isoflurophate has been researched along with Brain Injuries in 7 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Excerpt | Relevance | Reference |
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" We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure." | 5.72 | Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022) |
"Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
" We demonstrate that NV354, in combination with atropine and pralidoxime therapy, significantly improved cerebral mitochondrial complex IV-linked respiration and reduced signs of brain injury in a rodent model of acute DFP exposure." | 1.72 | Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning. ( Clayman, CL; Ehinger, JK; Elmér, E; Hansson, MJ; Jang, DH; Janowska, JI; Jose, JS; Karlsson, M; Kilbaugh, TJ; McManus, MJ; Piel, S; Sheldon, M; Starr, J; Ward, JL, 2022) |
"Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (42.86) | 24.3611 |
2020's | 4 (57.14) | 2.80 |
Authors | Studies |
---|---|
Piel, S | 3 |
Janowska, JI | 3 |
Ward, JL | 3 |
McManus, MJ | 3 |
Jose, JS | 3 |
Starr, J | 3 |
Sheldon, M | 3 |
Clayman, CL | 3 |
Elmér, E | 3 |
Hansson, MJ | 3 |
Jang, DH | 3 |
Karlsson, M | 3 |
Ehinger, JK | 3 |
Kilbaugh, TJ | 3 |
Rojas, A | 1 |
Wang, J | 1 |
Glover, A | 1 |
Dingledine, R | 1 |
Enderlin, J | 1 |
Igert, A | 1 |
Auvin, S | 1 |
Nachon, F | 1 |
Dal Bo, G | 1 |
Dupuis, N | 1 |
Reddy, DS | 2 |
Zaayman, M | 1 |
Kuruba, R | 2 |
Wu, X | 2 |
Hobson, BA | 1 |
Rowland, DJ | 1 |
Supasai, S | 1 |
Harvey, DJ | 1 |
Lein, PJ | 1 |
Garbow, JR | 1 |
Ferchmin, PA | 1 |
Andino, M | 1 |
Reyes Salaman, R | 1 |
Alves, J | 1 |
Velez-Roman, J | 1 |
Cuadrado, B | 1 |
Carrasco, M | 1 |
Torres-Rivera, W | 1 |
Segarra, A | 1 |
Martins, AH | 1 |
Lee, JE | 1 |
Eterovic, VA | 1 |
7 other studies available for isoflurophate and Brain Injuries
Article | Year |
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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain Injuries; Isoflurophate; Mitochondria; Organophosphat | 2022 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure.
Topics: Animals; Brain; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; Electrocorticogra | 2020 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.
Topics: Animals; Brain Injuries; Disease Models, Animal; Isoflurophate; Magnetic Resonance Imaging; Male; Ra | 2018 |
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration.
Topics: Acetylcholinesterase; Animals; Brain Injuries; CA1 Region, Hippocampal; Cell Death; Cholinesterase I | 2014 |