isoflurane and Myocardial Infarction studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

Research Excerpts

Excerpt	Relevance	Reference
" Here we compared sevoflurane and isoflurane with particular reference to their hemodynamic effects and ability to modify the effects of acute severe myocardial ischemia and reperfusion on ventricular arrhythmias and mortality in a porcine model of myocardial infarction."	9.15	Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. ( Ajenjo-Silverio, JM; Altónaga, JR; Cuellas-Ramón, C; de Prado, AP; Fernández-Vázquez, F; Gonzalo-Orden, JM; Orden, A; Regueiro-Purriños, M, 2011)
"The aim of this meta-analysis was to investigate the cardioprotective properties of isoflurane versus any comparator in terms of the rate of myocardial infarction and all-cause mortality."	8.89	The effect of isoflurane on survival and myocardial infarction: a meta-analysis of randomized controlled studies. ( Barile, L; Bignami, E; Biondi-Zoccai, G; Cama, E; Costagliola, R; Fochi, O; Greco, T; Landoni, G; Nicolotti, D; Silvetti, S; Zangrillo, A, 2013)
"Compared to isoflurane and s-ketamine, xenon limited progressive adverse cardiac remodeling and contractile dysfunction 28 days after perioperative myocardial infarction."	7.79	Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat. ( Becker, MM; Bleilevens, C; Funcke, S; Goetzenich, A; Hein, M; Roehl, AB; Rossaint, R; Steendijk, P, 2013)
"St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats."	7.76	Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010)
"The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury."	7.72	Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. ( Alcindor, D; Kersten, JR; Krolikowski, JG; Ludwig, LM; Pagel, PS; Pratt, PF; Tanaka, K; Warltier, DC, 2004)
"Acute hyperglycemia abolishes reductions in myocardial infarct size produced by isoflurane, but N-acetylcysteine restores these beneficial effects."	7.72	N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. ( Kehl, F; Kersten, JR; Krolikowski, JG; Pagel, PS; Warltier, DC; Weihrauch, D, 2003)
"The authors examined the effects of volatile anesthetics (enflurane, isoflurane, and halothane) on ventricular activation in a canine myocardial infarction model."	7.69	Effects of volatile anesthetics, enflurane, isoflurane, and halothane on ventricular delayed activation in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M, 1994)
"Myocardial infarction was induced for 90min, followed by reperfusion for 120min."	5.39	Effects of xenon and isoflurane on apoptosis and inflammation in a porcine myocardial infarction model. ( Classen-Linke, I; Mertens, C; Roehl, AB; Rossaint, R; Schiffl, K; Sopka, S, 2013)
"Isoflurane was discontinued, and blood glucose concentrations were allowed to return to baseline values before left anterior descending coronary artery occlusion."	5.31	Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. ( Kehl, F; Kersten, JR; Krolikowski, JG; Mraovic, B; Pagel, PS; Warltier, DC, 2002)
"In a randomized, single-blinded, placebo-controlled prospective study, serum troponin I concentration (cTnI) (baseline, and 1, 6, 12, 24, 48, and 72 h postoperatively) were measured during isoflurane/sufentanil or propofol/sufentanil anesthesia with or without RIPC (three 5-min periods of intermittent left upper arm ischemia with 5 min reperfusion each) in non-diabetic patients (n = 72) with three-vessel coronary artery disease (ClinicalTrials."	5.16	Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. ( Bergmann, L; Heine, T; Heusch, G; Jakob, H; Kottenberg, E; Peters, J; Thielmann, M, 2012)
" Here we compared sevoflurane and isoflurane with particular reference to their hemodynamic effects and ability to modify the effects of acute severe myocardial ischemia and reperfusion on ventricular arrhythmias and mortality in a porcine model of myocardial infarction."	5.15	Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. ( Ajenjo-Silverio, JM; Altónaga, JR; Cuellas-Ramón, C; de Prado, AP; Fernández-Vázquez, F; Gonzalo-Orden, JM; Orden, A; Regueiro-Purriños, M, 2011)
" Animals in the IC group received isoflurane anesthesia and respiratory support postoperatively."	5.12	Decreased mortality in a rat model of acute postinfarction heart failure. ( Lorentzon, M; Omerovic, E; Råmunddal, T, 2006)
" Cardiac morbidity (postoperative myocardial ischemia, postoperative myocardial infarction, and perioperative sympathoadrenal stress response), respiratory morbidity (postextubation apnea, alveolar-arterial oxygen gradient, pulmonary shunting, oxygen consumption, atelectasis, and reintubation), hemodynamic values and vasoactive medication requirements, intraoperative awareness, postoperative cognitive function, 30 day mortality, and intensive care unit and hospital lengths of stay were compared between the two groups."	5.08	Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996)
"The aim of this meta-analysis was to investigate the cardioprotective properties of isoflurane versus any comparator in terms of the rate of myocardial infarction and all-cause mortality."	4.89	The effect of isoflurane on survival and myocardial infarction: a meta-analysis of randomized controlled studies. ( Barile, L; Bignami, E; Biondi-Zoccai, G; Cama, E; Costagliola, R; Fochi, O; Greco, T; Landoni, G; Nicolotti, D; Silvetti, S; Zangrillo, A, 2013)
" A recent meta-analysis, pooling data regarding the use of desflurane and sevoflurane, found significant reductions of in-hospital mortality, myocardial infarction rate, intensive care unit and hospital stay, time on mechanical ventilation and incidence of long term cardiac events."	4.84	Cardiac protection by volatile anaesthetics: a review. ( Fochi, O; Landoni, G; Torri, G, 2008)
"Isoflurane can, through inhibiting the p38 MAPK signaling pathway, effectively protect the cardiac function of rats from myocardial ischemia-reperfusion injury, reduce the area of myocardial infarction, alleviate the pathological damage in myocardial cells and reduce the oxidative stress response."	3.91	Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway. ( Chong, H; Peng, DD; Wang, G; Zheng, SQ; Zhou, Y; Zhu, F, 2019)
"Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone."	3.80	Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3. ( Hamaguchi, E; Horikawa, YT; Kambe, N; Kasai, A; Kitahata, H; Sakai, Y; Tanaka, K; Tsutsumi, R; Tsutsumi, YM, 2014)
"The rat models were established and divided in acute myocardial ischemia model (myocardial ischemia 30 min, 1 h, 2 h groups), ischemia-reperfusion model (ischemia-reperfusion group), and isoflurane-pretreated ischemia-reperfusion model (isoflurane-pretreated group), respectively."	3.80	[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats]. ( Liang, Z; Yan, P; Zhang, GQ; Zhang, XJ, 2014)
"Compared to isoflurane and s-ketamine, xenon limited progressive adverse cardiac remodeling and contractile dysfunction 28 days after perioperative myocardial infarction."	3.79	Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat. ( Becker, MM; Bleilevens, C; Funcke, S; Goetzenich, A; Hein, M; Roehl, AB; Rossaint, R; Steendijk, P, 2013)
"St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats."	3.76	Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010)
"Pretreatment with isoflurane decreased myocardial infarction size in young rats (3-5 months) but not in old rats (20-24 months)."	3.76	Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart. ( Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Tan, M; Zhu, J, 2010)
"These data suggest that Pim-1 kinase mediates at least in part desflurane-induced preconditioning and IPC against myocardial infarction in mice."	3.75	Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. ( Blomeyer, CA; Kehl, F; Kellermann, A; Lange, M; Lotz, CA; Redel, A; Roewer, N; Smul, TM; Stumpner, J, 2009)
"The authors examined whether olprinone, a phosphodiesterase type 3 inhibitor, or isoflurane, a volatile anesthetic, could protect the heart against myocardial infarction in type 2 diabetic rats and whether the underlying mechanisms involve protein kinase C (PKC), mitochondrial ATP-sensitive potassium (m-K(ATP)) channels, or the phosphatidylinositol 3-kinase (PI3K)-Akt pathway."	3.75	Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway. ( Cho, S; Hara, T; Maekawa, T; Matsumoto, S; Sumikawa, K; Tosaka, S; Ureshino, H, 2009)
"Our data demonstrate that isoflurane protects the heart against ischaemia and decreases myocardial infarction by activation of PI3K."	3.73	Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-kinase/Akt signalling. ( Gozal, Y; Raphael, J; Rivo, J, 2005)
"Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling."	3.73	Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. ( Kersten, JR; Krolikowski, JG; Pagel, PS; Pratt, PF; Venkatapuram, S; Wang, C; Warltier, DC; Weihrauch, D, 2006)
"The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury."	3.72	Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. ( Alcindor, D; Kersten, JR; Krolikowski, JG; Ludwig, LM; Pagel, PS; Pratt, PF; Tanaka, K; Warltier, DC, 2004)
"Acute hyperglycemia abolishes reductions in myocardial infarct size produced by isoflurane, but N-acetylcysteine restores these beneficial effects."	3.72	N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. ( Kehl, F; Kersten, JR; Krolikowski, JG; Pagel, PS; Warltier, DC; Weihrauch, D, 2003)
"Combined administration of isoflurane and morphine enhances the protection against myocardial infarction to a greater extent than either drug alone."	3.72	Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. ( Gross, GJ; Kersten, JR; Ludwig, LM; Pagel, PS; Patel, HH; Warltier, DC, 2003)
"The results indicate that ROS produced following administration of isoflurane contribute to protection against myocardial infarction in vivo."	3.71	Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. ( Kehl, F; Kersten, JR; LaDisa, JF; Ludwig, LM; Pagel, PS; Tanaka, K; Warltier, DC; Weihrauch, D, 2002)
"The authors examined the effects of volatile anesthetics (enflurane, isoflurane, and halothane) on ventricular activation in a canine myocardial infarction model."	3.69	Effects of volatile anesthetics, enflurane, isoflurane, and halothane on ventricular delayed activation in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M, 1994)
"Eighty children scheduled for ventricular septal defect closure under cardioplegic arrest were assigned to preconditioning for five minutes after commencement of cardiopulmonary bypass (CPB) with one minimum alveolar concentration (MAC) of one of the following agents: isoflurane, sevoflurane, desflurane, or placebo (oxygen-air mixture)."	2.78	Comparison of cardioprotective effects of volatile anesthetics in children undergoing ventricular septal defect closure. ( Chauhan, S; Jain, G; Kiran, U; Makhija, N; Singh, P; Talwar, S, 2013)
"Desflurane had lower uptake than propofol (65 ± 21 × 10 vs 165 ± 51 × 10 g·mL·min/μmol; P = ."	1.48	Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition. ( Andrews, DT; Heiberg, J; Royse, AG; Royse, CF, 2018)
"Desflurane was administered 48 h before CAO either alone or in combination with the janus kinase/STAT3 inhibitor AG-490 (40 μg/g i."	1.43	The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase. ( Kehl, F; Lange, M; Lotz, C; Neuwirth, A; Redel, A; Roewer, N; Smul, TM; Stumpner, J; Tischer-Zeitz, T; Umminger, J, 2016)
"Isoflurane has been demonstrated to limit myocardial ischemic injury."	1.42	Isoflurane protects the myocardium against ischemic injury via the preservation of mitochondrial respiration and its supramolecular organization. ( Fang, C; Liem, D; Lotz, C; Ping, P; Zhang, J, 2015)
"Myocardial infarction was induced for 90min, followed by reperfusion for 120min."	1.39	Effects of xenon and isoflurane on apoptosis and inflammation in a porcine myocardial infarction model. ( Classen-Linke, I; Mertens, C; Roehl, AB; Rossaint, R; Schiffl, K; Sopka, S, 2013)
"Pretreatment with isoflurane prior to ischemia reduced LDH and CK-MB levels and infarct size, while it increased phosphorylation of ALDH2, which could be blocked by the ALDH2 inhibitor, cyanamide."	1.39	Isoflurane preconditioning confers cardioprotection by activation of ALDH2. ( Jin, JH; Lang, XE; Li, QS; Lv, JY; Wang, X; Zhang, KR, 2013)
"Myocardial infarction was induced by left anterior descending artery occlusion for 30 min followed by reperfusion for 2 h and infarct size measurements."	1.37	Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. ( Bienengraeber, M; Bosnjak, ZJ; Hirata, N; Kersten, JR; Lohr, NL; Pratt, PF; Pravdic, D; Shim, YH; Warltier, DC; Weihrauch, D, 2011)
"Hyperglycemia is known to inhibit ischemic and anesthetic preconditioning."	1.36	Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. ( Gozal, Y; Navot, N; Raphael, J; Zuo, Z, 2010)
"Isoflurane was inhaled at 1 MAC (0."	1.35	Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane. ( Li, SR; Lin, MT; Lu, LQ; Tao, X; Xu, Q, 2009)
"Isoflurane-treated mice subjected to ischemia and 2 weeks of reperfusion showed less expression of proapoptotic genes, significantly decreased expression of cleaved caspase-3, and significantly decreased deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling-positive nuclei compared with the control group."	1.33	Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. ( Head, BP; Lai, NC; Patel, HH; Roth, DM; Takahashi, T; Tsutsumi, YM, 2006)
"When isoflurane--2% was administered only during reperfusion, IS was not changed in control (53 +/- 3%) but combination with PCD reduced IS to 23 +/- 4% (P < 0."	1.33	Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism. ( Berdeaux, A; Ghaleh, B; Tessier-Vetzel, D; Tissier, R; Waintraub, X, 2006)
"Isoflurane was discontinued 15 min before coronary occlusion (memory period)."	1.32	Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species. ( Kersten, JR; Ludwig, LM; Pagel, PS; Warltier, DC; Weihrauch, D, 2004)
"We sought to determine whether brain death-induced catecholamine release preconditions the heart, and if not, whether it precludes further protection by repetitive ischemia or isoflurane."	1.31	Preservation of ischemia and isoflurane-induced preconditioning after brain death in rabbit hearts. ( Chiari, P; Ferrera, R; Hadour, G; Lehot, JJ; Loufouat, J; Ovize, M; Piriou, V; Rodriguez, C, 2002)
"Isoflurane can reproduce the protection afforded by ischemic preconditioning."	1.31	Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: possible involvement of mitochondrial adenosine triphosphate-sensitive potassium and stretch-activated channels. ( Annat, G; Bastien, O; Chiari, P; Foëx, P; Knezynski, S; Lehot, JJ; Loufoua, J; Ovize, M; Piriou, V, 2000)
"Isoflurane was discontinued, and blood glucose concentrations were allowed to return to baseline values before left anterior descending coronary artery occlusion."	1.31	Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. ( Kehl, F; Kersten, JR; Krolikowski, JG; Mraovic, B; Pagel, PS; Warltier, DC, 2002)
"Isoflurane was administered for 30 min and discontinued 30 min before left anterior descending coronary artery occlusion."	1.31	Is isoflurane-induced preconditioning dose related? ( Kehl, F; Kersten, JR; Krolikowski, JG; Mraovic, B; Pagel, PS; Warltier, DC, 2002)
"Colchicine pretreatment eliminated the preconditioning-like effect of isoflurane (IS:AR = 32."	1.30	Colchicine inhibits isoflurane-induced preconditioning. ( Cason, BA; Hickey, RF; Ismaeil, MS; Tkachenko, I, 1999)

