isoflurophate has been researched along with Organophosphorus Poisoning in 30 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure." | 5.72 | Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| " Combined treatments of organophosphate poisoning with atropine and obidoxime chloride in the high doses of 7." | 3.67 | [The effect of organophosphates on heart ATPase in the rat]. ( Dierkes-Tizek, U; Glaser, U; Hettwer, H; Oldiges, H, 1984) |
| "Exposures to seizure-inducing chemical threat agents are a major public health concern." | 2.53 | Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. ( Bruun, DA; Hammock, BD; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Wulff, H; Zolkowska, D, 2016) |
| " We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure." | 1.72 | Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022) |
| "In addition to these epileptiform seizure-like events, DFP-exposed larvae showed increased neuronal apoptosis, which were both partially alleviated by diazepam treatment, suggesting a causal link between neuronal hyperexcitation and cell death." | 1.56 | Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death. ( Bar, O; Brenet, A; Dal-Bo, G; Dupuis, N; Hassan-Abdi, R; Igert, A; Nachon, F; Romain, C; Saurat, D; Somkhit, J; Soussi-Yanicostas, N; Taudon, N; Yanicostas, C, 2020) |
| "DFP triggered rapid and sustained seizure behavior irrespective of PB pretreatment, and there was no significant difference in average seizure behavior score during the first 4 h following injection between DFP animals pretreated with PB or not." | 1.51 | Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. ( Bruun, DA; Guignet, M; Harvey, DJ; Lein, PJ, 2019) |
| "Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavioral disorders; however, early treatment will not be possible after mass release of OPs or NAs." | 1.51 | Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. ( Bealer, SL; Dudek, FE; Pouliot, W; Roach, B; Spampanato, J, 2019) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "Memantine promotes oxime-induced erythrocyte enzyme reactivation on the model of mice poisoning with anticholinesterase compound (0." | 1.39 | [Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate]. ( Bykov, VN; Chepur, SV; Iudin, MA; Ivanov, IM; Kurpiakova, AF; Nikiforov, AS; Subbotina, SN, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (63.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rojas, A | 2 |
| Abreu-Melon, J | 1 |
| Wang, S | 1 |
| Dingledine, R | 2 |
| Somkhit, J | 2 |
| Yanicostas, C | 2 |
| Soussi-Yanicostas, N | 2 |
| Piel, S | 3 |
| Janowska, JI | 3 |
| Ward, JL | 3 |
| McManus, MJ | 3 |
| Jose, JS | 3 |
| Starr, J | 3 |
| Sheldon, M | 3 |
| Clayman, CL | 3 |
| Elmér, E | 3 |
| Hansson, MJ | 3 |
| Jang, DH | 3 |
| Karlsson, M | 3 |
| Ehinger, JK | 3 |
| Kilbaugh, TJ | 3 |
| Brenet, A | 1 |
| Hassan-Abdi, R | 1 |
| Romain, C | 1 |
| Bar, O | 1 |
| Igert, A | 1 |
| Saurat, D | 1 |
| Taudon, N | 1 |
| Dal-Bo, G | 1 |
| Nachon, F | 1 |
| Dupuis, N | 1 |
| Wu, X | 1 |
| Kuruba, R | 1 |
| Reddy, DS | 1 |
| Ganesh, T | 1 |
| Wang, W | 1 |
| Wang, J | 1 |
| Bruun, DA | 3 |
| Guignet, M | 2 |
| Harvey, DJ | 2 |
| Lein, PJ | 3 |
| Dhakal, K | 1 |
| Flannery, BM | 1 |
| Hobson, BA | 1 |
| Zolkowska, D | 2 |
| Dhir, A | 1 |
| Li, S | 1 |
| Wahab, A | 1 |
| Silverman, JL | 1 |
| Rogawski, MA | 2 |
| Spampanato, J | 1 |
| Pouliot, W | 1 |
| Bealer, SL | 1 |
| Roach, B | 1 |
| Dudek, FE | 1 |
| Iudin, MA | 1 |
| Chepur, SV | 1 |
| Bykov, VN | 1 |
| Kurpiakova, AF | 1 |
| Subbotina, SN | 1 |
| Nikiforov, AS | 1 |
| Ivanov, IM | 1 |
| Pessah, IN | 1 |
| Tancredi, DJ | 1 |
| Wulff, H | 1 |
| Hammock, BD | 1 |
| BETHE, K | 1 |
| ERDMANN, WD | 1 |
| LENDLE, L | 1 |
| SCHMIDT, G | 1 |
| HOBBIGER, F | 1 |
| SADLER, PW | 1 |
| SIMON, G | 1 |
| SASVARI, K | 1 |
| GAL, M | 1 |
| SZUECS, J | 1 |
| HEATH, DF | 1 |
| HESS, AR | 1 |
| ANGEL, RW | 1 |
| BARRON, KD | 1 |
| BERNSOHN, J | 1 |
| BROWNLEE, G | 1 |
| JOHNSON, ES | 1 |
| MAIN, AR | 1 |
| GIULIANI, G | 1 |
| Dierkes-Tizek, U | 1 |
| Glaser, U | 1 |
| Oldiges, H | 1 |
| Hettwer, H | 1 |
| Jaiswal, DK | 1 |
| Pant, BP | 1 |
| Das Gupta, S | 1 |
| Ghosh, AK | 1 |
| Moorthy, MV | 1 |
| Lüllmann, H | 1 |
| Schmaus, H | 1 |
| Staemmler, C | 1 |
| Ziegler, A | 1 |
| Grudzińska, E | 1 |
| Gidyńska, T | 1 |
| Rump, S | 3 |
| Faff, J | 3 |
| Borkowska, G | 2 |
| Ilczuk, I | 1 |
| Rabsztyn, T | 2 |
| Bak, W | 1 |
| Kaliste-Korhonen, E | 1 |
| Ryhänen, R | 1 |
| Ylitalo, P | 1 |
| Hänninen, O | 1 |
| Preston, E | 1 |
| Heath, C | 1 |
| Meeter, E | 1 |
| Wolthuis, OL | 1 |
| van Benthem, RM | 1 |
| Bonderman, RP | 1 |
| Bonderman, DP | 1 |
4 reviews available for isoflurophate and Organophosphorus Poisoning
| Article | Year |
|---|---|
A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Indoles; Isoflurophate; Organophosphate | 2020 |
Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Inflammation; Isoflurophate; Male; Neuroto | 2020 |
Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.
