isoflurane has been researched along with Porphyria, Acute Intermittent in 3 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Porphyria, Acute Intermittent: An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " ALA-S activity was induced by acute administration of anaesthetics (89%), veronal (240%) and ethanol (80%), while ALA-S mRNA expression augmented by chronic administration of enflurane, AIA and veronal." | 1.33 | Heme oxygenase, aminolevulinate acid synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs. ( Batlle, A; Buzaleh, AM; Gerez, E; Martinez, Mdel C; Rodriguez, JA, 2005) |
| "Despite the low incidence of the acute porphyrias, a profound knowledge of the disease is essential for anaesthesiologists, as a variety of perioperatively administered drugs are potential triggers of an acute attack." | 1.32 | [Desflurane in acute intermittent porphyria]. ( Forst, H; Gerheuser, F; Messmer, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Messmer, M | 1 |
| Gerheuser, F | 1 |
| Forst, H | 1 |
| Rodriguez, JA | 1 |
| Martinez, Mdel C | 1 |
| Gerez, E | 1 |
| Batlle, A | 1 |
| Buzaleh, AM | 2 |
| Enriquez de Salamanca, R | 1 |
| del Carmen Batlle, AM | 1 |
3 other studies available for isoflurane and Porphyria, Acute Intermittent
| Article | Year |
|---|---|
[Desflurane in acute intermittent porphyria].
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Desflurane; Female; Hepatectomy; Humans; Isoflur | 2004 |
Heme oxygenase, aminolevulinate acid synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Barbital; Brain; Enflurane; Ethanol; Gene Expre | 2005 |
Administration of the anesthetic isoflurane to mice: a model for acute intermittent porphyria?
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Isofl | 1992 |