isoflurane has been researched along with Memory Disorders in 48 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 7.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| " We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling." | 7.85 | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. ( Chen, L; Jiang, C; Liu, N; Xie, W; Zhuang, W, 2017) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 5.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| " To test these hypotheses, 6- to 8-week old male mice were subjected to right carotid artery exposure under isoflurane anesthesia." | 4.02 | Toll-like receptor 2 activation and up-regulation by high mobility group box-1 contribute to post-operative neuroinflammation and cognitive dysfunction in mice. ( Lin, F; Pan, L; Shan, W; Zheng, Y; Zuo, Z, 2021) |
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 3.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| " We aimed to investigate whether apigenin can attenuate isoflurane exposure-induced cognitive decline by regulating histone acetylation and inflammatory signaling." | 3.85 | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. ( Chen, L; Jiang, C; Liu, N; Xie, W; Zhuang, W, 2017) |
| "Sleep disorders, including sleep fragmentation, are reported to aggravate memory impairment in neurocognitive-related diseases such as Alzheimer's disease (AD)." | 1.91 | A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation. ( Cong, P; Huang, X; Li, M; Tian, L; Wu, H; Wu, T; Xiong, L; Zhang, H; Zhang, Q, 2023) |
| "Adolescent alcohol abuse can lead to behavioral dysfunction and chronic, relapsing alcohol use disorder (AUD) in adulthood." | 1.56 | General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses. ( Gore-Langton, JK; Landin, JD; Spear, LP; Varlinskaya, EI; Werner, DF, 2020) |
| "Thus, we hypothesised that intestinal dysbacteriosis caused by anaesthesia/surgery induces POCD." | 1.51 | Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice. ( Chen, XM; Gu, XY; Jiang, XL; Qin, Y; Shen, L; Su, DS; Yang, YT; Yu, WF; Zhang, X; Zhou, XX, 2019) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 1.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| "Donepezil pretreatment prevented working memory impairment and the decrease of the protein levels of ChAT induced by anesthesia/surgery." | 1.48 | Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice. ( Chen, X; Gu, X; Huang, L; Jiang, X; Su, D; Tian, J; Tian, W; Yu, W; Zhang, X, 2018) |
| "Treating isoflurane-exposed rats with ciproxifan significantly improved the memory performance, as evidenced by an increased discrimination ratio in objects recognition and prolonged retention time in passive avoidance test." | 1.46 | Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure. ( Liu, M; Liu, ZG; Luo, T; Qin, J; Wang, Y, 2017) |
| "Mice treated with isoflurane for 4 h showed significantly decreased spontaneous alternations and decreased exploration parameters compared with the no anesthesia group, but this was not observed in mice treated with isoflurane for 1 or 2 h." | 1.46 | Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice. ( Chen, Y; Jiang, S; Miao, B, 2017) |
