isomethyleugenol has been researched along with Astrocytoma, Grade IV in 134 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.75) | 18.7374 |
1990's | 6 (4.48) | 18.2507 |
2000's | 16 (11.94) | 29.6817 |
2010's | 69 (51.49) | 24.3611 |
2020's | 42 (31.34) | 2.80 |
Authors | Studies |
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Brandner, S; Cheng, HY; Dawson, S; Faulkner, CL; Higgins, JPT; Jefferies, S; Kelly, C; Kurian, KM; McAleenan, A; Schmidt, L; Spiga, F; Wragg, C | 1 |
Li, H; Li, X; Lu, J | 1 |
Fujii, T; Ichimura, K; Kawauchi, D; Kobayashi, T; Kondo, A; Nakano, T; Narita, Y; Sasaki, N; Satomi, K; Takahashi, M; Tomiyama, A; Uchida, E; Wada, K; Yamamuro, S; Yoshino, A | 1 |
Hölzl, D; Kral, M; Kraus, TFJ; Ladisich, B; Machegger, L; Pöppe, J; Schlicker, HU; Schwartz, C; Sotlar, K; Spendel, M; Zellinger, B | 1 |
French, PJ; Golfinopoulos, V; Gorlia, T; Tesileanu, CMS; van den Bent, MJ | 1 |
Fan, J; Li, C; Wan, B; Wang, S; Xiong, W; Zhang, Y; Zheng, Z | 1 |
Hase, H; Hirade, Y; Kitae, K; Takahashi, H; Tashiro, J; Tsujikawa, K; Yoshida, T | 1 |
Cao, D; Huang, W; Su, Y; Xing, Z; Yang, X; Zhou, X | 1 |
Cao, H; Chao, M; Chen, F; Wang, L; Xie, X | 1 |
Dong, W; Liu, L; Liu, M; Liu, X; Ruan, X; Wang, D; Wang, P; Xue, Y; Yang, C; Zhang, M | 1 |
Liu, M; Liu, Q; Liu, R; Sun, G; Xu, B; Zhao, K | 1 |
Chen, Y; Lan, Q; Li, P; Li, Y; Li, Z; Wang, J; Wang, Q; Wang, Y; Wang, Z; Wu, C; Xiao, Z; Zhou, H | 1 |
Birkl-Toeglhofer, AM; Brawanski, KR; Freyschlag, CF; Haybaeck, J; Hoeftberger, R; Manzl, C; Sprung, S; Ströbel, T; Thomé, C | 1 |
Cui, J; Dong, W; Liu, L; Liu, X; Liu, Y; Ruan, X; Wang, P; Xue, Y; Zhang, M | 1 |
Angelini, C; Caccese, M; Cavallin, F; Cerretti, G; Chioffi, F; d'Avella, D; De Bonis, P; De Rossi, A; Giunco, S; Lombardi, G; Morello, M; Padovan, M; Puppa, AD; Rizzo, B; Zagonel, V | 1 |
Alafandi, A; Gorlia, T; Klein, S; Nabors, L; Rizopoulos, D; Smits, M; Stupp, R; Tonn, JC; van der Voort, SR; van Garderen, KA; Weller, M | 1 |
Chen, J; Chen, Y; Huang, H; Lan, C; Li, C; Li, X; Liu, C; Liu, W; Luo, K; Luo, Q; Qin, J; Tan, R; Wang, X; Wei, C; Wei, S; Zhang, G; Zheng, C | 1 |
Harter, PN; Herms, J; Katzendobler, S; Niedermeyer, S; Niyazi, M; Stoecklein, VM; Thon, N; Tonn, JC; Trumm, C; Weller, J | 1 |
Gao, Z; Hu, R; Li, M; Li, Y; Liu, C; Mei, M; Pang, B; Ren, Y; Wang, Y; Yang, J; Zhang, B; Zhang, X; Zhou, X | 1 |
Ferrer, VP; Machado, GC | 1 |
Deng, X; Gao, X; Hu, Z; Huang, Y; Sun, J; Sun, X; Wu, Y; Zhou, C | 1 |
Bruce, JN; Canoll, PD; Cheng, SK; Gill, BJA; Grinband, J; Horowitz, DP; Iwamoto, FM; Kachnic, LA; Kinslow, CJ; Kumar, P; McKhann, GM; Neugut, AI; Rae, AI; Siegelin, MD; Sisti, MB; Taparra, K; Wang, TJC; Yu, JB | 1 |
Camenisch Gross, U; Hofer, S; Lehnick, D; Leske, H; Leske, S; Neidert, MC; Rushing, EJ; Weller, M | 1 |
Alasmawi, H; Ridzuan, M; Saeed, N; Sobirov, I; Yaqub, M | 1 |
Chen, R; Chen, X; Gimple, RC; Jiang, T; Lin, P; Liu, L; Liu, Q; Liu, X; Liu, Z; Luo, J; Prager, BC; Rich, JN; Wang, D; Wu, E; Wu, Q; Wu, W; Xie, Q; Yu, J; Zhang, W; Zhang, Y; Zhao, W | 1 |
Bahador, M; Bifulco, E; Bindesbøll, C; Brekke, J; Chekenya, M; Engelsen, A; Enger, PØ; Gjertsen, BT; Goplen, D; Gras Navarro, A; Lie, SA; Rahman, MA; Sarowar, S; Selheim, F; Simonsen, A; Waha, A | 1 |
Berglund, AE; Etame, AB; MacAulay, RJ; Mulé, JJ; Wang, D; Wu, Q | 1 |
Acker, T; Becker, A; Brandner, S; Brokinkel, B; Buslei, R; Capper, D; Casalini, MB; Deckert, M; Dohmen, H; Ebrahimi, A; Felsberg, J; Fernández-Klett, F; Gramatzki, D; Hänggi, D; Hans, VH; Hartmann, C; Herold-Mende, C; Heß, K; Hewer, E; Huang, K; Jaunmuktane, Z; Jones, DTW; Koelsche, C; Korshunov, A; Mawrin, C; Paulus, W; Pfister, SM; Platten, M; Pohl, U; Prinz, M; Reifenberger, G; Reinhardt, A; Reuss, DE; Sahm, F; Schittenhelm, J; Schrimpf, D; Sievers, P; Staszewski, O; Stichel, D; Suwala, A; Unterberg, A; von Deimling, A; Wefers, AK; Weller, M; Wick, W | 1 |
Favia, A; Fontanella, RA; Illi, B; Iwamoto-Stohl, LK; Mai, A; Nanni, S; Nasi, S; Salvatori, L; Scagnoli, F; Totta, P; Valente, S | 1 |
Ichimura, K; Igaki, H; Matsushita, Y; Miyakita, Y; Narita, Y; Ohno, M; Takahashi, M | 1 |
Carrato, A; Esteban, J; Gutiérrez, JA; Ley, L; Torres, J; Vaz Salgado, MA | 1 |
Ahmadipour, Y; Gembruch, O; Jabbarli, R; Pierscianek, D; Sure, U | 1 |
Ciafrè, SA; Galardi, S; Michienzi, A | 1 |
Chen, H; Chen, W; Ge, J; Guo, L; Hou, G; Mao, Q; Yang, J; Zhang, X | 1 |
Arita, H; Fukai, J; Kanematsu, D; Kanemura, Y; Kinoshita, M; Kodama, Y; Mano, M; Mori, K; Nakao, N; Nonaka, M; Okita, Y; Sakamoto, D; Shofuda, T; Tsuyuguchi, N; Uda, T; Uematsu, Y; Umehara, T; Yoshioka, E | 1 |
Brinkmann, DH; Herman, MG; Hunt, CH; Kemp, BJ; Laack, NN; Lowe, V; Pafundi, DH; Qian, J | 1 |
Chen, WJ; Han, H; He, XS; Kang, EM; Liu, WP; Lv, JN; Wang, GH; Wang, J; Yu, YB; Zhang, W; Zhang, X; Zhang, YL | 1 |
Cheng, H; Dai, X; Hu, Y; Wang, H; Wang, J; Wu, B; Ye, L | 1 |
van der Hoorn, A; van Dijken, BRJ | 1 |
Caselli, M; Dührsen, L; Felce, JH; Fita, KD; Fuh, MM; Glatzel, M; Görgens, A; Heiland, DH; Jones, JC; Joosse, SA; Kaulich, K; Lamszus, K; Maire, CL; Miklosi, AG; Pantel, K; Pereno, V; Reifenberger, G; Reimer, R; Ricklefs, FL; Ricklefs, T; Sauvigny, T; Schlüter, H; Schüller, U; Stevic, I; Welsh, JA; Westphal, M | 1 |
Chen, JS; Fajardo, JE; Fiser, A; Guetta-Terrier, C; Karambizi, D; Sarkar, A; Snyder, KM; Tang, OY; Tapinos, N; Toms, SA; Zepecki, JP | 1 |
Clarke, PR | 1 |
