isoflurophate has been researched along with Muscle Contraction in 52 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Simultaneous measurement of gastrocnemius muscle contraction and efferent phrenic nerve activity was used to determine the primary cause of respiratory failure produced by neostigmine and diisopropyl fluorophosphate (DFP) in anesthetized cats." | 3.68 | Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate. ( Dretchen, KL; Fleming, NW; Henderson, TR, 1991) |
| "Pronounced muscle fasciculations and muscle fiber necrosis were seen when acetylcholinesterase (AChE) activity was reduced to less than 30% of control." | 1.31 | Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat. ( Dettbarn, WD; Hustedt, E; Milatovic, D; Zivin, M, 2000) |
| "Substance P inactivation was followed by the bioassay using the isolated guinea pig ileum." | 1.29 | Substance P inactivation by aqueous humor. ( Igić, R, 1993) |
| " The shifts caused by atropine and pirenzepine in the dose-response curves for ACh were not parallel after in vitro treatment of the muscle with DFP." | 1.27 | Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists. ( Dwyer, TM; Farley, JM; Murali Mohan, P; Yang, CM, 1988) |
| " Dose-response curves for ACh-induced increase in isometric tension of tracheal smooth muscle (TSM) showed a leftward shift from control, 2 h after DFP injection." | 1.27 | Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 1. Agonist changes. ( Dwyer, TM; Farley, JM; Huang Saunders, HM; Murali Mohan, P; Yang, CM, 1988) |
| " Continued dosing produced a slightly attenuated effect." | 1.27 | Effect of diisopropylfluorophosphate and soman on rat skeletal muscle contracture during tetanic stimulation. ( Anderson, RJ, 1987) |
| " The method used involved analysis of dose-response data before and after fractional inactivation of receptors with propylbenzilylcholine mustard." | 1.27 | Dissociation constants and relative efficacies of acetylcholine, (+)- and (-)-methacholine at muscarinic receptors in the guinea-pig ileum. ( Ringdahl, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (88.46) | 18.7374 |
| 1990's | 4 (7.69) | 18.2507 |
| 2000's | 2 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mense, S | 1 |
| Simons, DG | 1 |
| Hoheisel, U | 1 |
| Quenzer, B | 1 |
| HELLMANN, K | 1 |
| Edge, ND | 1 |
| Fermum, R | 2 |
| Möritz, KU | 2 |
| Schäfer, U | 1 |
| Leibelt, M | 1 |
| Tofelde, U | 1 |
| Baker, T | 4 |
| Lowndes, HE | 4 |
| Johnson, MK | 1 |
| Sandborg, IC | 1 |
| Gant, DB | 1 |
| Weber, LJ | 1 |
| Smith, JR | 1 |
| Kalir, A | 1 |
| Teomy, S | 1 |
| Amir, A | 1 |
| Fuchs, P | 1 |
| Lee, SA | 1 |
| Holsztynska, EJ | 1 |
| Rocki, W | 1 |
| Domino, EF | 1 |
| Yamada, S | 1 |
| Katsuoka, M | 1 |
| Okudaira, H | 1 |
| Hayashi, E | 1 |
| Igić, R | 1 |
| Chiou, LC | 1 |
| Ling, JY | 1 |
| Chang, CC | 1 |
| Milatovic, D | 1 |
| Zivin, M | 1 |
| Hustedt, E | 1 |
| Dettbarn, WD | 2 |
| Pagala, MK | 2 |
| Sandow, A | 1 |
| Faff, J | 2 |
| Bak, W | 1 |
| Salpeter, MM | 1 |
| Kasprzak, H | 1 |
| Feng, H | 1 |
| Fertuck, H | 1 |
| Uchida, S | 1 |
| Takeyasu, K | 1 |
| Matsuda, T | 1 |
| Yoshida, H | 1 |
| Heffron, PF | 1 |
| Hobbiger, F | 1 |
| Moritoki, H | 1 |
| Ishida, Y | 1 |
| Kewitz, H | 1 |
| Pleul, O | 1 |
| Mann, E | 1 |
| Riker, WF | 2 |
| Melchers, BP | 1 |
| Van der Laaken, AL | 1 |
| Fleming, NW | 1 |
| Henderson, TR | 1 |
| Dretchen, KL | 1 |
| Murali Mohan, P | 2 |
| Yang, CM | 2 |
| Dwyer, TM | 2 |
| Farley, JM | 2 |
| Maruyama, I | 2 |
| Oyamada, H | 1 |
| Hasegawa, T | 2 |
| Ohtsuka, K | 1 |
| Kobayashi, M | 1 |
| Momose, K | 2 |
| Yamamoto, T | 1 |
| Huang Saunders, HM | 1 |
| Bradley, RJ | 1 |
