isoflurane has been researched along with Nerve Degeneration in 33 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 7.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| "Our results demonstrate that the administration of inhaled isoflurane in spinal cord ischemia-reperfusion injury impairs the recovery of motor function." | 7.85 | Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats. ( Fang, SY; Lam, CF; Lee, JS; Roan, JN; Tsai, YC, 2017) |
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 3.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| "Our results demonstrate that the administration of inhaled isoflurane in spinal cord ischemia-reperfusion injury impairs the recovery of motor function." | 3.85 | Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats. ( Fang, SY; Lam, CF; Lee, JS; Roan, JN; Tsai, YC, 2017) |
| "This study determined the induction profiles of immediate-early genes in the ovine brain after cardiopulmonary bypass (CPB) and hypothermic circulatory arrest (HCA), and the effects of the noncompetitive N-methyl-D-aspartate antagonist, aptiganel, on immediate-early gene expression, neuronal necrosis, and functional outcome." | 3.70 | Differential immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest. ( Bokesch, PM; Kream, RM; Marchand, JE; Seirafi, PA; Trapp, B; Warner, KG, 1998) |
| "Melatonin plays an important role in aging and relevant neurodegeneration as an antioxidant and neuroprotector." | 1.39 | Melatonin premedication attenuates isoflurane anesthesia-induced β-amyloid generation and cholinergic dysfunction in the hippocampus of aged rats. ( Guo, X; Jia, D; Li, M; Luo, A; Ni, C; Qian, M; Tan, G; Tang, Y; Wang, J; Wu, C; Zhang, Y; Zhou, Y, 2013) |
| "Isoflurane treatments significantly increased apoptosis indicated by the activation of caspase-3 and elevation of poly-(ADP-ribose) polymerase in different brain regions." | 1.36 | Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. ( Huang, B; Liang, G; Peng, J; Ward, C; Wei, H; Zhao, Y, 2010) |
| "We examined in a rabbit model of transient spinal cord ischemia (SCI) whether isoflurane (Iso) preconditioning induces ischemic tolerance to SCI in a dose-response manner, and whether this effect is dependent on mitochondrial adenosine triphosphate-dependent potassium (K(ATP)) channel." | 1.33 | Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel. ( Hwang, JW; Jeon, YT; Kang, H; Kim, CS; Lim, SW; Oh, YS; Park, HP, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 18 (54.55) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, DA | 1 |
| DeYoung, TP | 1 |
| Kondoleon, NP | 1 |
| Eckenhoff, RG | 2 |
| Eckenhoff, MF | 2 |
| Leikas, JV | 1 |
| Kohtala, S | 1 |
| Theilmann, W | 1 |
| Jalkanen, AJ | 1 |
| Forsberg, MM | 1 |
| Rantamäki, T | 1 |
| Eifinger, F | 1 |
| Hünseler, C | 1 |
| Roth, B | 1 |
| Vierzig, A | 1 |
| Oberthuer, A | 1 |
| Mehler, K | 1 |
| Kribs, A | 1 |
| Menzel, C | 1 |
| Trieschmann, U | 1 |
| Jevtovic-Todorovic, V | 4 |
| Yang, B | 1 |
| Liang, G | 4 |
| Khojasteh, S | 1 |
| Wu, Z | 1 |
| Yang, W | 1 |
| Joseph, D | 1 |
| Wei, H | 4 |
| Joksovic, PM | 1 |
| Lunardi, N | 1 |
| Todorovic, SM | 1 |
| Wang, Q | 1 |
| Yin, J | 1 |
| Wang, S | 2 |
| Cui, D | 1 |
| Lin, H | 1 |
| Ge, M | 1 |
| Dai, Z | 1 |
| Xie, L | 1 |
| Si, J | 1 |
| Ma, K | 1 |
| Li, L | 1 |
| Zhao, L | 1 |
| Chai, D | 1 |
| Jiang, H | 1 |
| Li, Q | 1 |
| Fang, SY | 1 |
| Lee, JS | 1 |
| Roan, JN | 1 |
| Tsai, YC | 1 |
| Lam, CF | 1 |
| Wang, L | 1 |
| Wang, A | 1 |
| Supplee, WW | 1 |
| Koffler, K | 1 |
| Cheng, Y | 1 |
| Quezado, ZMN | 1 |
| Levy, RJ | 1 |
| Heinemann, U | 1 |
| Tétrault, S | 1 |
| Chever, O | 1 |
| Sik, A | 1 |
| Amzica, F | 1 |
| Loepke, AW | 1 |
| Istaphanous, GK | 1 |
| McAuliffe, JJ | 1 |
| Miles, L | 1 |
| Hughes, EA | 1 |
| McCann, JC | 1 |
| Harlow, KE | 1 |
| Kurth, CD | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Danzer, SC | 1 |
| Peretich, K | 1 |
| Zhao, Y | 3 |
| Meng, Q | 2 |
| Chen, Q | 1 |
| Joseph, DJ | 1 |
| Perucho, J | 1 |
| Rubio, I | 1 |
| Casarejos, MJ | 1 |
| Gomez, A | 1 |
| Rodriguez-Navarro, JA | 1 |
| Solano, RM | 1 |
| De Yébenes, JG | 1 |
| Mena, MA | 1 |
| Ward, C | 1 |
| Peng, J | 1 |
| Huang, B | 1 |
| Valentim, AM | 1 |
| Di Giminiani, P | 1 |
| Ribeiro, PO | 1 |
| Rodrigues, P | 1 |
| Olsson, IA | 1 |
| Antunes, LM | 1 |
| Cross, DA | 1 |
| Tsuchimoto, T | 1 |
| Ueki, M | 1 |
| Miki, T | 1 |
| Morishita, J | 1 |
| Maekawa, N | 1 |
| Shu, Y | 2 |
| Zhou, Z | 1 |
| Wan, Y | 1 |
| Sanders, RD | 2 |
| Li, M | 2 |
| Pac-Soo, CK | 1 |
| Maze, M | 2 |
| Ma, D | 2 |
| Menuet, C | 1 |
| Borghgraef, P | 1 |
| Voituron, N | 1 |
| Gestreau, C | 1 |
| Gielis, L | 1 |
| Devijver, H | 1 |
| Dutschmann, M | 1 |
| Van Leuven, F | 1 |
| Hilaire, G | 1 |
| Ni, C | 1 |
| Tan, G | 1 |
| Luo, A | 1 |
| Qian, M | 1 |
| Tang, Y | 1 |
| Zhou, Y | 1 |
| Wang, J | 1 |
| Zhang, Y | 1 |
| Jia, D | 1 |
| Wu, C | 1 |
| Guo, X | 1 |
| Li, J | 1 |
| Zheng, S | 2 |
| Zuo, Z | 2 |
| Beals, J | 1 |
| Benshoff, N | 1 |
| Olney, JW | 2 |
| Park, HP | 1 |
| Jeon, YT | 1 |
| Hwang, JW | 1 |
| Kang, H | 1 |
| Lim, SW | 1 |
| Kim, CS | 1 |
| Oh, YS | 1 |
| Wise-Faberowski, L | 1 |
| Zhang, H | 1 |
| Ing, R | 1 |
| Pearlstein, RD | 1 |
| Warner, DS | 1 |
| Baxter, MG | 1 |
| Murphy, KL | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
| Xu, J | 1 |
| Fidalgo, A | 1 |
| Kirby, CO | 1 |
| Bokesch, PM | 1 |
| Seirafi, PA | 1 |
| Warner, KG | 1 |
| Marchand, JE | 1 |
| Kream, RM | 1 |
| Trapp, B | 1 |
| Foster, AC | 1 |
| Gill, R | 1 |
| Woodruff, GN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238] | Phase 3 | 97 participants (Actual) | Interventional | 2021-01-14 | Completed | ||
| Cerebral Oxymetry and Neuronal Biomarkers in Newborns and Infants During Perioperative Period[NCT02423369] | 49 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
33 other studies available for isoflurane and Nerve Degeneration
| Article | Year |
|---|---|
Anesthetic Effects on the Progression of Parkinson Disease in the Rat DJ-1 Model.
Topics: Anesthetics, Inhalation; Animals; Behavior, Animal; Calcium-Binding Proteins; Disease Models, Animal | 2021 |
Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.
Topics: Anesthesia; Animals; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; | 2017 |
Observations on the effects of inhaled isoflurane in long-term sedation of critically Ill children using a modified AnaConDa©-system.
Topics: Anesthesia, Inhalation; Conscious Sedation; Critical Illness; Female; Humans; Infant; Intensive Care | 2013 |
Good gas, bad gas: isoflurane, carbon monoxide, and which is which?
Topics: Anesthetics, Inhalation; Carbon Monoxide; Gasotransmitters; Humans; Isoflurane; Nerve Degeneration; | 2014 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Biological Transport; Cell Membrane; Drug | 2015 |
Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning.
Topics: Animals; Cell Hypoxia; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Glucose; Hip | 2016 |
Isoflurane neurotoxicity involves activation of hypoxia inducible factor-1α via intracellular calcium in neonatal rodents.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Cells, Cu | 2016 |
Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 3; Disease Models, An | 2017 |
Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.
Topics: Anesthetics, Inhalation; Animals; Brain; CA3 Region, Hippocampal; Carbon Monoxide; Female; Isofluran | 2017 |
New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).
Topics: Anesthetics, Inhalation; Blood-Brain Barrier; Brain; Brain Diseases, Metabolic; Brain Edema; Epileps | 2008 |
Opening of the blood-brain barrier during isoflurane anaesthesia.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain; Brain Edema; Cats; Cerebral Cortex; Co | 2008 |
The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blood Glucose; Brai | 2009 |
Anesthesia-induced neurodegeneration in fetal rat brains.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Female; Fetus; Gestational Age; Humans; Isoflura | 2009 |
Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors.
Topics: Amyloid Precursor Protein Secretases; Anesthetics, Inhalation; Animals; Apoptosis; Aspartic Acid End | 2010 |
Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthesia, General; Anesthetics, Inhalation; Animals; Apo | 2010 |
Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice.
Topics: Age Factors; Animals; Animals, Newborn; Biomarkers; Brain; Female; Isoflurane; Male; Methyl Ethers; | 2010 |
Lower isoflurane concentration affects spatial learning and neurodegeneration in adult mice compared with higher concentrations.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Isoflurane; Male; M | 2010 |
Multiples of minimal alveolar concentration of volatile agents are not necessarily equipotent.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Brain; Dose-Response Relationship, Drug; Isoflur | 2011 |
Erythropoietin attenuates isoflurane-induced neurodegeneration and learning deficits in the developing mouse brain.
Topics: Air; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Dis | 2011 |
Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blotting, Western; | 2012 |
Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Brain Stem; Disease Models, Animal; Isoflurane; | 2012 |
Melatonin premedication attenuates isoflurane anesthesia-induced β-amyloid generation and cholinergic dysfunction in the hippocampus of aged rats.
Topics: Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Antioxidants; Choline O-Acetyltransferase; | 2013 |
Isoflurane decreases AMPA-induced dark cell degeneration and edematous damage of Purkinje neurons in the rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Size; Cerebellum; Female; Is | 2002 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; C | 2003 |
Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Brain; Cell Death; Diaze | 2003 |
Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel.
Topics: Anesthetics, Inhalation; Animals; Anterior Horn Cells; Cell Death; Cell Survival; Disease Models, An | 2005 |
Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures.
Topics: Anesthetics, Inhalation; Animals; Cell Death; Dentate Gyrus; Hippocampus; In Situ Hybridization; Iso | 2005 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |
General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord.
Topics: Anesthetics, General; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Caspase 3; Enzyme Acti | 2008 |
Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Inhalation; Animals; Brain Damage, Chronic; Dizocilpine Maleate; Excitatory Amino Acid | 1997 |
Differential immediate-early gene expression in ovine brain after cardiopulmonary bypass and hypothermic circulatory arrest.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Brain; Cardiopulmonary Bypass; Female; Gene E | 1998 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; | 1988 |