isoflurophate has been researched along with Sensitivity and Specificity in 17 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A physiologically-based pharmacokinetic and pharmacodynamic (PBPK/PD) model was recently developed to study the effect of diisopropylfluorophosphate (DFP) on acetylcholinesterase (AChE) activity in mouse and rat." | 1.35 | Sensitivity analysis on a physiologically-based pharmacokinetic and pharmacodynamic model for diisopropylfluorophosphate-induced toxicity in mice and rats. ( Chen, K; Seng, KY; Teo, S, 2009) |
| " BaP was the most toxic of all PAHs tested, and anthracene failed to produce a toxic response at any concentration tested." | 1.32 | Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures. ( Donnelly, KC; Mumtaz, MM; Tang, Y; Tiffany-Castiglioni, E, 2003) |
| "Full toxicologic profiles of chemical mixtures, including dose-response extrapolations to realistic exposures, is a prohibitive analytical problem, even for a restricted class of chemicals." | 1.31 | Protein binding of isofluorophate in vivo after coexposure to multiple chemicals. ( Buchholz, BA; Keating, GA; Vogel, JS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, M | 1 |
| Terry, AV | 1 |
| Bartlett, MG | 1 |
| Chen, K | 1 |
| Teo, S | 1 |
| Seng, KY | 1 |
| Vogel, JS | 1 |
| Keating, GA | 1 |
| Buchholz, BA | 1 |
| Tang, Y | 1 |
| Donnelly, KC | 1 |
| Tiffany-Castiglioni, E | 1 |
| Mumtaz, MM | 1 |
| Makower, A | 1 |
| Halámek, J | 1 |
| Skládal, P | 1 |
| Kernchen, F | 1 |
| Scheller, FW | 1 |
| NAESS, K | 1 |
| HOFSTEE, BH | 1 |
| Kropp, TJ | 1 |
| Richardson, RJ | 1 |
| Darzynkiewicz, Z | 1 |
| Rogers, AW | 1 |
| Barnard, EA | 1 |
| Lassiter, TL | 1 |
| Brimijoin, S | 1 |
| Ramanathan, M | 1 |
| Simonian, AL | 1 |
| Lucena-Fernandes, F | 1 |
| Dalpé, G | 1 |
| Dagenais, P | 1 |
| Richard, C | 1 |
| Calvert, R | 1 |
| Boire, G | 1 |
| Ménard, HA | 1 |
| Vicedo, JL | 1 |
| Carrera, V | 1 |
| Barril, J | 1 |
| Vilanova, E | 1 |
| Rose, C | 1 |
| Vargas, F | 1 |
| Bourgeat, P | 1 |
| Schwartz, JC | 1 |
| Grouls, RJ | 1 |
| Machielsen, E | 1 |
| Korsten, HH | 1 |
| Hellebrekers, LJ | 1 |
| Breimer, DD | 1 |
| Ackerman, EW | 1 |
| Li, W | 1 |
| Casida, JE | 1 |
| Lees, JE | 1 |
| Richards, PG | 1 |
17 other studies available for isoflurophate and Sensitivity and Specificity
| Article | Year |
|---|---|
Determination of diisopropylfluorophosphate in rat plasma and brain tissue by headspace solid-phase microextraction gas chromatography/mass spectrometry.
Topics: Animals; Brain Chemistry; Gas Chromatography-Mass Spectrometry; Isoflurophate; Male; Microchemistry; | 2008 |
Sensitivity analysis on a physiologically-based pharmacokinetic and pharmacodynamic model for diisopropylfluorophosphate-induced toxicity in mice and rats.
Topics: Acetylcholinesterase; Animals; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Confidence In | 2009 |
Protein binding of isofluorophate in vivo after coexposure to multiple chemicals.
Topics: Animals; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; D | 2002 |
Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures.
Topics: Amino Acids; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions | 2003 |
New principle of direct real-time monitoring of the interaction of cholinesterase and its inhibitors by piezolectric biosensor.
Topics: Biosensing Techniques; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrochemistry; Enzymes, | 2003 |
The specificity of diisopropylfluorophosphate (DFP).
Topics: Acetylcholine; Humans; Isoflurophate; Muscles; Sensitivity and Specificity | 1956 |
SOME ASPECTS OF THE SPECIFICITY OF FATTY ACID ESTERASES.
Topics: Acetylesterase; Biochemical Phenomena; Biochemistry; Esterases; Fatty Acids; Isoflurophate; Pharmaco | 1964 |
Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Humans; Isoflurophate; Kinetics; Mass Spectrometry; | 2006 |
The number of acetylcholinesterase molecules in the rat megakaryocyte.
Topics: Acetylcholinesterase; Animals; Autoradiography; Isoflurophate; Male; Megakaryocytes; Phosphorus Radi | 1966 |
A method to determine precise benchmark doses for carbamate anticholinesterases.
Topics: Animals; Biological Assay; Brain; Carbamates; Centrifugation; Cholinesterase Inhibitors; Cholinester | 2007 |
Array biosensor based on enzyme kinetics monitoring by fluorescence spectroscopy: application for neurotoxins detection.
Topics: Biosensing Techniques; Enzyme Stability; Enzymes, Immobilized; Hydrogen-Ion Concentration; Isoflurop | 2007 |
Detection of anti-neutrophil cytoplasmic antibodies by immunoprecipitation.
Topics: Adult; Aged; Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Enzyme-Linked Immunosorbent Ass | 1995 |
Properties of partly preinhibited hen brain neuropathy target esterase.
Topics: Animals; Binding Sites; Brain; Carboxylic Ester Hydrolases; Chickens; Female; Isoflurophate; Kinetic | 1993 |
A radioimmunoassay for the tripeptide Gly-Trp-Met, a major metabolite of endogenous cholecystokinin in brain.
Topics: Amino Acid Sequence; Animals; Benzoquinones; Cerebral Cortex; Cholecystokinin; Chromatography, High | 1996 |
Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples.
Topics: Anesthetics, Local; Animals; Benzocaine; Blood Specimen Collection; Calibration; Cholinesterase Inhi | 1995 |
Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells.
Topics: Acetylcholinesterase; Animals; Carboxylic Ester Hydrolases; Cell Differentiation; Cell Survival; Chl | 1998 |
Rapid, high-sensitivity imaging of radiolabeled gels with microchannel plate detectors.
Topics: Animals; Brain Chemistry; Electrophoresis; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, P | 1999 |