Research

Studies (131)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Clavien-Dindo Grade IIIb or Higher - Number of Complications

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.53)	18.7374
1990's	16 (12.21)	18.2507
2000's	70 (53.44)	29.6817
2010's	42 (32.06)	24.3611
2020's	1 (0.76)	2.80

Authors	Studies
Raupach, A	1
Torregroza, C	1
Niestegge, J	1
Feige, K	1
Klemm-Meyer, S	1
Bauer, I	1
Brandenburger, T	1
Grievink, H	1
Heinen, A	1
Huhn, R	3
Agnic, I	2
Filipovic, N	2
Vukojevic, K	2
Saraga-Babic, M	2
Grkovic, I	2
Heiberg, J	1
Royse, CF	2
Royse, AG	2
Andrews, DT	2
Zhou, Y	1
Peng, DD	1
Chong, H	1
Zheng, SQ	1
Zhu, F	1
Wang, G	1
Lang, XE	1
Wang, X	1
Zhang, KR	1
Lv, JY	1
Jin, JH	1
Li, QS	1
Hu, ZY	3
Peng, XY	1
Liu, F	1
Liu, J	7
Baotic, I	2
Ge, ZD	1
Sedlic, F	2
Coon, A	1
Weihrauch, D	13
Warltier, DC	27
Kersten, JR	26
Singh, P	1
Chauhan, S	1
Jain, G	1
Talwar, S	1
Makhija, N	1
Kiran, U	1
De Paulis, D	1
Chiari, P	4
Teixeira, G	1
Couture-Lepetit, E	1
Abrial, M	1
Argaud, L	1
Gharib, A	1
Ovize, M	4
Muravyeva, M	1
Bienengraeber, M	5
Lazar, J	1
Bosnjak, ZJ	8
Tsutsumi, YM	7
Tsutsumi, R	2
Horikawa, YT	2
Sakai, Y	2
Hamaguchi, E	2
Kitahata, H	1
Kasai, A	3
Kambe, N	1
Tanaka, K	9
Lotz, C	9
Zhang, J	1
Fang, C	1
Liem, D	1
Ping, P	1
Ma, L	1
Kong, F	1
Ge, H	1
Gong, F	1
Xu, L	1
Hu, B	1
Sun, R	1
Zhang, GQ	1
Liang, Z	1
Yan, P	1
Zhang, XJ	1
Wendlandt, B	1
Turinsky, S	1
Schmitz, M	1
Fukuta, K	2
Stumpner, J	11
Tischer-Zeitz, T	4
Umminger, J	1
Neuwirth, A	1
Smul, TM	11
Redel, A	13
Kehl, F	19
Roewer, N	13
Lange, M	12
Lemoine, S	1
Tritapepe, L	2
Hanouz, JL	2
Puddu, PE	1
Wang, Y	1
Li, H	2
Huang, H	2
Liu, S	2
Mao, X	1
Wang, S	1
Wong, SS	1
Xia, Z	2
Irwin, MG	1
Kinoshita, M	1
Yang, C	1
Jiao, Y	1
Yan, N	1
Wu, B	1
Ren, Y	1
Sun, J	1
Gao, J	1
Jazbutyte, V	2
Schnupp, V	1
Weber, NC	3
Goletz, C	1
Grueber, Y	1
Preckel, B	6
Schlack, W	6
Ebel, D	3
Hein, M	3
Roehl, AB	3
Baumert, JH	2
Bantes, B	1
Bleilevens, C	2
Bernstein, N	1
Steendijk, P	2
Rossaint, R	4
Rao, Y	2
Wang, YL	2
Chen, YQ	1
Zhang, WS	2
Blomeyer, C	2
Frank, A	1
Yildirim, V	1
Doganci, S	1
Aydin, A	1
Bolcal, C	1
Demirkilic, U	1
Cosar, A	1
Luo, NF	1
Gerets, C	1
Baltus, T	1
Hecker, KE	1
Matsumoto, S	1
Cho, S	1
Tosaka, S	1
Ureshino, H	1
Maekawa, T	1
Hara, T	1
Sumikawa, K	1
Tao, X	1
Lu, LQ	1
Xu, Q	1
Li, SR	1
Lin, MT	1
Kellermann, A	1
Lotz, CA	2
Blomeyer, CA	1
Zhang, W	1
Yanfang, C	1
Li, T	1
Raphael, J	4
Gozal, Y	4
Navot, N	1
Zuo, Z	2
Kawaraguchi, Y	1
Niesman, IR	1
Kidd, MW	1
Chin-Lee, B	1
Head, BP	2
Patel, PM	1
Roth, DM	4
Patel, HH	6
Zhu, J	1
Rebecchi, MJ	1
Tan, M	1
Glass, PS	1
Brink, PR	1
Liu, L	1
Karlsson, LO	1
Zhou, AX	1
Larsson, E	1
Aström-Olsson, K	1
Månsson, C	1
Akyürek, LM	1
Grip, L	1
Fisslthaler, B	1
Pociej, J	1
Fleming, I	1
Kingma, JG	1
Simard, D	1
Voisine, P	1
Rouleau, JR	1
Schmidt, J	1
Regueiro-Purriños, M	1
Fernández-Vázquez, F	1
de Prado, AP	1
Altónaga, JR	1
Cuellas-Ramón, C	1
Ajenjo-Silverio, JM	1
Orden, A	1
Gonzalo-Orden, JM	1
Hirata, N	1
Shim, YH	2
Pravdic, D	1
Lohr, NL	1
Pratt, PF	4
Kottenberg, E	1
Thielmann, M	1
Bergmann, L	1
Heine, T	1
Jakob, H	1
Heusch, G	1
Peters, J	1
Beck, A	1
Hilz, T	1
Eisenbarth, H	1
Schick, MA	1
Chang, DJ	1
Chang, CH	1
Kim, JS	1
Hong, YW	1
Lee, WK	1
Yan, L	1
Jiang, X	1
Tai, W	1
Shi, E	1
Bignami, E	2
Greco, T	1
Barile, L	1
Silvetti, S	1
Nicolotti, D	1
Fochi, O	3
Cama, E	1
Costagliola, R	1
Landoni, G	3
Biondi-Zoccai, G	1
Zangrillo, A	2
Lorenzen, JM	1
Thum, T	1
Sopka, S	1
Mertens, C	1
Schiffl, K	1
Classen-Linke, I	1
Funcke, S	1
Becker, MM	1
Goetzenich, A	1
Ludwig, LM	8
Fryer, RM	1
Hsu, AK	1
Gross, GJ	5
Piriou, V	3
Hadour, G	1
Rodriguez, C	1
Loufouat, J	1
Lehot, JJ	3
Ferrera, R	1
Pagel, PS	23
Krolikowski, JG	15
Gu, W	2
Toller, W	1
Lhuillier, F	1
Bastien, O	2
Loufoua, J	2
Raisky, O	1
David, JS	1
Thompson, K	1
Wisenberg, G	1
Sykes, J	1
Thompson, RT	1
LaDisa, JF	1
Haelewyn, B	1
Zhu, L	1
Persehaye, E	1
Roussel, S	1
Ducouret, P	1
Gérard, JL	1
Wakeno-Takahashi, M	1
Otani, H	1
Nakao, S	1
Uchiyama, Y	1
Imamura, H	1
Shingu, K	1
Alcindor, D	2
Müllenheim, J	3
Südkamp, H	1
Bohlen, T	1
Ferrari, J	1
Eells, JT	1
Chiari, PC	4
Trillo, RA	1
Puri, N	1
Obal, D	3
Zacharowski, K	1
Toma, O	2
Dettwiler, S	1
Wolter, JI	2
Kratz, M	1
Tsai, SK	1
Lin, SM	1
Huang, CH	1
Hung, WC	1
Chih, CL	1
Huang, SS	1
Bienengraeber, MW	2
Lucchinetti, E	5
da Silva, R	1
Pasch, T	2
Schaub, MC	3
Zaugg, M	5
Rivo, J	2
Berenshtein, E	1
Chevion, M	1
Drenger, B	1
Feng, J	2
Ahuja, P	1
Perriard, JC	1
Wang, F	1
Luo, T	1
Råmunddal, T	1
Lorentzon, M	1
Omerovic, E	1
Lai, NC	1
Takahashi, T	1
Galagudza, M	1
Vaage, J	1
Valen, G	1
Neff, DA	1
Tessier-Vetzel, D	1
Tissier, R	1
Waintraub, X	1
Ghaleh, B	1
Berdeaux, A	1
Huang, D	1
Wang, C	2
Burkhard, N	1
Venkatapuram, S	1
Biondi-Zoccai, GG	1
D'Avolio, S	1
Marchetti, C	1
Calabrò, MG	1
Guarracino, F	1
De Hert, S	1
Torri, G	2
Yokoyama, T	1
Horikawa, Y	1
An, J	1
Jiang, MT	1
Jamnicki, M	1
Fischer, G	2
Zhu, M	1
Zaugg, K	1
Abedat, S	1
Beeri, R	1
Mächler, H	1
Metzler, H	1
Sabin, K	1
Anelli-Monti, M	1
Rehak, P	1
Rigler, B	1
Gombotz, H	1
Haessler, R	1
Kuzume, K	1
Chien, GL	1
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Davis, RF	1
Van Winkle, DM	1
Imamura, S	1
Hashimoto, H	1
Ikeda, K	1
Nakashima, M	1
Turner, LA	3
Polic, S	3
Hoffmann, RG	2
Kampine, JP	3
Cheng, DC	1
Karski, J	1
Peniston, C	1
Asokumar, B	1
Raveendran, G	1
Carroll, J	1
Nierenberg, H	1
Roger, S	1
Mickle, D	1
Tong, J	1
Zelovitsky, J	1
David, T	1
Sandler, A	1
Boutros, A	1
Wang, J	1
Capuano, C	1
Schmeling, TJ	1
Cason, BA	2
Gamperl, AK	1
Slocum, RE	1
Hickey, RF	2
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Hogan, QH	1
Kulier, AH	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Remote Ischemic Preconditioning in Patients Undergoing On-pump Coronary Artery Bypass Graft Surgery With Crystalloid Cardioplegic Arrest[NCT01406678]	Phase 2/Phase 3	1,204 participants (Actual)	Interventional	2008-07-31	Completed
Remote Ischemic Conditioning (RIC) in Recipients of Brain Death Donor Livers - A Feasibility and Safety Study[NCT02635347]		31 participants (Actual)	Interventional	2015-11-30	Completed
Protection of Heart, Brain and Kidney by Remote Ischemic Preconditioning in Patients Undergoing Transcatheter Aortic Valve Implantation - a Randomized, Single-blind Study[NCT02080299]	Phase 2	100 participants (Actual)	Interventional	2013-09-30	Active, not recruiting
[NCT00005395]		0 participants	Observational	1995-09-30	Completed
Sevoflurane and Cardiac Protection in High Risk Patients Undergoing Cardiac Surgery. A Randomized Controlled Study.[NCT00821262]	Phase 4	200 participants (Actual)	Interventional	2008-09-30	Completed
Effects on Bleeding in Knee Arthroplasty After Ischemic Preconditioning With Sevoflurane[NCT03379103]		30 participants (Actual)	Interventional	2018-02-02	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

