isoflurophate has been researched along with Nervous System Disorders in 36 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intraperitoneal administration of DEF (tributyl phosphorotrithiolate) and Merphos (tributyl phosphorotrithioite) produced central and perpheral nervous system lesions accompanied by clinical signs of ataxia similar to those seen following administration of tri-o-cresyl phosphate." | 3.64 | NEUROLOGICAL DISRUPTION PRODUCED IN HENS BY TWO ORGANOPHOSPHATE ESTERS. ( BARON, RL; JOHNSON, H, 1964) |
| " This kind of interaction among esterase inhibitors should be considered to study the potentiation/promotion phenomenon, which is observed when some esterase inhibitors enhance the severity of the OP induced neuropathy if they are dosed after a non neuropathic low dose of a neuropathy inducer." | 1.39 | Interactions of neuropathy inducers and potentiators/promoters with soluble esterases. ( Estévez, J; Mangas, I; Sogorb, MÁ; Vilanova, E, 2013) |
| " However, if PMSF is dosed after a low non-neuropathic dose of a neuropathic OP, its neurotoxicity is 'promoted', causing severe neuropathy." | 1.30 | Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter. ( Barril, J; Céspedes, MV; Escudero, MA; Sogorb, MA; Vicedo, JL; Vilanova, E, 1997) |
| "Atropine and 2-PAM were administered to chlorpyrifos exposed cats one to two times a day for 14 to 24 days in response to the appearance of cholinergic signs." | 1.28 | Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat. ( Beasley, VR; Fikes, JD; Parker, AJ; Zachary, JF, 1992) |
| " In rats, these lesions were well developed in only the highest dosage group and confined to the rostral level of the fasciculus gracilis in the medulla oblongata." | 1.28 | Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox. ( Dyer, KR; Ehrich, M; Jortner, BS; Shell, LG, 1992) |
| " Prior administration of phenylmethylsulfonyl fluoride (PMSF) reduced the incidence of damage to the peripheral nerve of animals dosed with TPP, but did not prevent toxic effects on the cell bodies in the spinal cord or the clinical effects." | 1.27 | Histopathological assessment of triphenyl phosphite neurotoxicity in the hen. ( Abou-Donia, MB; Brown, HR; Carrington, CD, 1988) |
| " Conversely, another group of rats, pretreated with Mipafox, was dosed with PMSF when NTE inhibition was 90." | 1.27 | Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy. ( Padilla, S; Veronesi, B, 1985) |
| " When dosing with dimethyl phosphates was repeated NTE inhibition in cord increased and pair-dosed birds became ataxic." | 1.26 | The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity. ( Johnson, MK, 1978) |
| "Ataxia was evident with both materials, and the degree of peripheral neuropathy increased with higher doses of these agents." | 1.24 | Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study. ( BARON, RL; BENNETT, DR; CASIDA, JE, 1962) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (63.89) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Estévez, J | 1 |
| Mangas, I | 1 |
| Sogorb, MÁ | 2 |
| Vilanova, E | 2 |
| BARON, RL | 2 |
| BENNETT, DR | 1 |
| CASIDA, JE | 3 |
| JOHNSON, H | 1 |
| WOLMAN, M | 1 |
| Bigl, V | 1 |
| Woolf, NJ | 1 |
| Butcher, LL | 1 |
| Seifert, J | 1 |
| Caroldi, S | 2 |
| Lotti, M | 3 |
| Masutti, A | 1 |
| Ho, IK | 1 |
| Fernando, JC | 1 |
| Sivam, SP | 1 |
| Hoskins, B | 1 |
| Drakontides, AB | 1 |
| Baker, T | 2 |
| Wilson, BW | 2 |
| Ishikawa, Y | 1 |
| Chow, E | 1 |
| Cisson, CM | 1 |
| Gordon, JJ | 1 |
| Inns, RH | 1 |
| Johnson, MK | 3 |
| Leadbeater, L | 1 |
| Maidment, MP | 1 |
| Upshall, DG | 1 |
| Cooper, GH | 1 |
| Rickard, RL | 1 |
| Vranken, MA | 1 |
| De Bisschop, HC | 2 |
| Willems, JL | 2 |
| Gupta, RP | 1 |
| Abou-Donia, MB | 2 |
| Konno, N | 1 |
| Suzuki, N | 1 |
| Horiguchi, H | 1 |
| Fukushima, M | 1 |
| Yoshida, M | 1 |
| Wu, SY | 1 |