Topics: Animals; Anticonvulsants; Brain; Bridged-Ring Compounds; Cholinesterase Inhibitors; Disease Models, | 2016 |
SOME CENTRAL EFFECTS OF ORGANOPHOSPHORUS ANTICHOLINESTERASES.
Topics: Atropine; Cats; Cell Respiration; Cholinesterase Inhibitors; Diphosphates; Dogs; Isoflurophate; Orga | 1963 |
26 other studies available for isoflurophate and Organophosphorus Poisoning
| Article | Year |
|---|---|
Time-dependent neuropathology in rats following organophosphate-induced status epilepticus.
Topics: Animals; Brain; Disease Models, Animal; Isoflurophate; Organophosphate Poisoning; Organophosphates; | 2022 |
Microglia Remodelling and Neuroinflammation Parallel Neuronal Hyperactivation Following Acute Organophosphate Poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Cytokines; Humans; Isofl | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death.
Topics: Acetylcholinesterase; Animals; Apoptosis; Behavior, Animal; Brain; Calcium; Cell Death; Isoflurophat | 2020 |
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; GPI-Linked | 2019 |
Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Isoflurophate; Male; Midazolam; Neuroprotective Ag | 2019 |
[Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate].
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Brain; Butyrylcholinesterase; Cholinesterase Inhibit | 2013 |
[Specific antidote treatment in protracted poisoning with alkylphosphates (paraoxon, parathion, DFP) & eserin in guinea pigs].
Topics: Animals; Antidotes; Dental Care; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Human | 1957 |
Protection against lethal organophosphate poisoning by quaternary pyridine aldoximes.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Hydroxylamines; Isoflurophate; Mice; Neosti | 1959 |
[THE EFFECT OF VITAMIN E ADMINISTRATION ON THE CHOLINESTERASE ACTIVITY OF THE SERUM AND ERYTHROCYTES].
Topics: Blood; Cholinesterases; Cresols; Erythrocytes; Isoflurophate; Neostigmine; Organophosphate Poisoning | 1963 |
PROTEINS AND ISOZYMES OF ESTERASES AND CHOLINESTERASES FROM SERA OF DIFFERENT SPECIES.
Topics: Acetylcholinesterase; Animals; Blood Chemical Analysis; Blood Protein Electrophoresis; Blood Protein | 1963 |
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Choline; Ganglia; Ganglia, Autonomic; Ganglionic B | 1963 |
AFFINITY AND PHOSPHORYLATION CONSTANTS FOR THE INHIBITION OF ESTERASES BY ORGANOPHOSPHATES.
Topics: Chemical Phenomena; Chemistry; Cholinesterases; Enzyme Inhibitors; Esterases; Isoflurophate; Kinetic | 1964 |
[TREATMENT OF MYASTHENIA].
Topics: Adrenocorticotropic Hormone; Cyclopropanes; Epinephrine; Galantamine; Humans; Hypnotics and Sedative | 1964 |
[The effect of organophosphates on heart ATPase in the rat].
Topics: Adenosine Triphosphatases; Animals; Antidotes; Atropine; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting | 1984 |
Studies on thiohydroximic thioesters in combination with pyridine aldoximes in acute organophosphorus poisoning.
Topics: Animals; Atropine; Dichlorvos; Isoflurophate; Organophosphate Poisoning; Oximes; Rats | 1983 |
Comparison of atropine and dexetimide in treatment of intoxications by selected organophosphates.
Topics: Animals; Atropine; Dexetimide; Diet; Guinea Pigs; Insecticides; Isoflurophate; Lethal Dose 50; Mice; | 1982 |
Therapeutic value of anticonvulsant drugs in poisonings with an organophosphate.
Topics: Animals; Anticonvulsants; Atropine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fem | 1979 |
Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cholinesterase Inhibitors; Electroencephalography; Female | 1978 |
Therapeutic effects of some cholinolytics in organophosphate intoxications.
Topics: Animals; Antidotes; Atropine; Benzilates; Dichlorvos; Echothiophate Iodide; Isoflurophate; Lethal Do | 1976 |
Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice.
Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Cold Tempera | 1989 |
Investigations on the correlation between abnormalities of neuromuscular transmission due to some organophosphates and activity of acetylcholinesterase in the skeletal muscle.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Echothiophate Iodide; Isoflurophate; Male; | 1973 |
Atropine-insensitive vasodilatation and hypotension in the organophosphate-poisoned rabbit.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cholinesterase Inhibitors; Forelimb; Heart Rate; H | 1972 |
The anticholinesterase hypothermia in the rat: its practical application in the study of the central effectiveness of oximes.
Topics: Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Ethylamines; Hypothermia; Isoflurophate; Ma | 1971 |
Atypical and inhibited human serum pseudocholinesterase. A titrimetric method for differentiation.
Topics: Cholinesterase Inhibitors; Cholinesterases; Clinical Enzyme Tests; Dibucaine; Insecticides; Isofluro | 1971 |