| Edge, MT | 1 |
| Clinton, ME | 1 |
| Misulis, KE | 1 |
| Anderson, RJ | 1 |
| Ringdahl, B | 1 |
| Duxson, MJ | 1 |
| Vrbová, G | 1 |
| Lüllmann, H | 2 |
| Preuner, J | 1 |
| Schaube, H | 1 |
| Fleisch, JH | 1 |
| Ehrenpreis, S | 2 |
| Karczmar, AG | 1 |
| Koketsu, K | 1 |
| Soeda, S | 1 |
| Blaber, LC | 1 |
| Rabsztyn, T | 1 |
| Rump, S | 1 |
| Bell, C | 1 |
| Biggs, DF | 1 |
| Coutts, RT | 1 |
| Selley, ML | 1 |
| Towill, GA | 1 |
| Klaverkamp, JF | 1 |
| Dyer, DC | 1 |
| Kuba, K | 1 |
| Albuquerque, EX | 1 |
| Barnard, EA | 1 |
| Graham, D | 1 |
| Madden, J | 1 |
| Mitchelson, F | 1 |
| Harris, LS | 1 |
| Mittag, TW | 1 |
| Denmark, LW | 1 |
| Cohn, K | 1 |
| Galin, MA | 1 |
| Alkon, DL | 1 |
| Schmidt, DE | 1 |
| Green, JP | 1 |
| Szilagyi, PI | 1 |
| Meeter, E | 2 |
| Wolthuis, OL | 1 |
| Ohnesorge, FK | 1 |
| Schauwecker, GC | 1 |
| Wassermann, O | 1 |
| Roberts, CM | 1 |
| Konjovic, J | 1 |
| Schaeppi, U | 1 |
| Dodd, M | 1 |
| Bigo-Gullino, M | 1 |
| Avery, MA | 1 |
| Beani, L | 1 |
| Bianchi, C | 1 |
| Ledda, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Heal[NCT02403063] | Phase 4 | 18 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
52 other studies available for isoflurophate and Muscle Contraction
| Article | Year |
|---|---|
Lesions of rat skeletal muscle after local block of acetylcholinesterase and neuromuscular stimulation.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Electric Stimulation; Injections, Intramuscular; | 2003 |
Minute rhythmic contractile waves of the mammalian heart and the effect of urethane upon them.
Topics: Animals; Heart; Humans; Isoflurophate; Muscle Contraction; Urethane | 1953 |
pPy: a measure of potentiating activity.
Topics: Acetylcholine; Animals; Anura; Cholinesterase Inhibitors; Curare; Edrophonium; Isoflurophate; Muscle | 1967 |
[Adenosine-3',5'-monophosphate content and muscle tension in isolated coronary arteries under the effect of lanthanum ions].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; In Vitro Techniques; Iso | 1984 |
[Dissociation of the action of isoprenaline on muscle tension and adenosine-3',5'-monophosphate synthesis in isolated coronary arteries under the effect of diisopropylfluorophosphate].
Topics: Adenylyl Cyclases; Animals; Atropine; Cattle; Coronary Vessels; Cyclic AMP; In Vitro Techniques; Iso | 1984 |
Muscle spindle function in organophosphorus neuropathy.
Topics: Afferent Pathways; Animals; Cats; Evoked Potentials; Female; Hindlimb; Isoflurophate; Male; Mechanor | 1980 |
The effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy.
Topics: Action Potentials; Animals; Cats; Esterases; Isoflurophate; Motor Neurons; Muscle Contraction; Perip | 1980 |
Effects of neuromuscular blocking agents and acetylcholinesterase inhibitors on the response of pectoral fin muscle of the sculpin (Enophrys bison) to indirect stimulation.
Topics: Acetylcholinesterase; Animals; Bungarotoxins; Cholinesterase Inhibitors; Decamethonium Compounds; El | 1984 |
N-allyl analogues of phencyclidine: chemical synthesis and pharmacological properties.
Topics: Animals; Brain; Butyrylcholinesterase; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Dru | 1984 |
A pharmacological comparison of organophosphorus and carbamate anti-cholinesterase agents on guinea pig ileum.
Topics: Animals; Carbamates; Cholinesterase Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Isofluropha | 1982 |
Substance P inactivation by aqueous humor.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Aqueous Humor; Biological Assay; Dogs; Ileum; In Vitro Tec | 1993 |
beta-Eudesmol as an antidote for intoxication from organophosphorus anticholinesterase agents.
Topics: Animals; Anti-Ulcer Agents; Antidotes; Atropine; Cholinesterase Inhibitors; Electrophysiology; Femal | 1995 |
Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cyclic N-Oxides; Excitatory Amin | 2000 |
Twitch potentiation of skeletal muscle by physostigmine at different pH.
Topics: Action Potentials; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Isoflurophate; Muscle C | 1976 |
Increase in sensitivity to obidoxime induced by fluostigmine in the rat.
Topics: Acetylcholinesterase; Animals; Drug Synergism; In Vitro Techniques; Isoflurophate; Lethal Dose 50; M | 1978 |
Endplates after esterase inactivation in vivo: correlation between esterase concentration, functional response and fine structure.
Topics: Acetylcholinesterase; Animals; Bungarotoxins; Butyrylcholinesterase; Denervation; Isoflurophate; Mic | 1979 |
Changes in muscarinic acetylcholine receptors of mice by chronic administrations of diisopropylfluorophosphate and papaverine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Intestine, Small; Isoflurophate; Kinetics; Male; M | 1979 |
Relationship between inhibition of acetylcholinesterase and response of the rat phrenic nerve-diaphragm preparation to indirect stimulation at higher frequencies.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Isoflurophate; Male; Muscle Con | 1979 |
Aspects of the spasmogenic effects of acetate esters on ileal smooth muscle.
Topics: Acetates; Animals; Aspirin; Choline; Drug Interactions; Guinea Pigs; Ileum; In Vitro Techniques; Ins | 1977 |
Pre- and postnatal development and drug induced alterations of free and bound acetylcholine in rat brain.
Topics: Acetylcholine; Aging; Animals; Anura; Atropine; Biological Assay; Brain; Brain Chemistry; Cholineste | 1977 |
Motor nerve terminal response to edrophonium in delayed DFP neuropathy.
Topics: Action Potentials; Animals; Cats; Drug Synergism; Edrophonium; Female; Isoflurophate; Male; Motor Ne | 1975 |
On the mechanism of spontaneous recovery of neuromuscular transmission after acetylcholinesterase inhibition in the rat neuromuscular junction.
Topics: Animals; Carbachol; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Electrophysiology; I | 1991 |
Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate.
Topics: Animals; Atropine; Cats; Cholinesterase Inhibitors; Female; In Vitro Techniques; Isoflurophate; Male | 1991 |
Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropi | 1988 |
Loading of fura-2/AM with an aid of DFP on single smooth muscle cells prepared from guinea pig taenia coli.
Topics: Animals; Benzofurans; Biological Transport; Caffeine; Calcium; Carbachol; Cholinesterases; Colon; Eg | 1989 |
Effects of pluronic F-127 on loading of fura 2/AM into single smooth muscle cells isolated from guinea pig taenia coli.
Topics: Animals; Benzofurans; Carbachol; Colon; Egtazic Acid; Fluorescent Dyes; Fura-2; Guinea Pigs; In Vitr | 1989 |
Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 1. Agonist changes.
Topics: Acetylcholine; Animals; Bethanechol; Bethanechol Compounds; Cholinesterases; Dose-Response Relations | 1988 |
Curare can reverse the failure in muscle contraction caused by an AChE inhibitor.
Topics: Animals; Isoflurophate; Muscle Contraction; Neuromuscular Junction; Rats; Synaptic Transmission; Tub | 1986 |
Effects of phenytoin, ketamine, and atropine methyl nitrate in preventing neuromuscular toxicity of acetylcholinesterase inhibitors soman and diisopropylphosphorofluoridate.
Topics: Animals; Atropine Derivatives; Cholinesterase Inhibitors; Cholinesterase Reactivators; Isoflurophate | 1988 |
Effect of diisopropylfluorophosphate and soman on rat skeletal muscle contracture during tetanic stimulation.
Topics: Animals; Isoflurophate; Male; Muscle Contraction; Muscles; Rats; Rats, Inbred Strains; Soman | 1987 |
Dissociation constants and relative efficacies of acetylcholine, (+)- and (-)-methacholine at muscarinic receptors in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Isoflurophate; Male; Methacholine C | 1986 |
Inhibition of acetylcholinesterase accelerates axon terminal withdrawal at the developing rat neuromuscular junction.
Topics: Age Factors; Animals; Axons; Body Weight; Cholinesterase Inhibitors; Isoflurophate; Microscopy, Elec | 1985 |
A kinetic approach for an interpretation of the acetylcholine--d-tubocurarine interaction on chronically denervated skeletal muscle.