Anderson, SK; Brinkmann, D; Brown, P; Hunt, C; Kabat, B; Kaufmann, T; Kemp, B; Kizilbash, S; Laack, NN; Lowe, V; Pafundi, D; Ruff, M; Sarkaria, J; Seaberg, M; Uhm, J; Vogen, D; Wan Chan Tseung, HS; Yan, E; Zakhary, M; Zhang, Y | 1 |
Kleszcz, R; Krajka-Kuźniak, V; Kruhlenia, N; Majchrzak-Celińska, A; Misiorek, JO; Przybyl, L; Rolle, K | 1 |
Oudenaarden, C; Pietras, K; Sjölund, J | 1 |
Alirezaei, Z; Amouheidari, A; Ghahremani, F; Kefayat, A | 1 |
Bronsema, A; Guerreiro, H; Kresbach, C; Rutkowski, S; Schüller, U; Winkler, B | 1 |
Cutts, SM; Nudelman, A; Rephaeli, A; Rozic, G; Tarasenko, N | 1 |
Dixit, D; Rich, JN; Xie, Q; Zhao, JC | 1 |
Bartom, E; Bi, Y; Burant, CF; Calvert, AE; Chalastanis, A; Chandel, NS; Davuluri, RV; Dubrovskyi, O; Horbinski, C; Hua, Y; Hurley, LA; James, CD; Kachman, M; Kouri, FM; May, JL; Mazar, AP; Mishra, RK; Peter, ME; Schiltz, GE; Stegh, AH; Wu, Y; Zheng, H | 1 |
Back, M; Brazier, D; Cook, R; Gzell, C; Harris, G; Jayamanne, D; Kastelan, M; Khasraw, M; Louw, S; Parkinson, J; Schembri, G; Wheeler, H | 1 |
Chen, Y; Jiang, S; Peng, Y; Zhong, S | 1 |
Bender, B; Bier, G; Brendle, C; Castaneda Vega, S; Ernemann, U; Hempel, JM; Klose, U; Schittenhelm, J; Skardelly, M; Tabatabai, G | 1 |
Battenhouse, AM; Cowperthwaite, MC; Hall, AW; Iyer, VR; Morris, AR; Shivram, H; Shpak, M | 1 |
Ishikawa, H; Izumikawa, K; Simpson, RJ; Takahashi, N | 1 |
Li, W; Shi, J; Shi, L; Shi, X; Wen, H | 1 |
Han, P; Lee, A; Malakhov, N; Schreiber, D; Sheth, N; Wang, A | 1 |
Bähr, O; Belka, C; Braun, C; Gerlach, R; Glas, M; Goldbrunner, R; Hänel, M; Hattingen, E; Hau, P; Herrlinger, U; Junold, N; Kebir, S; Kortmann, RD; Krex, D; Mack, F; Niessen, M; Proescholdt, M; Rohde, V; Sabel, M; Schäfer, N; Schaub, C; Schlegel, U; Schmidt-Graf, F; Steinbach, JP; Stuplich, M; Tzaridis, T; Vatter, H; Weyerbrock, A | 1 |
Bao, L; Chen, Y; Chiang, CM; Fontenot, M; Hatanpaa, KJ; Lai, HT; Lega, B; Luo, W; Raisanen, JM; Semenza, GL; Wang, JE; Wang, Y; Wu, SY | 1 |
Ai, C; Dong, F; Gao, W; Huo, D; Kang, C; Kong, Y; Li, Q; Li, W; Liu, W; Liu, X; Sun, X; Wang, W; Wang, X; Wu, X; Yang, C; Zhou, Y | 1 |
Abril, L; Archila, P; Arrieta, O; Balaña, C; Behaine, J; Bermúdez, S; Cardona, AF; Carranza, H; Cifuentes, H; Feo, O; González, D; Hakim, F; Jacobo, J; Jiménez, E; Mantilla, MI; Marquez, JC; Mejía, JA; Ortiz, LD; Otero, J; Penagos, P; Pineda, D; Pino, LE; Ramón, JF; Ricaurte, L; Rodríguez, J; Rojas, L; Rosell, R; Ruiz-Patiño, A; Useche, N; Vargas, C; Wills, B; Zatarain-Barrón, ZL | 1 |
Cantero, D; de Velasco, G; Hernández-Laín, A; Hilario, A; Manneh Kopp, RA; Pérez Núñez, A; Ramos, A; Ruano, Y; Sánchez-Gómez, P; Sepúlveda-Sánchez, JM; Toldos, O | 1 |
Boldt, HB; Dahlrot, RH; Hansen, S; Hjelmborg, JB; Kreutzfeldt, MS; Kristensen, BW; Larsen, P | 1 |
Cai, J; Cao, L; Chen, Z; Gu, J; Guo, C; Li, C; Liang, J; Lin, Y; Liu, X; Liu, Y; Lu, B; Lu, W; Mai, J; Ou-Yang, Y; Qiu, P; Sai, K; Sheng, L; Su, X; Sun, H; Sun, S; Tan, Y; Wang, J; Xing, F; Xue, D; Yan, G; Yang, X; Yin, W; Zhu, W; Zhu, Z | 1 |
Bhargava, S; Bi, J; Brown, JM; Cang, H; Dong, Z; Gimple, RC; Gromovsky, AD; Huan, T; Jiang, L; Kidwell, RL; Kim, LJY; Lee, D; Lv, D; Mack, SC; Mischel, PS; Prager, BC; Rich, JN; Sloan, AE; Sun, T; Wang, X; Wolf, M; Wu, Q; Xie, Q; Ye, Q; Zhang, G; Zhao, L; Zhu, Z | 1 |
Allis, CD; Banaszynski, LA; Becher, OJ; Cordero, F; Garcia, BA; Koletsky, MS; Lewis, PW; Lin, S; Muir, TW; Müller, MM | 1 |
Chen, W; Chen, Y; Hu, F; Shao, H; Zhang, Y; Zhou, Y | 1 |
Chang, N; Joo, KM; Kim, E; Kim, H; Kim, M; Lee, C; Lee, J; Nakano, I; Nam, DH; Oh, YT; Rheey, J; Rich, JN; Shin, J; Shin, Y; Woo, DH | 1 |
Attar, R; Biray Avci, C; Caglar, HO; Dalbasti, T; Gunduz, C; Haydaroglu, A; Kitapcioglu, G; Oktar, N; Yurtsever, A | 1 |
Adamopoulos, C; Dalagiorgou, G; Gargalionis, A; Lea, RW; Papavassiliou, AG; Papavassiliou, KA; Piperi, C; Spyropoulou, A | 1 |
Abrams, JS; Conley, BA; Freidlin, B; Korn, EL; McShane, LM; Polley, MY | 1 |
Bender, S; Castel, D; Chen, S; Cho, YJ; Collins, VP; Ebinger, M; Grill, J; Gronych, J; Helin, K; Hovestadt, V; Højfeldt, JW; Jabado, N; Johann, PD; Jones, C; Jones, DT; Kool, M; Korshunov, A; Lichter, P; Lindroth, AM; Meyer, J; Milde, T; Monje, M; Monoranu, CM; Northcott, PA; Pfister, SM; Plass, C; Ponnuswami, A; Puget, S; Radlwimmer, B; Ryzhova, M; Schubert, S; Schuhmann, M; Seker-Cin, H; Stark, S; Sturm, D; Tang, Y; Truffaux, N; von Deimling, A; Wang, W; Witt, O; Zapatka, M | 1 |
Chamberlain, MC | 1 |
Bond, F; Bridges, LR; Burke, E; Crocker, M; Elderfield, K; Grobler, M; Taylor, R | 1 |
Balañà, C; Capdevila, L; Carrato, C; Cros, S; Cuadra, JL; Etxaniz, O; Hostalot, C; Massuet, A; Ramirez, JL; Romeo, M; Sanz, C; Villà, S | 1 |
Bauer, R; Bernaskova, M; Huefner, A; Kretschmer, N; Schuehly, W; Weis, R | 1 |
Cui, X; Nenoi, M; Ninomiya, Y; Sekine-Suzuki, E; Wang, B; Yasuda, T; Yu, D | 1 |
Bähr, O; Braczynski, AK; Dunst, M; Eibach, S; Harter, PN; Hattingen, E; Mittelbronn, M; Plate, KH; Rieger, J; Seifert, V; Steinbach, JP; Weise, LM | 1 |
Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C | 1 |
Berghoff, AS; Hainfellner, JA; Marosi, C; Preusser, M | 1 |
Adamopoulos, C; Boviatsis, E; Dalagiorgou, G; Gargalionis, A; Korkolopoulou, P; Levidou, G; Patsouris, E; Petraki, K; Piperi, C; Samaras, V; Sepsa, A; Spyropoulou, A; Themistocleous, MS; Thymara, I; Vrettakos, G; Zisakis, A | 1 |
