isoflurophate has been researched along with Absence Status in 22 studies
Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model." | 7.96 | Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats. ( Bruun, DA; Calsbeek, J; Dhir, A; González, E; Guignet, M; Harvey, DJ; Lein, PJ; Rogawski, MA; Saito, N; Tancredi, DJ; Tsai, YH; Vu, J, 2020) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 5.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 5.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model." | 3.96 | Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats. ( Bruun, DA; Calsbeek, J; Dhir, A; González, E; Guignet, M; Harvey, DJ; Lein, PJ; Rogawski, MA; Saito, N; Tancredi, DJ; Tsai, YH; Vu, J, 2020) |
| "Seizures were elicited within ∼8 minutes after DFP exposure that progressively developed into persistent SE lasting for hours." | 1.48 | Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. ( Kuruba, R; Reddy, DS; Wu, X, 2018) |
| "By contrast, astrogliosis was unaffected by EP2 inhibition 4 d after DFP." | 1.42 | Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus. ( Dingledine, R; Ganesh, T; Gueorguieva, P; Lelutiu, N; Rojas, A, 2015) |
| "Diazepam (10mg/kg) was administered 10min and 30min after the onset of continuous EEG seizures induced by paraoxon and it terminated SE in a majority of animals at both time points." | 1.38 | Characterization of status epilepticus induced by two organophosphates in rats. ( Balint, CA; Cowan, ML; Kapur, J; Sun, C; Todorovic, MS, 2012) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 1.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 13 (59.09) | 2.80 |
| Authors | Studies |
|---|---|
| Calsbeek, JJ | 1 |
| González, EA | 1 |
| Bruun, DA | 4 |
| Guignet, MA | 1 |
| Copping, N | 1 |
| Dawson, ME | 1 |
| Yu, AJ | 1 |
| MacMahon, JA | 1 |
| Saito, NH | 1 |
| Harvey, DJ | 5 |
| Silverman, JL | 2 |
| Lein, PJ | 5 |
| Rojas, A | 6 |
| Abreu-Melon, J | 2 |
| Wang, S | 2 |
| Dingledine, R | 6 |
| Putra, M | 2 |
| Gage, M | 2 |
| Sharma, S | 2 |
| Gardner, C | 1 |
| Gasser, G | 1 |
| Anantharam, V | 1 |
| Thippeswamy, T | 2 |
| Golden, M | 1 |
| Wang, J | 3 |
| Glover, A | 1 |
| Enderlin, J | 2 |
| Igert, A | 2 |
| Auvin, S | 2 |
| Nachon, F | 2 |
| Dal Bo, G | 2 |
| Dupuis, N | 2 |
| Spampanato, J | 1 |
| Bealer, SL | 1 |
| Smolik, M | 1 |
| Dudek, FE | 1 |
| Dhir, A | 2 |
| Guignet, M | 2 |
| Tsai, YH | 1 |
| González, E | 1 |
| Calsbeek, J | 1 |
| Vu, J | 1 |
| Saito, N | 1 |
| Tancredi, DJ | 1 |
| Rogawski, MA | 2 |
| McCarren, HS | 1 |
| Wang, W | 2 |
| McDonough, JH | 1 |
| Maupu, C | 1 |
| Oger, M | 1 |
| Hassan-Abdi, R | 1 |
| Soussi-Yanicostas, N | 1 |
| Brazzolotto, X | 1 |
| Reddy, DS | 2 |
| Zaayman, M | 1 |
| Kuruba, R | 2 |
| Wu, X | 2 |
| Sisó, S | 1 |
| Hobson, BA | 3 |
| Rowland, DJ | 2 |
| Garbow, JR | 2 |
| Supasai, S | 1 |
| Ganesh, T | 3 |
| Dhakal, K | 1 |
| Flannery, BM | 1 |
| Zolkowska, D | 1 |
| Li, S | 1 |
| Wahab, A | 1 |
| Lelutiu, N | 1 |
| Gueorguieva, P | 1 |
| Manji, Z | 1 |
| O'neill, T | 1 |
| Kadriu, B | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Auta, J | 1 |
| Demar, JC | 1 |
| Clarkson, ED | 1 |
| Ratcliffe, RH | 1 |
| Campbell, AJ | 1 |
| Thangavelu, SG | 1 |
| Herdman, CA | 1 |
| Leader, H | 1 |
| Schulz, SM | 1 |
| Marek, E | 1 |
| Medynets, MA | 1 |
| Ku, TC | 1 |
| Evans, SA | 1 |
| Khan, FA | 1 |
| Owens, RR | 1 |
| Nambiar, MP | 1 |
| Gordon, RK | 1 |
| Deshpande, LS | 1 |
| Carter, DS | 1 |
| Blair, RE | 1 |
| DeLorenzo, RJ | 1 |
| Todorovic, MS | 1 |
| Cowan, ML | 1 |
| Balint, CA | 1 |
| Sun, C | 1 |
| Kapur, J | 1 |
2 reviews available for isoflurophate and Absence Status
| Article | Year |
|---|---|
A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Indoles; Isoflurophate; Organophosphate | 2020 |
Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Inflammation; Isoflurophate; Male; Neuroto | 2020 |
20 other studies available for isoflurophate and Absence Status
| Article | Year |
|---|---|
Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Electroence | 2021 |
Time-dependent neuropathology in rats following organophosphate-induced status epilepticus.
Topics: Animals; Brain; Disease Models, Animal; Isoflurophate; Organophosphate Poisoning; Organophosphates; | 2022 |
Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model.
Topics: Acetophenones; Animals; Biphenyl Compounds; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Hi | 2020 |
Sex as a biological variable in the rat model of diisopropylfluorophosphate-induced long-term neurotoxicity.
Topics: Animals; Brain; Disease Models, Animal; Female; Isoflurophate; Male; Neurotoxicity Syndromes; Rats; | 2020 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure.
Topics: Animals; Brain; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; Electrocorticogra | 2020 |
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Dexmedetomidine; Disease Models, Animal; Dose-Response | 2020 |
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Drug Therapy, Combination; Electroencephalography; Isoflurophate; Male; M | 2020 |
Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Waves; Cell Death; Cyclooxygenase 2; Disease Models, Anim | 2021 |
Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice.
Topics: Animals; Cholinesterase Inhibitors; Isoflurophate; Male; Mice; Neuroglia; Neurotoxicity Syndromes; P | 2021 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Cholinesterase Inhibitors; Isoflurophate; Male; Necros | 2017 |
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.
Topics: Animals; Brain Injuries; Disease Models, Animal; Isoflurophate; Magnetic Resonance Imaging; Male; Ra | 2018 |
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Injuries; Cholinesterase Inhibitors; Drug Re | 2018 |
Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Body Weight; Chemokines; Cholinesterase Inhibitors; | 2015 |
Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats.
Topics: Animals; Anxiety; Brain; Discrimination, Psychological; Disease Models, Animal; Electroencephalograp | 2016 |
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Brain; Cholinesterase Inhibitors; Diaze | 2009 |
Pro-2-PAM therapy for central and peripheral cholinesterases.
Topics: Acetylcholinesterase; Animals; Apoptosis; Brain; Central Nervous System; Cholinesterase Reactivators | 2010 |
Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.
Topics: Animals; Calcium; Dizocilpine Maleate; Electroencephalography; Hippocampus; Isoflurophate; Male; Rat | 2010 |
Characterization of status epilepticus induced by two organophosphates in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Electroencephalography; Isoflurophate; Male; Ne | 2012 |