isoflurane has been researched along with Postoperative Cognitive Complications in 15 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Postoperative Cognitive Complications: COGNITIVE IMPAIRMENT or functional decline after a surgical procedure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia." | 8.31 | Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 8.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia." | 7.96 | Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. ( Cai, Y; Huang, P; Xie, Y, 2020) |
| "Ryanodine receptor agonist caffeine may improve cognitive dysfunction in mice after isoflurane anesthesia." | 4.31 | Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction. ( Gu, X; Liu, B; Ma, Z; Qian, Y; Su, Y; Xia, T; Zhou, Q; Zhu, X, 2023) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 4.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia." | 3.96 | Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. ( Cai, Y; Huang, P; Xie, Y, 2020) |
| "Surgical trauma, but not anesthesia, contributes to the development of PND and neuroinflammation." | 1.62 | Surgery Trauma Severity but not Anesthesia Length Contributes to Postoperative Cognitive Dysfunction in Mice. ( Lai, Z; Li, J; Min, J; Shan, W; Yu, W; Zuo, Z, 2021) |
| "In isoflurane anesthesia-treated group (IS), the percentage of target quadrant dwell time was significantly lower and the escape latency was significantly higher than in the control group (sham), and the freezing behavior of IS was significantly less in contextual fear conditioning tests." | 1.56 | Up-regulation of miR-106a targets LIMK1 and contributes to cognitive impairment induced by isoflurane anesthesia in mice. ( Wang, T; Wen, H; Yao, L; Ye, W; Zhang, N, 2020) |
| "Isoflurane is a widely used anesthetic agent, which is associated with the development of POCD; however, the precise mechanisms remain unclear." | 1.56 | Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. ( Fan, X; Li, F; Qiu, J; Zhang, X; Zhang, Y, 2020) |
| "Ginsenoside Rg1 treatment before I/S intervention significantly ameliorated learning and memory performance, reduced ROS levels and improved the OCR, MMP, expression and deacetylation activity of Sirt3." | 1.51 | Ginsenoside Rg1 attenuates isoflurane/surgery-induced cognitive disorders and sirtuin 3 dysfunction. ( Miao, HH; Tian, M; Wang, HX; Wang, M; Xue, FS, 2019) |
| "Thus, we hypothesised that intestinal dysbacteriosis caused by anaesthesia/surgery induces POCD." | 1.51 | Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice. ( Chen, XM; Gu, XY; Jiang, XL; Qin, Y; Shen, L; Su, DS; Yang, YT; Yu, WF; Zhang, X; Zhou, XX, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 13 (86.67) | 2.80 |
| Authors | Studies |
|---|---|
| Min, J | 2 |
| Lai, Z | 2 |
| Wang, H | 1 |
| Zuo, Z | 2 |
| Lian, F | 1 |
| Cao, C | 1 |
| Deng, F | 1 |
| Liu, C | 1 |
| Zhou, Z | 1 |
| Huang, X | 1 |
| Su, Z | 1 |
| Zhang, S | 1 |
| Xu, X | 2 |
| Yang, B | 1 |
| Kuzminskaite, V | 1 |
| Kontrimaviciute, E | 1 |
| Kauzonas, E | 1 |
| Slauzgalvyte, I | 1 |
| Bukelyte, G | 1 |
| Bruzyte-Narkiene, G | 1 |
| Jatuzis, D | 1 |
| Wang, W | 1 |
| Gao, W | 1 |
| Zhang, L | 1 |
| Xia, Z | 1 |
| Zhao, B | 1 |
| Liu, B | 1 |
| Zhu, X | 1 |
| Zhou, Q | 1 |
| Su, Y | 1 |
| Qian, Y | 1 |
| Ma, Z | 1 |
| Gu, X | 1 |
| Xia, T | 1 |
| Miao, HH | 2 |
| Wang, M | 1 |
| Wang, HX | 1 |
| Tian, M | 1 |
| Xue, FS | 1 |
| Zhang, N | 1 |
| Ye, W | 1 |
| Wang, T | 1 |
| Wen, H | 1 |
| Yao, L | 1 |
| Cai, Y | 1 |
| Huang, P | 1 |
| Xie, Y | 1 |
| Zhang, X | 2 |
| Fan, X | 1 |
| Li, F | 1 |
| Qiu, J | 1 |
| Zhang, Y | 1 |
| Shen, YX | 1 |
| Chen, YP | 1 |
| Zang, HC | 1 |
| Shao, G | 1 |
| Lin, H | 1 |
| Kang, Z | 1 |
| Li, S | 1 |
| Zeng, J | 1 |
| Zhao, J | 1 |
| Li, J | 1 |
| Shan, W | 1 |
| Yu, W | 1 |
| Liu, Q | 1 |
| Sun, YM | 1 |
| Huang, H | 1 |
| Chen, C | 1 |
| Wan, J | 1 |
| Ma, LH | 1 |
| Sun, YY | 1 |
| Wu, YQ | 1 |
| Jiang, XL | 1 |
| Gu, XY | 1 |
| Zhou, XX | 1 |
| Chen, XM | 1 |
| Yang, YT | 1 |
| Qin, Y | 1 |
| Shen, L | 1 |
| Yu, WF | 1 |
| Su, DS | 1 |
1 trial available for isoflurane and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Sevoflurane and desflurane effects on early cognitive function after low-risk surgery: A randomized clinical trial.