In patients with Clavien-Dindo >/= IIIb complications, number of such complications per patient. (NCT02635347)
Timeframe: Post-op days 0-30

Hospital LOS

Intervention	Complications (Median)
Remote Ischemic Conditioning (RIC) Group	1
Historical Control Cohort	0

Number of days in hospital post-transplant. Starting at post-op day 0 and ending on the calendar date that the patient is leaves the hospital, dies, or post-op day 90, whichever is soonest. (NCT02635347)
Timeframe: Post-op days 0 up to 90 days

Intensive Care Unit (ICU) Length of Stay (LOS)

Intervention	days (Median)
Remote Ischemic Conditioning (RIC) Group	13
Historical Control Cohort	10

Number of days in ICU post-transplant. Starting at post-op day 0 and ending on the calendar date that the patient is transferred out of ICU, dies, or post-op day 90, whichever is soonest. (NCT02635347)
Timeframe: Post-op days 0 up to 90 days

Intervention-related Pain Score

Intervention	days (Median)
Remote Ischemic Conditioning (RIC) Group	3.5
Historical Control Cohort	4

Median intervention-related pain score during each of the post-operative interventions, in extubated patients who are able to communicate. Using the Numerical Rating Scale (NRS, Ferrieira-Valente MA PAIN Volume 152, 2011), patients were asked to rate their pain following the intervention on a scale of 0-10 with 0 being no pain experienced to 10 as the maximum pain felt. (NCT02635347)
Timeframe: Post-op days 1-4

Liver Allograft Survival

Intervention	scores on a scale (Median)
Remote Ischemic Conditioning (RIC) Group	5

Percentage of patients with functioning allograft at 90 days post-transplant (NCT02635347)
Timeframe: Post-op day 90

Number of Subjects Not Completing Intervention Protocol

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	90
Historical Control Cohort	98.41

Number of subjects that received fewer than 6 interventions,. (NCT02635347)
Timeframe: Pre-op - Post-op day 4

Patient Survival

Intervention	participants (Number)
Remote Ischemic Conditioning (RIC) Group	9

Percentage of patients alive at 90 days post-transplant (NCT02635347)
Timeframe: Post-op day 90

Percentage of Participants Completing Entire Intervention Protocol

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	90.32
Historical Control Cohort	98.41

Proportion of enrolled liver recipients that complete all 6 remote ischemic conditioning (RIC) interventions. (NCT02635347)
Timeframe: Pre-op - Post-op day 4

Percentage of Participants Who Developed Acute Kidney Injury (AKI) Stages 2 or 3

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	70.96

"Percentage of participants who developed Acute Kidney Injury (AKI)~Based on Kidney Disease - Improving Global Outcomes (KDIGO) criteria, AKI criteria are:~Stage 2:~- 2.0-2.9 fold rise in serum creatinine from baseline~Stage 3:~> 3.0 fold rise in serum creatinine from baseline, or~Serum creatinine of > 4.0 mg/dL, with an acute (<48 hours) increase of 0.3 mg/dL in serum creatinine or subacute (< 7 days) increase in serum creatinine of 0.5 mg/dL, or~Initiation of renal replacement therapy." (NCT02635347)
Timeframe: Post-op days 0-7

Percentage of Participants Who Developed Early Allograft Dysfunction (EAD)

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	20.0
Historical Control Cohort	25.86

"Percentage of participants who developed Early Allograft Dysfunction (EAD) which is defined as:~Aspartate Transaminase (AST) or Alanine Transaminase (ALT)> 2,000 U/L at any point within the first seven post-transplant days, or~Total Bilirubin (TB) > 10 mg/dL on postoperative day 7,or~International Normalized Ratio (INR)> 1.6 on postoperative day 7." (NCT02635347)
Timeframe: Post-op days 0-7

Percentage of Participants Who Developed Prolonged Respiratory Insufficiency (PRI)

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	23.3
Historical Control Cohort	39.68