| Lehning, EJ | 1 |
| Tanaka, D | 1 |
| Bursian, SJ | 1 |
| Sharma, SK | 1 |
| Bhattacharya, BK | 1 |
| Milatovic, D | 1 |
| Moretto, A | 2 |
| Osman, KA | 1 |
| Céspedes, MV | 1 |
| Escudero, MA | 1 |
| Barril, J | 1 |
| Vicedo, JL | 1 |
| Lees, JE | 1 |
| Richards, PG | 1 |
| Bouldin, TW | 2 |
| Cavanagh, JB | 2 |
| Olajos, EJ | 1 |
| DeCaprio, AP | 1 |
| Rosenblum, I | 1 |
| Lowndes, HE | 1 |
| Riker, WF | 1 |
| Fikes, JD | 1 |
| Zachary, JF | 1 |
| Parker, AJ | 1 |
| Beasley, VR | 1 |
| Carboni, D | 1 |
| Ehrich, M | 3 |
| Dyer, K | 1 |
| Jortner, BS | 3 |
| Dyer, KR | 1 |
| Shell, LG | 1 |
| Capodicasa, E | 1 |
| Dighe, SK | 1 |
| Nashikkar, AB | 1 |
| Dube, DK | 1 |
| Batra, BS | 1 |
| Chattopadhyay, DP | 1 |
| Pope, CN | 1 |
| Padilla, SS | 1 |
| Kellner, TP | 1 |
| Henderson, JD | 1 |
| Higgins, RJ | 1 |
| Carrington, CD | 1 |
| Brown, HR | 1 |
| Gross, WB | 1 |
| Veronesi, B | 1 |
| Padilla, S | 1 |
| Read, DJ | 1 |
| Benschop, HP | 1 |
36 other studies available for isoflurophate and Nervous System Disorders
| Article | Year |
|---|---|
Interactions of neuropathy inducers and potentiators/promoters with soluble esterases.
Topics: Animals; Brain; Catalytic Domain; Chickens; Enzyme Inhibitors; Esterases; Isoflurophate; Kinetics; N | 2013 |
Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study.
Topics: Animals; Ataxia; Axons; Chickens; Humans; Isoflurophate; Nerve Degeneration; Nervous System Diseases | 1962 |
NEUROLOGICAL DISRUPTION PRODUCED IN HENS BY TWO ORGANOPHOSPHATE ESTERS.
Topics: Animals; Ataxia; Brain; Chickens; Enzyme Inhibitors; Esterases; Esters; Female; Injections, Intraper | 1964 |
IN VITRO BREAKDOWN OF MYELIN.
Topics: Animals; Demyelinating Diseases; Diphosphates; In Vitro Techniques; Isoflurophate; Mice; Myelin Shea | 1965 |
Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylcholinesterase analysis.
Topics: Acetylcholine; Acetylcholinesterase; Afferent Pathways; Aging; Animals; Axonal Transport; Behavior; | 1982 |
Possible role of microtubules and associated proteases in organophosphorus ester-induced delayed neurotoxicity.
Topics: Animals; Brain; Cattle; Chickens; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Isoflurophate; Mice; | 1982 |
Intra-arterial injection of diisopropylfluorophosphate or phenylmethanesulphonyl fluoride produces unilateral neuropathy or protection, respectively, in hens.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Female; Injections, Intra-Arterial; Isoflurophate; N | 1984 |
Roles of dopamine and GABA in neurotoxicity of organophosphorus cholinesterase inhibitors.
Topics: Animals; Cholinesterase Inhibitors; Dopamine; gamma-Aminobutyric Acid; Isoflurophate; Nervous System | 1984 |
An electrophysiologic and ultrastructural study of the phenylmethanesulfonyl fluoride protection against a delayed organophosphorus neuropathy.
Topics: Animals; Cats; Drug Evaluation, Preclinical; Evoked Potentials; Female; Gait; Isoflurophate; Male; M | 1983 |
Multilevel studies of organophosphate toxicity.
Topics: Acetylcholinesterase; Animals; Carboxylic Ester Hydrolases; Cells, Cultured; Coturnix; Isoflurophate | 1983 |
The delayed neuropathic effects of nerve agents and some other organophosphorus compounds.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Carboxylic Ester Hydrolases; Chemical Warfare; Chick | 1983 |
"In vitro" inhibition of neurotoxic esterase by organophosphorus nerve agents.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Isoflurophate; Nervous System Diseases; Organ | 1982 |
Diisopropyl phosphorofluoridate (DFP) treatment alters calcium-activated proteinase activity and cytoskeletal proteins of the hen sciatic nerve.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Brain Chemistry; Calpain; Chickens; Cytoskeletal P | 1995 |
Characterization of high-affinity binding sites for diisopropylfluorophosphate (DFP) from chicken spinal cord membranes.
Topics: Animals; Binding Sites; Chickens; Chromatography, Gel; Isoflurophate; Nervous System Diseases; Physo | 1994 |
Reactivity and stereospecificity of neuropathy target esterase and alpha-chymotrypsin with 2-substituted-4H-1,3,2-benzodioxaphosphorin 2-oxides.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Chymotrypsin; Female; Isoflurophate; Nervous System | 1994 |
Triphenyl phosphite and diisopropylphosphorofluoridate produce separate and distinct axonal degeneration patterns in the central nervous system of the rat.
Topics: Animals; Axons; Brain; Cerebral Cortex; Injections, Subcutaneous; Isoflurophate; Male; Mammillary Bo | 1996 |
Altered glycine transport by cerebral tissue and decreased Na+ and Ca++ pump activities during organophosphorus-ester-induced delayed neurotoxicity development period.
Topics: 2,4-Dinitrophenol; Animals; Brain Chemistry; Calcium-Transporting ATPases; Cerebral Cortex; Chickens | 1995 |
Phenyl valerate esterases other than neuropathy target esterase and the promotion of organophosphate polyneuropathy.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Enzyme Inhibitors; Female; Isoflurophate; Kin | 1997 |
Discrimination of carboxylesterases of chicken neural tissue by inhibition with a neuropathic, non-neuropathic organophosphorus compounds and neuropathy promoter.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Central Nervous System; Chickens; Cholinesterase Inhibi | 1997 |
Rapid, high-sensitivity imaging of radiolabeled gels with microchannel plate detectors.
Topics: Animals; Brain Chemistry; Electrophoresis; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, P | 1999 |
Organophosphorous neuropathy. I. A teased-fiber study of the spatio-temporal spread of axonal degeneraion.
Topics: Animals; Axons; Cats; Female; Isoflurophate; Laryngeal Nerves; Male; Nerve Degeneration; Nerve Fiber | 1979 |
Organophosphorous neuropathy. II. A fine-structural study of the early stages of axonal degeneration.
Topics: Animals; Axons; Cats; Isoflurophate; Laryngeal Nerves; Nerve Degeneration; Nerve Fibers; Nervous Sys | 1979 |
The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity.
Topics: Animals; Brain; Chickens; Esterases; Isoflurophate; Nervous System Diseases; Organophosphorus Compou | 1978 |
Central and peripheral neurotoxic esterase activity and dose-response relationship in adult hens after acute and chronic oral administration of diisopropyl fluorophosphate.
Topics: Animals; Brain; Chickens; Cholinesterases; Dose-Response Relationship, Drug; Esterases; Female; Isof | 1978 |
Motor nerve terminal response to edrophonium in delayed DFP neuropathy.
Topics: Action Potentials; Animals; Cats; Drug Synergism; Edrophonium; Female; Isoflurophate; Male; Motor Ne | 1975 |
Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat.
Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cats; Chlorpyrifos; Cholinesterases; Diaz | 1992 |
Comparative evolution of mipafox-induced delayed neuropathy in rats and hens.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Disease Models, Animal; Female; Isoflurophate; Male; | 1992 |
Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Disease Models, Animal; Dose-Response Relationship, | 1992 |
Promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride.
Topics: Animals; Carbamates; Carboxylic Ester Hydrolases; Chickens; Dose-Response Relationship, Drug; Drug S | 1991 |
Role of liver and brain lysosomal and mitochondrial enzymes in development of delayed neuropathy in hens by 0,0-diisopropyl phosphorofluoridate.
Topics: Animals; Brain; Chickens; Isoflurophate; Lysosomes; Mitochondria; Mitochondria, Liver; Nervous Syste | 1989 |
Chromatographic characterization of neurotoxic esterase.
Topics: Animals; Carboxylic Ester Hydrolases; Chickens; Cholic Acids; Chromatography, Gel; Female; Isoflurop | 1989 |
Atropine and DFP-induced delayed neurotoxicity.
Topics: Animals; Atropine; Chickens; Female; Isoflurophate; Nervous System; Nervous System Diseases | 1988 |
Histopathological assessment of triphenyl phosphite neurotoxicity in the hen.
Topics: Animals; Chickens; Female; Injections, Subcutaneous; Isoflurophate; Nervous System Diseases; Organop | 1988 |
Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Cholinesterase Inhibitors; Corticosterone; Is | 1985 |
Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy.
Topics: Animals; Brain; Injections, Intraperitoneal; Injections, Subcutaneous; Isoflurophate; Male; Nervous | 1985 |
Can soman cause delayed neuropathy?
Topics: Animals; Chickens; Esterases; Isoflurophate; Nervous System Diseases; Soman; Stereoisomerism | 1985 |