Cai, Q; Chen, Q; Daofeng, T; Dong, H; Guo, Z; Ji, B; Liu, B; Liu, Y; Wang, J; Wang, L; Wu, L; Zhang, S; Zhu, X | 1 |
Cloughesy, TF; Ha, W; Hitchins, MP; Lai, A; McDonald, KL; Nguyen, HN; Nowak, AK; Rapkins, RW; Wang, F | 1 |
Benecke, R; Grossmann, A; Hildebrandt, G; Kirschstein, T; Piek, J; Rösche, J | 1 |
Motomura, K; Natsume, A; Ohka, F; Ranjit, M; Wakabayashi, T | 1 |
Bartoli, L; Beji, S; Falchetti, ML; Farsetti, A; Favia, A; Illi, B; Levi, A; Mongiardi, MP; Nanni, S; Nasi, S; Savino, M; Scagnoli, F | 1 |
Mohile, NA | 1 |
Capper, D; Franco, P; Grauvogel, J; Heiland, DH; Hirsch, M; Masalha, W; Schrimpf, D; Staszewski, O; Urbach, H; Weyerbrock, A | 1 |
Luo, D; Luo, K; Wen, H | 1 |
Cui, HJ; Huang, MY; Liu, W; Xuan, F | 1 |
Choi, SH; Heo, DS; Jung, HW; Kim, DG; Kim, IH; Kim, SK; Kim, TM; Lee, SH; Lee, ST; Park, CK | 1 |
Balvers, RK; Dirven, CM; Lamfers, ML; Leenstra, S | 1 |
Drummond, KJ; Kaye, AH; Paldor, I; Pearce, FC | 1 |
Aster, JC; Bernstein, BE; Cahill, DP; Carey, CD; Donohue, LK; Flavahan, WA; Gillespie, SM; Hebert, CH; Liau, BB; Miller, TE; Najm, FJ; Patel, AP; Rich, JN; Rodig, SJ; Shareef, SJ; Sievers, C; Suvà, ML; van Galen, P; Venteicher, AS; Wakimoto, H | 1 |
Ando, N; Dong, X; Kobayashi, D; Maehara, T; Sumita, K; Tamura, K | 1 |
Berger, MS; Lin, C; Lin, CA; Phillips, JJ; Rhodes, CT | 1 |
Cui, Q; He, C; Huang, Y; Li, L; Lu, Z; Qu, Q; Riggs, AD; Shi, H; Shi, Y; Sun, G; Yang, CG; Ye, P | 1 |
Del Maestro, R; Guiot, MC; Kavan, P; Lambert, C; Leblanc, R; Muanza, T; Panet-Raymond, V; Roberge, D; Shakibnia, L; Shenouda, G; Souhami, L | 1 |
Bian, X; Chen, K; Dunlop, NM; Gao, Y; Gong, W; Howard, OM; Huang, J; Wang, JM | 1 |
Jaskolski, D; Jesien-Lewandowicz, E; Jesionek-Kupnicka, D; Kordek, R; Kulczycka-Wojdala, D; Liberski, PP; Och, W; Papierz, W; Potemski, P; Rieske, P; Sieruta, M; Sikorska, B; Skowronski, W; Szybka, M; Zawlik, I | 1 |
Haapasalo, H; Hahn, WC; Hector, ME; Junttila, MR; Kast, J; Ketola, K; Lin, S; Puustinen, P; Raheem, O; Sablina, AA; Teittinen, K; Vanhatupa, S; Westermarck, J | 1 |
Addeo, R; Caraglia, M; De Santi, MS; Del Prete, S | 1 |
Ballman, KA; Carlson, BL; Decker, PA; Giannini, C; Grogan, PT; James, CD; Kitange, GJ; Mladek, AC; Sarkaria, JN; Schroeder, MA; Wu, W | 1 |
Berger, H; Felsberg, J; Hartmann, C; Heese, O; Krex, D; Loeffler, M; Nikkhah, G; Pietsch, T; Reifenberger, G; Schackert, G; Schramm, J; Simon, M; Steinbach, JP; Tonn, JC; von Deimling, A; Weller, M; Westphal, M; Wiestler, O | 1 |
Carapella, CM; Carosi, M; Cognetti, F; Fabi, A; Giannarelli, D; Maschio, M; Metro, G; Mirri, MA; Pace, A; Pellegrini, D; Pompili, A; Russillo, M; Vidiri, A | 1 |
Agarwal, N; Ahluwalia, MS; Barnett, GH; Brewer, CJ; Elson, P; Peereboom, DM; Shepard, DR; Stevens, GH; Suh, JH; Toms, SA; Vogelbaum, MA; Weil, RJ | 1 |
Blechschmidt, C; Czabanka, M; Koch, A; Misch, M; Plotkin, M; Stockhammer, F; Tuettenberg, J; Vajkoczy, P | 1 |
Furuyama, N; Hamada, J; Hayashi, Y; Kamide, T; Nakada, M; Nakada, S; Sawada-Kitamura, S; Suzuki, T; Tanaka, S; Yano, S | 1 |
Fukushima, T; Katayama, Y; Nagase, H; Ohta, T; Shinojima, Y; Terui, T; Watanabe, T; Yachi, K; Yoshino, A | 1 |
Amano, T; Araki, Y; Iwaki, T; Mizoguchi, M; Nakamizo, A; Sasaki, T; Shono, T; Suzuki, SO; Yoshimoto, K | 1 |
Agnihotri, S; Guha, A; Munoz, D; Wolf, A | 1 |
Hirose, Y; Kanai, R; Louis, DN; Martuza, RL; Rabkin, SD; Sgubin, D; Wakimoto, H; Yip, S; Zaupa, CM | 1 |
Chatzisotiriou, A; Eleftheraki, AG; Fountzilas, G; Iliadis, G; Kotoula, V; Lambaki, S; Misailidou, D; Selviaridis, P; Televantou, D | 1 |
Ewelt, C; Felsberg, J; Jakobs, O; Martus, P; Meinel, T; Reifenberger, G; Stummer, W | 1 |
Batchelor, TT; Louis, DN; Sorensen, AG | 1 |
Carlson, BL; Cen, L; Decker, PA; Gupta, SK; Kitange, GJ; Lomberk, GA; Mladek, AC; Pokorny, JL; Sarkaria, JN; Schroeder, MA; Urrutia, RA; Wu, W | 1 |
Hamada, J; Hayashi, Y; Kato, Y; Nakada, M; Ooi, A; Sabit, H; Sato, H; Suzuki, S; Watanabe, T; Yoshikawa, A | 1 |
Laird, PW; Marczinek, K; Nürnberg, P; Rohde, K; Szymas, J; Thiel, G; Uhlmann, K; Vogel, S; Zeller, C | 1 |
Baeza, N; Kleihues, P; Ohgaki, H; Weller, M; Yonekawa, Y | 1 |
Berger, MS; Hirose, Y; Katayama, M; Mirzoeva, OK; Pieper, RO | 1 |
Altundag, K; Altundag, MB; Altundag, O; Boruban, C; Turen, S | 1 |
Ishida, E; Konishi, N; Nakamura, M; Nakase, H; Sakaki, T; Shimada, K | 1 |
Aldape, K; Black, PM; Chakravarti, A; Erkkinen, MG; Gilbert, MR; Loeffler, JS; Mehta, M; Nestler, U; Stupp, R | 1 |
Auger, N; Benouaich-Amiel, A; Crinière, E; Delattre, JY; Everhard, S; Hoang-Xuan, K; Kaloshi, G; Laigle-Donadey, F; Lejeune, J; Mokhtari, K; Polivka, M; Sanson, M; Thillet, J | 1 |
Cankovic, M; Mikkelsen, T; Rosenblum, ML; Zarbo, RJ | 1 |
Hau, P; Hegi, ME; Stupp, R | 1 |
Campain, JA; Cox, GS; Gutkin, DW | 1 |
Bourgeois, CA; Delattre, JY; Dutrillaux, AM; Dutrillaux, B; Kokalj-Vokac, N; Malfoy, B; Poisson, M; Vega, F | 1 |
Christensen, B; Fiskerstrand, T; Refsum, H; Tysnes, OB; Ueland, PM | 1 |
Baylin, SB; Brodeur, GM; Cavenee, WK; Chazin, VR; Makos, M; Nelkin, BD | 1 |
Berger, MS; Cavenee, WK; Costello, JF; Huang, HS | 1 |
Akhtar, S; Fell, PL; Hudson, AJ; Reynolds, MA; Usman, N | 1 |
Viale, GL | 1 |
12 review(s) available for isomethyleugenol and Astrocytoma, Grade IV
Article | Year |
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MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Systematic Review.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Glioma; Humans; Methylation; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2021 |
