isogranulatimide and Lung-Neoplasms

isogranulatimide has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for isogranulatimide and Lung-Neoplasms

ArticleYear
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
    Cancer research, 1998, Dec-15, Volume: 58, Issue:24

    Treatment of cancer cells lacking p53 function with G2 checkpoint inhibitors sensitizes them to the toxic effects of DNA damage and has been proposed as a strategy for cancer therapy. However, few inhibitors are known, and they have been found serendipitously. We report the development of a G2 checkpoint inhibition assay that is suitable for high-throughput screening and its application to a screen of 1300 natural extracts. We present the isolation of a new G2 checkpoint inhibitor, the structurally novel compound isogranulatimide. In combination with gamma-irradiation, isogranulatimide selectively kills MCF-7 cells lacking p53 function.

    Topics: Adenocarcinoma; Animals; Breast Neoplasms; DNA Repair; G2 Phase; Genes, p53; Humans; Imidazoles; Indoles; Lung Neoplasms; Radiation-Sensitizing Agents; Staurosporine; Succinimides; Tumor Cells, Cultured

1998