Compounds > isoleucine

isoleucine and Insulin Sensitivity

isoleucine has been researched along with Insulin Sensitivity in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.65)18.7374
1990's4 (9.30)18.2507
2000's8 (18.60)29.6817
2010's19 (44.19)24.3611
2020's10 (23.26)2.80

Authors

AuthorsStudies
Goh, HJ; Goh, JP; Govindharajulu, P; Henry, CJ; Leow, MK; Michael, N; Sadananthan, SA; Sun, L; Velan, SS; Verma, S1
Chen, S; Eguchi, M; Fukunaga, A; Kabe, I; Kochi, T; Miki, T; Mizoue, T; Nanri, A1
Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S1
Bi, Y; Chen, Y; Kong, L; Li, M; Lu, J; Ning, G; Wang, T; Wang, W; Wang, Y; Xu, M; Xu, Y; Ye, C; Zhao, Z; Zheng, J1
Guan, H; Li, D; Li, F; Ouyang, F; Rong, X; Tan, X; Wang, Y; Zhou, X1
Holmes, E; Johnson, MR; Kanu, C; Li, JV; Maric, T; McDonald, JAK; Nicholson, JK; Savvidou, MD; West, KA1
Chen, J; Hu, L; Ma, Q; Shan, A; Zhou, X; Zhu, J1
Arola, J; Hakkarainen, A; Juuti, A; Lehtimäki, TE; Luukkonen, PK; Orho-Melander, M; Penttilä, AK; Qadri, S; Sammalkorpi, H; Yki-Järvinen, H1
Cogger, VC; Cooney, GJ; de Cabo, R; Le Couteur, DG; Raubenheimer, D; Ribeiro, R; Simpson, SJ; Solon-Biet, SM1
Alizadeh, A; Hafezi, M; Hajitarkhani, S; Moini, A; Shahhoseini, M1
Barceló, A; Esquinas, C; Fortuna, AM; Gasa, M; Mayos, M; Monasterio, C; Montserrat, JM; Morell-Garcia, D; Pérez, A; Pérez, G; Salord, N1
Abate, ML; Bugianesi, E; Buzzigoli, E; Carli, F; Cassader, M; Ciociaro, D; Della Latta, V; Gaggini, M; Gambino, R; Gastaldelli, A; Marietti, M; Rosso, C1
He, T; Ma, X; Nie, C; Zhang, G; Zhang, W1
Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H1
Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J1
Du, W; Gao, F; Jian, LM; Lu, FR; Qin, Y; Wu, M; Xie, J; Yu, H; Zheng, N1
Chen, S; Deng, J; Du, Y; Guo, F; Guo, Y; Li, K; Sheng, H; Xiao, F; Yu, J; Zhu, J1
Jaiswal, N; Maurya, CK; Narender, T; Singh, R; Tamrakar, AK; Venkateswarlu, K1
Gautam, S; Korthikunta, V; Pal, S; Rawat, AK; Srivastava, AK; Tadigoppula, N; Tamrakar, AK1
Cai, Q; Du, W; Gao, F; Jian, L; Lu, F; Shafqat, RA; Zafar, MI2
Gautam, S; Ishrat, N; Narender, T; Singh, R; Srivastava, AK; Yadav, P1
Arrieta-Cruz, I; Gutiérrez-Juárez, R; Su, Y1
Feng, R; Gu, W; Jiang, L; Li, Q; Liu, L; Liu, Y; Ma, X1
Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X1
Avalos-Soriano, A; De la Cruz-Cordero, R; Garcia-Gasca, T; Rosado, JL1
Civantos, E; Egido, J; Mas, S; Peiró, C; Ruiz-Ortega, M; Sánchez, MS; Vázquez, C; Zhenyukh, O1
Ardekani, MR; Haeri, MR; Izaddoost, M; Nobar, MR; White, KN1
Bassols, J; Botas, P; Delgado, E; Fernández-Real, JM; Menéndez, JA; Moreno-Navarrete, JM; Ortega, FJ; Pardo, G; Ricart, W; Valdés, S; Vázquez-Martín, A1
Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ1
Ala-Korpela, M; Kähönen, M; Kangas, AJ; Lehtimäki, T; Raitakari, OT; Rönnemaa, T; Soininen, P; Viikari, JS; Würtz, P1
Epe, M; Fehmann, HC; Gross, U1
Breil, V; Broca, C; Cruciani-Guglielmacci, C; Derouet, M; Gross, R; Ktorza, A; Manteghetti, M; Pau, B; Petit, P; Reach, G; Ribes, G; Rizkalla, S; Rouault, C; Taouis, M1
Karhapää, P; Kuusisto, J; Laakso, M; Moilanen Mykkänen, L; Pihlajamäki, J; Rutanen, J; Vauhkonen, I1
Kondo, H; Shimomura, I1
Accili, D; al-Gazali, LI; Hone, J; Lestringant, G; Orban, T; Taylor, SI1
Bogardus, C; Janssen, RC; Knowler, WC; Takeda, J; Thompson, DB1
Häring, H; Jacob, S; Machicao, F; Rettig, A; Stumvoll, M; Wahl, HG1
Alfieri, R; Colao, A; Faggiano, A; Filippella, M; Lombardi, G; Melis, D; Pivonello, R; Salvatore, F; Spagnuolo, G1
Krook, A; O'Rahilly, S; Stratton, IM1
Cama, A; de la Luz Sierra, M; Gorden, P; Imperato-McGinley, J; Kadowaki, T; Ottini, L; Taylor, SI1
Herbertz, L; Langer, K; Schauder, P; Zavelberg, D1
Cahill, GF; Felig, P; Marliss, E1

Reviews

6 review(s) available for isoleucine and Insulin Sensitivity

ArticleYear
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review.
    Ginekologia polska, 2022, Volume: 93, Issue:8

    Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine

2022
Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites.
    Liver international : official journal of the International Association for the Study of the Liver, 2023, Volume: 43, Issue:4

    Topics: Adult; Alanine; Birth Weight; Child; Genome-Wide Association Study; Humans; Insulin Resistance; Isoleucine; Leucine; Non-alcoholic Fatty Liver Disease; Pediatric Obesity; Polymorphism, Single Nucleotide; Valine

2023
Branched chain amino acids, aging and age-related health.
    Ageing research reviews, 2020, Volume: 64

    Topics: Aging; Amino Acids, Branched-Chain; Humans; Insulin; Insulin Resistance; Isoleucine

2020
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
    International journal of molecular sciences, 2018, Mar-23, Volume: 19, Issue:4

    Topics: Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Isoleucine; Leucine; Metabolic Diseases; Signal Transduction; Valine

2018
4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity.
    Molecules (Basel, Switzerland), 2016, Nov-22, Volume: 21, Issue:11

    Topics: Animals; Glucose; Humans; In Vitro Techniques; Insulin Resistance; Isoleucine; Liver; Liver Function Tests; MAP Kinase Signaling System; Obesity; Plant Extracts; Trigonella

2016
[I164T polymorphism of adiponectin gene in diabetes].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2

    Topics: Adiponectin; Amino Acid Substitution; Animals; Diabetes Mellitus; Genetic Predisposition to Disease; Humans; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Isoleucine; Mutation, Missense; Threonine

2005

Trials

3 trial(s) available for isoleucine and Insulin Sensitivity

ArticleYear
Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE).
    Scientific reports, 2022, 03-07, Volume: 12, Issue:1

    Topics: Adipose Tissue, Brown; Amino Acids, Branched-Chain; Fluorodeoxyglucose F18; Humans; Hyperthyroidism; Insulin; Insulin Resistance; Isoleucine; Leucine; Valine

2022
A randomized controlled trial: branched-chain amino acid levels and glucose metabolism in patients with obesity and sleep apnea.
    Journal of sleep research, 2017, Volume: 26, Issue:6

    Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Continuous Positive Airway Pressure; Fasting; Female; Glucose Intolerance; Glycated Hemoglobin; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Middle Aged; Obesity, Morbid; Prospective Studies; Sleep Apnea, Obstructive

2017
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
    Diabetic medicine : a journal of the British Diabetic Association, 2018, Volume: 35, Issue:7

    Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine

2018

Other Studies

34 other study(ies) available for isoleucine and Insulin Sensitivity

ArticleYear
Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan.
    Clinical nutrition (Edinburgh, Scotland), 2022, Volume: 41, Issue:8

    Topics: Alanine; Animals; Humans; Insulin; Insulin Resistance; Isoleucine; Japan; Methionine; Obesity; Overweight; Prospective Studies; Thinness; Tyrosine; Valine

2022
The Potential Effects of Isoleucine Restricted Diet on Cognitive Impairment in High-Fat-Induced Obese Mice via Gut Microbiota-Brain Axis.
    Molecular nutrition & food research, 2023, Volume: 67, Issue:20

    Topics: Animals; Brain; Cognitive Dysfunction; Diet; Diet, High-Fat; Gastrointestinal Microbiome; Insulin Resistance; Isoleucine; Lipid Metabolism Disorders; Mice; Mice, Inbred C57BL; Mice, Obese

2023
Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery.
    Gut, 2020, Volume: 69, Issue:8

    Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Birth Weight; Body Mass Index; Clostridiales; Creatinine; Cresols; Enterococcus; Escherichia; Feces; Female; Fetal Development; Gastric Bypass; Gastrointestinal Microbiome; Gastroplasty; Glutamine; Hemiterpenes; Humans; Indican; Infant, Newborn; Insulin Resistance; Isobutyrates; Isoleucine; Keto Acids; Leucine; Metabolomics; Micrococcaceae; Phenotype; Phenylacetates; Pregnancy; Streptococcus; Sulfuric Acid Esters; Young Adult

2020
Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice.
    Food & function, 2020, Mar-26, Volume: 11, Issue:3

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cecum; Diet, High-Fat; Insulin Resistance; Isoleucine; Leucine; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese

2020
The PNPLA3-I148M Variant Confers an Antiatherogenic Lipid Profile in Insulin-resistant Patients.
    The Journal of clinical endocrinology and metabolism, 2021, 01-01, Volume: 106, Issue:1

    Topics: Adult; Amino Acid Substitution; Atherosclerosis; Cohort Studies; Cross-Sectional Studies; Disease Resistance; Female; Finland; Genetic Association Studies; Humans; Insulin Resistance; Isoleucine; Lipase; Lipid Metabolism; Lipidomics; Lipoproteins; Male; Membrane Proteins; Methionine; Middle Aged; Polymorphism, Single Nucleotide

2021
Differences in gene expression of enzymes involved in branched-chain amino acid metabolism of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS.
    Taiwanese journal of obstetrics & gynecology, 2021, Volume: 60, Issue:2

    Topics: Adult; Amino Acids, Branched-Chain; Body Mass Index; Female; Gene Expression; Humans; Insulin Resistance; Isoleucine; Leucine; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Subcutaneous Fat, Abdominal; Valine

2021
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:1

    Topics: Adult; Age Factors; Amino Acids; Biomarkers; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Insulin Resistance; Isoleucine; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Prognosis; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Tyrosine

2018
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
    Diabetes, 2019, Volume: 68, Issue:6

    Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine

2019
[Effect of Trigonella foenum-graecum 4-hydroxyisoleucine on high-glucose induced insulin resistance in 3T3-L1 adipocytes of mice].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2013, Volume: 33, Issue:10

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Glucose; Insulin; Insulin Resistance; Isoleucine; Male; Mice; Trigonella; Tumor Necrosis Factor-alpha

2013
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:6

    Topics: Amino Acids, Branched-Chain; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Cell Line; Gluconeogenesis; Glucose-6-Phosphatase; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Isoleucine; Male; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Valine

2014
4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells.
    Molecular and cellular endocrinology, 2014, Volume: 395, Issue:1-2

    Topics: Animals; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fatty Acids; Glucose Transporter Type 4; GTPase-Activating Proteins; Inflammation; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoleucine; MAP Kinase Signaling System; Muscle, Skeletal; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species

2014
4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway.
    Fitoterapia, 2014, Volume: 99

    Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Gene Expression Regulation; Insulin Resistance; Isoleucine; Male; Mitochondria; Muscle Fibers, Skeletal; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction

2014
4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-α and regulating the expression of insulin signal transduction proteins.
    Molecular medicine reports, 2015, Volume: 12, Issue:5

    Topics: ADAM Proteins; ADAM17 Protein; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Hep G2 Cells; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoleucine; Phosphorylation; Signal Transduction; Tissue Inhibitor of Metalloproteinase-3; Trigonella; Tumor Necrosis Factor-alpha

2015
4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: 3T3-L1 Cells; ADAM Proteins; ADAM17 Protein; Adipocytes; Animals; Deoxyglucose; Dose-Response Relationship, Drug; Insulin; Insulin Resistance; Isoleucine; Mice; Pioglitazone; Signal Transduction; Thiazolidinediones; Time Factors; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases

2015
4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS-1.
    Molecular and cellular biochemistry, 2016, Volume: 414, Issue:1-2

    Topics: Adenylate Kinase; Androstadienes; Animals; Cell Line; Deoxyglucose; Enzyme Activation; Glucose Transporter Type 4; Immunoprecipitation; Inflammation; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoleucine; Mice; Muscle Fibers, Skeletal; Phosphorylation; Suppressor of Cytokine Signaling 3 Protein; Tumor Necrosis Factor-alpha; Wortmannin

2016
Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition.
    Nutrients, 2016, Feb-15, Volume: 8, Issue:2

    Topics: Animals; Blood Glucose; Diet; Diet, High-Fat; Dietary Fats; Dietary Proteins; Gluconeogenesis; Hypothalamus; Insulin Resistance; Isoleucine; Liver; Male; Rats, Sprague-Dawley; Valine

2016
Amino Acid and Biogenic Amine Profile Deviations in an Oral Glucose Tolerance Test: A Comparison between Healthy and Hyperlipidaemia Individuals Based on Targeted Metabolomics.
    Nutrients, 2016, Jun-21, Volume: 8, Issue:6

    Topics: Adult; Amino Acids; Biogenic Amines; Blood Glucose; Case-Control Studies; Dietary Carbohydrates; Energy Intake; Exercise; Female; gamma-Aminobutyric Acid; Glucose Tolerance Test; Humans; Hyperlipidemias; Insulin; Insulin Resistance; Isoleucine; Male; Metabolomics; Middle Aged; Postprandial Period; Reproducibility of Results; Risk Factors

2016
Tryptophan Predicts the Risk for Future Type 2 Diabetes.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine

2016
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.
    Free radical biology & medicine, 2017, Volume: 104

    Topics: Amino Acids, Branched-Chain; Cell Movement; Humans; Inflammation; Insulin Resistance; Interleukin-6; Isoleucine; Leucine; Leukocytes, Mononuclear; Mechanistic Target of Rapamycin Complex 1; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Valine

2017
The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats.
    Phytotherapy research : PTR, 2009, Volume: 23, Issue:1

    Topics: Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Liver; Male; Plant Extracts; Rats; Rats, Wistar; Trigonella

2009
Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.
    Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:9

    Topics: Adipose Tissue; Adiposity; Adult; Age Factors; Blood Glucose; Blood Pressure; Body Mass Index; Case-Control Studies; Down-Regulation; Fatty Acid Synthase, Type I; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Insulin Resistance; Isoleucine; Male; Middle Aged; Obesity; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors; Time Factors; Valine; Waist-Hip Ratio; Weight Gain