A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature.
Topics: Astrocytoma; Biology; Brain Neoplasms; Chromosomes, Human, Pair 1; DNA; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Oligodendroglioma | 2022 |
The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma.
Topics: Adenosine; Glioblastoma; Glioma; Humans; Methylation; RNA; Tumor Microenvironment | 2022 |
Insights into the Regulatory Role of m
Topics: Adenosine; Brain Neoplasms; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; RNA, Ribosomal, 28S | 2020 |
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Topics: Animals; Arginine; beta-Thalassemia; Glioblastoma; Humans; Introns; Methylation; Mice; Nonsense Mediated mRNA Decay; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA Splicing; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2018 |
MGMT promoter methylation and glioblastoma prognosis: a systematic review and meta-analysis.
Topics: Brain Neoplasms; Disease-Free Survival; DNA Methylation; Genetic Heterogeneity; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic | 2013 |
Assessing MGMT methylation status and its current impact on treatment in glioblastoma.
Topics: Brain Neoplasms; DNA Modification Methylases; Glioblastoma; Humans; Methylation | 2015 |
Applicable advances in the molecular pathology of glioblastoma.
Topics: Basic Helix-Loop-Helix Transcription Factors; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Cyclin-Dependent Kinase Inhibitor p16; DNA Helicases; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gene Deletion; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Methylation; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Oligodendrocyte Transcription Factor 2; Promoter Regions, Genetic; Receptor, Platelet-Derived Growth Factor alpha; Telomerase; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; X-linked Nuclear Protein | 2015 |
How I treat glioblastoma in older patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Geriatric Assessment; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Middle Aged; Prognosis; Promoter Regions, Genetic; Quality of Life; Seizures; Standard of Care; Temozolomide; Tumor Suppressor Proteins | 2016 |
Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells.
Topics: Biopsy; Cell Culture Techniques; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; Neoplastic Stem Cells; Tumor Cells, Cultured | 2017 |
Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation.
Topics: Brain Neoplasms; Chemoradiotherapy; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Fatal Outcome; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Medulla Oblongata; Methylation; Middle Aged; Mutation; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2013 |
MGMT methylation status: the advent of stratified therapy in glioblastoma?
Topics: Animals; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Glioblastoma; Humans; Methylation; Tumor Suppressor Proteins | 2007 |
5 trial(s) available for isomethyleugenol and Astrocytoma, Grade IV
Article | Year |
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Initial Results of a Phase 2 Trial of
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Chemotherapy, Adjuvant; Cognition; Confidence Intervals; Dihydroxyphenylalanine; Dose Fractionation, Radiation; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Positron-Emission Tomography; Progression-Free Survival; Prospective Studies; Quality of Life; Radiopharmaceuticals; Radiotherapy, Image-Guided; Temozolomide; Young Adult | 2021 |
Tumor growth patterns of MGMT-non-methylated glioblastoma in the randomized GLARIUS trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cell Growth Processes; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Irinotecan; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Radiotherapy; Temozolomide; Tumor Suppressor Proteins | 2018 |
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoadjuvant Therapy; Radiation-Sensitizing Agents; Retrospective Studies; Survival Analysis; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2014 |
Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Deoxycytidine; DNA Modification Methylases; DNA Repair Enzymes; Female; Gemcitabine; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Radiation-Sensitizing Agents; Tumor Suppressor Proteins | 2010 |
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
117 other study(ies) available for isomethyleugenol and Astrocytoma, Grade IV
Article | Year |
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Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Topics: Brain Neoplasms; Diffusion Magnetic Resonance Imaging; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Methylation; Mutation; Perfusion; Retrospective Studies; Tumor Suppressor Proteins | 2021 |
Lomustine and nimustine exert efficient antitumor effects against glioblastoma models with acquired temozolomide resistance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glioblastoma; Histones; Humans; Injections, Intraperitoneal; Lomustine; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Recurrence, Local; Nimustine; Salvage Therapy; Temozolomide; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2021 |
MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas.
Topics: Algorithms; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Temozolomide; Tumor Suppressor Proteins | 2022 |
N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in Glioblastoma.
Topics: Adenosine; Glioblastoma; Humans; Methylation; Tumor Microenvironment | 2022 |
Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme.
Topics: AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Glioblastoma; Humans; Methylation; RNA | 2022 |
Non-invasive prediction of p53 and Ki-67 labelling indices and O-6-methylguanine-DNA methyltransferase promoter methylation status in adult patients with isocitrate dehydrogenase wild-type glioblastomas using diffusion-weighted imaging and dynamic suscept
Topics: Adult; Brain Neoplasms; DNA; Glioblastoma; Guanine; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Magnetic Resonance Imaging; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Perfusion; Retrospective Studies; Tumor Suppressor Protein p53 | 2022 |
The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
Topics: Animals; Cyclin-Dependent Kinases; DNA-Binding Proteins; Glioblastoma; Methylation; Methyltransferases; Mice; Mice, Nude; Microcirculation; Neovascularization, Pathologic; Phosphorylation; RNA-Binding Proteins; RNA, Messenger | 2022 |
MR Imaging, MGMT Promoter Methylation Features and Prognostic Analysis of Subventricular Zone Contacting IDH Wild-type Glioblastoma.
Topics: Adult; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Lateral Ventricles; Magnetic Resonance Imaging; Methylation; Prognosis; Retrospective Studies; Tumor Suppressor Proteins | 2023 |
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B.
Topics: Cdc20 Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Glioblastoma; Histones; Humans; Methylation; Nuclear Proteins; Protein-Arginine N-Methyltransferases | 2023 |
Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Mismatch Repair; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Progression-Free Survival; Temozolomide; Tumor Suppressor Proteins | 2023 |
SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
Topics: Animals; Cell Line, Tumor; Glioblastoma; Histone Acetyltransferases; Humans; Methylation; Mice; Mice, Nude; RNA, Messenger | 2023 |
Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients.
Topics: Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Prognosis; Prospective Studies; Retrospective Studies; Telomerase; Telomere; Tumor Suppressor Proteins | 2023 |
Association of pre-radiotherapy tumour burden and overall survival in newly diagnosed glioblastoma adjusted for MGMT promoter methylation status.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Retrospective Studies; Tumor Burden; Tumor Suppressor Proteins | 2023 |
Integrating machine learning and bioinformatics analysis to m6A regulator-mediated methylation modification models for predicting glioblastoma patients' prognosis and immunotherapy response.
Topics: Computational Biology; Glioblastoma; Humans; Immunotherapy; Machine Learning; Methylation; Prognosis; Tumor Microenvironment | 2023 |
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status.
Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Prognosis; Tumor Suppressor Proteins | 2023 |
Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma.
Topics: ErbB Receptors; Glioblastoma; Humans; Lysine; Methylation; NFATC Transcription Factors; Temozolomide; TNF Receptor-Associated Factor 6; Transcription Factors | 2023 |
MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients.
Topics: Adult; Brain Neoplasms; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Mucins; Mutation; Prognosis; Retrospective Studies | 2023 |
Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment.
Topics: Adaptor Proteins, Signal Transducing; B7-H1 Antigen; Glioblastoma; GTP-Binding Proteins; Humans; Methylation; Methyltransferases; Nuclear Proteins; Programmed Cell Death 1 Receptor; RNA; RNA-Binding Proteins; Tumor Microenvironment | 2023 |
MGMT Promoter Methylation Predicts Overall Survival after Chemotherapy for 1p/19q-Codeleted Gliomas.
Topics: Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Methylation; Prognosis; Tumor Suppressor Proteins | 2023 |
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value.
Topics: DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Isocitrate Dehydrogenase; Methylation; Prognosis; Prospective Studies; Retrospective Studies; Temozolomide; Tumor Suppressor Proteins | 2023 |
MGMT promoter methylation status prediction using MRI scans? An extensive experimental evaluation of deep learning models.
Topics: Aged; Brain Neoplasms; Deep Learning; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Imaging; Methylation; Reproducibility of Results; Tumor Suppressor Proteins | 2023 |
LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2'-O-methylation.
Topics: Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Methylation; Neoplastic Stem Cells; Ribonucleoproteins, Small Nucleolar; RNA, Long Noncoding | 2023 |
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
Topics: Animals; Antineoplastic Agents; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Drug Administration Schedule; Drug Resistance, Neoplasm; Glioblastoma; High-Throughput Nucleotide Sequencing; Humans; Kaplan-Meier Estimate; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Transcription Factor RelA | 2019 |
Paradoxical epigenetic regulation of XAF1 mediates plasticity towards adaptive resistance evolution in MGMT-methylated glioblastoma.
Topics: Adaptation, Physiological; Adaptor Proteins, Signal Transducing; Antineoplastic Agents, Alkylating; Apoptosis Regulatory Proteins; Cell Line, Tumor; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Epigenesis, Genetic; Evolution, Molecular; Glioblastoma; Humans; Methylation; Temozolomide; Tumor Suppressor Proteins | 2019 |
Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cerebellar Neoplasms; Child; Child, Preschool; Cyclin-Dependent Kinase Inhibitor p16; ErbB Receptors; Female; Glioblastoma; Humans; Infant; Infant, Newborn; Infratentorial Neoplasms; Male; Methylation; Middle Aged; Retrospective Studies; Telomerase; Young Adult | 2019 |
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
Topics: Antibodies; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Glioblastoma; HEK293 Cells; Humans; Methylation; Neoplastic Stem Cells; Promoter Regions, Genetic; Protein Binding; Protein Stability; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Interference; RNA, Small Interfering; SOXB1 Transcription Factors | 2019 |
Survival benefits of hypofractionated radiotherapy combined with temozolomide or temozolomide plus bevacizumab in elderly patients with glioblastoma aged ≥ 75 years.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain; Brain Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Radiation Dose Hypofractionation; Retrospective Studies; Temozolomide; Treatment Outcome | 2019 |
Survey of treatment recommendations for elderly patients with glioblastoma.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Health Care Surveys; Humans; Methylation; Oncologists; Physical Functional Performance; Radiotherapy Dosage; Spain; Temozolomide; Tumor Suppressor Proteins | 2020 |
Does the expression of glial fibrillary acid protein (GFAP) stain in glioblastoma tissue have a prognostic impact on survival?
Topics: Aged; Biomarkers; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Kaplan-Meier Estimate; Karnofsky Performance Status; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Survival Analysis; Tumor Suppressor Proteins | 2020 |
SOX9-activated PXN-AS1 promotes the tumorigenesis of glioblastoma by EZH2-mediated methylation of DKK1.
Topics: Animals; Apoptosis; Base Sequence; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; Intercellular Signaling Peptides and Proteins; Male; Methylation; Mice, Inbred BALB C; Promoter Regions, Genetic; RNA, Long Noncoding; SOX9 Transcription Factor; Wnt Signaling Pathway | 2020 |
Molecular characteristics and clinical outcomes of elderly patients with IDH-wildtype glioblastomas: comparative study of older and younger cases in Kansai Network cohort.
Topics: Age Factors; Aged; Aged, 80 and over; Brain Neoplasms; Cohort Studies; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Japan; Male; Methylation; Middle Aged; Prognosis; Survival Rate; Tumor Suppressor Proteins | 2020 |
Prediction of MGMT Status for Glioblastoma Patients Using Radiomics Feature Extraction From
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain Neoplasms; Dihydroxyphenylalanine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Machine Learning; Male; Methylation; Middle Aged; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Tomography, X-Ray Computed; Tumor Suppressor Proteins; Young Adult | 2020 |
The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status.
Topics: Adult; Brain Neoplasms; Chitinase-3-Like Protein 1; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Neoplasm Recurrence, Local; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Proteins | 2020 |
Methylation associated miR-1246 contributes to poor prognosis in gliomas treated with temozolomide.
Topics: Brain Neoplasms; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; MicroRNAs; Prognosis; Temozolomide | 2021 |
Radiology in the lead: towards radiological profiling for precision medicine in glioblastoma patients? Editorial comment on Glioblastoma patients with a moderate vascular profile benefit the most from MGMT methylation.
Topics: Biomarkers, Tumor; Brain Neoplasms; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Methylation; Precision Medicine; Prognosis; Radiology; Tumor Suppressor Proteins | 2021 |
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification.
Topics: Brain Neoplasms; DNA; DNA Copy Number Variations; DNA Methylation; Extracellular Vesicles; Glioblastoma; Humans; Methylation | 2021 |
miRNA-mediated loss of m6A increases nascent translation in glioblastoma.
Topics: 3' Untranslated Regions; Adenosine; Base Sequence; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; MicroRNAs; Microtubule-Associated Proteins; Protein Biosynthesis; RNA Interference; RNA, Messenger; Transcriptome; Tumor Cells, Cultured | 2021 |
Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis.
Topics: Carcinogenesis; Cell Cycle Proteins; Cell Proliferation; Chromosomes; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Methylation; Mitosis; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Stem Cells | 2021 |
COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells.
Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; beta Catenin; Brain Neoplasms; Celecoxib; Cell Cycle; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; DNA Modification Methylases; DNA Repair Enzymes; Dose-Response Relationship, Drug; Etoricoxib; Female; Glioblastoma; Humans; Isoxazoles; Lactones; Male; Methylation; Middle Aged; Neoplasm Proteins; Pyrazoles; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides; Sulfones; Temozolomide; Tumor Suppressor Proteins; Wnt Signaling Pathway | 2021 |
Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma.
Topics: Animals; Brain Neoplasms; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Pericytes; Sequence Analysis, RNA; Single-Cell Analysis; Tumor Microenvironment; Tumor Suppressor Proteins; Up-Regulation | 2022 |
Diagnostic and prognostic value of stem cell factor plasma level in glioblastoma multiforme patients.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Diagnosis, Differential; DNA Modification Methylases; DNA Repair Enzymes; Enzyme-Linked Immunosorbent Assay; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Preoperative Period; Prognosis; Progression-Free Survival; ROC Curve; Stem Cell Factor; Tumor Burden; Tumor Suppressor Proteins | 2021 |
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling.
Topics: Adolescent; Brain Neoplasms; Glioblastoma; Humans; Methylation; Prognosis; Temozolomide; Valproic Acid; Vinblastine | 2022 |
Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft.
Topics: Acetylation; Animals; Antineoplastic Agents; Astrocytes; Brain; Cell Line, Tumor; Cell Survival; DNA Damage; Doxorubicin; Epigenesis, Genetic; Glioblastoma; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Methylation; Mice, Nude; Myocardium; Prodrugs; Xenograft Model Antitumor Assays | 2017 |
Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Glioblastoma; Humans; Methylation; RNA, Messenger | 2017 |
Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Disease Progression; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Histones; Isocitrate Dehydrogenase; Ketoglutaric Acids; Lipids; Methylation; Mice; Mice, SCID; Molecular Targeted Therapy; Mutation; NADP; Neoplastic Stem Cells; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA, Messenger | 2017 |
Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Kaplan-Meier Estimate; Methylation; Multivariate Analysis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Regression Analysis; Retrospective Studies; Temozolomide; Time Factors; Tumor Suppressor Proteins | 2017 |
Further Investigation About Copy Number Variations and Methylation of AURKA, KIF4A, and NUSAP1 in Glioblastoma.
Topics: Aurora Kinase A; Cell Line, Tumor; DNA Copy Number Variations; Glioblastoma; Methylation | 2018 |
In Vivo Molecular Profiling of Human Glioma : Cross-Sectional Observational Study Using Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Brain Neoplasms; Cerebral Blood Volume; Chromosome Deletion; Chromosomes, Human, 1-3; Contrast Media; Cross-Sectional Studies; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Profiling; Glioblastoma; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Angiography; Methylation; Middle Aged; Mutation; Retrospective Studies; Tumor Suppressor Proteins; X-linked Nuclear Protein; Young Adult | 2019 |
Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells.
Topics: Binding Sites; Brain Neoplasms; CCCTC-Binding Factor; Cell Dedifferentiation; Cell Line, Tumor; Cell Movement; Chromatin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glioblastoma; Histone Code; Humans; Methylation; Neoplastic Stem Cells; Protein Domains | 2018 |
Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
Topics: Bone Neoplasms; Brain Neoplasms; Child; Epigenesis, Genetic; Giant Cell Tumor of Bone; Glioblastoma; HeLa Cells; Histones; Humans; Lysine; Methylation; Mutation | 2018 |
Patterns of care and outcomes of chemoradiation versus radiation alone for MGMT promoter unmethylated glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Cohort Studies; Databases, Factual; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Survival Rate; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2018 |
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.
Topics: Autoantigens; Cell Hypoxia; Cell Line; Cell Movement; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Golgi Matrix Proteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Response Elements; Transcription, Genetic | 2018 |
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma.
Topics: Arginine; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Enhancer Elements, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Oncogenes; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Transcription, Genetic | 2018 |
A comprehensive analysis of factors related to carmustine/bevacizumab response in recurrent glioblastoma.
Topics: AC133 Antigen; Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Bevacizumab; Brain Neoplasms; Carmustine; Chitinase-3-Like Protein 1; Colombia; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Neoplasm Recurrence, Local; Progression-Free Survival; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Survival Analysis; Tumor Suppressor Proteins; Young Adult | 2019 |
Correlation of radiological and immunochemical parameters with clinical outcome in patients with recurrent glioblastoma treated with Bevacizumab.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents, Immunological; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Cerebrovascular Circulation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Amplification; Genes, erbB-1; Glioblastoma; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Methylation; Microvessels; Middle Aged; Mitotic Index; Neoplasm Recurrence, Local; Retrospective Studies; Tissue Array Analysis; Tumor Suppressor Proteins | 2019 |
Posttreatment Effect of MGMT Methylation Level on Glioblastoma Survival.
Topics: Aged; Brain Neoplasms; CpG Islands; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epigenesis, Genetic; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Progression-Free Survival; Survival Analysis; Tumor Suppressor Proteins | 2019 |
Negative regulation of miR-1275 by H3K27me3 is critical for glial induction of glioblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Methylation; Mice, Inbred BALB C; MicroRNAs; Neuroglia; Transcriptome | 2019 |
Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enhancer Elements, Genetic; Epigenesis, Genetic; ErbB Receptors; Fatty Acid Elongases; Fatty Acids, Unsaturated; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Methylation; Neoplastic Stem Cells; Signal Transduction; SOXB1 Transcription Factors; Up-Regulation | 2019 |
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
Topics: Amino Acid Substitution; Animals; Brain Neoplasms; Child; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glioblastoma; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mice; Mutation, Missense; Polycomb Repressive Complex 2; Transgenes | 2013 |
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
Topics: Animals; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Glioblastoma; Humans; Methylation; Mice; Phosphorylation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; Transplantation, Heterologous; Tumor Cells, Cultured | 2013 |
Assessment of genetic markers and glioblastoma stem-like cells in activation of dendritic cells.
