isoleucine has been researched along with Acute Confusional Senile Dementia in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (22.73) | 18.2507 |
| 2000's | 10 (22.73) | 29.6817 |
| 2010's | 21 (47.73) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Amaral, AP; Conde, R; Graça, G; Morais, E; Oliveira, N; Sousa, A; Verde, I | 1 |
| Chang, S; Chu, X; Ding, J; Du, C; Feng, T; Ge, C; Geng, M; Gong, Y; Huang, X; Lian, W; Lin, F; Liu, J; Ruan, L; Sun, G; Wang, H; Wang, T; Wang, X; Xiao, S; Xie, Z; Yan, S; Yang, D; Yang, J; Zhang, G; Zhang, H; Zhang, J; Zhang, Q | 1 |
| Longo, FM; Massa, SM; Tran, KC; Yang, T; Zeng, AY | 1 |
| Bradshaw, PC; Griffin, JWD | 1 |
| Andrews, LE; Belichenko, NP; Condon, C; Gambhir, SS; Hoehne, A; James, ML; Jones, P; Longo, FM; Nguyen, TV; Rao, J; Reiser, V; Shuhendler, AJ; Trigg, W | 1 |
| Larsson, SC; Markus, HS | 1 |
| An, SSA; Bagyinszky, E; Jeong, JH; Kim, S; Koh, SB; Lee, HM; Van Giau, V | 1 |
| Arancio, O; Buckwalter, MS; Chang, T; Knowles, JK; Longo, FM; Massa, SM; Nguyen, TV; Pollak, J; Simmons, DA; Vander Griend, L; Wyss-Coray, T; Xie, Y; Yang, T; Zhang, H | 1 |
| Alvarez-Retuerto, AI; Benzinger, T; Chakraverty, S; Coppola, G; Fagan, A; Goate, A; Hecimovic, S; Kepe, V; Porter, V; Ringman, JM; Ting, SK | 1 |
| Banerjee, G; Belichenko, NP; Finkle, C; Knowles, JK; Longo, FM; Massa, SM; Simmons, DA | 1 |
| Achouri-Rassas, A; Anane, N; Belal, S; Ben Ali, N; Chabbi, S; Cherif, A; Fray, S; Gouider, R; Hadj Fredj, S; Kechaou, M; Messaoud, T; Zakraoui, NO | 1 |
| Chan, AO; Chiu, PK; Chu, LW; Law, CY; Lee, SC; See, CH; Shea, YF; Yiu, KL | 1 |
| Feng, X; Jia, J; Wang, W; Xie, Y; Zhang, G | 1 |
| Antane, M; Aschmies, SH; Atchison, KP; Casebier, DS; Cole, DC; Comery, TA; Diamantidis, G; Ellingboe, JW; Harrison, BL; Hu, Y; Jacobsen, JS; Jin, M; Kreft, AF; Kubrak, DM; Lu, P; Mann, CW; Martone, RL; Moore, WJ; Oganesian, A; Riddell, DR; Sonnenberg-Reines, J; Stock, JR; Sun, SC; Wagner, E; Wang, Z; Woller, KR; Xu, Z; Zhou, H | 1 |
| Fahrenholz, F; Schmitt, U; Schroeder, A | 1 |
| Blesa, R; Clarimón, J; Coma, M; Ferrer, I; Gómez-Isla, T; Guardia-Laguarta, C; Lladó, A; Lleó, A; Molinuevo, JL; Pera, M; Sánchez-Valle, R | 1 |
| Bird, TD; Jayadev, S; Klunk, W; Leverenz, JB; Stahl, J; Steinbart, E; Yu, CE | 1 |
| Chance, P; Church, A; Lillis, S; Morris, HR; Prescott, J; Rees, J; Williamson, K | 1 |
| Anfossi, M; Bernardi, L; Bruni, AC; Bugiani, O; Clodomiro, A; Colao, R; Curcio, SA; Di Lorenzo, R; Frangipane, F; Gallo, M; Geracitano, S; Ghidoni, E; Giaccone, G; Maletta, R; Marcello, N; Mirabelli, M; Muraca, G; Puccio, G; Smirne, N; Tagliavini, F; Vasso, F | 1 |
| Armstrong, AH; Chen, J; Hecht, MH; McKoy, AF | 1 |
| Brouwers, N; Funamoto, S; Ihara, Y; Iwata, N; Matsuba, Y; Mihira, N; Nilsson, P; Nishimura, M; Saido, TC; Saito, T; Sleegers, K; Suemoto, T; Takano, J; Van Broeckhoven, C; Yamada, K | 1 |
| Bartic, C; Benilova, I; Callewaert, G; Chong, SA; De Strooper, B; Devijver, H; Eberle, W; Moechars, D; Shaban, H; Van Leuven, F | 1 |
| Cagnin, A; Fabrizi, GM; Pompanin, S; Testi, S | 1 |
| Huster, D; Morgado, I; Scheidt, HA | 1 |
| Calero, M; Calero, O; Cuadrado-Corrales, N; de Pedro-Cuesta, J; Díaz-Hurtado, M; Ipiens, JR; López-Gastón, JI; Muñoz-Nieto, M; Ramón y Cajal, S; Ramonet, N | 1 |
| Govitrapong, P; Hernandez, JF; Htoo, HH; Jargaval, MR; Javagal, MR; Narasingapa, RB; Narasingappa, RB; Pullabhatla, S; Rao, JK; Vincent, B | 1 |
| Andreoli, V; Annesi, F; Cittadella, R; Gambardella, A; La Russa, A; Manna, I; Messina, D; Nicoletti, G; Quattrone, A; Romeo, N; Serra, P; Spadafora, P; Zappia, M | 1 |
| Aiso, S; Chiba, T; Iwatsubo, T; Kato, S; Kawasumi, M; Kouyama, K; Matsuoka, M; Miyamae-Kaneko, M; Nakahara, J; Nishimoto, I; Tomita, T; Yamada, M | 1 |
| Cittadella, R; La Bella, V; Liguori, M; Manna, I; Piccoli, F; Piccoli, T; Quattrone, A; Settipani, N | 1 |
| Cai, L; Chen, L; Jiang, S; Ren, D; Tang, G; Zhang, B | 1 |
| Berciano, J; Combarros, O; Infante, J; Llorca, J; Mateo, I; Rodríguez, E | 1 |
| Choi, CY; Ha, HJ; Han, JH; Jang, CH; Jeon, JH; Joung, H; Kim, H; Kim, HS; Kim, YH; Mook-Jung, I; Youm, JW | 1 |
| Cherubini, A; Ercolani, S; Ingegni, T; Mangialasche, F; Mariani, E; Mecocci, P; Metastasio, A; Nocentini, G; Pilotto, A; Senin, U; Seripa, D | 1 |
| Cuijt, I; De Deyn, PP; Kumar-Singh, S; Michalik, A; Pirici, D; Theuns, J; Van Broeck, B; Van Broeckhoven, C; Van Dam, D; Van der Linden, A; Vanhoutte, G; Vennekens, K; Wils, H; Zabielski, M | 1 |
| Almqvist, E; Axelman, K; Johansson, K; Lake, S; Winblad, B | 1 |
| Kamino, K; Kobayashi, H; Miki, T; Miyatake, T; Naruse, S; Onodera, O; Sakaki, Y; Seki, K; Shibata, A; Tanaka, H | 1 |
| Frackowiak, RS; Kennedy, AM; Lantos, P; Newman, S; Rossor, MN | 1 |
| Bryder, M; Bus, C; Jørgensen, AL; Jørgensen, P; Pallisgaard, N | 1 |
| Arthur, H; Broe, GA; Brooks, W; Creasey, H; Halliday, G | 1 |
| Lantos, PL; McLaughlin, JL; Revesz, T; Rossor, MN | 1 |
| Albert, M; Beisiegel, U; Binetti, G; Blacker, D; Clatworthy, A; Finckh, U; Gomez-Isla, T; Greenberg, SM; Growdon, JH; Hock, C; Hyman, BT; Liao, A; Mann, U; Mueller-Thomsen, T; Nitsch, RM; Rebeck, GW; Staehelin, H; Tanzi, RE; Zuchowski, K | 1 |
| Ihara, Y; Miyatake, T; Yanagisawa, K | 1 |
| Haines, JL; Huang, TL; Hyman, BT; Jenkins, BJ; Mortilla, M; Romano, DM; Tanzi, RE; Tupler, RG; Vaula, G; Wasco, W | 1 |
| Katsuya, T; Miki, T; Ogihara, T; Sakaki, Y; Yoshioka, K | 1 |
1 review(s) available for isoleucine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Alzheimer's disease families with amyloid precursor protein mutations.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Brain; Glycine; Humans; Isoleucine; Point Mutation; Valine | 1993 |
43 other study(ies) available for isoleucine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.
Topics: Acetone; Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Glutamates; Histidine; Humans; Isobutyrates; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Tyrosine; Valine | 2024 |
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression.
Topics: Alzheimer Disease; Amino Acids; Animals; Anti-Bacterial Agents; Bacteria; Clinical Trials, Phase III as Topic; Cognitive Dysfunction; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Humans; Isoleucine; Mannose; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Oligosaccharides; Phenylalanine; Th1 Cells | 2019 |
Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Disease Models, Animal; Green Fluorescent Proteins; Hippocampus; Isoleucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Neurites; Phosphorylation; Receptors, Nerve Growth Factor; rhoA GTP-Binding Protein; Signal Transduction; tau Proteins; Transfection | 2020 |
Residue Interaction Network Analysis Predicts a Val24-Ile31 Interaction May be Involved in Preventing Amyloid-Beta (1-42) Primary Nucleation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Databases, Protein; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Models, Molecular; Peptide Fragments; Protein Aggregation, Pathological; Protein Stability; Valine | 2021 |
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Topics: Alzheimer Disease; Animals; Carbazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Isoleucine; Mice; Microglia; Morpholines; Radiopharmaceuticals; Receptors, GABA; Sensitivity and Specificity | 2017 |
Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis.
Topics: Alzheimer Disease; Amino Acids, Branched-Chain; DEAD-box RNA Helicases; Genetic Pleiotropy; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Isoleucine; Mendelian Randomization Analysis; Nerve Tissue Proteins; Nucleocytoplasmic Transport Proteins; Odds Ratio; Polymorphism, Single Nucleotide; Protein Phosphatase 2C; Protein Precursors | 2017 |
Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Humans; Hydrogen Bonding; Isoleucine; Male; Middle Aged; Models, Molecular; Pedigree; Presenilin-1; Protein Structure, Secondary; Republic of Korea; Sequence Analysis, DNA; Structural Homology, Protein; Threonine | 2018 |
Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Disease Models, Animal; Female; Isoleucine; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Molecular Targeted Therapy; Morpholines; Nerve Degeneration; Neurites; Receptors, Nerve Growth Factor | 2013 |
A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Black or African American; Brain; Female; Green Fluorescent Proteins; HEK293 Cells; Humans; Isoleucine; Methionine; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Thiazoles; Transfection | 2014 |
A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cholinergic Neurons; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Female; Humans; Isoleucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Nerve Degeneration; Neurites; Protective Agents; Receptor, Nerve Growth Factor; Signal Transduction | 2014 |
Novel presenilin 1 mutation (p.I83T) in Tunisian family with early-onset Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Exons; Female; Genes, Dominant; Genetic Association Studies; Humans; Isoleucine; Male; Middle Aged; Mutation, Missense; Presenilin-1; Protein Structure, Tertiary; Threonine; Tunisia | 2015 |
Novel presenilin 1 mutation (p.F386I) in a Chinese family with early-onset Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Asian People; Codon; Female; Genes, Dominant; Genetic Association Studies; Heterozygote; Humans; Isoleucine; Male; Middle Aged; Mutation, Missense; Phenylalanine; Presenilin-1 | 2017 |
Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Apolipoprotein E4; Asian People; Cognition Disorders; DNA Mutational Analysis; Family Health; Female; Humans; Isoleucine; Magnetic Resonance Imaging; Male; Middle Aged; Mood Disorders; Mutation; Neuropsychological Tests; Valine | 2017 |
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Topics: Alcohols; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Drug Design; Humans; Isoleucine; Models, Chemical; Propanolamines; Receptor, Notch1; Sulfonamides | 2009 |
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
Topics: ADAM Proteins; ADAM10 Protein; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Disease Models, Animal; Glutamic Acid; Humans; Isoleucine; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time; Swimming; Valine | 2009 |
Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.
Topics: Adult; Age of Onset; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Enzyme-Linked Immunosorbent Assay; Humans; Isoleucine; Male; Mutation; Neurologic Examination; Phenylalanine; Transfection | 2010 |
Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Asparagine; Female; Genetic Carrier Screening; Genotype; Humans; Isoleucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Presenilin-2 | 2010 |
A novel presenilin 1 mutation, I202F occurring at a previously predicted pathogenic site causing autosomal dominant Alzheimer's disease.
Topics: Alzheimer Disease; Female; Humans; Isoleucine; Male; Middle Aged; Mutation; Phenylalanine; Predictive Value of Tests; Presenilin-1 | 2011 |
A novel pathogenic PSEN1 mutation in a family with Alzheimer's disease: phenotypical and neuropathological features.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Disease; Humans; Isoleucine; Male; Mental Status Schedule; Middle Aged; Mutation; Phenotype; Presenilin-1; Valine | 2011 |
Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amino Acids, Aromatic; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Leucine; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Phenylalanine; Protein Processing, Post-Translational | 2011 |
Potent amyloidogenicity and pathogenicity of Aβ43.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginine; Cell Line, Tumor; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Immunoprecipitation; Isoleucine; L-Lactate Dehydrogenase; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mutation; Neuroblastoma; Neurons; Peptide Fragments; Presenilin-1 | 2011 |
Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Electrodes; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Isoleucine; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; Synapses; tau Proteins; Time Factors; Valine | 2011 |
Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene.
Topics: Alzheimer Disease; Cognition Disorders; DNA Mutational Analysis; Family Health; Female; Genetic Association Studies; Humans; Isoleucine; Language Disorders; Magnetic Resonance Imaging; Methionine; Middle Aged; Mutation; Presenilin-2; Tomography, Emission-Computed, Single-Photon | 2012 |
Solid-state NMR reveals a close structural relationship between amyloid-β protofibrils and oligomers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Glutamic Acid; Humans; Hydrogen Bonding; Isoleucine; Models, Chemical; Neurofibrillary Tangles; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary | 2012 |
A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer's diseases in three patients with divergent clinical phenotypes.
Topics: 14-3-3 Proteins; Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Creutzfeldt-Jakob Syndrome; Glial Fibrillary Acidic Protein; Humans; Isoleucine; Male; Models, Molecular; Mutation; Phenotype; Prion Proteins; Prions; Spain; Valine | 2013 |
Activation of α-secretase by curcumin-aminoacid conjugates.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Curcumin; Enzyme Activation; HEK293 Cells; Humans; Isoleucine; Membrane Proteins; Phenylalanine; Valine | 2012 |
Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.
Topics: Age of Onset; Aged; alpha-Macroglobulins; Alzheimer Disease; Apolipoproteins E; Case-Control Studies; Chi-Square Distribution; Confidence Intervals; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Isoleucine; Italy; Male; Middle Aged; Odds Ratio; Peroxidase; Polymerase Chain Reaction; Polymorphism, Genetic; Risk; Valine | 2004 |
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
Topics: Age Factors; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blotting, Southern; Brain Chemistry; Choice Behavior; Disease Models, Animal; Female; Genotype; Humans; Immunohistochemistry; Isoleucine; Male; Maze Learning; Mice; Mice, Transgenic; Molecular Sequence Data; Motor Activity; Mutation; Neurofibrillary Tangles; Peptide Fragments; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors; Survival Rate; tau Proteins; Valine | 2004 |
A novel mutation (Thr116Ile) in the presenilin 1 gene in a patient with early-onset Alzheimer's disease.
Topics: Alzheimer Disease; DNA Mutational Analysis; Female; Humans; Isoleucine; Membrane Proteins; Middle Aged; Mutation; Presenilin-1; Threonine | 2004 |
Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.
Topics: Adult; Aged; Aged, 80 and over; alpha-Macroglobulins; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoproteins E; Asian People; Aspartic Acid Endopeptidases; Chi-Square Distribution; China; DNA Mutational Analysis; Endopeptidases; Female; Gene Frequency; Genotype; Humans; Isoleucine; Male; Meta-Analysis as Topic; Middle Aged; Polymorphism, Genetic; Valine | 2005 |
Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Carrier Proteins; Cholesterol Ester Transfer Proteins; Confidence Intervals; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycoproteins; Humans; Isoleucine; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Risk Factors; Spain; Valine | 2006 |
Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Brain; Cell Line; Cell Survival; Disease Models, Animal; Escherichia coli; Humans; Immunization; Isoleucine; Mice; Mice, Transgenic; Models, Biological; Molecular Sequence Data; Plants, Genetically Modified; Plaque, Amyloid; Solanum tuberosum; Tandem Repeat Sequences; Time Factors; Vaccines | 2005 |
Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alanine; alpha-Macroglobulins; Alzheimer Disease; Cathepsin D; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Isoleucine; Male; Odds Ratio; Polymorphism, Genetic; Risk; Valine | 2006 |
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Animal; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Isoleucine; Magnetic Resonance Imaging; Maze Learning; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Psychomotor Performance; Tyrosine | 2008 |
Screening of amyloid precursor protein gene mutation (APP 717 Val-->Ile) in Swedish families with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Chromosomes, Human, Pair 21; Down Syndrome; Genetic Testing; Humans; Isoleucine; Middle Aged; Mutation; Polymerase Chain Reaction; Sweden; Valine | 1993 |
Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val-->Ile mutation.
Topics: Alleles; Alzheimer Disease; Amyloid beta-Protein Precursor; Humans; Isoleucine; Japan; Linkage Disequilibrium; Mutation; Polymorphism, Genetic; Valine | 1993 |
Familial Alzheimer's disease co-segregates with a Met146I1e substitution in presenilin-1.
Topics: Adult; Aged; Alzheimer Disease; Female; Humans; Isoleucine; Male; Membrane Proteins; Methionine; Pedigree; Presenilin-1 | 1996 |
Further evidence for an association between a mutation in the APP gene and Lewy body formation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Brain; Chromosomes, Human, Pair 21; Female; Humans; Isoleucine; Lewy Bodies; Middle Aged; Point Mutation | 1997 |
Pathology of familial Alzheimer's disease with Lewy bodies.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Brain; Brain Chemistry; Cytoskeletal Proteins; Female; Humans; Immunohistochemistry; Isoleucine; Lewy Bodies; Male; Middle Aged; Mutation; Neurofibrillary Tangles; Pedigree; Plaque, Amyloid | 1997 |
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Topics: Alleles; alpha-Macroglobulins; Alzheimer Disease; Amyloid beta-Peptides; DNA; Female; Gene Frequency; Genotype; Humans; Isoleucine; Logistic Models; Male; Multivariate Analysis; Neurofibrillary Tangles; Odds Ratio; Polymorphism, Genetic; Valine | 1998 |
Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Cells, Cultured; Humans; Isoleucine; Mutation; Nervous System Diseases; Valine | 1992 |
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Base Sequence; DNA; DNA Mutational Analysis; Humans; Isoleucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Recombination, Genetic; Valine | 1992 |
The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Base Sequence; Ethnicity; Exons; Female; Humans; Isoleucine; Japan; Male; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Pedigree; Polymerase Chain Reaction; Protein Precursors; Valine; White People | 1991 |