isoleucine and Disease Models, Animal

Topics: Animals; Colitis; Dextran Sulfate; Dipeptidyl Peptidase 4; Disease Models, Animal; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Indicators and Reagents; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Isoleucine; Mice; Mice, Knockout; Peptide Fragments; Serine Proteinase Inhibitors

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Disease Models, Animal; Hippocampus; Isoleucine; Meningitis, Pneumococcal; Morpholines; Nerve Tissue Proteins; Neurogenesis; Neuroinflammatory Diseases; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor

Topics: Amino Acids, Branched-Chain; Animals; Anthrax; Bacillus anthracis; Bacterial Proteins; Cattle; Disease Models, Animal; Isoleucine; Mammals; Membrane Transport Proteins; Mice; Valine; Virulence

Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Animal; Epilepsy; Glucose; Glutamates; Isoleucine; Ketone Bodies; Lactates; Leucine; Pentylenetetrazole; Pyruvates; Rats; Seizures; Succinates; Valine

Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Firmicutes; Fructose; Gastrointestinal Microbiome; Glucans; Humans; Isoleucine; Leucine; Metabolome; Mice; Non-alcoholic Fatty Liver Disease; Ornithine; RNA, Ribosomal, 16S; Spermidine; Succinic Acid; Telmisartan; Tryptophan; Water

Topics: Animals; Disease Models, Animal; DNA, Viral; Genome, Viral; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Isoleucine; Leucine; Male; Mice; Mice, Inbred BALB C; Mutation; Phenotype; Viral Core Proteins; Virion; Virus Assembly; Virus Replication

Topics: Alzheimer Disease; Amino Acids; Animals; Anti-Bacterial Agents; Bacteria; Clinical Trials, Phase III as Topic; Cognitive Dysfunction; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Humans; Isoleucine; Mannose; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Oligosaccharides; Phenylalanine; Th1 Cells

Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease Models, Animal; Docosahexaenoic Acids; Fasting; Humans; Insulin; Isoleucine; Lactic Acid; Leucine; Metabolomics; Mice; Neoplasm Metastasis; Phenylalanine; Pyruvic Acid

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Disease Models, Animal; Green Fluorescent Proteins; Hippocampus; Isoleucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Neurites; Phosphorylation; Receptors, Nerve Growth Factor; rhoA GTP-Binding Protein; Signal Transduction; tau Proteins; Transfection

Topics: Administration, Oral; Animals; Disease Models, Animal; Endothelial Cells; Erectile Dysfunction; Humans; Isoleucine; Male; Mice; Mice, Inbred C57BL; Morpholines; Penile Erection; Penis; Receptor, Nerve Growth Factor

Topics: Alzheimer Disease; Animals; Carbazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Isoleucine; Mice; Microglia; Morpholines; Radiopharmaceuticals; Receptors, GABA; Sensitivity and Specificity

Topics: Adipose Tissue; Animals; Biocompatible Materials; Cell Survival; Disease Models, Animal; Gelatin; Humans; Hydrogels; Isoleucine; Maleic Anhydrides; Morpholines; Nerve Regeneration; Peptides; Polycarboxylate Cement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Shear Strength; Stem Cells; Tyrosine

Topics: Amino Acids; Animals; Citric Acid; Creatine; Disease Models, Animal; Energy Metabolism; Glutamine; Glycoproteins; Isoleucine; Leucine; Metabolomics; Phenylalanine; Rats; Rats, Wistar; Syndrome

Topics: Animals; Cerebral Cortex; Disease Models, Animal; Disease Progression; Fluorodeoxyglucose F18; Hippocampus; Humans; Huntington Disease; Isoleucine; Male; Mice; Microglia; Morpholines; Positron-Emission Tomography; Protein Binding; Receptors, GABA; Receptors, Nerve Growth Factor

Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Disease Models, Animal; Female; Isoleucine; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Molecular Targeted Therapy; Morpholines; Nerve Degeneration; Neurites; Receptors, Nerve Growth Factor

Topics: Acids, Acyclic; Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Humans; Isoleucine; Large Neutral Amino Acid-Transporter 1; Methylation; Mice; Mice, Transgenic; Molecular Targeted Therapy; Organ Specificity; Phenylalanine; Phenylketonurias; Protein Conformation; Protein Folding; Valine

Topics: Analysis of Variance; Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Electroencephalography; Fluoresceins; Isoleucine; Morpholines; Muscarinic Agonists; Nerve Tissue Proteins; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Spectrum Analysis; Status Epilepticus; Time Factors

Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; beta-Alanine; Depressive Disorder, Major; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glycerol; Isoleucine; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Psychological

Topics: Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Neurons; Cognition Disorders; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Isoleucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Mutation; Nerve Degeneration; Nerve Tissue Proteins; NIH 3T3 Cells; Phosphorylation; Protein Folding; Receptors, Nerve Growth Factor; tau Proteins

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cholinergic Neurons; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Female; Humans; Isoleucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Nerve Degeneration; Neurites; Protective Agents; Receptor, Nerve Growth Factor; Signal Transduction

Topics: Adaptation, Physiological; Animals; Cytosol; Disease Models, Animal; Female; Francisella tularensis; Gene Deletion; Isoleucine; Membrane Transport Proteins; Mice, Inbred BALB C; Phagosomes; Tularemia

Topics: alpha-Defensins; Animals; beta-Defensins; Disease Models, Animal; Drug Combinations; Family Characteristics; Humans; Intubation, Intratracheal; Isoleucine; Male; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Tuberculosis, Pulmonary

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cardiotonic Agents; Dipeptides; Disease Models, Animal; Humans; Hypertension; Isoleucine; Male; Protein Hydrolysates; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Tryptophan; Whey

Topics: Age Factors; Animals; Autoantigens; Disease Models, Animal; Genotype; Golgi Matrix Proteins; Humans; Isoleucine; Leucine; Mice; Mice, Transgenic; Muscular Dystrophies, Limb-Girdle; Mutation; Pentosyltransferases; Phenotype; Proteins; RNA, Untranslated

Topics: Adipose Tissue; Animals; Binding Sites; CRISPR-Cas Systems; Disease Models, Animal; Energy Metabolism; Female; Homeostasis; Isoleucine; Leptin; Male; Mice, Obese; Models, Molecular; Mutation; Obesity; Protein Binding; Rats; Receptors, Leptin; Signal Transduction; Whole Genome Sequencing

Topics: Animals; Disease Models, Animal; Huntingtin Protein; Huntington Disease; Isoleucine; Ligands; Male; Mice; Mice, Transgenic; Molecular Targeted Therapy; Morpholines; Phenotype; Protein Binding; Random Allocation; Receptors, Nerve Growth Factor; Signal Transduction

Topics: Alanine; Amino Acids; Animals; Atherosclerosis; Combinatorial Chemistry Techniques; Depsipeptides; Disease Models, Animal; Isoleucine; Lipid Metabolism; Macrophages; Mice; Molecular Structure; Sterol O-Acyltransferase; Structure-Activity Relationship

Topics: Ammonia; Animals; Astrocytes; Brain; Carbon Radioisotopes; Cells, Cultured; Cholestasis; Citric Acid Cycle; Disease Models, Animal; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Isoleucine; Muscle, Skeletal; Neurons; Rats; Rats, Wistar

Topics: ADAM Proteins; ADAM10 Protein; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Disease Models, Animal; Glutamic Acid; Humans; Isoleucine; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time; Swimming; Valine

Topics: Animals; Asparagine; Cell Line, Transformed; Cell Proliferation; Charcot-Marie-Tooth Disease; Cranial Nerve Diseases; Disease Models, Animal; Early Growth Response Protein 2; Humans; Immunoprecipitation; Isoleucine; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Myelin Proteins; Neoplasm Proteins; Neural Conduction; Ranvier's Nodes; Repressor Proteins; Schwann Cells; Sciatic Nerve

Topics: Administration, Oral; Aminoacetonitrile; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hippocampus; Isoleucine; Leucine; Male; Memory Disorders; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Oligopeptides; Peptide Fragments; Phosphorylation; Recognition, Psychology; Time Factors

Topics: Animals; beta-Defensins; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Gene Expression Regulation; Humans; Immunohistochemistry; Immunotherapy; Isoleucine; Lung; Male; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Reverse Transcriptase Polymerase Chain Reaction; Tuberculosis; Tuberculosis, Pulmonary

Topics: Animals; Biomarkers; Colitis; Dextran Sulfate; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Ileum; Intestine, Small; Isoleucine; Jejunum; Mice; Mice, Inbred C57BL; Mice, Knockout; Microvilli; Neutrophil Infiltration; Peroxidase; Sucrase; Thiazoles; Time Factors

Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginine; Cell Line, Tumor; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Immunoprecipitation; Isoleucine; L-Lactate Dehydrogenase; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation; Neuroblastoma; Neurons; Peptide Fragments; Presenilin-1

Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Electrodes; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Isoleucine; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; Synapses; tau Proteins; Time Factors; Valine

Topics: Animals; Astrocytes; Cats; Cells, Cultured; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Immunohistochemistry; In Vitro Techniques; Isoleucine; Ligands; Microglia; Morpholines; Neurons; Neuroprotective Agents; Real-Time Polymerase Chain Reaction; Receptor, Nerve Growth Factor

Topics: Acetylcholinesterase; Aminophenols; Animals; Biophysics; Diaphragm; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Hand Strength; Humans; In Vitro Techniques; Isoleucine; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Miniature Postsynaptic Potentials; Motor Endplate; Mutagenesis; Myasthenic Syndromes, Congenital; Neurofilament Proteins; Neuromuscular Junction; Patch-Clamp Techniques; Phenylalanine; Receptors, Nicotinic; S100 Proteins; Synaptophysin; Time Factors

Topics: Age Factors; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blotting, Southern; Brain Chemistry; Choice Behavior; Disease Models, Animal; Female; Genotype; Humans; Immunohistochemistry; Isoleucine; Male; Maze Learning; Mice; Mice, Transgenic; Molecular Sequence Data; Motor Activity; Mutation; Neurofibrillary Tangles; Peptide Fragments; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors; Survival Rate; tau Proteins; Valine

Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chromosome Mapping; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Glucokinase; Glucose; Glucose Intolerance; Heterozygote; Homozygote; Isoleucine; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenylalanine; Phosphorylation; Thymine

Topics: Administration, Oral; Animals; Carbon Tetrachloride; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Glycogen Synthase; Isoleucine; Leucine; Liver Cirrhosis; Male; Monosaccharide Transport Proteins; Muscle Proteins; Rats; Rats, Sprague-Dawley

Topics: Animals; Antioxidants; Brain; Catalase; Cerebral Cortex; Chromans; Disease Models, Animal; Enzyme Inhibitors; Fluoresceins; Free Radicals; Glutathione; Glutathione Peroxidase; Humans; Isoleucine; Leucine; Male; Maple Syrup Urine Disease; Mitochondria; Neurons; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Valine

Topics: alpha-Crystallins; Angiography; Animals; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Crystallins; Disease Models, Animal; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Ethylnitrosourea; Fluorescein; gamma-Crystallins; Genetic Linkage; Homozygote; Immunohistochemistry; Isoleucine; Lens, Crystalline; Mice; Mice, Mutant Strains; Mutagenesis; Mutagens; Mutation; Mutation, Missense; Phenotype; Phenylalanine; Protein Binding; Recombinant Proteins; Retinal Vessels; Sequence Analysis, DNA; Ultraviolet Rays

Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cricetinae; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acids; Hypoglycemic Agents; Hypolipidemic Agents; Isoleucine; Male; Molecular Structure; Seeds; Structure-Activity Relationship; Triglycerides; Trigonella

Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Brain; Cell Line; Cell Survival; Disease Models, Animal; Escherichia coli; Humans; Immunization; Isoleucine; Mice; Mice, Transgenic; Models, Biological; Molecular Sequence Data; Plants, Genetically Modified; Plaque, Amyloid; Solanum tuberosum; Tandem Repeat Sequences; Time Factors; Vaccines

Topics: Alanine Transaminase; Amyloidosis, Familial; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Gene Silencing; Humans; Immunohistochemistry; Isoleucine; Liver; Mice; Mice, Transgenic; Mutation; Oligonucleotides, Antisense; Prealbumin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Time Factors

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Animal; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Isoleucine; Magnetic Resonance Imaging; Maze Learning; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Psychomotor Performance; Tyrosine

Topics: Administration, Oral; Alcoholism; Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Drug Therapy, Combination; Ethanol; Gas Chromatography-Mass Spectrometry; Isoleucine; Isotope Labeling; Male; Microwaves; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley

Topics: Animals; Disease Models, Animal; Humans; Isoleucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microscopy, Electron, Transmission; Muscle Proteins; Muscle, Skeletal; Muscular Dystrophies, Limb-Girdle; Mutation; Threonine

Topics: Acidosis; Animals; Body Weight; Cholesterol; Creatinine; Disease Models, Animal; Eating; Isoleucine; Kidney Failure, Chronic; Leucine; Male; Muscle, Skeletal; Nephrectomy; Proteins; Rats; Rats, Wistar; Urea; Uremia; Valine

Topics: Amino Acids; Animals; Body Weight; Brain; Disease Models, Animal; Female; Humans; Isoleucine; Organ Size; Phenylalanine; Phenylketonurias; Pregnancy; Rats

Topics: Animals; Brain; Disease Models, Animal; Fatty Acids; Histidine; Hydroxyindoleacetic Acid; Hypothalamus; Isoleucine; Leucine; Liver Cirrhosis; Phenylalanine; Portacaval Shunt, Surgical; Rats; Serotonin; Tryptophan; Tyrosine; Valine

Topics: Ammonium Sulfate; Animals; Antibiosis; Bacteria; Bacterial Proteins; Bacteriocins; Bacteriophage Typing; Chemical Fractionation; Chromatography, Gel; Cricetinae; Disease Models, Animal; DNA, Bacterial; Impetigo; Isoleucine; RNA, Bacterial; Species Specificity; Staphylococcus; Staphylococcus Phages; Streptococcus; Temperature; Tritium; Uracil

Topics: Animals; Autoradiography; Diet; Disease Models, Animal; Electroretinography; Epithelium; Eye Proteins; Follow-Up Studies; Isoleucine; Phenylalanine; Photoreceptor Cells; Rats; Retina; Retinal Diseases; Tritium; Vitamin A; Vitamin A Deficiency