Topics: Antigens, CD; Brain Neoplasms; Cell- and Tissue-Based Therapy; Coculture Techniques; Dendritic Cells; DNA Modification Methylases; DNA Repair Enzymes; Fetal Blood; Gene Expression Regulation, Neoplastic; Genetic Markers; Glioblastoma; Humans; Methylation; Neoplastic Stem Cells; Prognosis; PTEN Phosphohydrolase; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2013 |
Methylation by EZH2 activates STAT3 in glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Neoplastic Stem Cells; Polycomb Repressive Complex 2; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2013 |
Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation.
Topics: Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Induction; Glioblastoma; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Neoplasm Grading; Neoplasm Proteins; Protein Methyltransferases; Protein Processing, Post-Translational; Repressor Proteins; RNA Interference; RNA, Small Interfering; Tumor Stem Cell Assay; Up-Regulation | 2014 |
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins | 2013 |
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
Topics: Brain Neoplasms; Brain Stem Neoplasms; Cell Line, Tumor; Child; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genes, Dominant; Glioblastoma; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Molecular Sequence Data; Mutation, Missense; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Binding; Protein Processing, Post-Translational; Transcription Factors; Transcription, Genetic | 2013 |
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy.
Topics: Aged; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Chemoradiotherapy; Dacarbazine; Glioblastoma; Guanosine; Humans; Methylation; Middle Aged; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Survival Rate; Temozolomide | 2013 |
Double-labelling immunohistochemistry for MGMT and a "cocktail" of non-tumourous elements is a reliable, quick and easy technique for inferring methylation status in glioblastomas and other primary brain tumours.
Topics: Antigens, CD; Antigens, CD34; Antigens, Differentiation, Myelomonocytic; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; False Negative Reactions; False Positive Reactions; Glioblastoma; Humans; Immunohistochemistry; Leukocyte Common Antigens; Methylation; Oligodendroglioma; Photomicrography; Retrospective Studies; Sensitivity and Specificity; Tumor Suppressor Proteins | 2013 |
Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Glioblastoma; HCT116 Cells; Humans; Inhibitory Concentration 50; Leukemia; Lignans; Methylation; Microwaves | 2014 |
Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells.
Topics: Arsenites; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Glioblastoma; Histones; Humans; Lysine; Methylation; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Confounding factors in diagnostics of MGMT promoter methylation status in glioblastomas in stereotactic biopsies.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Prospective Studies; Registries; Retrospective Studies; Stereotaxic Techniques; Tumor Suppressor Proteins | 2014 |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histones; Humans; Methylation; Mixed Function Oxygenases; Nuclear Proteins; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2014 |
Emerging role of linker histone variant H1x as a biomarker with prognostic value in astrocytic gliomas. A multivariate analysis including trimethylation of H3K9 and H4K20.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Brain; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cohort Studies; Female; Glioblastoma; Histones; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Neoplasm Grading; Prognosis; Young Adult | 2015 |
LRIG1, human EGFR inhibitor, reverses multidrug resistance through modulation of ABCB1 and ABCG2.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Membrane Glycoproteins; Methylation; Neoplasm Proteins; Promoter Regions, Genetic; RNA, Messenger; Temozolomide; Tumor Suppressor Proteins; Up-Regulation | 2015 |
The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antineoplastic Agents, Alkylating; Biomarkers; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Genotype; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
[Perampanel in the treatment of a patient with glioblastoma multiforme without IDH1 mutation and without MGMT promotor methylation].
Topics: Alkylating Agents; Brain Neoplasms; Dacarbazine; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Glioblastoma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Mutation; Nitriles; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Pyridones; Survival Analysis; Temozolomide | 2015 |
Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells.
Topics: Adaptor Proteins, Signal Transducing; Arginine; Blotting, Western; Cell Line, Tumor; Chromatin; Glioblastoma; HEK293 Cells; Histones; Humans; Methylation; Microscopy, Confocal; Peptide Fragments; Protein Binding; Protein-Arginine N-Methyltransferases; Proto-Oncogene Proteins c-myc; RNA Interference | 2015 |
Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis.
Topics: Adult; Autoantigens; Brain Neoplasms; Cell Transformation, Neoplastic; Cluster Analysis; DNA Copy Number Variations; DNA Mutational Analysis; Genome, Human; Glial Fibrillary Acidic Protein; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Neoplasms, Neuroepithelial; Proteasome Endopeptidase Complex | 2016 |
Homeobox genes gain trimethylation of histone H3 lysine 4 in glioblastoma tissue.
Topics: Brain Neoplasms; Cadherins; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Glioblastoma; Histones; Humans; Lysine; Methylation; Middle Aged; Promoter Regions, Genetic | 2016 |
MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Cyclins; Dioxygenases; Disease Progression; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Demethylases; Histones; Humans; Methylation; Mice; Neoplasm Transplantation; Nuclear Proteins; Prognosis; Survival Analysis | 2017 |
The survival significance of a measurable enhancing lesion after completing standard treatment for newly diagnosed glioblastoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2016 |
Frontal glioblastoma multiforme may be biologically distinct from non-frontal and multilobar tumors.
Topics: Adult; Aged; Brain Neoplasms; Female; Frontal Lobe; Glioblastoma; Humans; Isocitrate Dehydrogenase; Ki-67 Antigen; Male; Methylation; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Retrospective Studies | 2016 |
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
Topics: Acetylation; Base Sequence; Biomarkers, Tumor; Brain; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatin Assembly and Disassembly; Drug Resistance, Neoplasm; Enhancer Elements, Genetic; Glioblastoma; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplastic Stem Cells; Nuclear Proteins; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Receptors, Notch; Signal Transduction; Transcription, Genetic | 2017 |
LAPTM4B-35 is a novel prognostic factor for glioblastoma.
Topics: Adult; Brain Neoplasms; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Ki-67 Antigen; Male; Membrane Proteins; Methylation; Middle Aged; Multivariate Analysis; Neovascularization, Pathologic; Oncogene Protein v-akt; Retrospective Studies; Tumor Suppressor Proteins | 2017 |
Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma.
Topics: Brain Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Lateral Ventricles; Lysine; Magnetic Resonance Imaging; Methylation; Mutation; Neoplastic Stem Cells; Neural Stem Cells; Sequence Analysis, RNA | 2017 |
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Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Base Sequence; Brain Neoplasms; Carcinogenesis; Cell Differentiation; Cell Proliferation; Cell Self Renewal; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Humans; Meclofenamic Acid; Methylation; Methyltransferases; Mice; Neoplastic Stem Cells; RNA; RNA, Messenger | 2017 |
Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: a safety and efficacy analysis.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Glioblastoma; Humans; Male; Methylation; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Radiotherapy, Intensity-Modulated; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Burden | 2009 |
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Topics: Animals; Azacitidine; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Formyl Peptide; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2009 |
High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations.
