isoflurane has been researched along with Status Epilepticus in 25 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to determine the association between seizure termination and side effects of isoflurane for the treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensive care units (neuro-ICUs)." | 8.02 | Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation. ( Bösel, J; Dimitriadis, K; Fink, GR; Fuchs, K; Fuhrer, H; Gerner, ST; Huttner, HB; Lehmann, F; Luger, S; Malter, MP; Müller, M; Neumann, B; Nichtweiß, J; Schaal, A; Scheibe, F; Schönenberger, S; Stetefeld, HR, 2021) |
| "Isoflurane is an alternative treatment for refractory status epilepticus." | 7.76 | Prolonged high-dose isoflurane for refractory status epilepticus: is it safe? ( Burns, JD; Fugate, JE; Jankowski, CJ; Rabinstein, AA; Warner, DO; Wijdicks, EF, 2010) |
| "The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring." | 7.01 | [Use of isoflurane as treatment for super-refractory status epilepticus]. ( Blázquez-Alcaide, V; Bodí, M; Daniel, X; Gil-Castillejos, D; Plans-Galván, O; Rosich, S, 2023) |
| "Isoflurane was then used to control seizures." | 5.30 | Electrographic tachyphylaxis to etomidate and ketamine used for refractory status epilepticus controlled with isoflurane. ( Bloom, MJ; Brenner, RP; Kofke, WA; Van Cott, A, 1997) |
| "When conventional treatment for status epilepticus fails, general anaesthesia is recommended." | 5.28 | Isoflurane in the management of status epilepticus after surgery for lesion around the motor area. ( Abe, K; Furuya, H; Hoshida, T; Miyamoto, S; Morimoto, T; Okuchi, K; Sakaki, T; Tsunoda, S, 1992) |
| "Isoflurane, which has no reported organ toxicity and produces electrographic suppression at clinically useful concentrations in normal humans, should be a better volatile anesthetic for this purpose." | 5.28 | Isoflurane for refractory status epilepticus: a clinical series. ( Davis, P; Gelb, A; Gray, L; Johnson, D; Kofke, WA; Meeke, R; Pearson, KS; Warner, DS; Woelfel, SK; Young, RS, 1989) |
| "We aimed to determine the association between seizure termination and side effects of isoflurane for the treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensive care units (neuro-ICUs)." | 4.02 | Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation. ( Bösel, J; Dimitriadis, K; Fink, GR; Fuchs, K; Fuhrer, H; Gerner, ST; Huttner, HB; Lehmann, F; Luger, S; Malter, MP; Müller, M; Neumann, B; Nichtweiß, J; Schaal, A; Scheibe, F; Schönenberger, S; Stetefeld, HR, 2021) |
| " Finally, we examined the effects of different types of anesthesia (chloral hydrate, isoflurane) on kainate-induced status epilepticus (SE) and epileptogenesis." | 3.83 | Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. ( Brandt, C; Löscher, W; Töllner, K; Twele, F, 2016) |
| "Isoflurane is an alternative treatment for refractory status epilepticus." | 3.76 | Prolonged high-dose isoflurane for refractory status epilepticus: is it safe? ( Burns, JD; Fugate, JE; Jankowski, CJ; Rabinstein, AA; Warner, DO; Wijdicks, EF, 2010) |
| "The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring." | 3.01 | [Use of isoflurane as treatment for super-refractory status epilepticus]. ( Blázquez-Alcaide, V; Bodí, M; Daniel, X; Gil-Castillejos, D; Plans-Galván, O; Rosich, S, 2023) |
| "When midazolam has failed to control RSE, the evidence points to barbiturate anesthesia as the next frequently used option." | 2.50 | Continuous infusion, general anesthesia and other intensive care treatment for uncontrolled status epilepticus. ( Tasker, RC; Vitali, SH, 2014) |
| "Diazepam was significantly less efficacious than other treatments (P = ." | 2.40 | Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. ( Gartside, PS; Gilbert, DL; Glauser, TA, 1999) |
| "Isoflurane was then used to control seizures." | 1.30 | Electrographic tachyphylaxis to etomidate and ketamine used for refractory status epilepticus controlled with isoflurane. ( Bloom, MJ; Brenner, RP; Kofke, WA; Van Cott, A, 1997) |
| "In flurothyl-treated rats, there were significant reductions in SNPR neuropathologic grade (P = 0." | 1.29 | Effect of anesthetics on neuropathologic sequelae of status epilepticus in rats. ( Garman, RH; Graybeal, JM; Hawkins, RA; Housman, C; Kofke, WA; Towfighi, J, 1993) |
| "When conventional treatment for status epilepticus fails, general anaesthesia is recommended." | 1.28 | Isoflurane in the management of status epilepticus after surgery for lesion around the motor area. ( Abe, K; Furuya, H; Hoshida, T; Miyamoto, S; Morimoto, T; Okuchi, K; Sakaki, T; Tsunoda, S, 1992) |
| "Isoflurane, which has no reported organ toxicity and produces electrographic suppression at clinically useful concentrations in normal humans, should be a better volatile anesthetic for this purpose." | 1.28 | Isoflurane for refractory status epilepticus: a clinical series. ( Davis, P; Gelb, A; Gray, L; Johnson, D; Kofke, WA; Meeke, R; Pearson, KS; Warner, DS; Woelfel, SK; Young, RS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Plans-Galván, O | 1 |
| Daniel, X | 1 |
| Rosich, S | 1 |
| Blázquez-Alcaide, V | 1 |
| Gil-Castillejos, D | 1 |
| Bodí, M | 1 |
| Swissa, E | 2 |
| Bar-Klein, G | 2 |
| Serlin, Y | 2 |
| Weissberg, I | 1 |
| Kamintsky, L | 2 |
| Eisenkraft, A | 2 |
| Statlender, L | 1 |
| Shrot, S | 1 |
| Rosman, Y | 2 |
| Prager, O | 1 |
| Friedman, A | 2 |
| Stetefeld, HR | 1 |
| Schaal, A | 1 |
| Scheibe, F | 1 |
| Nichtweiß, J | 1 |
| Lehmann, F | 1 |
| Müller, M | 1 |
| Gerner, ST | 1 |
| Huttner, HB | 1 |
| Luger, S | 1 |
| Fuhrer, H | 1 |
| Bösel, J | 1 |
| Schönenberger, S | 1 |
| Dimitriadis, K | 1 |
| Neumann, B | 1 |
| Fuchs, K | 1 |
| Fink, GR | 1 |
| Malter, MP | 1 |
| Bryan Young, G | 1 |
| Lublinsky, S | 1 |
| Noyman, I | 1 |
| Veksler, R | 1 |
| Dalipaj, H | 1 |
| Senatorov, VV | 1 |
| Rosenbach, D | 1 |
| Elazary, N | 1 |
| Milikovsky, DZ | 1 |
| Milk, N | 1 |
| Kassirer, M | 1 |
| Chassidim, Y | 1 |
| Parmet, Y | 1 |
| Kaufer, D | 1 |
| Tasker, RC | 1 |
| Vitali, SH | 1 |
| Twele, F | 1 |
| Töllner, K | 1 |
| Brandt, C | 1 |
| Löscher, W | 1 |
| Ikeda, KM | 1 |
| Connors, R | 1 |
| Lee, DH | 1 |
| Khandji, AG | 1 |
| Claassen, J | 1 |
| Young, GB | 3 |
| Fugate, JE | 1 |
| Burns, JD | 1 |
| Wijdicks, EF | 1 |
| Warner, DO | 1 |
| Jankowski, CJ | 1 |
| Rabinstein, AA | 1 |
| Sharpe, MD | 3 |
| Mirsattari, S | 1 |
| Harris, C | 1 |
| Young, B | 1 |
| Osvath, L | 1 |
| Jones, D | 1 |
| Socha, E | 1 |
| Mirsattari, SM | 1 |
| Giannini, A | 1 |
| Salvo, I | 1 |
| Kofke, WA | 4 |
| Towfighi, J | 1 |
| Garman, RH | 1 |
| Graybeal, JM | 1 |
| Housman, C | 1 |
| Hawkins, RA | 1 |
| Cascino, GD | 1 |
| Bloom, MJ | 1 |
| Van Cott, A | 1 |
| Brenner, RP | 1 |
| Gilbert, DL | 1 |
| Gartside, PS | 1 |
| Glauser, TA | 1 |
| Hughes, DR | 1 |
| McLachlan, RS | 1 |
| Breheny, FX | 1 |
| Hilz, MJ | 1 |
| Bauer, J | 1 |
| Claus, D | 1 |
| Stefan, H | 1 |
| Neundörfer, B | 1 |
| Prescott, RJ | 1 |
| Roberts, SP | 1 |
| Williams, G | 1 |
| Sakaki, T | 1 |
| Abe, K | 1 |
| Hoshida, T | 1 |
| Morimoto, T | 1 |
| Tsunoda, S | 1 |
| Okuchi, K | 1 |
| Miyamoto, S | 1 |
| Furuya, H | 1 |
| Young, RS | 2 |
| Davis, P | 1 |
| Woelfel, SK | 1 |
| Gray, L | 1 |
| Johnson, D | 1 |
| Gelb, A | 1 |
| Meeke, R | 1 |
| Warner, DS | 1 |
| Pearson, KS | 1 |
| Lippert, MM | 1 |
| Snider, MT | 1 |
| Ramer, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus (I-Seizure)[NCT05830864] | 120 participants (Anticipated) | Observational [Patient Registry] | 2023-05-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for isoflurane and Status Epilepticus
| Article | Year |
|---|---|
[Use of isoflurane as treatment for super-refractory status epilepticus].
