isoguvacine has been researched along with Drug Withdrawal Symptoms in 1 studies
isoguvacine: A GABA agonist; RN given refers to parent cpd; structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves of isoguvacine, a specific GABAA agonist, showed a shift to the right for the intrinsic bursting cells whatever the parameter measured (depolarization or conductance increase): the ED50 was 50-100 times higher for intrinsic bursting cells than for other non-intrinsic bursting cells, thus indicating that intrinsic bursting cells are tolerant to GABAA agonist." | 1.28 | Relationship between tolerance to GABAA agonist and bursting properties in neocortical neurons during GABA-withdrawal syndrome. ( Brailowsky, S; Champagnat, J; Menini, C; Naquet, R; Silva-Barrat, C, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silva-Barrat, C | 1 |
| Champagnat, J | 1 |
| Brailowsky, S | 1 |
| Menini, C | 1 |
| Naquet, R | 1 |
1 other study available for isoguvacine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Relationship between tolerance to GABAA agonist and bursting properties in neocortical neurons during GABA-withdrawal syndrome.
Topics: Animals; Cerebral Cortex; Drug Tolerance; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techn | 1989 |