Page last updated: 2024-11-08

isoflurophate and Brain Injuries

isoflurophate has been researched along with Brain Injuries in 7 studies

Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.

Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Research Excerpts

ExcerptRelevanceReference
" We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure."5.72Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022)
"Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours."5.48Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018)
" We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure."1.72Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022)
"Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours."1.48Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (42.86)24.3611
2020's4 (57.14)2.80

Authors

AuthorsStudies
Piel, S3
Janowska, JI3
Ward, JL3
McManus, MJ3
Jose, JS3
Starr, J3
Sheldon, M3
Clayman, CL3
Elmér, E3
Hansson, MJ3
Jang, DH3
Karlsson, M3
Ehinger, JK3
Kilbaugh, TJ3
Rojas, A1
Wang, J1
Glover, A1
Dingledine, R1
Enderlin, J1
Igert, A1
Auvin, S1
Nachon, F1
Dal Bo, G1
Dupuis, N1
Reddy, DS2
Zaayman, M1
Kuruba, R2
Wu, X2
Hobson, BA1
Rowland, DJ1
Supasai, S1
Harvey, DJ1
Lein, PJ1
Garbow, JR1
Ferchmin, PA1
Andino, M1
Reyes Salaman, R1
Alves, J1
Velez-Roman, J1
Cuadrado, B1
Carrasco, M1
Torres-Rivera, W1
Segarra, A1
Martins, AH1
Lee, JE1
Eterovic, VA1

Other Studies

7 other studies available for isoflurophate and Brain Injuries

ArticleYear
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
    Scientific reports, 2022, 11-25, Volume: 12, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat

2022
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
    Neurobiology of disease, 2020, Volume: 140

    Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra

2020
Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure.
    Epilepsia, 2020, Volume: 61, Issue:6

    Topics: Animals; Brain; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; Electrocorticogra

2020
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
    Neuropharmacology, 2021, 06-15, Volume: 191

    Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons

2021
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.
    Neurotoxicology, 2018, Volume: 66

    Topics: Animals; Brain Injuries; Disease Models, Animal; Isoflurophate; Magnetic Resonance Imaging; Male; Ra

2018
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:2

    Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re

2018
4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration.
    Neurotoxicology, 2014, Volume: 44

    Topics: Acetylcholinesterase; Animals; Brain Injuries; CA1 Region, Hippocampal; Cell Death; Cholinesterase I

2014