Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Trial | Phase | Enrollment | Study Type | Start Date | Status |
Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed |
Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed |
The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) |
Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed |
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
Article | Year |
[Effects of combined transdermal acupoint electric stimulation and isoflurane anesthesia on isoflurane-induced hypotension and tissue oxygen metabolism in patients undergoing craniotomy].Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2001, Volume: 21, Issue:3
Topics: Acupuncture Points; Adult; Anesthetics, Inhalation; Craniotomy; Female; Humans; Hypotension, Control | 2001 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |