isoflurane has been researched along with Neurodegenerative Diseases in 8 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Berkowitz, BA | 1 |
| Podolsky, RH | 1 |
| Childers, KL | 1 |
| Gow, A | 1 |
| Schneider, BL | 1 |
| Lloyd, SC | 1 |
| Bosse, KE | 1 |
| Conti, AC | 1 |
| Roberts, R | 1 |
| Berri, AM | 1 |
| Graffice, E | 1 |
| Sinan, K | 1 |
| Eliwat, W | 1 |
| Shen, Y | 1 |
| Huang, BY | 1 |
| Huang, HB | 1 |
| Zhang, ZJ | 1 |
| Liu, ZG | 1 |
| Luo, J | 1 |
| Liu, M | 1 |
| Luo, T | 1 |
| Wang, WY | 1 |
| Luo, Y | 1 |
| Jia, LJ | 1 |
| Hu, SF | 1 |
| Lou, XK | 1 |
| Shen, SL | 1 |
| Lu, H | 1 |
| Zhang, HH | 1 |
| Yang, R | 1 |
| Wang, H | 1 |
| Ma, ZW | 1 |
| Xue, QS | 1 |
| Yu, BW | 1 |
| DeYoung, TP | 1 |
| Li, JC | 1 |
| Tang, X | 1 |
| Ward, CG | 1 |
| Dworkin, BR | 1 |
| Eckenhoff, MF | 2 |
| Kofke, WA | 1 |
| Eckenhoff, RG | 1 |
| Jiang, H | 1 |
| Huang, Y | 1 |
| Xu, H | 1 |
| Sun, Y | 1 |
| Han, N | 1 |
| Li, QF | 1 |
| Jevtovic-Todorovic, V | 1 |
| Hartman, RE | 1 |
| Izumi, Y | 1 |
| Benshoff, ND | 1 |
| Dikranian, K | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Sanders, RD | 1 |
| Ma, D | 1 |
| Maze, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102] | Phase 3 | 104 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915] | Phase 3 | 48 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351] | 30 participants (Actual) | Observational | 2006-01-01 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.696 |
| Oxygen | 4.253 |
Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 5.486 |
| Oxygen | 5.433 |
Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 1 |
| Oxygen | 0.88 |
Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.286 |
| Oxygen | 6.920 |
Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 6.136 |
| Oxygen | 6.080 |
1 review available for isoflurane and Neurodegenerative Diseases
| Article | Year |
|---|---|
Anaesthesia induced neuroprotection.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Humans; Isoflurane; Nervous System Diseases; Neurodege | 2005 |
7 other studies available for isoflurane and Neurodegenerative Diseases
| Article | Year |
|---|---|
Age-related murine hippocampal CA1 laminae oxidative stress measured in vivo by QUEnch-assiSTed (QUEST) MRI: impact of isoflurane anesthesia.
Topics: Anesthesia; Animals; Hippocampus; Humans; Isoflurane; Magnetic Resonance Imaging; Mice; Neurodegener | 2020 |
Cell cycle activation contributes to isoflurane-induced neurotoxicity in the developing brain and the protective effect of CR8.
Topics: Anesthetics, Inhalation; Animals; Brain; Caspase 3; Cell Cycle; Cyclin B1; Isoflurane; Mice, Inbred | 2019 |
Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain.
Topics: Animals; Cells, Cultured; Cyclin-Dependent Kinase 5; Hippocampus; Isoflurane; Maze Learning; Neurode | 2014 |
Absence of Neuropathology With Prolonged Isoflurane Sedation in Healthy Adult Rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Blood Glucose; Conscious Sedation; | 2017 |
A smoking gun but still no victim.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Humans; Isoflurane; Neurodegenerative Diseases | 2010 |
Hypoxia inducible factor-1α is involved in the neurodegeneration induced by isoflurane in the brain of neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Calcium; Cell Survival; Cells, | 2012 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |