conventional MRI Predict MGMT Promoter Methylation Status in Lower Grade Gliomas.
Topics: Adult; Area Under Curve; Brain; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Reproducibility of Results; Retrospective Studies; ROC Curve; Tumor Suppressor Proteins | 2019 |
Survival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Radiation Dose Hypofractionation; Retrospective Studies; Temozolomide; Treatment Outcome | 2019 |
DR5 related autophagy can promote apoptosis in gliomas after irradiation.
Topics: Apoptosis; Autophagy; Brain Neoplasms; Caspase 8; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Methylation; Receptors, TNF-Related Apoptosis-Inducing Ligand; Transcription, Genetic | 2020 |
Survey of treatment recommendations for elderly patients with glioblastoma.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Health Care Surveys; Humans; Methylation; Oncologists; Physical Functional Performance; Radiotherapy Dosage; Spain; Temozolomide; Tumor Suppressor Proteins | 2020 |
Does the expression of glial fibrillary acid protein (GFAP) stain in glioblastoma tissue have a prognostic impact on survival?
Topics: Aged; Biomarkers; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Survival Analysis; Tumor Suppressor Proteins | 2020 |
SOX9-activated PXN-AS1 promotes the tumorigenesis of glioblastoma by EZH2-mediated methylation of DKK1.
Topics: Animals; Apoptosis; Base Sequence; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; Intercellular Signaling Peptides and Proteins; Male; Methylation; Mice, Inbred BALB C; Promoter Regions, Genetic; RNA, Long Noncoding; SOX9 Transcription Factor; Wnt Signaling Pathway | 2020 |
Molecular characteristics and clinical outcomes of elderly patients with IDH-wildtype glioblastomas: comparative study of older and younger cases in Kansai Network cohort.
Topics: Age Factors; Aged; Aged, 80 and over; Brain Neoplasms; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Japan; Male; Methylation; Middle Aged; Prognosis; Survival Rate; Tumor Suppressor Proteins | 2020 |
Polycomb-like 2 regulates PRC2 components to affect proliferation in glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioma; Histones; Humans; Methylation; Polycomb Repressive Complex 2 | 2020 |
Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling.
Topics: Biomarkers, Tumor; Brain Neoplasms; Computational Biology; Gene Expression; Glioma; Humans; Methylation; Protein Kinase C | 2020 |
A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma.
Topics: Adult; Aged; Alcohol Oxidoreductases; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Line, Tumor; CRISPR-Associated Protein 9; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Pilot Projects; Sequence Analysis, RNA; Tumor Suppressor Proteins; Young Adult | 2020 |
Prediction of MGMT Status for Glioblastoma Patients Using Radiomics Feature Extraction From
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain Neoplasms; Dihydroxyphenylalanine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Machine Learning; Male; Methylation; Middle Aged; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Tomography, X-Ray Computed; Tumor Suppressor Proteins; Young Adult | 2020 |
Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant.
Topics: Adolescent; Aged; Biomarkers, Tumor; Brain Neoplasms; Child; DEAD-box RNA Helicases; Female; High-Throughput Nucleotide Sequencing; Histones; Humans; Immunohistochemistry; Infant; Lysine; Male; Methylation; Mutation; Ribonuclease III; Sarcoma; Transducin | 2021 |
Methylation extends the reach of liquid biopsy in cancer detection.
Topics: Brain Neoplasms; Cell-Free Nucleic Acids; Epigenome; Humans; Liquid Biopsy; Methylation | 2020 |
The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status.
Topics: Adult; Brain Neoplasms; Chitinase-3-Like Protein 1; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2020 |
Methylation associated miR-1246 contributes to poor prognosis in gliomas treated with temozolomide.
Topics: Brain Neoplasms; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; MicroRNAs; Prognosis; Temozolomide | 2021 |
LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Methylation; MicroRNAs; Phenotype; Promoter Regions, Genetic; Proteolysis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; RNA, Long Noncoding; Signal Transduction; Survival Analysis; TOR Serine-Threonine Kinases; Ubiquitination | 2020 |
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methylation; Mice, Knockout; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53 | 2020 |
Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells.
Topics: Astrocytes; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Chromatin Immunoprecipitation; Chromatin Immunoprecipitation Sequencing; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; High-Throughput Nucleotide Sequencing; Histone Code; Histones; Humans; Methylation; Mutation, Missense | 2020 |
Automated machine learning to predict the co-occurrence of isocitrate dehydrogenase mutations and O
Topics: Brain Neoplasms; DNA; Glioma; Humans; Isocitrate Dehydrogenase; Machine Learning; Magnetic Resonance Imaging; Methylation; Methyltransferases; Mutation; Retrospective Studies | 2021 |
Radiology in the lead: towards radiological profiling for precision medicine in glioblastoma patients? Editorial comment on Glioblastoma patients with a moderate vascular profile benefit the most from MGMT methylation.
Topics: Biomarkers, Tumor; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Precision Medicine; Prognosis; Radiology; Tumor Suppressor Proteins | 2021 |
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification.
Topics: Brain Neoplasms; DNA; DNA Copy Number Variations; DNA Methylation; Extracellular Vesicles; Glioblastoma; Humans; Methylation | 2021 |
Noninvasive Assessment of O(6)-Methylguanine-DNA Methyltransferase Promoter Methylation Status in World Health Organization Grade II-IV Glioma Using Histogram Analysis of Inflow-Based Vascular-Space-Occupancy Combined with Structural Magnetic Resonance Im
Topics: Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Magnetic Resonance Imaging; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Retrospective Studies; World Health Organization | 2021 |
Editorial for "Noninvasive Assessment of MGMT Promoter Methylation Status in World Health Organization Grade II-IV Glioma Using Histogram Analysis of Inflow-Based Vascular-Space Occupancy Combined with Structural MR Imaging".
Topics: Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Magnetic Resonance Imaging; Methylation; Promoter Regions, Genetic; Tumor Suppressor Proteins; World Health Organization | 2021 |
MGMT promoter methylation is associated with patient age and 1p/19q status in IDH-mutant gliomas.
Topics: Brain Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Humans; Infant; Isocitrate Dehydrogenase; Methylation; Mutation; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2021 |
COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells.
Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Brain Neoplasms; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Etoricoxib; Female; Glioblastoma; Humans; Isoxazoles; Lactones; Male; Methylation; Middle Aged; Neoplasm Proteins; Pyrazoles; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Sulfones; Temozolomide; Tumor Suppressor Proteins; Wnt Signaling Pathway | 2021 |
Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma.
Topics: Animals; Brain Neoplasms; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Pericytes; Sequence Analysis, RNA; Single-Cell Analysis; Tumor Microenvironment; Tumor Suppressor Proteins; Up-Regulation | 2022 |
Identification of Critical m
Topics: Biomarkers, Tumor; Brain Neoplasms; Cluster Analysis; Computational Biology; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Methylation; Middle Aged; Prognosis; Risk Factors; RNA; Transcriptome; Tumor Microenvironment | 2021 |
Diagnostic and prognostic value of stem cell factor plasma level in glioblastoma multiforme patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Diagnosis, Differential; DNA Modification Methylases; DNA Repair Enzymes; Enzyme-Linked Immunosorbent Assay; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Preoperative Period; Prognosis; Progression-Free Survival; ROC Curve; Stem Cell Factor; Tumor Burden; Tumor Suppressor Proteins | 2021 |
Expression, methylation and prognostic feature of EMILIN2 in Low-Grade-Glioma.
Topics: Adult; Aging; Biomarkers, Tumor; Brain Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Survival Analysis; Transcriptome | 2021 |
Histone Mark Profiling in Pediatric Astrocytomas Reveals Prognostic Significance of H3K9 Trimethylation and Histone Methyltransferase SUV39H1.
Topics: Adolescent; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Child; Child, Preschool; Cohort Studies; Female; Gene Expression Profiling; Histone Code; Histone-Lysine N-Methyltransferase; Humans; Infant; Male; Methylation; Methyltransferases; Prognosis; Repressor Proteins | 2021 |
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling.