| "At this time cytokines associated with memory deficits and brain injury processes were significantly elevated in serum and brain." | 1.43 | Isoflurane in the presence or absence of surgery increases hippocampal cytokines associated with memory deficits and responses to brain injury in rats. ( Callaway, JK; Jenkins, TA; Royse, AG; Royse, CF; Wood, C, 2016) |
| "Sevoflurane-treated animals had a deficit in early long-term memory, and isoflurane-treated animals had a deficit in both short-term and early long-term memory." | 1.39 | Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats. ( Alvi, RS; Barbour, KC; Ben-Tzur, D; Chang, FL; Di Geronimo, RT; Elphick, SA; Huang, P; Kang, H; Kong, CL; McCreery, MS; Park, A; Quitoriano, GR; Ramage, TM; Rau, V; Rossi, MJ; Sall, JW; Shih, J; Stratmann, G; Tantoco, NK; Uy, J; Zhao, C, 2013) |
| "Melatonin is an endogenous hormone with neuroprotective effects." | 1.39 | Melatonin attenuates isoflurane-induced acute memory impairments in aged rats. ( Chui, D; Guo, X; Li, Z; Liu, Y; Ni, C; Qian, M; Tang, Y; Tian, X; Zhou, Y, 2013) |
| "The isoflurane-exposed rats were further divided into a learning/memory-impaired subgroup and a non-learning/memory-impaired subgroup according to their behavioral performance, which was measured using Morris water maze." | 1.39 | Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment. ( Ji, C; Jia, X; Liu, W; Qu, X; Wang, H; Wang, Y; Wu, A; Xie, Z; Xu, C; Xu, J; Xu, Z; Yue, Y, 2013) |
| "The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group." | 1.38 | Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012) |
| "Gabra5-/- mice showed no short-term memory deficits 24 hours after isoflurane (effect of isoflurane F(1,47) = 0." | 1.38 | Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia. ( Bridgwater, EM; Orser, BA; Zurek, AA, 2012) |
| "Xenon pretreatment prevented the memory deficit typically seen on day 1 (P = 0." | 1.37 | Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. ( Lloyd, DG; Ma, D; Maze, M; Palazzo, MG; Vizcaychipi, MP; Wan, Y, 2011) |
| "However, postanesthesia memory deficits represent an undesirable and poorly understood adverse effect." | 1.36 | Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708. ( Kanisek, M; Maclean, AJ; Martin, LJ; Orser, BA; Roder, JC; Saab, BJ; Zurek, AA, 2010) |
| "Isoflurane was administered to P7 rats at 1 minimum alveolar concentration for 0, 1, 2, or 4 h." | 1.35 | Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. ( Alvi, RS; Bell, JS; Dai, R; Firouzian, A; Guggenheim, J; Hilton, JF; Ku, B; Lee, MT; May, LD; Ormerod, BK; Rau, V; Sall, JW; Stratmann, G; Visrodia, KH; Zusmer, EJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (12.50) | 29.6817 |
| 2010's | 36 (75.00) | 24.3611 |
| 2020's | 6 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Mineshima, H | 1 |
| Kimoto, H | 1 |
| Hitomi, M | 1 |
| Akizawa, F | 1 |
| Terayama, Y | 1 |
| Yoshikawa, T | 1 |
| Wu, T | 1 |
| Li, M | 1 |
| Tian, L | 1 |
| Cong, P | 1 |
| Huang, X | 1 |
| Wu, H | 1 |
| Zhang, Q | 1 |
| Zhang, H | 1 |
| Xiong, L | 1 |
| Chinn, GA | 1 |
| Sasaki Russell, JM | 1 |
| Banh, ET | 1 |
| Lee, SC | 1 |
| Sall, JW | 4 |
| Landin, JD | 1 |
| Gore-Langton, JK | 1 |
| Varlinskaya, EI | 1 |
| Spear, LP | 1 |
| Werner, DF | 1 |
| Yang, W | 2 |
| Chini, M | 1 |
| Pöpplau, JA | 1 |
| Formozov, A | 1 |
| Dieter, A | 1 |
| Piechocinski, P | 1 |
| Rais, C | 1 |
| Morellini, F | 1 |
| Sporns, O | 1 |
| Hanganu-Opatz, IL | 1 |
| Wiegert, JS | 1 |
| Lin, F | 1 |
| Shan, W | 1 |
| Zheng, Y | 1 |
| Pan, L | 1 |
| Zuo, Z | 3 |
| Liu, F | 1 |
| Qiu, F | 1 |
| Chen, H | 1 |
| Chen, L | 1 |
| Xie, W | 2 |
| Zhuang, W | 1 |
| Jiang, C | 1 |
| Liu, N | 1 |
| Cai, Y | 2 |
| Peng, Z | 1 |
| Guo, H | 1 |
| Wang, F | 1 |
| Zeng, Y | 1 |
| Song, J | 1 |
| Chu, S | 1 |
| Cui, Y | 1 |
| Qian, Y | 1 |
| Li, X | 1 |
| Xu, F | 1 |
| Shao, X | 1 |
| Ma, Z | 1 |
| Xia, T | 1 |
| Gu, X | 2 |
| Bedirli, N | 1 |
| Bagriacik, EU | 1 |
| Yilmaz, G | 1 |
| Ozkose, Z | 1 |
| Kavutçu, M | 1 |
| Cavunt Bayraktar, A | 1 |
| Bedirli, A | 1 |
| Zhang, X | 2 |
| Jiang, X | 1 |
| Huang, L | 1 |
| Tian, W | 1 |
| Chen, X | 2 |
| Yu, W | 1 |
| Tian, J | 1 |
| Su, D | 2 |
| Hong-Qiang, H | 1 |
| Mang-Qiao, S | 1 |
| Fen, X | 1 |
| Shan-Shan, L | 1 |
| Hui-Juan, C | 1 |
| Wu-Gang, H | 1 |
| Wen-Jun, Y | 1 |
| Zheng-Wu, P | 1 |
| Schaefer, ML | 1 |
| Wang, M | 1 |
| Perez, PJ | 1 |
| Coca Peralta, W | 1 |
| Xu, J | 2 |
| Johns, RA | 1 |
| Jiang, XL | 1 |
| Gu, XY | 1 |
| Zhou, XX | 1 |
| Chen, XM | 1 |
| Yang, YT | 1 |
| Qin, Y | 1 |
| Shen, L | 1 |
| Yu, WF | 1 |
| Su, DS | 1 |
| Ramage, TM | 1 |
| Chang, FL | 1 |
| Shih, J | 1 |
| Alvi, RS | 3 |
| Quitoriano, GR | 1 |
| Rau, V | 3 |
| Barbour, KC | 1 |
| Elphick, SA | 1 |
| Kong, CL | 1 |
| Tantoco, NK | 1 |
| Ben-Tzur, D | 1 |
| Kang, H | 1 |
| McCreery, MS | 1 |
| Huang, P | 1 |
| Park, A | 1 |
| Uy, J | 1 |
| Rossi, MJ | 1 |
| Zhao, C | 1 |
| Di Geronimo, RT | 1 |
| Stratmann, G | 3 |
| Liu, Y | 1 |
| Ni, C | 1 |
| Tang, Y | 1 |
| Tian, X | 1 |
| Zhou, Y | 1 |
| Qian, M | 1 |
| Li, Z | 1 |
| Chui, D | 1 |
| Guo, X | 1 |
| Tan, H | 2 |
| Cao, J | 1 |
| Zhang, J | 3 |
| Yang, B | 1 |
| Liang, G | 1 |
| Khojasteh, S | 1 |
| Wu, Z | 1 |
| Joseph, D | 1 |
| Wei, H | 1 |
| Zurek, AA | 3 |
| Yu, J | 1 |
| Wang, DS | 1 |
| Haffey, SC | 1 |
| Bridgwater, EM | 2 |
| Penna, A | 1 |
| Lecker, I | 1 |
| Lei, G | 1 |
| Chang, T | 1 |
| Salter, EW | 1 |
| Orser, BA | 3 |
| Callaway, JK | 2 |
| Jones, NC | 1 |
| Royse, AG | 2 |
| Royse, CF | 2 |
| Li, G | 1 |
| Xue, Q | 1 |
| Luo, Y | 1 |
| Hu, X | 1 |
| Yu, B | 1 |
| Jiang, W | 1 |
| Luo, T | 2 |
| Yin, S | 1 |
| Shi, R | 1 |
| Xu, C | 2 |
| Wang, Y | 4 |
| Cai, J | 1 |
| Yue, Y | 3 |
| Wu, A | 3 |
| Wang, W | 1 |
| Zhao, Y | 2 |
| Li, S | 1 |
| Tan, L | 1 |
| Gao, J | 2 |
| Fang, X | 1 |
| Luo, A | 1 |
| Yi, X | 1 |
| Li, W | 2 |
| Wu, J | 1 |
| Bie, B | 1 |
| Naguib, M | 1 |
| Wood, C | 1 |
| Jenkins, TA | 1 |
| Chai, D | 1 |
| Jiang, H | 2 |
| Li, Q | 2 |
| Wang, L | 1 |
| Wang, A | 1 |
| Supplee, WW | 1 |
| Koffler, K | 1 |
| Cheng, Y | 1 |
| Quezado, ZMN | 1 |
| Levy, RJ | 1 |
| Qin, J | 1 |
| Liu, ZG | 1 |
| Liu, M | 1 |
| Jiang, S | 1 |
| Miao, B | 1 |
| Chen, Y | 1 |
| May, LD | 2 |
| Bell, JS | 2 |
| Ormerod, BK | 1 |
| Hilton, JF | 1 |
| Dai, R | 2 |
| Lee, MT | 2 |
| Visrodia, KH | 2 |
| Ku, B | 2 |
| Zusmer, EJ | 1 |
| Guggenheim, J | 1 |
| Firouzian, A | 1 |
| Magnusson, KR | 1 |
| Zhu, C | 1 |
| Karlsson, N | 1 |
| Zhang, Y | 1 |
| Huang, Z | 1 |
| Li, H | 1 |
| Kuhn, HG | 1 |
| Blomgren, K | 1 |
| Tan, W | 1 |
| Cao, X | 1 |
| Wang, J | 1 |
| Lv, H | 1 |
| Wu, B | 1 |
| Ma, H | 1 |
| Saab, BJ | 1 |
| Maclean, AJ | 1 |
| Kanisek, M | 1 |
| Martin, LJ | 1 |
| Roder, JC | 1 |
| Vizcaychipi, MP | 1 |
| Lloyd, DG | 1 |
| Wan, Y | 2 |
| Palazzo, MG | 1 |
| Maze, M | 1 |
| Ma, D | 2 |
| Huang, Y | 1 |
| Xu, H | 2 |
| Sun, Y | 1 |
