isoleucine has been researched along with Diabetes Mellitus, Type 2 in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (20.83) | 18.2507 |
| 2000's | 7 (14.58) | 29.6817 |
| 2010's | 16 (33.33) | 24.3611 |
| 2020's | 15 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Banerjee, D; Dubey, SK; Katiyar, C; Krishna, KV; Narwaria, A; Taliyan, R; Tandon, N; Wadhwa, G; Yadav, SS | 1 |
| Ang, K; Ang, SF; Ching, J; Kovalik, JP; Lee, LS; Lim, SC; Lim, Z; Low, S; Moh, A; Shao, YM; Subramaniam, T; Sum, CF; Tang, WE; Wang, J; Wee, HN | 1 |
| Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S | 1 |
| Bai, M; Chen, J; Dai, H; Han, F; Lin, W; Wang, J; Weng, C; Xie, X; Zhu, H | 1 |
| Huang, C; Lin, D; Lu, R; Zhang, Y; Zhou, L; Zou, H | 1 |
| Álvarez, C; Álvarez-Cilleros, D; Amigó, N; Chagoyen, M; Correig, X; Fernández-Millán, E; Martín, MÁ; Ramos, S; Samino, S | 1 |
| Ardavani, A; Atherton, PJ; Idris, I; Mellett, A; Ramzan, I; Vanweert, F | 1 |
| Li, HL; Li, ZY; Shen, QM; Tan, YT; Tuo, JY; Wang, J; Xiang, YB | 1 |
| Berska, J; Bugajska, J; Gotfryd-Bugajska, K; Pasternak, A; Sztefko, K; Szura, M | 1 |
| Kiens, B; Piper, MDW; Rose, AJ; Schmoll, D; Sjøberg, KA | 1 |
| Cruz, M; Locia-Morales, D; Meyre, D; Sharma, T; Valladares-Salgado, A; Vázquez-Moreno, M; Wacher-Rodarte, N | 1 |
| Elovaris, RA; Feinle-Bisset, C; Fitzgerald, PCE; Hajishafiee, M; Horowitz, M; Lange, K; Ullrich, SS | 1 |
| Adams-Huet, B; Devaraj, S; Jialal, I; Patel, A | 1 |
| Agah, S; Bitarafan, V; Elovaris, RA; Feinle-Bisset, C; Horowitz, M; Lange, K; Ullrich, SS | 1 |
| Hao, H; Hu, W; Li, J; Li, S; Liu, Z; Lu, Y; Qi, X; Wang, X; Wen, S; Yu, W; Zhou, H | 1 |
| Baum, SJ; Chakravarthy, MV; Chera, H; Gunn, NT; Harrison, SA; Kohli, A; Koziel, MJ; Patil, R; Younes, ZH; Zhao, J | 1 |
| He, X; Wang, L; Wang, S; Yuan, Y; Zhang, Y; Zhong, J; Zhou, Y | 1 |
| Birech, Z; Bukachi, F; Mandela, KM; Mwangi, PW | 1 |
| Boerwinkle, E; Chang, P; Coresh, J; Köttgen, A; Rebholz, CM; Selvin, E; Tin, A; Wagenknecht, LE; Yu, B; Zheng, Z | 1 |
| He, T; Ma, X; Nie, C; Zhang, G; Zhang, W | 1 |
| Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H | 1 |
| Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J | 1 |
| Chen, HY; Chen, KH; Huang, CH; Huang, YY; Hung, SY; Lin, CN; Lin, CW; Tsai, JS; Yang, HM; Yeh, JT | 1 |
| Hu, AM; Liu, HL; Sun, QQ; Wang, Q; Yin, YW | 1 |
| Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Liu, J; Ma, X; Ni, Y; Xie, G; Zhao, A | 1 |
| Gao, F; Zafar, MI | 1 |
| Askar, T; Mansour, AA; Mergani, A; Mohammed, MA; Mustafa, AM; Saleh, OM; Zahran, RN | 1 |
| Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X | 1 |
| Ouazzani, J; Sasaki, NA; Sergent, D; Wang, Q | 1 |
| Chen, BD; Fu, ZY; Li, XM; Liu, F; Ma, X; Ma, YT; Xie, X; Yang, SJ; Yang, YN; Zheng, YY | 1 |
| Mori, Y; Ohta, T; Shiozaki, M; Utsunomiya, K; Yokoyama, J | 1 |
| Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ | 1 |
| Bierhaus, A; Chavakis, T; Hamann, A; Humpert, PM; Isermann, B; Nawroth, P; Nosikov, VV; Reismann, P; Rudofsky, G; Tafel, J; Witte, S | 1 |
| Epe, M; Fehmann, HC; Gross, U | 1 |
| Bentley, L; Browne, M; Cox, RD; Goldsworthy, M; Haynes, A; Hough, T; Hugill, A; Hunter, AJ; Mijat, V; Moir, L; Quarterman, J; Spurr, N; Toye, AA | 1 |
| Beconi, MG; Biftu, T; Chan, CC; Edmondson, S; Eiermann, GJ; Feeney, WP; He, H; Ippolito, DE; Kim, D; Lankas, GR; Leiting, B; Lyons, KA; Ok, HO; Patel, RA; Petrov, AN; Pryor, KA; Qian, X; Reigle, L; Roy, RS; Thornberry, NA; Weber, AE; Woods, A; Wu, JK; Zaller, D; Zhang, X; Zhu, L | 1 |
| Bhatia, G; Chandra, R; Khaliq, T; Narender, T; Puri, A; Saxena, R | 1 |
| Ikehara, O; Kawasaki, N; Komatsu, M; Konishi, A; Maezono, K | 1 |
| Carrera, P; Esposito, L; Ferrari, M; Pontiroli, AE | 1 |
| Bogardus, C; Janssen, RC; Knowler, WC; Takeda, J; Thompson, DB | 1 |
| Andersen, CB; Clausen, JO; Echwald, SM; Hansen, L; Hansen, T; Owens, D; Pedersen, O; Urhammer, SA; Vestergaard, H | 1 |
| Andersen, CB; Hansen, T; Ito, C; Kasuga, M; Kawanishi, M; Masugi, J; Mori, H; Pedersen, O; Tamori, Y | 1 |
| Bell, GI; Boutin, P; Chèvre, JC; Demenais, F; Durand, E; Froguel, P; Furuta, H; Hani, EH; Laine, B; Philippi, A; Suaud, L; Velho, G; Vionnet, N | 1 |
| Clausen, JO; Eiberg, H; Ekstrøm, CT; Hansen, T; Møller, AM; Nyholm, B; Pedersen, O; Schmitz, O; Urhammer, SA | 1 |
| Albu, J; Allison, DB; Burn, P; Chin, W; Deng, N; Duprat, L; Fisher, SL; Franco, LS; Gu, W; Heymsfield, S; Kissebah, A; Kleyn, PW; Lee, J; Maruti, S; Nathan, J; Pi-Sunyer, FX; Tu, Z; Yagaloff, KA | 1 |
| Gallwitz, B; Schmidt, WE | 1 |
| Broca, C; Gomis, R; Gross, R; Manteghetti, M; Masiello, P; Petit, P; Ribes, G; Sauvaire, Y; Tournier, M | 1 |
| Krook, A; O'Rahilly, S; Stratton, IM | 1 |
5 review(s) available for isoleucine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review.
Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine | 2022 |
The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis.
Topics: Amino Acids, Branched-Chain; Biomarkers; Diabetes Mellitus, Type 2; Humans; Isoleucine; Leucine; Valine | 2022 |
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
Topics: Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Isoleucine; Leucine; Metabolic Diseases; Signal Transduction; Valine | 2018 |
Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabetes mellitus: a meta-analysis of 15,059 subjects.
Topics: Amino Acid Substitution; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glycine; Humans; Isoleucine; Models, Genetic; Observational Studies as Topic; Polymorphism, Single Nucleotide; Threonine; Toll-Like Receptor 4 | 2015 |
4-Hydroxyisoleucine: A Potential New Treatment for Type 2 Diabetes Mellitus.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Humans; Isoleucine; Plants, Medicinal; Rats; Trigonella | 2016 |
3 trial(s) available for isoleucine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Intragastric administration of leucine and isoleucine does not reduce the glycaemic response to, or slow gastric emptying of, a carbohydrate-containing drink in type 2 diabetes.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Energy Drinks; Gastric Emptying; Humans; Isoleucine; Leucine; Male; Middle Aged; Postprandial Period | 2021 |
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease.
Topics: Acetylcysteine; Administration, Oral; Arginine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Female; Glutamine; Humans; Isoleucine; Leucine; Liver; Magnetic Resonance Imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Single-Blind Method; Treatment Outcome; Valine | 2021 |
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine | 2018 |
40 other study(ies) available for isoleucine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats.
Topics: Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diosgenin; Female; Isoleucine; Limit of Detection; Linear Models; Plant Extracts; Rats; Rats, Wistar; Reproducibility of Results; Trigonella | 2022 |
Amino acid profile of skeletal muscle loss in type 2 diabetes: Results from a 7-year longitudinal study in asians.
Topics: Amino Acids; Amino Acids, Branched-Chain; Asian People; Diabetes Mellitus, Type 2; Humans; Isoleucine; Leucine; Longitudinal Studies; Muscle, Skeletal; Prospective Studies; Valine | 2022 |
Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus.
Topics: Asparagine; Betaine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Follow-Up Studies; Humans; Isoleucine; Methionine; Prospective Studies; Valine | 2022 |
NMR-Based Metabolomic Analysis for the Effects of Trimethylamine N-Oxide Treatment on C2C12 Myoblasts under Oxidative Stress.
Topics: Alanine; Catalase; Diabetes Mellitus, Type 2; Glycine; Histidine; Humans; Hydrogen Peroxide; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Malondialdehyde; Methylamines; Myoblasts; Oxidative Stress; Phenylalanine; Phosphorylcholine; Superoxide Dismutase; Threonine; Valine | 2022 |
Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via
Topics: Amino Acids, Branched-Chain; Animals; Blood Glucose; Cacao; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Flavonoids; Glycated Hemoglobin; Isoleucine; Ketone Bodies; Leucine; Male; Metabolomics; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Zucker; Valine | 2022 |
Sex-Specific Correlation Analysis of Branched-Chain Amino Acids in Dietary Intakes and Plasma among Chinese Adults.
Topics: Amino Acids, Branched-Chain; Case-Control Studies; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; East Asian People; Female; Humans; Isoleucine; Leucine; Male; Middle Aged; Prospective Studies; Valine | 2023 |
Characteristics of amino acid profiles and incretin hormones in patients with gallstone disease: a pilot study.
Topics: Adult; Aged; Cholecystolithiasis; Diabetes Mellitus, Type 2; Female; Humans; Incretins; Isoleucine; Leucine; Lysine; Male; Metabolic Diseases; Middle Aged; Pilot Projects; Valine | 2019 |
Effects of Short-Term Dietary Protein Restriction on Blood Amino Acid Levels in Young Men.
Topics: Adult; Amino Acids; Amino Acids, Essential; Diabetes Mellitus, Type 2; Diet, Protein-Restricted; Dietary Proteins; Fasting; Humans; Isoleucine; Male | 2020 |
Sex/Gender Modifies the Association Between the MC4R p.Ile269Asn Mutation and Type 2 Diabetes in the Mexican Population.
Topics: Adult; Aged; Amino Acid Substitution; Asparagine; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Effect Modifier, Epidemiologic; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Isoleucine; Male; Mexico; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Melanocortin, Type 4; Risk Factors; Sex Factors | 2021 |
Metabolites that activate the inflammasome in nascent metabolic syndrome.
Topics: Adult; Carnitine; Caspase 1; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Humans; Inflammasomes; Isoleucine; Metabolic Syndrome; NLR Family, Pyrin Domain-Containing 3 Protein | 2021 |
Comparative Effects of the Branched-Chain Amino Acids, Leucine, Isoleucine and Valine, on Gastric Emptying, Plasma Glucose, C-Peptide and Glucagon in Healthy Men.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Humans; Insulin; Isoleucine; Leucine; Male; Middle Aged; Postprandial Period; Valine; Whey Proteins; Young Adult | 2021 |
Effects of
Topics: Aged; Amino Acids, Branched-Chain; Cardiovascular Diseases; China; Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Incidence; Isoleucine; Leucine; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide; Protein Phosphatase 2C; Valine | 2021 |
Serum metabolomics differentiating pancreatic cancer from new-onset diabetes.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Biomarkers, Tumor; Body Mass Index; CA-19-9 Antigen; Carcinoma, Pancreatic Ductal; Chromatography, Liquid; Diabetes Mellitus, Type 2; Diagnosis, Differential; Early Detection of Cancer; Feasibility Studies; Female; Humans; Isoleucine; Leucine; Lipid Metabolism; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms; Principal Component Analysis; Sensitivity and Specificity; Serologic Tests; Valine | 2017 |
Application of Raman spectroscopy in type 2 diabetes screening in blood using leucine and isoleucine amino-acids as biomarkers and in comparative anti-diabetic drugs efficacy studies.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Isoleucine; Leucine; Momordica; Plant Extracts; Rats; Rats, Sprague-Dawley; Spectrum Analysis, Raman | 2017 |
Serum metabolomic profile of incident diabetes.
Topics: Amino Acids, Branched-Chain; Asparagine; Atherosclerosis; Blood Glucose; Diabetes Mellitus, Type 2; Erythritol; Female; Glucose; Humans; Isoleucine; Lactic Acid; Leucine; Male; Maryland; Metabolome; Middle Aged; Minnesota; Mississippi; North Carolina; Prospective Studies; Risk Factors; Trehalose; Valine | 2018 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine | 2019 |
Amino acids and wound healing in people with limb-threatening diabetic foot ulcers.
Topics: Aged; Aged, 80 and over; Amino Acids; Amputation, Surgical; Arginine; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Foot; Female; Hospitalization; Humans; Isoleucine; Leucine; Male; Threonine; Treatment Outcome; Wound Healing | 2019 |
Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations.
Topics: Adult; Aged; Amino Acids, Aromatic; Amino Acids, Branched-Chain; China; Chromatography, Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Isoleucine; Leucine; Longitudinal Studies; Male; Mass Spectrometry; Middle Aged; Phenylalanine; Risk Factors; Tyrosine; Valine; Young Adult | 2016 |
Glutathione S-Transferase Pi-Ile 105 Val Polymorphism and Susceptibility to T2DM in Population from Turabah Region of Saudi Arabia.
Topics: Adult; Aged; Amplified Fragment Length Polymorphism Analysis; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Glutathione S-Transferase pi; Humans; Isoleucine; Middle Aged; Polymorphism, Single Nucleotide; Saudi Arabia; Valine | 2016 |
Tryptophan Predicts the Risk for Future Type 2 Diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine | 2016 |
Synthesis of hydantoin analogues of (2S,3R,4S)-4-hydroxyisoleucine with insulinotropic properties.
Topics: Animals; Diabetes Mellitus, Type 2; Hydantoins; Insulin; Insulin Secretion; Isoleucine; Molecular Structure; Rats; Stereoisomerism; Structure-Activity Relationship | 2008 |
S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes.
Topics: Adult; Aged; Alleles; Asian People; Cardiovascular Diseases; Case-Control Studies; China; Diabetes Mellitus, Type 2; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Hyperlipidemia, Familial Combined; Isoleucine; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptor, Anaphylatoxin C5a; Receptors, Chemokine; Risk Factors; Serine | 2011 |
The effect of a low-carbohydrate/high-monounsaturated fatty acid liquid diet and an isoleucine-containing liquid diet on 24-h glycemic variability in diabetes patients on tube feeding: a comparison by continuous glucose monitoring.
Topics: Aged; Blood Glucose; Blood Glucose Self-Monitoring; Cross-Over Studies; Deglutition Disorders; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Energy Intake; Enteral Nutrition; Fatty Acids, Monounsaturated; Female; Glycated Hemoglobin; Humans; Isoleucine; Male; Prospective Studies | 2012 |
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine | 2013 |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
Topics: Amino Acid Substitution; Aspartic Acid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Genotype; Glycine; Humans; Isoleucine; Membrane Glycoproteins; Mutation, Missense; Odds Ratio; Polymorphism, Single Nucleotide; Prevalence; Receptors, Cell Surface; Threonine; Toll-Like Receptor 4; Toll-Like Receptors; White People | 2004 |
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Homozygote; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Mutation; Nuclear Proteins; Proline; Serine; Transcription Factors | 2004 |
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Chromosome Mapping; Diabetes Mellitus, Type 2; Disease Models, Animal; Ethylnitrosourea; Glucokinase; Glucose; Glucose Intolerance; Heterozygote; Homozygote; Isoleucine; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagens; Mutation, Missense; Phenylalanine; Phosphorylation; Thymine | 2004 |
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidases; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Female; Humans; Hypoglycemic Agents; Isoleucine; Isomerism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Rats; Recombinant Proteins; Thiazoles | 2005 |
4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
Topics: Administration, Oral; Animals; Cholesterol; Cholesterol, HDL; Cricetinae; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acids; Hypoglycemic Agents; Hypolipidemic Agents; Isoleucine; Male; Molecular Structure; Seeds; Structure-Activity Relationship; Triglycerides; Trigonella | 2006 |
Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Drug Administration Schedule; Female; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Isoleucine; Male; Mice; Mice, Inbred C57BL; Sucrose | 2008 |
Failure to detect Glut4-Ile383 and IR-Gln1152 variants in NIDDM (non-insulin dependent diabetes mellitus) and control subjects in an Italian population.
Topics: Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Glucose Transporter Type 4; Glutamine; Humans; Isoleucine; Italy; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle Proteins; Mutation; Receptor, Insulin | 1995 |
Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2.
Topics: Amino Acid Sequence; Arizona; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Epidemiologic Methods; Family; Genetic Linkage; Glucokinase; Glucose Transporter Type 2; Humans; Indians, North American; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Longitudinal Studies; Molecular Sequence Data; Monosaccharide Transport Proteins; Point Mutation; Polymerase Chain Reaction; Threonine | 1994 |
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.
Topics: Adolescent; Adult; Blood Glucose; Blood Pressure; C-Peptide; Child; Denmark; Diabetes Mellitus, Type 2; DNA; DNA Primers; Genetic Variation; Genotype; Heterozygote; Homozygote; Humans; Insulin; Isoleucine; Macromolecular Substances; Methionine; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Reference Values; White People | 1997 |
Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85 alpha regulatory subunit (codon 326 Met-->Ile) in Japanese NIDDM patients.
Topics: Base Sequence; Codon; Diabetes Mellitus, Type 2; Gene Frequency; Humans; Isoleucine; Japan; Macromolecular Substances; Methionine; Middle Aged; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Polymorphism, Genetic; Reference Values | 1997 |
A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
Topics: Age of Onset; Animals; Apolipoprotein C-III; Apolipoproteins C; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; COS Cells; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Female; Glucose Tolerance Test; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Hepatocyte Nuclear Factor 4; Humans; Insulin; Insulin Secretion; Isoleucine; Male; Middle Aged; Nuclear Proteins; Pedigree; Phosphoproteins; Point Mutation; Thymidine Kinase; Tissue Distribution; Transcription Factors; Transcriptional Activation; Valine | 1998 |
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
Topics: Adult; Amino Acid Substitution; Asparagine; C-Peptide; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Female; Genetic Variation; Glucose Tolerance Test; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Insulin; Islets of Langerhans; Isoleucine; Leucine; Male; Middle Aged; Nuclear Proteins; Serine; Transcription Factors; White People | 1998 |
Identification and functional analysis of novel human melanocortin-4 receptor variants.
Topics: Adolescent; Adult; Amino Acid Substitution; Animals; Body Mass Index; Cloning, Molecular; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Isoleucine; Male; Methionine; Mice; Middle Aged; Obesity; Pedigree; Polymorphism, Single-Stranded Conformational; Receptor, Melanocortin, Type 4; Receptors, Peptide; Recombinant Proteins; Threonine; Valine | 1999 |
[Inhibition of incretin degradation--a new therapy principle for treatment of type 2 diabetes?].
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Isoleucine; Peptide Fragments; Rats; Rats, Zucker; Thiazoles | 1999 |
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
Topics: Acids; Animals; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoleucine; Male; Niacinamide; Rats; Rats, Wistar; Reference Values | 1999 |
Rapid and simultaneous detection of multiple mutations by pooled and multiplex single nucleotide primer extension: application to the study of insulin-responsive glucose transporter and insulin receptor mutations in non-insulin-dependent diabetes.
Topics: Alleles; Amino Acid Sequence; Blood Donors; Diabetes Mellitus, Type 2; Exons; Genetic Variation; Genotype; Humans; Insulin Resistance; Isoleucine; Middle Aged; Monosaccharide Transport Proteins; Mutation; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Receptor, Insulin; United Kingdom; Wales; White People | 1992 |