Topics: Compassionate Use Trials; Humans; Intensive Care Units; Isoflurane; Retrospective Studies; Seizures; | 2023 |
Continuous infusion, general anesthesia and other intensive care treatment for uncontrolled status epilepticus.
Topics: Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anticonvulsants; Child; Critical Care; Die | 2014 |
Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Isoflurane; | 1999 |
22 other studies available for isoflurane and Status Epilepticus
| Article | Year |
|---|---|
Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Isoflurane; Male; Midazolam; Paraoxon; Rats | 2020 |
Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation.
Topics: Anticonvulsants; Electroencephalography; Humans; Isoflurane; Retrospective Studies; Seizures; Status | 2021 |
Commentary on Isoflurane in Refractory and Super-Refractory Status Epilepticus.
Topics: Drug Resistant Epilepsy; Humans; Isoflurane; Status Epilepticus | 2021 |
Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Angiotensin II Type 1 Receptor Blockers; Animals; B | 2017 |
Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Anesthesia; Anesthetics; Animals; Chloral Hydrate; Electroencephalography; Epilepsy, Temporal Lobe; | 2016 |
Isoflurane Use in the Treatment of Super-Refractory Status Epilepticus is Associated with Hippocampal Changes on MRI.
Topics: Adult; Anesthetics, Inhalation; Case-Control Studies; Drug Resistant Epilepsy; Female; Hippocampus; | 2017 |
Prolonged high-dose isoflurane for refractory status epilepticus: is it safe?
Topics: Adult; Anticonvulsants; Cerebellum; Child, Preschool; Drug Administration Schedule; Female; Humans; | 2010 |
Prolonged desflurane administration for refractory status epilepticus.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Biotransformation; Desflurane; Electroencephalography; He | 2002 |
A novel EEG artifact in the intensive care unit.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Artifacts; Brain Ischemia; Electro | 2002 |
Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Desflurane; Drug Therapy, Combination; Female; Hum | 2004 |
Isoflurane sedation for critically ill patients.
Topics: Adult; Critical Care; Female; Humans; Isoflurane; Status Epilepticus | 1993 |
Effect of anesthetics on neuropathologic sequelae of status epilepticus in rats.
Topics: 3-Mercaptopropionic Acid; Administration, Inhalation; Anesthetics; Animals; Brain Diseases; Flurothy | 1993 |
Generalized convulsive status epilepticus.
Topics: Adolescent; Adult; Aged; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy, Generalized | 1996 |
Electrographic tachyphylaxis to etomidate and ketamine used for refractory status epilepticus controlled with isoflurane.
Topics: Adult; Anesthetics, General; Anticonvulsants; Electroencephalography; Etomidate; Humans; Intraoperat | 1997 |
Control of epilepsia partialis continua and secondarily generalised status epilepticus with isoflurane.
Topics: Administration, Inhalation; Adult; Electroencephalography; Epilepsia Partialis Continua; Epilepsies, | 1992 |
Inorganic fluoride in prolonged isoflurane sedation.
Topics: Adolescent; Critical Care; Female; Fluorides; Humans; Hypnotics and Sedatives; Isoflurane; Respirati | 1992 |
Isoflurane anaesthesia in the treatment of convulsive status epilepticus. Case report.
Topics: Adult; Anesthesia, Inhalation; Anticonvulsants; Combined Modality Therapy; Electroencephalography; F | 1992 |
Malignant hyperpyrexia: a rare cause of postoperative death.
Topics: Humans; Isoflurane; Male; Malignant Hyperthermia; Middle Aged; Muscular Diseases; Necrosis; Postoper | 1992 |
Isoflurane in the management of status epilepticus after surgery for lesion around the motor area.
Topics: Adult; Anesthesia, General; Brain Neoplasms; Electroencephalography; Female; Frontal Lobe; Humans; I | 1992 |
Isoflurane for refractory status epilepticus: a clinical series.
Topics: Adolescent; Adult; Anesthesia, General; Child; Child, Preschool; Electroencephalography; Female; Hum | 1989 |
Isoflurane anaesthesia for status epilepticus.
Topics: Female; Humans; Infant; Isoflurane; Status Epilepticus | 1989 |
Prolonged low flow isoflurane anesthesia for status epilepticus.
Topics: Anesthesia, Inhalation; Anticonvulsants; Child; Drug Resistance; Electroencephalography; Female; Flu | 1985 |