"Percentage of Participants who developed Prolonged Respiratory Insufficiency (PRI) defined as:~Ventilator support for >2 postoperative days after transplant, or~Reintubation after extubation, within 7 days of transplant. Patients who require brief re-intubation for an endoscopic, radiologic, or surgical procedure would not be considered to have PRI if they are extubated within 2 days of the end of the procedure." (NCT02635347)
Timeframe: Post-op days 0-7

Presence of Clavien-Dindo Grade IIIb or Higher Complications

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	33.3
Historical Control Cohort	28.57

"Percentage of patients with Clavien-Dindo >/= grade III b complications (Dindo D, Demartines N, Clavien P, Annals of Surgery 2004).~The Clavien-Dindo Complications grade ranges from Grade I (Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic and radiological interventions Allowed therapeutic regimens are: drugs as antiemetics, antipyretics, analgetics, diuretics and electrolytes and physiotherapy. This grade also includes wound infections opened at the bedside) to Grade V (Death). Grade IIIb would be any intervention requiring general anesthesia." (NCT02635347)
Timeframe: Post-op days 0-30

Time to Dialysis Discontinuation

Intervention	percentage of participants (Number)
Remote Ischemic Conditioning (RIC) Group	51.1
Historical Control Cohort	47.62

In patients who are receiving dialysis pre-op, time to discontinuation of dialysis, if occurring within 90 days of transplantation. (NCT02635347)
Timeframe: Post-op days 0-90

Withdrawal of Consent Due to Pain

Intervention	days (Median)
Remote Ischemic Conditioning (RIC) Group	2
Historical Control Cohort	15.5

- Withdrawal of consent due to discomfort/pain in the lower extremity (NCT02635347)
Timeframe: Pre-op - Post-op day 7

Article	Year
The mechanisms of cardio-protective effects of desflurane and sevoflurane at the time of reperfusion: anaesthetic post-conditioning potentially translatable to humans? British journal of anaesthesia, 2016, Volume: 116, Issue:4 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Desflurane; Humans; Is	2016
The effect of isoflurane on survival and myocardial infarction: a meta-analysis of randomized controlled studies. Journal of cardiothoracic and vascular anesthesia, 2013, Volume: 27, Issue:1 Topics: Anesthetics, Inhalation; Cardiotonic Agents; Humans; Isoflurane; Myocardial Infarction; Randomized C	2013
Desflurane and sevoflurane in cardiac surgery: a meta-analysis of randomized clinical trials. Journal of cardiothoracic and vascular anesthesia, 2007, Volume: 21, Issue:4 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiac Surgical Procedures; Desflurane; Hospital M	2007
Cardiac protection by volatile anaesthetics: a review. Current vascular pharmacology, 2008, Volume: 6, Issue:2 Topics: Anesthetics, Inhalation; Animals; Coronary Artery Bypass; Critical Care; Desflurane; Heart; Hospital	2008

Article	Year
Comparison of cardioprotective effects of volatile anesthetics in children undergoing ventricular septal defect closure. World journal for pediatric & congenital heart surgery, 2013, Volume: 4, Issue:1 Topics: Anesthetics, Inhalation; Cardiopulmonary Bypass; Cardiotonic Agents; Creatine Kinase, MB Form; Desfl	2013
Cardioprotective effects of sevoflurane, isoflurane, and propofol in coronary surgery patients: a randomized controlled study. The heart surgery forum, 2009, Volume: 12, Issue:1 Topics: Administration, Inhalation; Aged; Anesthetics, Inhalation; Cardiotonic Agents; Coronary Artery Bypas	2009
The effect of xenon on isoflurane protection against experimental myocardial infarction. Journal of cardiothoracic and vascular anesthesia, 2009, Volume: 23, Issue:5 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Ischemic Preconditioning, Myocar	2009
Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. Journal of the American Association for Laboratory Animal Science : JAALAS, 2011, Volume: 50, Issue:1 Topics: Anesthetics, Inhalation; Animal Welfare; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Fema	2011
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno	2012
Decreased mortality in a rat model of acute postinfarction heart failure. Biochemical and biophysical research communications, 2006, Mar-10, Volume: 341, Issue:2 Topics: Amiodarone; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Critical Care; Diseas	2006
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:3 Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines;	1996
Does isoflurane lead to a higher incidence of myocardial infarction and perioperative death than enflurane in coronary artery surgery? A clinical study of 1178 patients. Anesthesia and analgesia, 1990, Volume: 71, Issue:5 Topics: Aged; Anesthesia, Inhalation; Coronary Artery Bypass; Enflurane; Female; Humans; Isoflurane; Male; M	1990

Article	Year
MiR-21-5p but not miR-1-3p expression is modulated by preconditioning in a rat model of myocardial infarction. Molecular biology reports, 2020, Volume: 47, Issue:9 Topics: Animals; Apoptosis Regulatory Proteins; Disease Models, Animal; Heme Oxygenase-1; Hypoxia-Inducible	2020
Isoflurane post-conditioning influences myocardial infarct healing in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2018, Volume: 93, Issue:5 Topics: Animals; Cell Differentiation; Fibroblasts; Isoflurane; Myocardial Infarction; Myocardium; Nestin; R	2018
Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition. Anesthesia and analgesia, 2018, Volume: 127, Issue:2 Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cardiotonic Agents; Deoxyglucose; Desflurane; Drug Ad	2018
Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:3 Topics: Administration, Inhalation; Animals; Disease Models, Animal; Heart Function Tests; Isoflurane; Male;	2019
Isoflurane preconditioning confers cardioprotection by activation of ALDH2. PloS one, 2013, Volume: 8, Issue:2 Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiotonic Agents; Creatine	2013
Emulsified isoflurane protects rat heart in situ after regional ischemia and reperfusion. Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:2 Topics: Anesthetics, Inhalation; Animals; Cytochromes c; Disease Models, Animal; Emulsions; Energy Metabolis	2014
Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia. American journal of physiology. Heart and circulatory physiology, 2013, Jul-15, Volume: 305, Issue:2 Topics: Acute Disease; Animals; Apolipoprotein A-I; Blood Glucose; Caveolin 1; Cells, Cultured; Coronary Ves	2013
Isoflurane post-conditioning stimulates the proliferative phase of myocardial recovery in an ischemia-reperfusion model of heart injury in rats. Histology and histopathology, 2014, Volume: 29, Issue:1 Topics: Anesthetics, Inhalation; Animals; Disease Models, Animal; Female; Ischemic Postconditioning; Isoflur	2014
Cyclosporine A at reperfusion fails to reduce infarct size in the in vivo rat heart. Basic research in cardiology, 2013, Volume: 108, Issue:5 Topics: Anesthetics, Inhalation; Animals; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Ischemic	2013
Cardioprotection during diabetes: the role of mitochondrial DNA. Anesthesiology, 2014, Volume: 120, Issue:4 Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal;	2014
Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3. Journal of anesthesia, 2014, Volume: 28, Issue:5 Topics: Anesthetics, Inhalation; Animals; Caveolae; Caveolin 3; Diterpenes; Drug Synergism; Isoflurane; Male	2014
Isoflurane protects the myocardium against ischemic injury via the preservation of mitochondrial respiration and its supramolecular organization. Anesthesia and analgesia, 2015, Volume: 120, Issue:2 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Electron Transport; Ischemic Preconditioning,	2015
Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling. Scientific reports, 2014, Nov-17, Volume: 4 Topics: Animals; Apoptosis; Caspase 3; Cyclooxygenase 2; Hemodynamics; Humans; Hypertrophy, Left Ventricular	2014
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats]. Fa yi xue za zhi, 2014, Volume: 30, Issue:4 Topics: Animals; Biomarkers; Cathepsin L; Isoflurane; Myocardial Infarction; Myocardial Ischemia; Myocardial	2014
[Isoflurane-induced malignant hyperthermia during intensive-care treatment]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2015, Volume: 110, Issue:2 Topics: Administration, Inhalation; Cardiopulmonary Resuscitation; Combined Modality Therapy; Conscious Seda	2015
Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolin-3 expression. European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:7 Topics: Anesthetics, Inhalation; Animals; Caveolin 3; Drug Therapy, Combination; Exenatide; Glucagon-Like Pe	2015
The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase. Acta anaesthesiologica Scandinavica, 2016, Volume: 60, Issue:1 Topics: Anesthetics, Inhalation; Animals; bcl-Associated Death Protein; Blood Pressure; Desflurane; Heart Ra	2016
Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling. Clinical science (London, England : 1979), 2016, 05-01, Volume: 130, Issue:10 Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Helicases; Ischemic Postcondit	2016
Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels. The journal of medical investigation : JMI, 2016, Volume: 63, Issue:1-2 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Ischemic Postconditioning; Isoflurane; Male; M	2016
NOD2 mediates isoflurane preconditioning-induced protection of myocardial injury. Neuroscience letters, 2017, 01-10, Volume: 637 Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Isoflurane; Mitogen-Activated Protein Kinases; M	2017
Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: metoprolol blocks desflurane-induced preconditioning. Anesthesiology, 2008, Volume: 109, Issue:1 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiotonic Agents; Desflurane; Ischemi	2008
Blockade of anaesthetic-induced preconditioning in the hyperglycaemic myocardium: the regulation of different mitogen-activated protein kinases. European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3 Topics: Anesthetics; Anesthetics, Inhalation; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Des	2008
Establishment of a porcine right ventricular infarction model for cardioprotective actions of xenon and isoflurane. Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:9 Topics: Angiography; Animals; Biomarkers; Disease Models, Animal; Heart Ventricles; Hemodynamics; Isoflurane	2008
Protective effects of emulsified isoflurane after myocardial ischemia-reperfusion injury and its mechanism in rabbits. Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2009, Volume: 12, Issue:1 Topics: Animals; Emulsions; Isoflurane; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfus	2009
Effects of emulsified isoflurane on haemodynamics and cardiomyocyte apoptosis in rats with myocardial ischaemia. Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:8 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blood Pressure; Cardiotonic Agents; Caspase 3; Disea	2009
Desflurane-induced postconditioning is mediated by beta-adrenergic signaling: role of beta 1- and beta 2-adrenergic receptors, protein kinase A, and calcium/calmodulin-dependent protein kinase II. Anesthesiology, 2009, Volume: 110, Issue:3 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; D	2009
The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:2 Topics: Anesthetics, Inhalation; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase	2009
Time course of desflurane-induced preconditioning in rabbits. Journal of cardiothoracic and vascular anesthesia, 2010, Volume: 24, Issue:1 Topics: Anesthetics, Inhalation; Animals; Arginine; Desflurane; Disease Models, Animal; Ischemic Preconditio	2010
Comparison of isoflurane-, sevoflurane-, and desflurane-induced pre- and postconditioning against myocardial infarction in mice in vivo. Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:10 Topics: Anesthetics, Inhalation; Animals; Desflurane; Ischemic Preconditioning, Myocardial; Isoflurane; Male	2009
Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway. Cardiovascular drugs and therapy, 2009, Volume: 23, Issue:4 Topics: Anesthetics, Inhalation; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Imidaz	2009
Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loops. British journal of anaesthesia, 2009, Volume: 103, Issue:5 Topics: Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Desflurane; Drug Evaluation	2009
Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane. Journal of Zhejiang University. Science. B, 2009, Volume: 10, Issue:10 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Cardiotonic Agents; Drug Inte	2009
Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. Anesthesiology, 2009, Volume: 111, Issue:6 Topics: Anesthetics, Inhalation; Animals; bcl-Associated Death Protein; Blood Pressure; Blotting, Western; C	2009
Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. Journal of cardiothoracic and vascular anesthesia, 2010, Volume: 24, Issue:1 Topics: Anesthetics, Inhalation; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine K	2010
Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:4 Topics: Anesthetics; Animals; Blood Glucose; Blood Pressure; Creatine Kinase, MB Form; Glucose; Heart; Heart	2010
Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology, 2010, Volume: 112, Issue:5 Topics: Animals; Cardiotonic Agents; Caveolin 3; Glucose Transporter Type 4; Ischemic Preconditioning, Myoca	2010
Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:6 Topics: Aging; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Glycogen Synthase Kinase 3; Glycogen Sy	2010
Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model. Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:2 Topics: Anesthetics; Animals; Apoptosis Inducing Factor; Caspase 3; Cyclosporine; Disease Models, Animal; Dr	2010
Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo. Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anesthetics, Inhalation; Animals; Body Te	2011
Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs. Cardiovascular research, 2011, Feb-01, Volume: 89, Issue:2 Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Autonomic Denervation; Autonomic Nervous Syst	2011
Propofol inhibits desflurane-induced preconditioning in rabbits. Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:2 Topics: Animals; Desflurane; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocardial Infarction;	2011
Peroxisome-proliferator-activated receptor γ mediates the second window of anaesthetic-induced preconditioning. Experimental physiology, 2011, Volume: 96, Issue:3 Topics: Anesthetics, Inhalation; Anilides; Animals; Arteries; Coronary Occlusion; Desflurane; DNA-Binding Pr	2011
Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. Anesthesiology, 2011, Volume: 115, Issue:3 Topics: Anesthetics, Inhalation; Animals; Cyclic N-Oxides; Electron Transport; Electron Transport Complex I;	2011
Desflurane-induced post-conditioning against myocardial infarction is mediated by calcium-activated potassium channels: role of the mitochondrial permeability transition pore. British journal of anaesthesia, 2012, Volume: 108, Issue:4 Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Desflurane; Disease Models, Animal; Ischemic	2012
Desflurane-induced and ischaemic postconditioning against myocardial infarction are mediated by Pim-1 kinase. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:7 Topics: Anesthetics, Inhalation; Animals; bcl-Associated Death Protein; Desflurane; Gene Expression Regulati	2012
Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:7 Topics: Aging; Animals; Cardiotonic Agents; Drug Evaluation, Preclinical; Glycogen Synthase Kinase 3; Glycog	2012
Emulsified isoflurane induces postconditioning against myocardial infarction via JAK-STAT pathway. The Journal of surgical research, 2012, Volume: 178, Issue:2 Topics: Animals; Emulsions; Infusions, Intravenous; Ischemic Postconditioning; Isoflurane; Janus Kinase 2; M	2012
Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo. PloS one, 2012, Volume: 7, Issue:8 Topics: Anesthetics, Inhalation; Animals; Aromatase; Aromatase Inhibitors; Desflurane; Gene Expression Regul	2012
Effects of xenon and isoflurane on apoptosis and inflammation in a porcine myocardial infarction model. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2013, Volume: 195, Issue:2 Topics: Anesthetics; Animals; Apoptosis; Humans; Isoflurane; Myocardial Infarction; Myocarditis; Swine; Xeno	2013
Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat. Anesthesiology, 2013, Volume: 118, Issue:6 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Disease Models, Animal; Electrocardiography; I	2013
Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:11 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzamides; Cardiotonic Agents; Diazoxide;	2002
Preservation of ischemia and isoflurane-induced preconditioning after brain death in rabbit hearts. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:5 Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Death; Catecholamines; Female; Heart Rate; I	2002
Isoflurane does not produce a second window of preconditioning against myocardial infarction in vivo. Anesthesia and analgesia, 2002, Volume: 95, Issue:5 Topics: Anesthetics, Inhalation; Animals; Calibration; Coronary Circulation; Dogs; Female; Heart; Hemodynami	2002
Pharmacological preconditioning: comparison of desflurane, sevoflurane, isoflurane and halothane in rabbit myocardium. British journal of anaesthesia, 2002, Volume: 89, Issue:3 Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Desflurane; Female; Halothane; Heart; Ischemic Pre	2002
Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:9 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Coronary Circulation; Dogs; Female; Hemo	2002
Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology, 2002, Volume: 97, Issue:6 Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Hemodynamics; Isoflurane; Male; Myocardial I	2002
Morphine enhances pharmacological preconditioning by isoflurane: role of mitochondrial K(ATP) channels and opioid receptors. Anesthesiology, 2003, Volume: 98, Issue:3 Topics: Adenosine Triphosphate; Animals; Drug Synergism; GTP-Binding Protein alpha Subunits, Gi-Go; Hemodyna	2003
Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species. Anesthesiology, 2003, Volume: 98, Issue:4 Topics: Adenosine Triphosphatases; Anesthetics, Inhalation; Animals; Ethidium; Fluorescent Dyes; Free Radica	2003
N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. Anesthesiology, 2003, Volume: 98, Issue:6 Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Collateral Circulation; Coronary Circulation; Dogs	2003
Cardioprotective effects of desflurane: effect of timing and duration of administration in rat myocardium. British journal of anaesthesia, 2004, Volume: 92, Issue:4 Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiotonic Agents; Desflur	2004
Adenosine and a nitric oxide donor enhances cardioprotection by preconditioning with isoflurane through mitochondrial adenosine triphosphate-sensitive K+ channel-dependent and -independent mechanisms. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Adenosine; Anesthetics, Inhalation; Animals; Cardiovascular Agents; Diazoxide; Dose-Response Relatio	2004
Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Blotting, Western; Celecoxib; Coronary Circulation	2004
Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Anesthetics, Inhalation; Animals; Coronary Circulation; Fluorescent Antibody Technique; Hemodynamics	2004
Role of tyrosine kinase in desflurane-induced preconditioning. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: Anesthetics, Inhalation; Animals; Desflurane; Enzyme Activation; Enzyme Inhibitors; Genistein; Hemod	2004
Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo. Anesthesiology, 2004, Volume: 100, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anesthetics, Inhalation; Animals; Aspirin; Celecoxib; C	2004
Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. Anesthesia and analgesia, 2004, Volume: 99, Issue:5 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Coenzymes; Electron Transport; Enzyme Inhi	2004
Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits. Anesthesiology, 2004, Volume: 101, Issue:5 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Chemistry, Pharmaceu	2004
Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection. British journal of anaesthesia, 2005, Volume: 94, Issue:2 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Cell Membrane; Cytosol; Dose-Response Relation	2005
Desflurane preconditioning induces time-dependent activation of protein kinase C epsilon and extracellular signal-regulated kinase 1 and 2 in the rat heart in vivo. Anesthesiology, 2004, Volume: 101, Issue:6 Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Cell Membrane; Cytosol; Desflurane; Enzyme Acti	2004
Effect of desflurane-induced preconditioning following ischemia-reperfusion on nitric oxide release in rabbits. Life sciences, 2004, Dec-24, Volume: 76, Issue:6 Topics: Anesthetics, Inhalation; Animals; Creatine Kinase; Desflurane; Enzyme Inhibitors; Hemodynamics; Isof	2004
Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits. Anesthesiology, 2005, Volume: 102, Issue:1 Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activa	2005
Anaesthetic preconditioning but not postconditioning prevents early activation of the deleterious cardiac remodelling programme: evidence of opposing genomic responses in cardioprotection by pre- and postconditioning. British journal of anaesthesia, 2005, Volume: 95, Issue:2 Topics: Anesthetics; Animals; Gene Expression Profiling; Ischemic Preconditioning, Myocardial; Isoflurane; M	2005
Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium. Anesthesiology, 2005, Volume: 103, Issue:1 Topics: Animals; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocardial Infarction; Myocardium;	2005
Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical production in the rabbit. British journal of anaesthesia, 2005, Volume: 95, Issue:4 Topics: Anesthetics, Inhalation; Animals; Gentisates; Hemodynamics; Hydroxybenzoates; Hydroxyl Radical; Isch	2005
Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits. Anesthesia and analgesia, 2005, Volume: 101, Issue:4 Topics: Animals; In Situ Nick-End Labeling; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Morphine	2005
Isoflurane postconditioning prevents opening of the mitochondrial permeability transition pore through inhibition of glycogen synthase kinase 3beta. Anesthesiology, 2005, Volume: 103, Issue:5 Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Chromones; Coloring Agents; Conditioning, Psych	2005
Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-kinase/Akt signalling. British journal of anaesthesia, 2005, Volume: 95, Issue:6 Topics: Androstadienes; Anesthetics, Inhalation; Animals; Blotting, Western; Creatine Kinase, MB Form; Enzym	2005
Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels. Anesthesia and analgesia, 2005, Volume: 101, Issue:6 Topics: Anesthetics, Inhalation; Animals; Ion Channels; Isoflurane; Male; Mitochondrial Membrane Transport P	2005
Effectiveness of isoflurane in inducing delayed preconditioning against myocardial infarction in vivo. Anesthesiology, 2006, Volume: 104, Issue:2 Topics: Aging; Anesthetics, Inhalation; Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, M	2006
Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology, 2006, Volume: 104, Issue:3 Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cardiac Catheterization; Heart; Heart Rate; Isoflurane;	2006
Isoflurane and other commonly used anaesthetics do not protect the isolated buffer perfused mouse heart from ischemia-reperfusion injury. Clinical and experimental pharmacology & physiology, 2006, Volume: 33, Issue:4 Topics: Anesthetics, Inhalation; Animals; Anticoagulants; Heart Function Tests; Heparin; In Vitro Techniques	2006
Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo. Anesthesia and analgesia, 2006, Volume: 102, Issue:5 Topics: Animals; Drug Synergism; Glycogen Synthase Kinases; Isoflurane; Male; Myocardial Infarction; Myocard	2006
Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:3 Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Heart Rate; Ischemic P	2006
Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:2 Topics: Anesthetics, Inhalation; Animals; Arachidonate 12-Lipoxygenase; Blood Gas Analysis; Blotting, Wester	2006
Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase. Anesthesia and analgesia, 2006, Volume: 103, Issue:2 Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Female; Guanidines; Heart Rate; Indazoles; Ischemi	2006
Desflurane-induced preconditioning against myocardial infarction is mediated by nitric oxide. Anesthesiology, 2006, Volume: 105, Issue:4 Topics: Anesthetics, Inhalation; Animals; Desflurane; Enzyme Inhibitors; Hemodynamics; Ischemic Precondition	2006
Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. Anesthesia and analgesia, 2006, Volume: 103, Issue:6 Topics: Animals; Benzothiazoles; Glycogen Synthase Kinases; Ischemic Preconditioning, Myocardial; Isoflurane	2006
Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life sciences, 2007, Sep-22, Volume: 81, Issue:15 Topics: Analgesics, Opioid; Animals; Cells, Cultured; Free Radical Scavengers; Hemodynamics; Ischemic Precon	2007
Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels. Anesthesia and analgesia, 2007, Volume: 105, Issue:5 Topics: Animals; Calcium; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Mitoc	2007
Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts. Anesthesia and analgesia, 2008, Volume: 106, Issue:1 Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Decanoic Acids; D	2008
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB. Cardiovascular research, 2008, Apr-01, Volume: 78, Issue:1 Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; Cardiovascular Agents; Colorimetry; Cycl	2008
Isoflurane preconditioning decreases myocardial infarction in rabbits via up-regulation of hypoxia inducible factor 1 that is mediated by mammalian target of rapamycin. Anesthesiology, 2008, Volume: 108, Issue:3 Topics: Animals; Hypoxia-Inducible Factor 1; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocard	2008
Emulsified intravenous versus evaporated inhaled isoflurane for heart protection: old wine in a new bottle or true innovation? Anesthesia and analgesia, 2008, Volume: 106, Issue:5 Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Chemistry, Pharmaceutical; Coronary Ve	2008
Emulsified isoflurane produces cardiac protection after ischemia-reperfusion injury in rabbits. Anesthesia and analgesia, 2008, Volume: 106, Issue:5 Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Coronary Vessels; Creatine Kinase; Cyt	2008
Preoperative myocardial cell damage in patients with unstable angina undergoing coronary artery bypass graft surgery. Anesthesiology, 1994, Volume: 81, Issue:6 Topics: Adult; Aged; Angina, Unstable; Biomarkers; Coronary Artery Bypass; Creatine Kinase; Electrocardiogra	1994
Anaesthetics alter the magnitude of infarct limitation by ischaemic preconditioning. Cardiovascular research, 1994, Volume: 28, Issue:10 Topics: Anesthetics; Animals; Blood Glucose; Constriction; Coronary Vessels; Heart; Isoflurane; Ketamine; My	1994
Effects of volatile anesthetics, enflurane, isoflurane, and halothane on ventricular delayed activation in a canine myocardial infarction model. Journal of electrocardiology, 1994, Volume: 27, Issue:1 Topics: Animals; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Enflurane; Halothane; Heart Conducti	1994
Actions of halothane and isoflurane on Purkinje fibers in the infarcted canine heart: conduction, regional refractoriness, and reentry. Anesthesia and analgesia, 1993, Volume: 76, Issue:4 Topics: Animals; Disease Models, Animal; Dogs; Electric Stimulation; Electrophysiology; Halothane; Heart Con	1993
Actions of volatile anesthetics on ischemic and nonischemic Purkinje fibers in the canine heart: regional action potential characteristics. Anesthesia and analgesia, 1993, Volume: 76, Issue:4 Topics: Action Potentials; Anesthetics; Animals; Dogs; Enflurane; Halothane; Isoflurane; Myocardial Infarcti	1993
Isoflurane and halothane increase adenosine triphosphate preservation, but do not provide additive recovery of function after ischemia, in preconditioned rat hearts. Anesthesiology, 1997, Volume: 86, Issue:1 Topics: Adenosine Triphosphate; Animals; Blood Pressure; Halothane; Hemodynamics; Isoflurane; Male; Myocardi	1997
Isoflurane mimics ischemic preconditioning via activation of K(ATP) channels: reduction of myocardial infarct size with an acute memory phase. Anesthesiology, 1997, Volume: 87, Issue:2 Topics: Anesthetics, Inhalation; Animals; Coronary Circulation; Dogs; Glyburide; Hemodynamics; Hypoglycemic	1997
Anesthetic-induced preconditioning: previous administration of isoflurane decreases myocardial infarct size in rabbits. Anesthesiology, 1997, Volume: 87, Issue:5 Topics: Anesthetics, Inhalation; Animals; Hemodynamics; Ischemic Preconditioning, Myocardial; Isoflurane; My	1997
Effects of desflurane, sevoflurane and halothane on postinfarction spontaneous dysrhythmias in dogs. Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:3 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Desflurane; Dogs; El	1998
Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo. British journal of anaesthesia, 1998, Volume: 81, Issue:6 Topics: Anesthetics, Inhalation; Animals; Coronary Disease; Desflurane; Enflurane; Hemodynamics; Isoflurane;	1998
Colchicine inhibits isoflurane-induced preconditioning. Anesthesiology, 1999, Volume: 91, Issue:6 Topics: Anesthetics, Inhalation; Animals; Colchicine; Hemodynamics; Ischemic Preconditioning, Myocardial; Is	1999
Isoflurane preconditions myocardium against infarction via activation of inhibitory guanine nucleotide binding proteins. Anesthesiology, 2000, Volume: 92, Issue:5 Topics: Anesthetics, Inhalation; Animals; Dogs; GTP-Binding Proteins; Hemodynamics; Ischemic Preconditioning	2000
Sarcolemmal and mitochondrial adenosine triphosphate- dependent potassium channels: mechanism of desflurane-induced cardioprotection. Anesthesiology, 2000, Volume: 92, Issue:6 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzamides; Decanoic Acids; Desflurane; Do	2000
Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: possible involvement of mitochondrial adenosine triphosphate-sensitive potassium and stretch-activated channels. Anesthesiology, 2000, Volume: 93, Issue:3 Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Female; Gadolinium; Hemodynamics; Hydroxy Acids; Is	2000
Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. Anesthesiology, 2002, Volume: 96, Issue:1 Topics: Anesthetics, Inhalation; Animals; Dogs; Female; Hemodynamics; Ischemic Preconditioning; Isoflurane;	2002
Is isoflurane-induced preconditioning dose related? Anesthesiology, 2002, Volume: 96, Issue:3 Topics: Anesthetics, Inhalation; Animals; Collateral Circulation; Coronary Circulation; Dogs; Dose-Response	2002
Isoflurane preconditions myocardium against infarction via release of free radicals. Anesthesiology, 2002, Volume: 96, Issue:4 Topics: Anesthetics, Inhalation; Animals; Free Radicals; Glycine; Hemodynamics; Ischemic Preconditioning, My	2002
Torsade de pointes and sudden death induced by thiopental and isoflurane anesthesia in dogs with cardiac electrical remodeling. Journal of cardiovascular pharmacology and therapeutics, 2002, Volume: 7, Issue:1 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Death, Sudden, Cardiac; Disease Models,	2002
Isoflurane-induced preconditioning is attenuated by diabetes. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6 Topics: Anesthetics, Inhalation; Animals; Blood Glucose; Constriction; Coronary Vessels; Diabetes Mellitus,	2002
Delayed cardioprotection by isoflurane: role of K(ATP) channels. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:1 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzamides; Cytoprotection; Decanoic Acids; Dose-	2002
Halothane, enflurane and isoflurane on abnormal automaticity and triggered rhythmic activity of Purkinje fibers from 24-hour-old infarcted canine hearts. Anesthesiology, 1991, Volume: 75, Issue:5 Topics: Action Potentials; Animals; Cardiac Pacing, Artificial; Dogs; Electrophysiology; Enflurane; Halothan	1991
Isoflurane and outcome after coronary artery surgery. Anesthesia and analgesia, 1991, Volume: 72, Issue:6 Topics: Coronary Artery Bypass; Humans; Isoflurane; Myocardial Infarction; Postoperative Complications; Prog	1991
Suppression of ventricular arrhythmias by volatile anesthetics in a canine model of chronic myocardial infarction. Anesthesiology, 1990, Volume: 72, Issue:6 Topics: Anesthetics; Animals; Blood Pressure; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Enflura	1990
Myocardial infarction in carotid endarterectomy patients anesthetized with halothane, enflurane, or isoflurane. Anesthesiology, 1988, Volume: 69, Issue:5 Topics: Anesthesia, Inhalation; Carotid Arteries; Endarterectomy; Enflurane; Halothane; Humans; Isoflurane;	1988
Is anesthesia beneficial for the ischemic heart? III. Anesthesiology, 1986, Volume: 64, Issue:2 Topics: Adult; Age Factors; Aged; Anesthesia; Coronary Circulation; Coronary Disease; Hemodynamics; Humans;	1986

isoflurane and Myocardial Infarction