isoflurophate has been researched along with Status Epilepticus in 22 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model." | 7.96 | Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats. ( Bruun, DA; Calsbeek, J; Dhir, A; González, E; Guignet, M; Harvey, DJ; Lein, PJ; Rogawski, MA; Saito, N; Tancredi, DJ; Tsai, YH; Vu, J, 2020) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 5.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model." | 3.96 | Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats. ( Bruun, DA; Calsbeek, J; Dhir, A; González, E; Guignet, M; Harvey, DJ; Lein, PJ; Rogawski, MA; Saito, N; Tancredi, DJ; Tsai, YH; Vu, J, 2020) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "By contrast, astrogliosis was unaffected by EP2 inhibition 4 d after DFP." | 1.42 | Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus. ( Dingledine, R; Ganesh, T; Gueorguieva, P; Lelutiu, N; Rojas, A, 2015) |
| "Diazepam (10mg/kg) was administered 10min and 30min after the onset of continuous EEG seizures induced by paraoxon and it terminated SE in a majority of animals at both time points." | 1.38 | Characterization of status epilepticus induced by two organophosphates in rats. ( Balint, CA; Cowan, ML; Kapur, J; Sun, C; Todorovic, MS, 2012) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 1.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 13 (59.09) | 2.80 |
| Authors | Studies |
|---|---|
| Calsbeek, JJ | 1 |
| González, EA | 1 |
| Bruun, DA | 4 |
| Guignet, MA | 1 |
| Copping, N | 1 |
| Dawson, ME | 1 |
| Yu, AJ | 1 |
| MacMahon, JA | 1 |
| Saito, NH | 1 |
| Harvey, DJ | 5 |
| Silverman, JL | 2 |
| Lein, PJ | 5 |
| Rojas, A | 6 |
| Abreu-Melon, J | 2 |
| Wang, S | 2 |
| Dingledine, R | 6 |
| Putra, M | 2 |
| Gage, M | 2 |
| Sharma, S | 2 |
| Gardner, C | 1 |
| Gasser, G | 1 |
| Anantharam, V | 1 |
| Thippeswamy, T | 2 |
| Golden, M | 1 |
| Wang, J | 3 |
| Glover, A | 1 |
| Enderlin, J | 2 |
| Igert, A | 2 |
| Auvin, S | 2 |
| Nachon, F | 2 |
| Dal Bo, G | 2 |
| Dupuis, N | 2 |
| Spampanato, J | 1 |
| Bealer, SL | 1 |
| Smolik, M | 1 |
| Dudek, FE | 1 |
| Dhir, A | 2 |
| Guignet, M | 2 |
| Tsai, YH | 1 |
| González, E | 1 |
| Calsbeek, J | 1 |
| Vu, J | 1 |
| Saito, N | 1 |
| Tancredi, DJ | 1 |
| Rogawski, MA | 2 |
| McCarren, HS | 1 |
| Wang, W | 2 |
| McDonough, JH | 1 |
| Maupu, C | 1 |
| Oger, M | 1 |
| Hassan-Abdi, R | 1 |
| Soussi-Yanicostas, N | 1 |
| Brazzolotto, X | 1 |
| Reddy, DS | 2 |
| Zaayman, M | 1 |
| Kuruba, R | 2 |
| Wu, X | 2 |
| Sisó, S | 1 |
| Hobson, BA | 3 |
| Rowland, DJ | 2 |
| Garbow, JR | 2 |
| Supasai, S | 1 |
| Ganesh, T | 3 |
| Dhakal, K | 1 |
| Flannery, BM | 1 |
| Zolkowska, D | 1 |
| Li, S | 1 |
| Wahab, A | 1 |
| Lelutiu, N | 1 |
| Gueorguieva, P | 1 |
| Manji, Z | 1 |
| O'neill, T | 1 |
| Kadriu, B | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Auta, J | 1 |
| Demar, JC | 1 |
| Clarkson, ED | 1 |
| Ratcliffe, RH | 1 |
| Campbell, AJ | 1 |
| Thangavelu, SG | 1 |
| Herdman, CA | 1 |
| Leader, H | 1 |
| Schulz, SM | 1 |
| Marek, E | 1 |
| Medynets, MA | 1 |
| Ku, TC | 1 |
| Evans, SA | 1 |
| Khan, FA | 1 |
| Owens, RR | 1 |
| Nambiar, MP | 1 |
| Gordon, RK | 1 |
| Deshpande, LS | 1 |
| Carter, DS | 1 |
| Blair, RE | 1 |
| DeLorenzo, RJ | 1 |
| Todorovic, MS | 1 |
| Cowan, ML | 1 |
| Balint, CA | 1 |
| Sun, C | 1 |
| Kapur, J | 1 |
2 reviews available for isoflurophate and Status Epilepticus
| Article | Year |
|---|---|
A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Indoles; Isoflurophate; Organophosphate | 2020 |
Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Inflammation; Isoflurophate; Male; Neuroto | 2020 |
20 other studies available for isoflurophate and Status Epilepticus
| Article | Year |
|---|---|
Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Electroence | 2021 |
Time-dependent neuropathology in rats following organophosphate-induced status epilepticus.
Topics: Animals; Brain; Disease Models, Animal; Isoflurophate; Organophosphate Poisoning; Organophosphates; | 2022 |
Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model.
Topics: Acetophenones; Animals; Biphenyl Compounds; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hi | 2020 |
Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity.
Topics: Animals; Brain; Disease Models, Animal; Female; Isoflurophate; Male; Neurotoxicity Syndromes; Rats; | 2020 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure.
Topics: Animals; Brain; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; Electrocorticogra | 2020 |
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Dexmedetomidine; Disease Models, Animal; Dose-Response | 2020 |
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Drug Therapy, Combination; Electroencephalography; Isoflurophate; Male; M | 2020 |
Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Waves; Cell Death; Cyclooxygenase 2; Disease Models, Anim | 2021 |
Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice.
Topics: Animals; Cholinesterase Inhibitors; Isoflurophate; Male; Mice; Neuroglia; Neurotoxicity Syndromes; P | 2021 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Cholinesterase Inhibitors; Isoflurophate; Male; Necros | 2017 |
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.
Topics: Animals; Brain Injuries; Disease Models, Animal; Isoflurophate; Magnetic Resonance Imaging; Male; Ra | 2018 |
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Body Weight; Chemokines; Cholinesterase Inhibitors; | 2015 |
Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats.
Topics: Animals; Anxiety; Brain; Discrimination, Psychological; Disease Models, Animal; Electroencephalograp | 2016 |
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Brain; Cholinesterase Inhibitors; Diaze | 2009 |
Pro-2-PAM therapy for central and peripheral cholinesterases.
Topics: Acetylcholinesterase; Animals; Apoptosis; Brain; Central Nervous System; Cholinesterase Reactivators | 2010 |
Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.
Topics: Animals; Calcium; Dizocilpine Maleate; Electroencephalography; Hippocampus; Isoflurophate; Male; Rat | 2010 |
Characterization of status epilepticus induced by two organophosphates in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Electroencephalography; Isoflurophate; Male; Ne | 2012 |