isoflurane has been researched along with Parkinson Disease in 5 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 7.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 3.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| "We report a patient with Parkinson's disease undergoing craniotomy for a brain tumor, who had clinically adequate hypnosis at a very low concentration of isoflurane." | 1.35 | Adequate hypnosis at very low isoflurane concentration during craniotomy monitored by electroencephalography. ( Jaganath, A; Radhakrishnan, M; Ramesh, M; Umamaheswara Rao, GS, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leikas, JV | 1 |
| Kohtala, S | 1 |
| Theilmann, W | 1 |
| Jalkanen, AJ | 1 |
| Forsberg, MM | 1 |
| Rantamäki, T | 1 |
| Lerner, RP | 1 |
| Bimpisidis, Z | 2 |
| Agorastos, S | 1 |
| Scherrer, S | 1 |
| Dewey, SL | 1 |
| Cenci, MA | 2 |
| Eidelberg, D | 1 |
| Öberg, CM | 1 |
| Maslava, N | 1 |
| Lundblad, C | 1 |
| Lin, SH | 1 |
| Chen, TY | 1 |
| Lin, SZ | 1 |
| Shyr, MH | 1 |
| Chou, YC | 1 |
| Hsieh, WA | 1 |
| Tsai, ST | 1 |
| Chen, SY | 1 |
| Jaganath, A | 1 |
| Ramesh, M | 1 |
| Radhakrishnan, M | 1 |
| Umamaheswara Rao, GS | 1 |
5 other studies available for isoflurane and Parkinson Disease
| Article | Year |
|---|---|
Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.
Topics: Anesthesia; Animals; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; | 2017 |
Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model.
Topics: Analgesics; Animals; Antiparkinson Agents; Cerebrovascular Circulation; Disease Models, Animal; Fema | 2016 |
Differential effects of gaseous versus injectable anesthetics on changes in regional cerebral blood flow and metabolism induced by l-DOPA in a rat model of Parkinson's disease.
Topics: Anesthetics; Animals; Basal Ganglia; Cerebrovascular Circulation; Dyskinesia, Drug-Induced; Dyskines | 2017 |
Subthalamic deep brain stimulation after anesthetic inhalation in Parkinson disease: a preliminary study.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Deep Brain Stimulation; Desf | 2008 |
Adequate hypnosis at very low isoflurane concentration during craniotomy monitored by electroencephalography.
Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Brain Neoplasms; Craniotomy; Electroencephal | 2008 |