2009
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
    Pediatric obesity, 2013, Volume: 8, Issue:1

    Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine

2013
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults.
    Diabetes care, 2013, Volume: 36, Issue:3

    Topics: Adult; Amino Acids; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Phenylalanine; Tyrosine; Valine; Young Adult

2013
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2004, Volume: 112, Issue:2

    Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Homozygote; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Mutation; Nuclear Proteins; Proline; Serine; Transcription Factors

2004
Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Diet; Enzyme Activation; Glucose; Glucose Clamp Technique; Hyperinsulinism; Insulin; Insulin Resistance; Isoleucine; Lipids; Liver; Male; Muscle, Skeletal; Niacinamide; Obesity; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Rats, Zucker; Signal Transduction; Sucrose

2004
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.
    Obesity research, 2004, Volume: 12, Issue:7

    Topics: Adult; Aged; Alleles; Blood Glucose; Calorimetry, Indirect; Energy Metabolism; Fatty Acids, Nonesterified; Finland; Gene Frequency; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Isoleucine; Middle Aged; Oxidation-Reduction; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prospective Studies; Receptor, Melanocortin, Type 4; Sequence Analysis, DNA; Valine; Weight Gain

2004
Homozygosity for a new mutation (Ile119-->Met) in the insulin receptor gene in five sibs with familial insulin resistance.
    Journal of medical genetics, 1994, Volume: 31, Issue:9

    Topics: Exons; Female; Homozygote; Humans; Insulin Resistance; Isoleucine; Lod Score; Male; Methionine; Mutation; Pedigree; Receptor, Insulin

1994
Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2.
    Diabetes, 1994, Volume: 43, Issue:4

    Topics: Amino Acid Sequence; Arizona; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Epidemiologic Methods; Family; Genetic Linkage; Glucokinase; Glucose Transporter Type 2; Humans; Indians, North American; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Longitudinal Studies; Molecular Sequence Data; Monosaccharide Transport Proteins; Point Mutation; Polymerase Chain Reaction; Threonine

1994
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
    Journal of lipid research, 2001, Volume: 42, Issue:11

    Topics: Adult; Alleles; Aspartic Acid; Blood Glucose; Exons; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Glutamic Acid; Glycerol; Humans; Insulin; Insulin Resistance; Isoleucine; Kinetics; Lipolysis; Male; Mutation; Obesity; Polymorphism, Genetic; Regulatory Sequences, Nucleic Acid; Sequence Analysis, DNA; Serine; Sterol Esterase; Triglycerides

2001
Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease.
    Journal of endocrinological investigation, 2002, Volume: 25, Issue:2

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Creatinine; Cushing Syndrome; Cystine; Cystinuria; Fasting; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Insulin Resistance; Isoleucine; Kidney; Leucine; Male; Middle Aged; Valine

2002
Rapid and simultaneous detection of multiple mutations by pooled and multiplex single nucleotide primer extension: application to the study of insulin-responsive glucose transporter and insulin receptor mutations in non-insulin-dependent diabetes.
    Human molecular genetics, 1992, Volume: 1, Issue:6

    Topics: Alleles; Amino Acid Sequence; Blood Donors; Diabetes Mellitus, Type 2; Exons; Genetic Variation; Genotype; Humans; Insulin Resistance; Isoleucine; Middle Aged; Monosaccharide Transport Proteins; Mutation; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Receptor, Insulin; United Kingdom; Wales; White People

1992
A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman.
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 73, Issue:4

    Topics: Adult; Exons; Female; Fibroblasts; Humans; Insulin Resistance; Isoleucine; Methionine; Mutation; Obesity; Protein-Tyrosine Kinases; Receptor, Insulin

1991
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
    The American journal of clinical nutrition, 1987, Volume: 46, Issue:1

    Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine

1987
Plasma amino acid levels and insulin secretion in obesity.
    The New England journal of medicine, 1969, Oct-09, Volume: 281, Issue:15

    Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine

1969