Topics: Adult; Aged; Female; Gene Silencing; Genes, p53; Glioblastoma; Humans; Incidence; Male; Methylation; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Tumor Suppressor Protein p53; Young Adult | 2009 |
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
Topics: Animals; Carboxylic Ester Hydrolases; Cell Growth Processes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Glioblastoma; HeLa Cells; Humans; Leucine; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Methylation; Mice; NIH 3T3 Cells; Protein Phosphatase 2; RNA, Small Interfering; Transfection | 2009 |
Fotemustine and recurrent glioblastoma: possible new opportunities for an old drug.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioblastoma; Humans; Methylation; Neoplasm Recurrence, Local; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Randomized Controlled Trials as Topic | 2009 |
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Drug Administration Schedule; Genes, erbB-1; Genes, p53; Glioblastoma; Humans; Methylation; Mice; O(6)-Methylguanine-DNA Methyltransferase; PTEN Phosphohydrolase; Radiation-Sensitizing Agents; Random Allocation; Survival Analysis; Temozolomide; Xenograft Model Antitumor Assays | 2009 |
Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p16; Disease Progression; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Female; Glioblastoma; Humans; Isocitrate Dehydrogenase; Male; Methylation; Middle Aged; Mutation; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2; Survival Rate; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Young Adult | 2009 |
Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Fluorine Radioisotopes; Follow-Up Studies; Glioblastoma; Humans; Male; Methylation; Middle Aged; Positron-Emission Tomography; Pyrazoles; Retrospective Studies; Sulfonamides; Temozolomide; Tumor Suppressor Proteins; Tyrosine | 2010 |
Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Glioblastoma; Humans; Magnetic Resonance Angiography; Male; Methylation; Middle Aged; Neuronavigation; Polymerase Chain Reaction; Protoporphyrins; Spectrometry, Fluorescence; Tumor Suppressor Proteins | 2011 |
Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors.
Topics: Astrocytoma; Brain; Brain Neoplasms; Case-Control Studies; Cell Line, Tumor; Egg Proteins; Glioblastoma; Glioma; Humans; Mass Spectrometry; Melanoma; Methylation; Nevus; Oligodendroglioma; Pituitary Neoplasms; Reference Values | 2010 |
Quantitative digital assessment of MGMT immunohistochemical expression in glioblastoma tissue.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Gliosarcoma; Humans; Immunohistochemistry; Male; Methylation; Middle Aged; Tumor Suppressor Proteins | 2011 |
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Topics: Animals; Brain; Brain Chemistry; Brain Neoplasms; Cell Line; Central Nervous System; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Glioblastoma; Hexokinase; Humans; Introns; Isoenzymes; Methylation; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sulfites | 2011 |
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Dacarbazine; DNA Damage; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Genetic Vectors; Glioblastoma; Humans; Immunoblotting; Immunohistochemistry; Methylation; Mice; Mice, Nude; Neoplastic Stem Cells; Oncolytic Virotherapy; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Simplexvirus; Temozolomide; Tumor Suppressor Proteins; Vero Cells; Virus Replication | 2012 |
Volumetric and MGMT parameters in glioblastoma patients: survival analysis.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Profiling; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Survival Analysis; Temozolomide; Tumor Burden; Tumor Suppressor Proteins | 2012 |
Prospective cohort study of radiotherapy with concomitant and adjuvant temozolomide chemotherapy for glioblastoma patients with no or minimal residual enhancing tumor load after surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Postoperative Complications; Radiotherapy; Retrospective Studies; Temozolomide; Treatment Outcome; Tumor Suppressor Proteins; Young Adult | 2012 |
Case records of the Massachusetts General Hospital. Case 17-2012. A 54-year-old man with visual-field loss and a mass in the brain.
Topics: Brain; Brain Neoplasms; Chemoradiotherapy; Diagnosis, Differential; Disease Progression; DNA Modification Methylases; DNA Repair Enzymes; Fatal Outcome; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Neoplasms, Second Primary; Recurrence; Tumor Suppressor Proteins; Vision Disorders | 2012 |
Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.
Topics: Acetylation; Animals; Antineoplastic Agents, Alkylating; Blotting, Western; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Tumor Suppressor Proteins; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays | 2012 |
Distinct methylation profiles of glioma subtypes.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; CpG Islands; Female; Glioblastoma; Glioma; Humans; Infant; Male; Methylation; Middle Aged; Oligodendroglioma; Prognosis; Sulfites | 2003 |
PTEN methylation and expression in glioblastomas.
Topics: Adult; Aged; Brain Neoplasms; Cell Line, Tumor; Chromosomes, Human, Pair 10; DNA Mutational Analysis; Female; Glioblastoma; Humans; Immunohistochemistry; Loss of Heterozygosity; Male; Methylation; Middle Aged; Phosphoric Monoester Hydrolases; Polymerase Chain Reaction; Promoter Regions, Genetic; PTEN Phosphohydrolase; Tumor Suppressor Proteins | 2003 |
Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence.
Topics: Antineoplastic Agents, Alkylating; Astrocytes; Cell Line, Transformed; Cell Line, Tumor; Checkpoint Kinase 2; Dacarbazine; Enzyme Activation; G2 Phase; Glioblastoma; Humans; Methylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Temozolomide | 2005 |
Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma.
Topics: Dacarbazine; DNA Repair; Glioblastoma; Humans; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Phenytoin; Temozolomide | 2005 |
Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Chromosomes, Human, Pair 22; Cohort Studies; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; In Situ Nick-End Labeling; Loss of Heterozygosity; Male; Methylation; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.
Topics: Animals; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Dacarbazine; Disease Models, Animal; DNA Damage; Glioblastoma; Guanine; Humans; Methylation; Mice; Mice, Nude; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2006 |
MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; DNA Modification Methylases; DNA Repair Enzymes; Drug Administration Schedule; Female; Glioblastoma; Humans; In Vitro Techniques; Methylation; Middle Aged; Prognosis; Retrospective Studies; Statistics, Nonparametric; Survival Analysis; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2007 |
A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; DNA Modification Methylases; DNA Repair Enzymes; Female; Fixatives; Formaldehyde; Gene Silencing; Glioblastoma; Humans; Male; Methylation; Middle Aged; Oligodendroglioma; Paraffin Embedding; Promoter Regions, Genetic; Reproducibility of Results; Tumor Suppressor Proteins | 2007 |
Differential DNA methylation of the chorionic gonadotropin beta-subunit multigene family.
Topics: Base Sequence; Cell Line, Transformed; Choriocarcinoma; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; DNA, Neoplasm; Female; Gene Expression; Glioblastoma; Humans; Luteinizing Hormone; Methylation; Molecular Sequence Data; Multigene Family; Peptide Fragments; Placenta; Restriction Mapping; RNA, Messenger; Simian virus 40; Tumor Cells, Cultured | 1993 |
[Characterization of chromosomal rearrangements by in situ hybridization in glioblastoma].
Topics: Azacitidine; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; DNA, Neoplasm; DNA, Satellite; Glioblastoma; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Male; Methylation; Middle Aged; Tumor Cells, Cultured | 1994 |
Development and reversion of methionine dependence in a human glioma cell line: relation to homocysteine remethylation and cobalamin status.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Brain Neoplasms; Female; Folic Acid; Glioblastoma; Homocysteine; Humans; Methionine; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1994 |
DNA hypermethylation is associated with 17p allelic loss in neural tumors.
Topics: Alleles; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 17; DNA, Neoplasm; Glioblastoma; Humans; Methylation; Neuroblastoma | 1993 |
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.
Topics: Astrocytoma; Azacitidine; Base Sequence; Brain Chemistry; Brain Neoplasms; Carrier Proteins; Chromatin; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; Molecular Sequence Data; Neoplasm Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1996 |
Cellular uptake properties of a 2'-amino/2'-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA.
Topics: Base Sequence; Binding, Competitive; Biological Transport; Conserved Sequence; Dextran Sulfate; DNA; Endocytosis; Endosomes; ErbB Receptors; Glioblastoma; Heparin; Humans; Kinetics; Methylation; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides, Antisense; Phosphorus Radioisotopes; RNA, Catalytic; RNA, Messenger; Spermidine; Subcellular Fractions; Thionucleotides; Tumor Cells, Cultured | 1997 |
Transfer RNA and transfer RNA methylase in human brain tumors.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Glioblastoma; Humans; Meningioma; Methylation; Methyltransferases; Nucleosides; Oligodendroglioma; RNA, Transfer; Transferases | 1971 |