| Han, N | 1 |
| Li, QF | 1 |
| Wang, B | 1 |
| Chen, J | 1 |
| Wang, X | 1 |
| Wang, H | 2 |
| Xu, Z | 2 |
| Feng, C | 1 |
| Jia, X | 2 |
| Fidalgo, AR | 1 |
| Cibelli, M | 1 |
| White, JP | 1 |
| Nagy, I | 1 |
| Qu, X | 1 |
| Liu, W | 1 |
| Xie, Z | 1 |
| Ji, C | 1 |
| Jevtovic-Todorovic, V | 1 |
| Hartman, RE | 1 |
| Izumi, Y | 1 |
| Benshoff, ND | 1 |
| Dikranian, K | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Culley, DJ | 2 |
| Baxter, MG | 2 |
| Yukhananov, R | 1 |
| Crosby, G | 2 |
| Nishikawa, K | 1 |
| Murphy, KL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102] | Phase 3 | 104 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915] | Phase 3 | 48 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351] | 30 participants (Actual) | Observational | 2006-01-01 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538] | Phase 4 | 285 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.696 |
| Oxygen | 4.253 |
Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 5.486 |
| Oxygen | 5.433 |
Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 1 |
| Oxygen | 0.88 |
Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.286 |
| Oxygen | 6.920 |
Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 6.136 |
| Oxygen | 6.080 |
Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| DEX Group | 7 |
| CTRL Group | 11 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery
| Intervention | days (Median) |
|---|---|
| DEX Group | 9 |
| CTRL Group | 9 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery
| Intervention | hours (Median) |
|---|---|
| DEX Group | 45.0 |
| CTRL Group | 46.0 |
"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery
| Intervention | units on a scale (Median) | |
|---|---|---|
| MMSE score on postoperative day 6 | m-TICS score on postoperative day 30 | |
| CTRL Group | 29 | 34 |
| DEX Group | 29 | 34 |
Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Stroke | New onset arrythmia | Pulmonary complications | Upper gastrointestinal bleeding | Surgical bleeding | Wound dehiscence or infection | Acute kidney injury | IABP assistance | |
| CTRL Group | 3 | 51 | 27 | 4 | 3 | 7 | 44 | 12 |
| DEX Group | 3 | 42 | 15 | 2 | 3 | 11 | 37 | 6 |
Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pain score after surgery(d1), at rest | Pain score after surgery(d2), at rest | Pain score after surgery(d3), at rest | Pain score after surgery(d4), at rest | Pain score after surgery(d5), at rest | Pain score after surgery(d1), with coughing | Pain score after surgery(d2), with coughing | Pain score after surgery(d3), with coughing | Pain score after surgery(d4), with coughing | Pain score after surgery(d5), with coughing | |
| CTRL Group | 3 | 3 | 2 | 2 | 1 | 4 | 4 | 4 | 3 | 2 |
| DEX Group | 3 | 4 | 3 | 2 | 2 | 4 | 5 | 4 | 3 | 2 |
Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| Subjective sleep quality after surgery(d1), score | Subjective sleep quality after surgery(d2), score | Subjective sleep quality after surgery(d3), score | Subjective sleep quality after surgery(d4), score | Subjective sleep quality after surgery(d5), score | |
| CTRL Group | 2 | 3 | 2 | 2 | 2 |
| DEX Group | 2 | 3 | 2 | 2 | 2 |
1 review available for isoflurane and Memory Disorders
| Article | Year |
|---|---|
[Volatile anesthetics and synaptic transmission in the central nervous system].