Topics: Anesthetics, Inhalation; Cognition; Desflurane; Humans; Isoflurane; Methyl Ethers; Postoperative Cog | 2023 |
14 other studies available for isoflurane and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Preoperative environment enrichment preserved neuroligin 1 expression possibly via epigenetic regulation to reduce postoperative cognitive dysfunction in mice.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Epigenesis, Genetic; Hippocampus; Isoflurane; Male; Maze | 2022 |
Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats.
Topics: Animals; Cognitive Dysfunction; Humans; Inflammation; Isoflurane; MicroRNAs; Postoperative Cognitive | 2022 |
ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
Topics: Angiopoietin-Like Protein 2; Animals; Cognitive Dysfunction; Inflammation; Isoflurane; Mice; Neuroin | 2023 |
SNAP25 ameliorates postoperative cognitive dysfunction by facilitating PINK1-dependent mitophagy and impeding caspase-3/GSDME-dependent pyroptosis.
Topics: Animals; Caspase 3; Humans; Isoflurane; Lipopolysaccharides; Mitophagy; Neuroblastoma; Postoperative | 2023 |
Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Cognitive Dysfunction; Hippocampus; Isoflurane; Male; Mi | 2023 |
Ginsenoside Rg1 attenuates isoflurane/surgery-induced cognitive disorders and sirtuin 3 dysfunction.
Topics: Animals; Gene Expression Regulation, Enzymologic; Ginsenosides; Hippocampus; Isoflurane; Male; Maze | 2019 |
Up-regulation of miR-106a targets LIMK1 and contributes to cognitive impairment induced by isoflurane anesthesia in mice.
Topics: 3' Untranslated Regions; Anesthetics, Inhalation; Animals; Apoptosis; Isoflurane; Lim Kinases; Male; | 2020 |
Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.
Topics: Alkaloids; Anesthesia; Anesthetics, Inhalation; Animals; Enzyme-Linked Immunosorbent Assay; Hippocam | 2020 |
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Disease Models, Animal; Gene Silencing; Hippocampus; Inflam | 2020 |
Evaluation of the efficiency of propofol versus isoflurane anesthesia interventions in treating elderly patients with postoperative cognitive dysfunction: A protocol for systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Anesthetics; Female; Humans; Isoflurane; Male; Meta-Analysis as Topic; Midd | 2020 |
Sarm1 is Essential for Anesthesia-Induced Neuroinflammation and Cognitive Impairment in Aged Mice.
Topics: Aged; Anesthesia; Animals; Armadillo Domain Proteins; Calpain; Cognitive Dysfunction; Cytoskeletal P | 2022 |
Surgery Trauma Severity but not Anesthesia Length Contributes to Postoperative Cognitive Dysfunction in Mice.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Encephalitis; Hippocampus; Interleukin-1be | 2021 |
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.
Topics: Aging; Anesthetics, Inhalation; Animals; Hippocampus; Inflammation Mediators; Isoflurane; Male; Mice | 2021 |
Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Cognition Disorders; Dysbiosis; Gastrointes | 2019 |