Topics: Adolescent; Brain Neoplasms; Glioblastoma; Humans; Methylation; Prognosis; Temozolomide; Valproic Acid; Vinblastine | 2022 |
Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Calcinosis; Child; Child, Preschool; Female; Glioma; Histones; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Mutation; Neoplasm Staging; Prevalence; Retrospective Studies; Young Adult | 2017 |
Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Kaplan-Meier Estimate; Methylation; Multivariate Analysis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Regression Analysis; Retrospective Studies; Temozolomide; Time Factors; Tumor Suppressor Proteins | 2017 |
Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glioma; Histones; Humans; Lysine; Methylation; Mice, Nude; Temozolomide; X-linked Nuclear Protein; Xenograft Model Antitumor Assays | 2018 |
Methylation-induced downregulation and tumor-suppressive role of microRNA-98 in glioma through targeting Sal-like protein 4.
Topics: Adult; Aged; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Methylation; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Transcription Factors; Young Adult | 2018 |
In Vivo Molecular Profiling of Human Glioma : Cross-Sectional Observational Study Using Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain Neoplasms; Cerebral Blood Volume; Chromosome Deletion; Chromosomes, Human, 1-3; Contrast Media; Cross-Sectional Studies; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Profiling; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Angiography; Methylation; Middle Aged; Mutation; Retrospective Studies; Tumor Suppressor Proteins; X-linked Nuclear Protein; Young Adult | 2019 |
Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells.
Topics: Binding Sites; Brain Neoplasms; CCCTC-Binding Factor; Cell Dedifferentiation; Cell Line, Tumor; Cell Movement; Chromatin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Histone Code; Humans; Methylation; Neoplastic Stem Cells; Protein Domains | 2018 |
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M
Topics: Animals; Brain Neoplasms; Gangliosides; Glioma; Histones; Humans; Immunotherapy, Adoptive; Lysine; Methylation; Mice; Receptors, Antigen, T-Cell; Xenograft Model Antitumor Assays | 2018 |
Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
Topics: Bone Neoplasms; Brain Neoplasms; Child; Epigenesis, Genetic; Giant Cell Tumor of Bone; Glioblastoma; HeLa Cells; Histones; Humans; Lysine; Methylation; Mutation | 2018 |
Patterns of care and outcomes of chemoradiation versus radiation alone for MGMT promoter unmethylated glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Databases, Factual; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2018 |
Survival gain with re-Op/RT for recurred high-grade gliomas depends upon risk groups.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Male; Methylation; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Radiotherapy, Adjuvant; Reoperation; Retreatment; Retrospective Studies; Risk Factors; Tumor Suppressor Proteins | 2018 |
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Topics: Arginine; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Oncogenes; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Transcription, Genetic | 2018 |
A comprehensive analysis of factors related to carmustine/bevacizumab response in recurrent glioblastoma.
Topics: AC133 Antigen; Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Carmustine; Chitinase-3-Like Protein 1; Colombia; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Neoplasm Recurrence, Local; Progression-Free Survival; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Survival Analysis; Tumor Suppressor Proteins; Young Adult | 2019 |
Correlation of radiological and immunochemical parameters with clinical outcome in patients with recurrent glioblastoma treated with Bevacizumab.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Immunological; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Cerebrovascular Circulation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Amplification; Genes, erbB-1; Glioblastoma; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Methylation; Microvessels; Middle Aged; Mitotic Index; Neoplasm Recurrence, Local; Retrospective Studies; Tissue Array Analysis; Tumor Suppressor Proteins | 2019 |
Posttreatment Effect of MGMT Methylation Level on Glioblastoma Survival.
Topics: Aged; Brain Neoplasms; CpG Islands; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Progression-Free Survival; Survival Analysis; Tumor Suppressor Proteins | 2019 |
Negative regulation of miR-1275 by H3K27me3 is critical for glial induction of glioblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Methylation; Mice, Inbred BALB C; MicroRNAs; Neuroglia; Transcriptome | 2019 |
Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma.
Topics: Animals; beta Catenin; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Glioma; Glycogen Synthase Kinases; Histones; Humans; Methylation; Mice; Mice, Nude; MicroRNAs; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prognosis; Proto-Oncogene Proteins c-akt; Signal Transduction; Transplantation, Heterologous | 2019 |
H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans.