Topics: Anesthetics, Inhalation; Animals; Hippocampus; Humans; Isoflurane; Long-Term Potentiation; Memory; M | 2004 |
47 other studies available for isoflurane and Memory Disorders
| Article | Year |
|---|---|
Comparative study on detectability of learning and memory disorder between two water maze tests commonly used in juvenile rat toxicity studies using isoflurane inhaled rat model.
Topics: Animals; Brain; Female; Isoflurane; Learning Disabilities; Male; Maze Learning; Memory Disorders; Ra | 2022 |
A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation.
Topics: Aging; Animals; Disease Models, Animal; Isoflurane; Memory Disorders; Mice; Neurocognitive Disorders | 2023 |
Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats.
Topics: Anesthetics, Inhalation; Animals; Brain-Derived Neurotrophic Factor; Hippocampus; Isoflurane; Male; | 2019 |
General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses.
Topics: Adolescent; Alcohol Drinking; Alcoholism; Anesthetics, General; Animals; Ethanol; Humans; Isoflurane | 2020 |
Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation.
Topics: Anesthesia; Anesthetics; Animals; Electrophysiological Phenomena; Female; Fentanyl; Hippocampus; Iso | 2021 |
Toll-like receptor 2 activation and up-regulation by high mobility group box-1 contribute to post-operative neuroinflammation and cognitive dysfunction in mice.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Behavior, Animal; Benzocycloheptenes; Cognition Disord | 2021 |
miR-124-3p Ameliorates Isoflurane-Induced Learning and Memory Impairment via Targeting STAT3 and Inhibiting Neuroinflammation.
Topics: Animals; Hippocampus; Isoflurane; Memory Disorders; MicroRNAs; Rats | 2021 |
Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats.
Topics: Acetylation; Animals; Apigenin; Cognition; Cognition Disorders; Cognitive Dysfunction; Epigenesis, G | 2017 |
TREK-1 pathway mediates isoflurane-induced memory impairment in middle-aged mice.
Topics: Animals; Hippocampus; Isoflurane; Male; Maze Learning; Memory; Memory Disorders; Mice, Inbred C57BL; | 2017 |
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Body Temperature; Circadian Rhythm; CLOCK Proteins; Cogniti | 2018 |
Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis.
Topics: Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Apoptosis; bcl-2-Associated X Protein; Brai | 2018 |
Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice.
Topics: Acetylcholinesterase; Anesthetics, Inhalation; Animals; Choline O-Acetyltransferase; Cholinergic Age | 2018 |
Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice.
Topics: Anesthetics, Inhalation; Animals; Disease Models, Animal; Gene Knockdown Techniques; Heme Oxygenase- | 2018 |
Nitric Oxide Donor Prevents Neonatal Isoflurane-induced Impairments in Synaptic Plasticity and Memory.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Disease Models, Animal; Female; Isoflurane; Male | 2019 |
Intestinal dysbacteriosis mediates the reference memory deficit induced by anaesthesia/surgery in aged mice.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Cognition Disorders; Dysbiosis; Gastrointes | 2019 |
Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Conditioning, Classical; Drug Administration Sch | 2013 |
Melatonin attenuates isoflurane-induced acute memory impairments in aged rats.
Topics: Animals; Cognition Disorders; Hippocampus; Isoflurane; Male; Maze Learning; Melatonin; Memory; Memor | 2013 |
Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats.
Topics: Animals; Carotid Arteries; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampu | 2014 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
Sustained increase in α5GABAA receptor function impairs memory after anesthesia.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Cognition Disorders; Disease Models, Animal; | 2014 |
Memory impairment in rats after desflurane anesthesia is age and dose dependent.
Topics: Age Factors; Aging; Anesthetics, Inhalation; Animals; Desflurane; Dose-Response Relationship, Drug; | 2015 |
S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Hippocampus; Isoflurane; Learning Disabilities; | 2015 |
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
Topics: Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Buprenorphine; Cal | 2015 |
miRNA expression profile and involvement of Let-7d-APP in aged rats with isoflurane-induced learning and memory impairment.
Topics: Amyloid beta-Protein Precursor; Animals; Down-Regulation; Gene Expression Profiling; Gene Expression | 2015 |
Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity.
Topics: Anesthetics; Animals; Animals, Newborn; Anti-Inflammatory Agents; Apoptosis; Cognition Disorders; Di | 2016 |
Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling.
Topics: Animals; Apoptosis; