isoguvacine has been researched along with Seizures in 4 studies
isoguvacine: A GABA agonist; RN given refers to parent cpd; structure
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The immature brain is prone to seizures but the underlying mechanisms are poorly understood." | 1.32 | Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. ( Ben-Ari, Y; Holmes, GL; Khalilov, I; Khazipov, R; Morozova, E; Tyzio, R, 2004) |
| "Isoguvacine pre-treatment prevented the increase in DOPAC concentrations in the median eminence produced by SR 95531." | 1.29 | GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat. ( Goudreau, JL; Lookingland, KJ; Moore, KE; Wagner, EJ, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naderi, N | 1 |
| Ahmad-Molaei, L | 1 |
| Aziz Ahari, F | 1 |
| Motamedi, F | 1 |
| Khazipov, R | 2 |
| Khalilov, I | 1 |
| Tyzio, R | 1 |
| Morozova, E | 1 |
| Ben-Ari, Y | 1 |
| Holmes, GL | 2 |
| Isaev, D | 1 |
| Isaeva, E | 1 |
| Wagner, EJ | 1 |
| Goudreau, JL | 1 |
| Moore, KE | 1 |
| Lookingland, KJ | 1 |
4 other studies available for isoguvacine and Seizures
| Article | Year |
|---|---|
Modulation of anticonvulsant effects of cannabinoid compounds by GABA-A receptor agonist in acute pentylenetetrazole model of seizure in rat.
Topics: Animals; Anticonvulsants; Benzamides; Benzoxazines; Biphenyl Compounds; Brain; Calcium Channel Block | 2011 |
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Disease Susceptibility; Excitatory Postsynaptic Poten | 2004 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 2005 |
GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Baclofen; Dopamine; GABA Agonists; GABA Antagonists; gamma- | 1994 |