isoflurophate has been researched along with Encephalopathy, Toxic in 31 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to evaluate the comparative non-cholinergic neurotoxic effects of paraoxon, which is acutely neurotoxic, and diisopropyl fluorophosphate (DFP), which induces OPIDN, in the human neuroblastoma SY5Y and the human astrocytoma cell line CCF-STTG1." | 7.74 | Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. ( Barhoumi, R; Datta, A; Pal, R; Qian, Y; Tiffany-Castiglioni, E; Venkatraj, J; Wild, JR, 2007) |
| "The objective of this study was to evaluate the comparative non-cholinergic neurotoxic effects of paraoxon, which is acutely neurotoxic, and diisopropyl fluorophosphate (DFP), which induces OPIDN, in the human neuroblastoma SY5Y and the human astrocytoma cell line CCF-STTG1." | 3.74 | Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. ( Barhoumi, R; Datta, A; Pal, R; Qian, Y; Tiffany-Castiglioni, E; Venkatraj, J; Wild, JR, 2007) |
| "Liraglutide is a long-lasting GLP-1 analog clinically used as antidiabetic." | 1.51 | The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells. ( Dos Santos, AC; Dos Santos, NAG; Emerick, GL; Fernandes, LS, 2019) |
| "DFP triggered rapid and sustained seizure behavior irrespective of PB pretreatment, and there was no significant difference in average seizure behavior score during the first 4 h following injection between DFP animals pretreated with PB or not." | 1.51 | Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. ( Bruun, DA; Guignet, M; Harvey, DJ; Lein, PJ, 2019) |
| "Neuroinflammation is widely posited to influence these persistent neurological consequences." | 1.51 | TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat. ( Bandara, SB; Bruun, DA; Chaudhari, AJ; Garbow, JR; Guignet, MA; Harmany, ZT; Harvey, DJ; Hobson, BA; Lein, PJ; Rowland, DJ; Saito, N; Sisó, S, 2019) |
| " The biosensor was used to establish correlations of NTE inhibitions in blood with that in lymphocytes and brain after dosing hens with a neuropathic OP." | 1.34 | Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress. ( Eremenko, AV; Kurochkin, IN; Makhaeva, GF; Malygin, VV; Richardson, RJ; Sigolaeva, LV; Sokolovskaya, LG; Strakhova, NN, 2007) |
| "Ataxia was evident with both materials, and the degree of peripheral neuropathy increased with higher doses of these agents." | 1.24 | Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study. ( BARON, RL; BENNETT, DR; CASIDA, JE, 1962) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 7 (22.58) | 2.80 |
| Authors | Studies |
|---|---|
| Putra, M | 3 |
| Gage, M | 3 |
| Sharma, S | 3 |
| Gardner, C | 1 |
| Gasser, G | 2 |
| Anantharam, V | 2 |
| Thippeswamy, T | 3 |
| Golden, M | 1 |
| González, EA | 2 |
| Rindy, AC | 1 |
| Guignet, MA | 3 |
| Calsbeek, JJ | 1 |
| Bruun, DA | 7 |
| Dhir, A | 2 |
| Andrew, P | 1 |
| Saito, N | 3 |
| Rowland, DJ | 5 |
| Harvey, DJ | 7 |
| Rogawski, MA | 2 |
| Lein, PJ | 7 |
| Supasai, S | 1 |
| Hobson, B | 1 |
| Soares, S | 1 |
| Singh, V | 1 |
| Wulff, H | 1 |
| Maupu, C | 1 |
| Enderlin, J | 1 |
| Igert, A | 1 |
| Oger, M | 1 |
| Auvin, S | 1 |
| Hassan-Abdi, R | 1 |
| Soussi-Yanicostas, N | 1 |
| Brazzolotto, X | 1 |
| Nachon, F | 1 |
| Dal Bo, G | 1 |
| Dupuis, N | 1 |
| Hobson, BA | 4 |
| Sisó, S | 3 |
| Garbow, JR | 3 |
| Liang, LP | 1 |
| Pearson-Smith, JN | 1 |
| Huang, J | 1 |
| McElroy, P | 1 |
| Day, BJ | 1 |
| Patel, M | 1 |
| Fernandes, LS | 1 |
| Dos Santos, NAG | 1 |
| Emerick, GL | 1 |
| Dos Santos, AC | 1 |
| Chaubey, K | 1 |
| Alam, SI | 1 |
| Waghmare, CK | 1 |
| Singh, L | 1 |
| Srivastava, N | 1 |
| Bhattacharya, BK | 1 |
| Guignet, M | 2 |
| Dhakal, K | 1 |
| Flannery, BM | 1 |
| Zolkowska, D | 1 |
| Li, S | 1 |
| Wahab, A | 1 |
| Silverman, JL | 1 |
| Hinojo-Perez, A | 1 |
| Olson, A | 1 |
| Gregory-Flores, A | 1 |
| Puttachary, S | 1 |
| Wang, C | 1 |
| Harmany, ZT | 1 |
| Bandara, SB | 1 |
| Chaudhari, AJ | 1 |
| Zaja-Milatovic, S | 1 |
| Gupta, RC | 1 |
| Aschner, M | 1 |
| Milatovic, D | 1 |
| Damodaran, TV | 2 |
| Gupta, RP | 2 |
| Attia, MK | 2 |
| Abou-Donia, MB | 3 |
| Mangas, I | 1 |
| Vilanova, E | 3 |
| Estévez, J | 1 |
| Tarhoni, MH | 1 |
| Vigneswara, V | 1 |
| Smith, M | 1 |
| Anderson, S | 1 |
| Wigmore, P | 1 |
| Lees, JE | 1 |
| Ray, DE | 1 |
| Carter, WG | 1 |
| Brewer, KL | 1 |
| Troendle, MM | 1 |
| Pekman, L | 1 |
| Meggs, WJ | 1 |
| BARON, RL | 1 |
| BENNETT, DR | 1 |
| CASIDA, JE | 1 |
| LANCASTER, MC | 1 |
| Janowsky, DS | 1 |
| Davis, JM | 1 |
| Overstreet, DH | 1 |
| Quesada, E | 2 |
| Sogorb, MA | 2 |
| Carrera, V | 2 |
| De Luca, CJ | 1 |
| Buccafusco, JJ | 1 |
| Roy, SH | 1 |
| De Luca, G | 1 |
| Nawab, SH | 1 |
| Sabater, E | 1 |
| Qian, Y | 1 |
| Venkatraj, J | 1 |
| Barhoumi, R | 1 |
| Pal, R | 1 |
| Datta, A | 1 |
| Wild, JR | 1 |
| Tiffany-Castiglioni, E | 1 |
| Makhaeva, GF | 1 |
| Malygin, VV | 1 |
| Strakhova, NN | 1 |
| Sigolaeva, LV | 1 |
| Sokolovskaya, LG | 1 |
| Eremenko, AV | 1 |
| Kurochkin, IN | 1 |
| Richardson, RJ | 1 |
| Petrović, RM | 1 |
| Jokanović, M | 1 |
| Maksimović, M | 1 |
| Ugresić, N | 1 |
| Bosković, B | 1 |
| Kamata, R | 1 |
| Saito, SY | 1 |
| Suzuki, T | 1 |
| Takewaki, T | 1 |
| Kofujita, H | 1 |
| Ota, M | 1 |
| Kobayashi, H | 1 |
| Xie, K | 1 |
1 review available for isoflurophate and Encephalopathy, Toxic
| Article | Year |
|---|---|
Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Inflammation; Isoflurophate; Male; Neuroto | 2020 |
30 other studies available for isoflurophate and Encephalopathy, Toxic
| Article | Year |
|---|---|
Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model.
Topics: Acetophenones; Animals; Biphenyl Compounds; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hi | 2020 |
Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity.
Topics: Animals; Brain; Disease Models, Animal; Female; Isoflurophate; Male; Neurotoxicity Syndromes; Rats; | 2020 |
The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Brain Waves; Cholinesterase Inhibitors; Conv | 2020 |
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Topics: Animals; Brain Diseases; Cholinesterase Inhibitors; Diazepam; GABA Modulators; Gliosis; Isoflurophat | 2020 |
Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice.
Topics: Animals; Cholinesterase Inhibitors; Isoflurophate; Male; Mice; Neuroglia; Neurotoxicity Syndromes; P | 2021 |
From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.
Topics: Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Diffusion Magnetic Resonance Imaging; I | 2017 |
Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Cholinesterase Inhibitors; Isoflurophate; Male; Necros | 2017 |
Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model.
Topics: Animals; Antioxidants; Disease Models, Animal; Isoflurophate; Male; Metalloporphyrins; Neurons; Neur | 2018 |
The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells.
Topics: Cell Line, Tumor; Glucose; Humans; Hypoglycemic Agents; Interleukin-1beta; Isoflurophate; Liraglutid | 2019 |
Differential proteome analysis of rat plasma after diisopropyl fluorophosphate (DFP) intoxication, a surrogate of nerve agent sarin.
Topics: Animals; Blood Proteins; Cholinesterase Inhibitors; Cholinesterases; Homeostasis; Injections, Subcut | 2019 |
Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; GPI-Linked | 2019 |
Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.
Topics: Amidines; Animals; Benzylamines; Brain; Disease Models, Animal; Enzyme Inhibitors; Isoflurophate; Ma | 2020 |
TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat.
Topics: Animals; Carrier Proteins; Chemokines; Cytokines; Fluorine Radioisotopes; Inflammation; Isoflurophat | 2019 |
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist.
Topics: Animals; Antioxidants; Biomarkers; Brain; Cholinesterase Inhibitors; Cyclic N-Oxides; Disease Models | 2009 |
DFP initiated early alterations of PKA/p-CREB pathway and differential persistence of beta-tubulin subtypes in the CNS of hens contributes to OPIDN.
Topics: Animals; Antidotes; Atropine; Blotting, Northern; Blotting, Western; Central Nervous System; Cerebru | 2009 |
Kinetics of the inhibitory interaction of organophosphorus neuropathy inducers and non-inducers in soluble esterases in the avian nervous system.
Topics: Animals; Brain; Carboxylic Ester Hydrolases; Chickens; Drug Interactions; Enzyme Induction; Isofluro | 2011 |
Early differential cell death and survival mechanisms initiate and contribute to the development of OPIDN: a study of molecular, cellular, and anatomical parameters.
Topics: Animals; Apoptosis; Atropine; Blotting, Northern; Brain; Cell Death; Cell Survival; Chickens; Cholin | 2011 |
Detection, quantification, and microlocalisation of targets of pesticides using microchannel plate autoradiographic imagers.
Topics: Animals; Autoradiography; Binding Sites; Isoflurophate; Isotope Labeling; Mice; Mice, Inbred C57BL; | 2011 |
Naltrexone prevents delayed encephalopathy in rats poisoned with the sarin analogue diisopropylflurophosphate.
Topics: Animals; Brain Diseases; Central Nervous System Agents; Cholinesterase Inhibitors; Female; Injection | 2013 |
Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study.
Topics: Animals; Ataxia; Axons; Chickens; Humans; Isoflurophate; Nerve Degeneration; Nervous System Diseases | 1962 |
A note on the demyelination produced in hens by dialkylfluoridates.
Topics: Animals; Central Nervous System; Chickens; Demyelinating Diseases; Female; Fluorides; Humans; Isoflu | 1960 |
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study.
Topics: Animals; Behavior, Animal; Body Temperature; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug In | 2004 |
Bovine chromaffin cell cultures as model to study organophosporus neurotoxicity.
Topics: Adrenal Medulla; Animals; Carboxylic Ester Hydrolases; Cattle; Chromaffin Cells; Enzyme Inhibitors; | 2004 |
The electromyographic signal as a presymptomatic indicator of organophosphates in the body.
Topics: Action Potentials; Algorithms; Animals; Cholinesterase Inhibitors; Data Interpretation, Statistical; | 2006 |
Recovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell cultures.
Topics: Animals; Carboxylic Ester Hydrolases; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; | 2007 |
Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines.
Topics: Astrocytoma; Blotting, Western; Calcium; Cell Line, Tumor; Cytosol; Endoplasmic Reticulum Chaperone | 2007 |
Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress.
Topics: Animals; Biomarkers; Biosensing Techniques; Carboxylic Ester Hydrolases; Chickens; Dose-Response Rel | 2007 |
The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens.
Topics: Animals; Atropine; Chickens; Cholinesterase Inhibitors; Female; GABA Modulators; Isoflurophate; Mida | 2000 |
A comparative study of binding sites for diisopropyl phosphorofluoridate in membrane and cytosol preparations from spinal cord and brain of hens.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Chickens; Cholinesterase Inhibitors; | 2001 |
Protein levels of neurofilament subunits in the hen central nervous system following prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity(1).
Topics: Animals; Chickens; Drug Interactions; Isoflurophate; Neurofilament Proteins; Neurotoxicity Syndromes | 2002 |