isoflurophate has been researched along with Depression in 6 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was conducted to evaluate the further persistence of changes in the forced swim test out to 4 months and to compare responses in a sucrose preference test, a measure of anhedonia." | 4.02 | Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats. ( Hester, K; Liu, J; Pope, C, 2021) |
| "Two lines of rats that were selectively bred to vary in their sensitivity to the anticholinesterase DFP exhibited different degrees of behavioral depression after injection of the muscarinic agonist arecoline (2 mg/kg)." | 3.67 | Selective breeding for increased cholinergic function: development of a new animal model of depression. ( Overstreet, DH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Hester, K | 1 |
| Pope, C | 1 |
| Phillips, KF | 1 |
| Deshpande, LS | 1 |
| Kanemaru, K | 1 |
| Diksic, M | 1 |
| Schiller, GD | 1 |
| Pucilowski, O | 1 |
| Wienicke, C | 1 |
| Overstreet, DH | 2 |
| Hollingsworth, PJ | 1 |
6 other studies available for isoflurophate and Depression
| Article | Year |
|---|---|
Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admin | 2021 |
Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness.
Topics: Anhedonia; Animals; Anxiety; Depression; Disease Models, Animal; Hippocampus; Isoflurophate; Male; M | 2016 |
The Flinders Sensitive Line of rats, a rat model of depression, has elevated brain glucose utilization when compared to normal rats and the Flinders Resistant Line of rats.
Topics: Animals; Autoradiography; Brain Chemistry; Cholinesterase Inhibitors; Depression; Dopamine; Glucose; | 2009 |
Immobility-reducing effects of antidepressants in a genetic animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Depression, Chemical; Desipramine; Disease Models, Anima | 1992 |
Chronic treatment with cholinesterase inhibitors increases alpha 2-adrenoceptors in rat brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Clonidine; Depression; Histocytochemistry; Isoflurophate; | 1988 |
Selective breeding for increased cholinergic function: development of a new animal model of depression.
Topics: Animals; Arecoline; Breeding; Depression; Depressive Disorder; Disease Models, Animal; Electroshock; | 1986 |