isoflurane has been researched along with Sepsis in 15 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables." | 9.51 | Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022) |
| "This study addressed the effect of MRI under isoflurane anesthesia on blood-brain barrier integrity, cyclooxygenase-2 expression, and glial cell activation during cecal ligature and puncture-induced sepsis-associated brain dysfunction in rats." | 8.02 | Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats. ( Dhaya, I; Griton, M; Konsman, JP, 2021) |
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 7.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| "The effects of combined therapy with isoflurane and oxygen on lung injury and sepsis were determined in animal models of sepsis induced by cecal ligation and puncture (CLP) or intraperitoneal injection of lipopolysaccharide (LPS) or zymosan." | 7.85 | Sub-anesthesia Dose of Isoflurane in 60% Oxygen Reduces Inflammatory Responses in Experimental Sepsis Models. ( Dong, HL; Han, H; Hou, LC; Hou, ZX; Huang, Y; Pu, ZS; Shao, T; Sun, DD; Wang, XX; Xiong, LZ; Yang, WW; Zhang, EF; Zhang, ZX, 2017) |
| " As hyperactive uncontrolled inflammation can lead to mortality and morbidity during early sepsis, we questioned whether the volatile anesthetic isoflurane could reduce mortality and protect against sepsis induced renal and hepatic dysfunction." | 7.74 | Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis. ( Emala, CW; Joo, JD; Kim, M; Lee, HT, 2007) |
| "Acute lung injury is one of major complications associated with sepsis, responsible for morbidity and mortality." | 5.72 | Isoflurane attenuates sepsis-associated lung injury. ( Kobayashi, Y; Koutsogiannaki, S; Ogawa, N; Okuno, T; Yuki, K, 2022) |
| "To compare dexmedetomidine and fentanyl constant rate infusions in anesthetic protocols for septic dogs with pyometra, using microcirculatory, hemodynamic and metabolic variables." | 5.51 | Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. ( Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS, 2022) |
| "This study addressed the effect of MRI under isoflurane anesthesia on blood-brain barrier integrity, cyclooxygenase-2 expression, and glial cell activation during cecal ligature and puncture-induced sepsis-associated brain dysfunction in rats." | 4.02 | Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats. ( Dhaya, I; Griton, M; Konsman, JP, 2021) |
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 3.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| "The effects of combined therapy with isoflurane and oxygen on lung injury and sepsis were determined in animal models of sepsis induced by cecal ligation and puncture (CLP) or intraperitoneal injection of lipopolysaccharide (LPS) or zymosan." | 3.85 | Sub-anesthesia Dose of Isoflurane in 60% Oxygen Reduces Inflammatory Responses in Experimental Sepsis Models. ( Dong, HL; Han, H; Hou, LC; Hou, ZX; Huang, Y; Pu, ZS; Shao, T; Sun, DD; Wang, XX; Xiong, LZ; Yang, WW; Zhang, EF; Zhang, ZX, 2017) |
| "Mice (N = 12 per treatment group) were exposed to anesthetic concentrations of desflurane, isoflurane, and sevoflurane either during induction of sepsis or when the mice showed pronounced symptoms of inflammation." | 3.79 | Volatile anesthetics improve survival after cecal ligation and puncture. ( Beck-Schimmer, B; Castellon, M; Hasler, M; Herrmann, IK; Hu, G; Minshall, RD; Schwartz, DE; Urner, M, 2013) |
| "Isoflurane (ISO) has been shown to attenuate acute lung injury (ALI)." | 3.79 | Isoflurane post-treatment improves pulmonary vascular permeability via upregulation of heme oxygenase-1. ( Dong, X; Hu, R; Jiang, H; Li, Q; Sun, Y, 2013) |
| "This study aimed to evaluate the differential protective effects of isoflurane or sevoflurane on lung inflammation in a rat model of cecal ligation and puncture (CLP) induced sepsis." | 3.78 | Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation. ( Akkaya, T; Alper, M; Bedirli, A; Bedirli, N; Demirtas, CY; Pasaoglu, H; Salman, B, 2012) |
| " As hyperactive uncontrolled inflammation can lead to mortality and morbidity during early sepsis, we questioned whether the volatile anesthetic isoflurane could reduce mortality and protect against sepsis induced renal and hepatic dysfunction." | 3.74 | Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis. ( Emala, CW; Joo, JD; Kim, M; Lee, HT, 2007) |
| "Acute lung injury is one of major complications associated with sepsis, responsible for morbidity and mortality." | 1.72 | Isoflurane attenuates sepsis-associated lung injury. ( Kobayashi, Y; Koutsogiannaki, S; Ogawa, N; Okuno, T; Yuki, K, 2022) |
| "Ketamine has hepatoprotective effects against LPS-induced liver injury that appear to be mediated, at least in part, by differential modulation of the oxidative stress proteins iNOS and HO-1." | 1.33 | Differential effects of anesthetics on endotoxin-induced liver injury. ( Gonzalez, EA; Helmer, KS; Kennison, SD; Mercer, DW; Suliburk, JW, 2005) |
| "A case of malignant hyperthermia (mh) in a 27-year-old man is described." | 1.31 | Fatal malignant hyperthermia--delayed onset and atypical course. ( Karger, B; Teige, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dhaya, I | 1 |
| Griton, M | 1 |
| Konsman, JP | 1 |
| Koutsogiannaki, S | 2 |
| Okuno, T | 2 |
| Kobayashi, Y | 1 |
| Ogawa, N | 1 |
| Yuki, K | 2 |
| Nagashima, JK | 1 |
| Gonçalves, LA | 1 |
| Pereira, MA | 1 |
| Talib, MS | 1 |
| de Olveira, CM | 1 |
| Ambrósio, AM | 1 |
| Fantoni, DT | 1 |
| Huang, Y | 1 |
| Wang, XX | 1 |
| Sun, DD | 1 |
| Zhang, ZX | 1 |
| Yang, WW | 1 |
| Shao, T | 1 |
| Han, H | 1 |
| Zhang, EF | 1 |
| Pu, ZS | 1 |
| Hou, ZX | 1 |
| Dong, HL | 1 |
| Xiong, LZ | 1 |
| Hou, LC | 1 |
| Bedirli, N | 2 |
| Bagriacik, EU | 1 |
| Yilmaz, G | 1 |
| Ozkose, Z | 1 |
| Kavutçu, M | 1 |
| Cavunt Bayraktar, A | 1 |
| Bedirli, A | 2 |
| Herrmann, IK | 1 |
| Castellon, M | 1 |
| Schwartz, DE | 1 |
| Hasler, M | 1 |
| Urner, M | 1 |
| Hu, G | 1 |
| Minshall, RD | 1 |
| Beck-Schimmer, B | 1 |
| Dong, X | 1 |
| Hu, R | 1 |
| Sun, Y | 1 |
| Li, Q | 1 |
| Jiang, H | 1 |
| Schaefers, MM | 1 |
| Ohba, M | 1 |
| Yokomizo, T | 1 |
| Priebe, GP | 1 |
| DiNardo, JA | 1 |
| Sulpicio, SG | 1 |
| Osuchowski, MF | 1 |
| Teener, J | 1 |
| Remick, D | 1 |
| Hoemberg, M | 1 |
| Vierzig, A | 1 |
| Roth, B | 1 |
| Eifinger, F | 1 |
| Demirtas, CY | 1 |
| Akkaya, T | 1 |
| Salman, B | 1 |
| Alper, M | 1 |
| Pasaoglu, H | 1 |
| Karger, B | 1 |
| Teige, K | 1 |
| Suliburk, JW | 1 |
| Gonzalez, EA | 1 |
| Kennison, SD | 1 |
| Helmer, KS | 1 |
| Mercer, DW | 1 |
| Lee, HT | 1 |
| Emala, CW | 1 |
| Joo, JD | 1 |
| Kim, M | 1 |
| Gill, R | 1 |
| Martin, C | 1 |
| McKinnon, T | 1 |
| Lam, C | 1 |
| Cunningham, D | 1 |
| Sibbald, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238] | Phase 3 | 97 participants (Actual) | Interventional | 2021-01-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for isoflurane and Sepsis
| Article | Year |
|---|---|
Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Dexmedetomidine; Dog Diseases; Dogs; Female; Fentanyl; | 2022 |
14 other studies available for isoflurane and Sepsis
| Article | Year |
|---|---|
Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats.
Topics: Anesthesia; Animals; Cyclooxygenase 2; Isoflurane; Magnetic Resonance Imaging; Neuroglia; Rats; Seps | 2021 |
Isoflurane attenuates sepsis-associated lung injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Chemotaxis; Disease Models, Animal; Eicosanoids | 2022 |
Sub-anesthesia Dose of Isoflurane in 60% Oxygen Reduces Inflammatory Responses in Experimental Sepsis Models.
Topics: Adult; Anesthesia; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Disease Models, Animal; | 2017 |
Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis.
Topics: Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Apoptosis; bcl-2-Associated X Protein; Brai | 2018 |
Volatile anesthetics improve survival after cecal ligation and puncture.
Topics: Anesthetics, Inhalation; Animals; Cecum; Desflurane; Disease Models, Animal; Inflammation; Isofluran | 2013 |
Isoflurane post-treatment improves pulmonary vascular permeability via upregulation of heme oxygenase-1.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Disease Models, Animal; Heme Oxygenase-1; Isoflu | 2013 |
From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.
Topics: Anesthetics, Inhalation; Animals; Cytokines; Disease Models, Animal; Isoflurane; Lymphocyte Function | 2017 |
Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data.
Topics: Action Potentials; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cecum; Electromyography | 2009 |
Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy.
Topics: Anesthetics, Inhalation; Child, Preschool; Conscious Sedation; Fentanyl; Fluorides; Humans; Hypnotic | 2012 |
Volatile anesthetic preconditioning attenuated sepsis induced lung inflammation.
Topics: Anesthetics, Inhalation; Animals; Cecum; Disease Models, Animal; Intercellular Adhesion Molecule-1; | 2012 |
Fatal malignant hyperthermia--delayed onset and atypical course.
Topics: Adult; Anesthetics, Inhalation; Autopsy; Fatal Outcome; Humans; Isoflurane; Male; Malignant Hyperthe | 2002 |
Differential effects of anesthetics on endotoxin-induced liver injury.
Topics: Anesthetics; Animals; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Isoflurane; Ketamine; | 2005 |
Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis.
Topics: Anesthetics, Inhalation; Animals; Disease Models, Animal; Isoflurane; Kidney; Liver; Male; Mice; Mic | 2007 |
Sepsis reduces isoflurane MAC in a normotensive animal model of sepsis.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Disease Models, Animal; Isoflurane; Male; Pulmonar | 1995 |