Topics: Animals; Brain Neoplasms; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carcinogenesis; Cell Cycle; Chromatin; DNA Replication; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Germ Cells; Glioma; Heterochromatin; Histone Code; Histones; MAP Kinase Signaling System; Methylation; Polycomb Repressive Complex 2 | 2019 |
Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enhancer Elements, Genetic; Epigenesis, Genetic; ErbB Receptors; Fatty Acid Elongases; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Methylation; Neoplastic Stem Cells; Signal Transduction; SOXB1 Transcription Factors; Up-Regulation | 2019 |
8-plex LC-MS/MS Analysis of Permethylated
Topics: Brain Neoplasms; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Chromatography, Liquid; Female; Glycomics; Glycoproteins; Humans; Hydrocarbons, Iodinated; Methylation; Polysaccharides; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2019 |
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.
Topics: Adolescent; Adult; Age Factors; Brain Neoplasms; Case-Control Studies; Child; Cohort Studies; Exome; Glioma; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant; Methylation; Middle Aged; Mutation; Neoplasm Grading; Young Adult | 2013 |
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
Topics: Amino Acid Substitution; Animals; Brain Neoplasms; Child; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glioblastoma; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mice; Mutation, Missense; Polycomb Repressive Complex 2; Transgenes | 2013 |
High grade glioma--the arrival of the molecular diagnostic era for patients over the age of 65 years in the UK.
Topics: Age Factors; Aged; Brain Neoplasms; Glioma; Humans; Methylation; Molecular Diagnostic Techniques; Molecular Targeted Therapy; Neoplasm Grading; United Kingdom | 2013 |
Assessment of genetic markers and glioblastoma stem-like cells in activation of dendritic cells.
Topics: Antigens, CD; Brain Neoplasms; Cell- and Tissue-Based Therapy; Coculture Techniques; Dendritic Cells; DNA Modification Methylases; DNA Repair Enzymes; Fetal Blood; Gene Expression Regulation, Neoplastic; Genetic Markers; Glioblastoma; Humans; Methylation; Neoplastic Stem Cells; Prognosis; PTEN Phosphohydrolase; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2013 |
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Brain Neoplasms; DNA-Binding Proteins; Glioma; HEK293 Cells; HeLa Cells; Humans; Immunohistochemistry; Lysine; Methylation; Models, Biological; Phosphorylation; Protein Binding; Protein Phosphatase 2; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha | 2013 |
Methylation by EZH2 activates STAT3 in glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2013 |
Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation.
Topics: Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Induction; Glioblastoma; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Neoplasm Grading; Neoplasm Proteins; Protein Methyltransferases; Protein Processing, Post-Translational; Repressor Proteins; RNA Interference; RNA, Small Interfering; Tumor Stem Cell Assay; Up-Regulation | 2014 |
TERT promoter mutations rather than methylation are the main mechanism for TERT upregulation in adult gliomas.
Topics: Adult; Brain Neoplasms; Glioma; Humans; Methylation; Mutation; Promoter Regions, Genetic; Telomerase; Up-Regulation | 2013 |
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cell Line, Tumor; Child; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genes, Dominant; Glioblastoma; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Sequence Data; Mutation, Missense; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Binding; Protein Processing, Post-Translational; Transcription Factors; Transcription, Genetic | 2013 |
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Glioblastoma; Guanosine; Humans; Methylation; Middle Aged; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide | 2013 |
Double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours.
Topics: Antigens, CD; Antigens, CD34; Antigens, Differentiation, Myelomonocytic; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; False Negative Reactions; False Positive Reactions; Glioblastoma; Humans; Immunohistochemistry; Leukocyte Common Antigens; Methylation; Oligodendroglioma; Photomicrography; Retrospective Studies; Sensitivity and Specificity; Tumor Suppressor Proteins | 2013 |
Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Prospective Studies; Registries; Retrospective Studies; Stereotaxic Techniques; Tumor Suppressor Proteins | 2014 |
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Topics: AC133 Antigen; Antigens, CD; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; Quinazolines; Signal Transduction; SOXB1 Transcription Factors; Transfection | 2014 |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histones; Humans; Methylation; Mixed Function Oxygenases; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2014 |
Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electron Transport Complex I; Glioma; Humans; Male; Methylation; Mitochondria; Promoter Regions, Genetic; Rats, Sprague-Dawley; Tamoxifen; Temozolomide; Tumor Suppressor Proteins | 2015 |
[Aberrant expression of sox2 gene in malignant gliomas].
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Methylation; Primary Cell Culture; Protein Processing, Post-Translational; SOXB1 Transcription Factors; Tumor Microenvironment | 2014 |
The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas.
Topics: Adult; Aged; Animals; Apoptosis; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Products, tat; Genes, Tumor Suppressor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Meningioma; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Recombinant Fusion Proteins; Sequence Analysis, DNA; Transcription Factors | 2015 |
[Perampanel in the treatment of a patient with glioblastoma multiforme without IDH1 mutation and without MGMT promotor methylation].
Topics: Alkylating Agents; Brain Neoplasms; Dacarbazine; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Mutation; Nitriles; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Pyridones; Survival Analysis; Temozolomide | 2015 |
Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Adult; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Caco-2 Cells; Case-Control Studies; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mutational Analysis; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Genetic Predisposition to Disease; Genetic Testing; Germ-Line Mutation; HCT116 Cells; Heredity; Humans; Lymphocytes; Male; Methylation; Microsatellite Instability; Mismatch Repair Endonuclease PMS2; Multiplex Polymerase Chain Reaction; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplastic Syndromes, Hereditary; Nuclear Proteins; Phenotype; Predictive Value of Tests; Reproducibility of Results; Transfection; Young Adult | 2015 |
Methylation of the miR-126 gene associated with glioma progression.
Topics: Adult; Aged; Brain Neoplasms; Case-Control Studies; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Glioma; Humans; Male; Methylation; MicroRNAs; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis.
Topics: Adult; Autoantigens; Brain Neoplasms; Cell Transformation, Neoplastic; Cluster Analysis; DNA Copy Number Variations; DNA Mutational Analysis; Genome, Human; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Neoplasms, Neuroepithelial; Proteasome Endopeptidase Complex | 2016 |
Effect of α-Methyl versus α-Hydrogen Substitution on Brain Availability and Tumor Imaging Properties of Heptanoic [F-18]Fluoroalkyl Amino Acids for Positron Emission Tomography (PET).
Topics: Amino Acid Substitution; Amino Acids; Amino Acids, Neutral; Animals; Biological Transport; Brain; Brain Neoplasms; Fluorine Radioisotopes; Glioma; Hydrogen; Male; Methylation; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution; Tyrosine | 2016 |
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Topics: Brain Neoplasms; Carcinogenesis; Catalytic Domain; Crystallography, X-Ray; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutation; Oncogenes; Polycomb Repressive Complex 2; Protein Binding; Protein Domains | 2016 |
Homeobox genes gain trimethylation of histone H3 lysine 4 in glioblastoma tissue.
Topics: Brain Neoplasms; Cadherins; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Glioblastoma; Histones; Humans; Lysine; Methylation; Middle Aged; Promoter Regions, Genetic | 2016 |
MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Cyclins; Dioxygenases; Disease Progression; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasm Transplantation; Nuclear Proteins; Prognosis; Survival Analysis | 2017 |
Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis.
Topics: Astrocytes; Benzeneacetamides; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Glioma; Glutarates; Histones; Humans; Imidazoles; Isocitrate Dehydrogenase; Methylation; Mutation | 2016 |
The survival significance of a measurable enhancing lesion after completing standard treatment for newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2016 |
Frontal glioblastoma multiforme may be biologically distinct from non-frontal and multilobar tumors.
Topics: Adult; Aged; Brain Neoplasms; Female; Frontal Lobe; Glioblastoma; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Male; Methylation; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies | 2016 |
LAPTM4B-35 is a novel prognostic factor for glioblastoma.
Topics: Adult; Brain Neoplasms; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Ki-67 Antigen; Male; Membrane Proteins; Methylation; Middle Aged; Multivariate Analysis; Neovascularization, Pathologic; Oncogene Protein v-akt; Retrospective Studies; Tumor Suppressor Proteins | 2017 |
The new mindset for embracing precision medicine: Developing new approaches for exploring diseases.
Topics: Biosensing Techniques; Brain Neoplasms; Computational Biology; Diagnosis, Computer-Assisted; DNA Modification Methylases; DNA Repair Enzymes; Humans; Machine Learning; Magnetic Resonance Imaging; Methylation; Precision Medicine; Tumor Suppressor Proteins | 2017 |
Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma.
Topics: Brain Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Lateral Ventricles; Lysine; Magnetic Resonance Imaging; Methylation; Mutation; Neoplastic Stem Cells; Neural Stem Cells; Sequence Analysis, RNA | 2017 |
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Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Base Sequence; Brain Neoplasms; Carcinogenesis; Cell Differentiation; Cell Proliferation; Cell Self Renewal; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Humans; Meclofenamic Acid; Methylation; Methyltransferases; Mice; Neoplastic Stem Cells; RNA; RNA, Messenger | 2017 |
Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Burden | 2009 |
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Topics: Animals; Azacitidine; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Formyl Peptide; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2009 |
Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site.
Topics: Acetylation; Animals; Binding Sites; Brain; Brain Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; Female; Glioma; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoglobulins; Membrane Proteins; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; p300-CBP Transcription Factors; Promoter Regions, Genetic; RNA, Messenger; Sequence Analysis, DNA; Sp1 Transcription Factor | 2009 |
Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas.
Topics: Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cerebral Cortex; Deuterium; Glioma; Glucose; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Methylation; Neoplasm Transplantation; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Wistar | 2009 |
Fotemustine and recurrent glioblastoma: possible new opportunities for an old drug.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioblastoma; Humans; Methylation; Neoplasm Recurrence, Local; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Randomized Controlled Trials as Topic | 2009 |
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Methylation; Mice; O(6)-Methylguanine-DNA Methyltransferase; PTEN Phosphohydrolase; Radiation-Sensitizing Agents; Random Allocation; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays | 2009 |
O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Temozolomide; Tumor Suppressor Proteins | 2010 |
Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2; Survival Rate; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Young Adult | 2009 |
Recurrent PNET with MGMT methylation responds to temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance Imaging; Male; Methylation; Neuroectodermal Tumors, Primitive; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2009 |
Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorine Radioisotopes; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Positron-Emission Tomography; Pyrazoles; Retrospective Studies; Sulfonamides; Temozolomide; Tumor Suppressor Proteins; Tyrosine | 2010 |
Natural mutagenesis of human genomes by endogenous retrotransposons.
Topics: Alu Elements; Brain Neoplasms; Genome, Human; Humans; Long Interspersed Nucleotide Elements; Lung Neoplasms; Methylation; Mutagenesis; Sequence Analysis, DNA | 2010 |
Retrospective protein expression and epigenetic inactivation studies of CDH1 in patients affected by low-grade glioma.
Topics: Adolescent; Adult; Aged; Antigens, CD; Brain Neoplasms; Cadherins; Disease-Free Survival; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Ki-67 Antigen; Male; Methylation; Middle Aged; Retrospective Studies; Statistics, Nonparametric; Young Adult | 2011 |
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Angiography; Male; Methylation; Middle Aged; Neuronavigation; Polymerase Chain Reaction; Protoporphyrins; Spectrometry, Fluorescence; Tumor Suppressor Proteins | 2011 |
Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors.
Topics: Astrocytoma; Brain; Brain Neoplasms; Case-Control Studies; Cell Line, Tumor; Egg Proteins; Glioblastoma; Glioma; Humans; Mass Spectrometry; Melanoma; Methylation; Nevus; Oligodendroglioma; Pituitary Neoplasms; Reference Values | 2010 |
Quantitative digital assessment of MGMT immunohistochemical expression in glioblastoma tissue.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Gliosarcoma; Humans; Immunohistochemistry; Male; Methylation; Middle Aged; Tumor Suppressor Proteins | 2011 |
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Topics: Animals; Brain; Brain Chemistry; Brain Neoplasms; Cell Line; Central Nervous System; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Glioblastoma; Hexokinase; Humans; Introns; Isoenzymes; Methylation; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sulfites | 2011 |
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Genetic Vectors; Glioblastoma; Humans; Immunoblotting; Immunohistochemistry; Methylation; Mice; Mice, Nude; Neoplastic Stem Cells; Oncolytic Virotherapy; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Simplexvirus; Temozolomide; Tumor Suppressor Proteins; Vero Cells; Virus Replication | 2012 |
Volumetric and MGMT parameters in glioblastoma patients: survival analysis.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Profiling; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; Temozolomide; Tumor Burden; Tumor Suppressor Proteins | 2012 |
Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Postoperative Complications; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2012 |
A study of clinico-pathological parameters and O⁶-methylguanine DNA methyltransferase (MGMT) promoter methylation status in the prognostication of gliosarcoma.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; DNA; DNA Modification Methylases; DNA Repair Enzymes; Endpoint Determination; Female; Follow-Up Studies; Gliosarcoma; Humans; Immunohistochemistry; Karnofsky Performance Status; Male; Methylation; Middle Aged; Neurosurgical Procedures; Prognosis; Promoter Regions, Genetic; Survival; Survival Analysis; Tumor Suppressor Proteins; Young Adult | 2012 |
Case records of the Massachusetts General Hospital. Case 17-2012. A 54-year-old man with visual-field loss and a mass in the brain.
Topics: Brain; Brain Neoplasms; Chemoradiotherapy; Diagnosis, Differential; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Fatal Outcome; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Neoplasms, Second Primary; Recurrence; Tumor Suppressor Proteins; Vision Disorders | 2012 |
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.
Topics: Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Decitabine; Down-Regulation; Epigenesis, Genetic; Gene Silencing; Glioma; Humans; Methylation; MicroRNAs; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide | 2012 |
Distinct methylation profiles of glioma subtypes.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; CpG Islands; Female; Glioblastoma; Glioma; Humans; Infant; Male; Methylation; Middle Aged; Oligodendroglioma; Prognosis; Sulfites | 2003 |
[Therapeutic efficacy and prognostic factors in diffuse astrocytomas].
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Interferon-beta; Male; Methylation; Middle Aged; Neurosurgical Procedures; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies | 2003 |
PTEN methylation and expression in glioblastomas.
Topics: Adult; Aged; Brain Neoplasms; Cell Line, Tumor; Chromosomes, Human, Pair 10; DNA Mutational Analysis; Female; Glioblastoma; Humans; Immunohistochemistry; Loss of Heterozygosity; Male; Methylation; Middle Aged; Phosphoric Monoester Hydrolases; Polymerase Chain Reaction; Promoter Regions, Genetic; PTEN Phosphohydrolase; Tumor Suppressor Proteins | 2003 |
Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines.
Topics: Alleles; Animals; Base Sequence; Brain Neoplasms; Chromosomes, Human, Pair 19; Expressed Sequence Tags; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Humans; Kruppel-Like Transcription Factors; Methylation; Mice; Molecular Sequence Data; Polymorphism, Single Nucleotide; Protein Kinases; Transcription Factors; Tumor Cells, Cultured | 2004 |
Hypermethylation of the RASSF1A gene in gliomas.
Topics: Adolescent; Adult; Aged; Apoptosis Regulatory Proteins; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p16; Death-Associated Protein Kinases; DNA, Complementary; Female; Gene Expression; Gene Frequency; Genes, Tumor Suppressor; Glioma; Humans; Male; Methylation; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Characteristics; Tumor Suppressor Proteins | 2004 |
Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors.
Topics: Animals; Blotting, Northern; Brain; Brain Neoplasms; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Glioma; Humans; Immunohistochemistry; Male; Methylation; Neoplasm Transplantation; Phosphopyruvate Hydratase; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours.
Topics: ADAM Proteins; ADAMTS Proteins; Angiogenesis Inhibitors; Binding Sites; Blotting, Western; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Down-Regulation; Gene Expression Profiling; Humans; Methylation; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Vascular Endothelial Growth Factor A | 2006 |
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
Topics: Adult; Antimetabolites, Antineoplastic; Apoptosis; Astrocytoma; Azacitidine; Brain Neoplasms; Cell Line, Tumor; Dealkylation; DNA; Down-Regulation; Female; Flow Cytometry; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfates; Tumor Suppressor Proteins | 2006 |
MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Glioblastoma; Humans; In Vitro Techniques; Methylation; Middle Aged; Prognosis; Retrospective Studies; Statistics, Nonparametric; Survival Analysis; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2007 |
Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours.
Topics: Alternative Splicing; Amino Acid Sequence; Brain Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; DNA, Complementary; Down-Regulation; Exons; Gene Expression Regulation, Neoplastic; Glioma; GPI-Linked Proteins; Humans; Methylation; Molecular Sequence Data; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm | 2007 |
A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Fixatives; Formaldehyde; Gene Silencing; Glioblastoma; Humans; Male; Methylation; Middle Aged; Oligodendroglioma; Paraffin Embedding; Promoter Regions, Genetic; Reproducibility of Results; Tumor Suppressor Proteins | 2007 |
Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; CpG Islands; Female; Humans; Male; Methylation; Middle Aged; Mutation; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Survival Analysis; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2007 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin | 1983 |
Antiproliferative effects and DNA hypomethylation by 5-aza-2'-deoxycytidine in human neuroblastoma cell lines.
Topics: Antigens, Differentiation; Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Division; Decitabine; Deoxycytidine; Deoxycytidine Kinase; DNA-Cytosine Methylases; DNA, Neoplasm; Humans; Methylation; Neuroblastoma; Tumor Cells, Cultured | 1993 |
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Topics: Amino Acid Sequence; Brain Neoplasms; Breast Neoplasms; Cell Division; Chromosomes, Human, Pair 17; Colonic Neoplasms; CpG Islands; Female; Fibroblasts; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Growth Inhibitors; Humans; Kruppel-Like Transcription Factors; Lung Neoplasms; Methylation; Molecular Sequence Data; Organ Specificity; Recombinant Proteins; Sequence Alignment; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Zinc Fingers | 1995 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Contribution of O6-methylguanine-DNA methyltransferase to monofunctional alkylating-agent resistance in human brain tumor-derived cell lines.
Topics: Alkylating Agents; Antineoplastic Agents; Brain Neoplasms; Cell Adhesion; Colonic Neoplasms; Culture Media; Drug Resistance; Drug Screening Assays, Antitumor; Ethylnitrosourea; Glioma; Medulloblastoma; Methylation; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 1995 |
Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Brain Neoplasms; Female; Folic Acid; Glioblastoma; Homocysteine; Humans; Methionine; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1994 |
DNA hypermethylation is associated with 17p allelic loss in neural tumors.
Topics: Alleles; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 17; DNA, Neoplasm; Glioblastoma; Humans; Methylation; Neuroblastoma | 1993 |
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.
Topics: Astrocytoma; Azacitidine; Base Sequence; Brain Chemistry; Brain Neoplasms; Carrier Proteins; Chromatin; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; Molecular Sequence Data; Neoplasm Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1996 |
A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.
Topics: Adult; Aged; Brain Neoplasms; Carrier Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Female; Gene Deletion; Genes, p53; Genes, Tumor Suppressor; Glioma; Humans; Male; Methylation; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1996 |
Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.
Topics: Brain Neoplasms; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p16; Dinucleoside Phosphates; Down-Regulation; Glioma; Humans; Immunohistochemistry; Methylation | 1996 |
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured | 1996 |
CDKN2A/p16 in ependymomas.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Brain Neoplasms; Cell Nucleus; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p16; Ependymoma; Humans; Immunohistochemistry; Ki-67 Antigen; Methylation; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Tissue Embedding | 2001 |
Transfer RNA and transfer RNA methylase in human brain tumors.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Glioblastoma; Humans; Meningioma; Methylation; Methyltransferases; Nucleosides; Oligodendroglioma; RNA, Transfer; Transferases | 1971 |
Analysis of intact gangliosides by mass spectrometry. Comparison of different derivatives of a hematoside of a tumour and the major monosialoganglioside of brain.
Topics: Aluminum; Brain; Brain Neoplasms; Carcinoma; Ceramides; Fatty Acids; Gangliosides; Humans; Kidney Neoplasms; Lithium; Mass Spectrometry; Methylation; Molecular Weight; Neoplasm Metastasis; Neuraminic Acids; Oxidation-Reduction; Silicon Dioxide; Temperature | 1974 |
Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA.
Topics: Adenine; Animals; Brain; Brain Neoplasms; Carcinogens; DNA; DNA Repair; Female; Guanine; Kidney; Kidney Neoplasms; Liver; Methylation; Neoplasms, Experimental; Nitrosourea Compounds; Purines; Rats | 1974 |
Biochemical patterns in brain tumours. 3. Transfer ribonucleic acid.
Topics: Astrocytoma; Biological Transport; Brain Chemistry; Brain Neoplasms; Glioma; Humans; Medulloblastoma; Methylation; Nucleosides; RNA, Neoplasm; Spectrophotometry | 1969 |
Transfer and ribosomal ribonucleic acids in brain tumors.
Topics: Brain Neoplasms; Glioma; Humans; Methylation; Ribosomes; RNA, Neoplasm; RNA, Transfer | 1971 |