Topics: Acetylcholine; Animals; Denervation; Diaphragm; Diffusion; Dose-Response Relationship, Drug; Drug In | 1974 |
Thermal alteration in receptor activity of the rat fundal strip.
Topics: Acetylcholine; Angiotensin II; Animals; Atropa belladonna; Bradykinin; Cold Temperature; Hot Tempera | 1968 |
Possible reactivating and sensitizing action of neuromyally acting agents.
Topics: Acetylcholine; Ambenonium Chloride; Animals; Anura; Cholinesterase Inhibitors; Diphosphates; Fluorid | 1968 |
A comparison of the antagonism of TEPP and DFP by sodium fluoride and N-methylpyridinium-2-aldoxime methane sulphonate in the rat isolated phrenic nerve-diaphragm.
Topics: Animals; Diaphragm; Diphosphates; Drug Antagonism; Female; Fluorides; In Vitro Techniques; Isoflurop | 1970 |
Investigations on the correlation between abnormalities of neuromuscular transmission due to some organophosphates and activity of acetylcholinesterase in the skeletal muscle.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Echothiophate Iodide; Isoflurophate; Male; | 1973 |
Effects of physostigmine on smooth muscle.
Topics: Acetylcholine; Animals; Anura; Atropine; Biphenyl Compounds; Carbachol; Electric Stimulation; Gangli | 1966 |
Potential hypotensive compounds: substituted 3-aminopropionates and 3-aminopropionohydroxamic acids.
Topics: Amino Acids; Animals; Antihypertensive Agents; Blood Pressure; Depression, Chemical; Ganglionic Bloc | 1972 |
Autonomic receptors in isolated rainbow trout vasculature.
Topics: Acetylcholine; Animals; Aorta; Arteries; Cholinesterase Inhibitors; Cocaine; Dopamine; Dose-Response | 1974 |
Motor nerve dysfunction in delayed DFP neuropathy.
Topics: Action Potentials; Animals; Cats; Electric Stimulation; Electrophysiology; Female; Isoflurophate; Ma | 1974 |
Diisopropylfluorophosphate: suppression of ionic conductance of the cholinergic receptor.
Topics: Animals; Anura; Biological Transport; Electric Stimulation; Isoflurophate; Membrane Potentials; Musc | 1973 |
Changes in the sensitivity to cholinomimetic drugs of smooth and cardiac muscle in the rat induced by subacute administration of di-isopropyl phosphorofluoridate.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Blood Pressure; Carbachol; Cholinesterases; Electric S | 1973 |
In vitro effects of diisopropylfluorophosphate on cholinesterases and contractility of intact cat iris.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Carbon Isotopes; Cats; Cholinesterase Inhibitors; Chol | 1972 |
The release of acetylcholine from the innervated and denervated diaphragm.
Topics: Acetylcholine; Animals; Chromatography, Gas; Denervation; Diaphragm; Electric Stimulation; Isoflurop | 1970 |
The spontaneous recovery of respiration and neuromuscular transmission in the rat after anticholinesterase poisoning.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Diaphragm; Isoflurophate; Male; Muscle Contraction; Mu | 1968 |
Desensitization of the end-plate membrane following cholinesterase inhibition, an adjustment to a new working situation.
Topics: Acetylcholine; Animals; Calcium; Cholinesterase Inhibitors; Diaphragm; Isoflurophate; Membrane Poten | 1969 |
Inhibition of the actions of carbachol and DFP on guinea pig isolated atria by alkane-bis-ammonium compounds.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Chemical Phenomena; Chemistry; Guinea Pigs; Heart; Hear | 1969 |
Differences in the chronotropic and inotropic response of the rat atrium to choline esters, cholinesterase inhibitors and certain blocking agents.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Choline; Curare; Drug Synergism; Electric Stimulation; | 1969 |
Non-ganglionic effects of nicotine in the pig iris sphincter.
Topics: Acetylcholine; Animals; Atropine; Denervation; Hexamethonium Compounds; Iris; Isoflurophate; Muscle | 1965 |
The effect of cholinesterase inhibitors and lipid soluble quaternary ammonium compounds on contractions of rabbit aortic strip.
Topics: Acetylcholine; Animals; Aorta; Histamine; In Vitro Techniques; Isoflurophate; Muscle Contraction; Mu | 1965 |
The effect of 2,4-dinitrophenol on neuromuscular transmission.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Choline; Diaphragm; Dinitrophenols; Electric Stimula | 1966 |