isoindigotin has been researched along with Leukemia, Promyelocytic, Acute in 2 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aljada, A; Aziz, MA; El-Abadelah, MM; Sabri, SS; Saleh, AM; Taha, MO; Zahra, JA | 1 |
| Aljada, A; Aziz, MA; El-Abadelah, MM; Nasr, A; Sabri, SS; Saleh, AM; Zahra, JA | 1 |
2 other study(ies) available for isoindigotin and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
The anticancer activity of the substituted pyridone-annelated isoindigo (5'-Cl) involves G0/G1 cell cycle arrest and inactivation of CDKs in the promyelocytic leukemia cell line HL-60.
Topics: Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; G1 Phase Cell Cycle Checkpoints; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Molecular Docking Simulation; Phosphorylation; Pyridones; Retinoblastoma Protein | 2015 |
The pyridone-annelated isoindigo (5'-Cl) induces apoptosis, dysregulation of mitochondria and formation of ROS in leukemic HL-60 cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cytochromes c; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridones; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates | 2015 |