isoflurophate has been researched along with Ataxia in 15 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hens treated with Mipafox (10 mg/kg, sc), sarin (50 micrograms/kg, sc) or parathion (1 mg/kg, sc) daily for 10 days exhibited severe, moderate and no ataxia respectively on 14th day after the start of exposure." | 3.69 | A comparative study of delayed neurotoxicity in hens following repeated administration of organophosphorus compounds. ( Das Gupta, S; Husain, K; Pant, SC; Raza, SK; Singh, R, 1995) |
| " Intraperitoneal administration of DEF (tributyl phosphorotrithiolate) and Merphos (tributyl phosphorotrithioite) produced central and perpheral nervous system lesions accompanied by clinical signs of ataxia similar to those seen following administration of tri-o-cresyl phosphate." | 3.64 | NEUROLOGICAL DISRUPTION PRODUCED IN HENS BY TWO ORGANOPHOSPHATE ESTERS. ( BARON, RL; JOHNSON, H, 1964) |
| "Low-dose DFP caused minimal ataxia and increased frequency of axonal lesions in dorsal and lateral cervical spinal cord, ventral lumbar spinal cord, and inferior cerebellar peduncles (ICP) compared to control." | 1.30 | Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: distribution of axonal lesions. ( Randall, JC; Richardson, RJ; Yano, BL, 1997) |
| " Partial protection was seen in three out of three birds dosed prior to DFP challenge with sufficient C(-)P(+) isomer of soman (1." | 1.27 | High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not. ( Benschop, HP; De Bisschop, HC; Johnson, MK; Read, DJ; Willems, JL, 1988) |
| " Serum testosterone levels also measured 15 days after dosing were not different from those of a control group." | 1.27 | Neurotoxic esterase in rooster testis. ( Becker, CE; Lotti, M; Spear, RC; Wei, ET, 1985) |
| "Ataxia was evident with both materials, and the degree of peripheral neuropathy increased with higher doses of these agents." | 1.24 | Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study. ( BARON, RL; BENNETT, DR; CASIDA, JE, 1962) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BARON, RL | 2 |
| BENNETT, DR | 1 |
| CASIDA, JE | 2 |
| JOHNSON, H | 1 |
| Metcalf, RL | 1 |
| Peraica, M | 1 |
| Moretto, A | 1 |
| Lotti, M | 2 |
| Husain, K | 1 |
| Pant, SC | 1 |
| Raza, SK | 1 |
| Singh, R | 1 |
| Das Gupta, S | 1 |
| Carrera, V | 1 |
| Díaz-Alejo, N | 1 |
| Sogorb, MA | 1 |
| Vicedo, JL | 1 |
| Vilanova, E | 1 |
| Wu, SY | 1 |
| Randall, JC | 1 |
| Yano, BL | 1 |
| Richardson, RJ | 1 |
| Gupta, RP | 1 |
| Abou-Donia, MB | 1 |
| Jokanović, M | 1 |
| Stepanović Petrović, RM | 1 |
| Maksimović, M | 1 |
| Jovanovic, D | 1 |
| Kosanović, M | 1 |
| Piperski, V | 1 |
| Tanaka, D | 1 |
| Bursian, SJ | 1 |
| Lehning, E | 1 |
| Johnson, MK | 2 |
| Willems, JL | 1 |
| De Bisschop, HC | 1 |
| Read, DJ | 1 |
| Benschop, HP | 1 |
| Ehrich, M | 1 |
| Jortner, BS | 1 |
| Gross, WB | 1 |
| Wei, ET | 1 |
| Spear, RC | 1 |
| Becker, CE | 1 |
| Barnes, JM | 1 |
15 other studies available for isoflurophate and Ataxia
| Article | Year |
|---|---|
Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate--a clinical and pathological study.
Topics: Animals; Ataxia; Axons; Chickens; Humans; Isoflurophate; Nerve Degeneration; Nervous System Diseases | 1962 |
NEUROLOGICAL DISRUPTION PRODUCED IN HENS BY TWO ORGANOPHOSPHATE ESTERS.
Topics: Animals; Ataxia; Brain; Chickens; Enzyme Inhibitors; Esterases; Esters; Female; Injections, Intraper | 1964 |
Historical perspective of organophosphorus ester-induced delayed neurotoxicity.
Topics: Animals; Ataxia; Carboxylic Ester Hydrolases; Chickens; Drug Contamination; Humans; Insecticides; Is | 1982 |
Selective promotion by phenylmethanesulfonyl fluoride of peripheral and spinal cord neuropathies initiated by diisopropyl phosphorofluoridate in the hen.
Topics: Animals; Ataxia; Axons; Brain; Carboxylic Ester Hydrolases; Chickens; Drug Interactions; Enzyme Inhi | 1995 |
A comparative study of delayed neurotoxicity in hens following repeated administration of organophosphorus compounds.
Topics: Animals; Ataxia; Blood Platelets; Brain; Carboxylic Ester Hydrolases; Central Nervous System; Chicke | 1995 |
In vivo inhibition by mipafox of soluble and particulate forms of organophosphorus neuropathy target esterase (NTE) in hen sciatic nerve.
Topics: Animals; Ataxia; Carboxylic Ester Hydrolases; Chickens; Female; Isoflurophate; Reflex; Sciatic Nerve | 1994 |
Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors.
Topics: Animals; Ataxia; Biomarkers; Brain; Brain Edema; Carboxylic Ester Hydrolases; Cholinesterase Inhibit | 1996 |
Potentiation of organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the central and peripheral nervous system of the adult hen: distribution of axonal lesions.
Topics: Animals; Ataxia; Axons; Biomarkers; Brain; Brain Diseases; Carboxylic Ester Hydrolases; Chickens; Dr | 1997 |
Enhanced activity and level of protein kinase A in the spinal cord supernatant of diisopropyl phosphorofluoridate (DFP)-treated hens. Distribution of protein kinases and phosphatases in spinal cord subcellular fractions.
Topics: Animals; Ataxia; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin | 2001 |
Effects of atropine, trimedoxime and methylprednisolone on the development of organophosphate-induced delayed polyneuropathy in the hen.
Topics: Animals; Ataxia; Atropine; Chickens; Drug Therapy, Combination; Female; Isoflurophate; Methylprednis | 2001 |
Selective axonal and terminal degeneration in the chicken brainstem and cerebellum following exposure to bis(1-methylethyl)phosphorofluoridate (DFP).
Topics: Animals; Ataxia; Axons; Brain; Brain Stem; Carboxylic Ester Hydrolases; Cerebellum; Chickens; Cholin | 1990 |
High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not.
Topics: Animals; Ataxia; Atropine; Carboxylic Ester Hydrolases; Chickens; Diazepam; Drug Interactions; Femal | 1988 |
Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.
Topics: Administration, Oral; Animals; Ataxia; Brain; Carboxylic Ester Hydrolases; Chickens; Cholinesterases | 1986 |
Neurotoxic esterase in rooster testis.
Topics: Animals; Ataxia; Brain; Carboxylic Ester Hydrolases; Chickens; Isoflurophate; Male; Organophosphorus | 1985 |
Age and the sensitivity of chicks to the delayed neurotoxic effects on some organophosphorus compounds.
Topics: Administration, Oral; Age Factors; Animals; Ataxia; Atropine; Brain; Chickens; Cholinesterase Inhibi | 1970 |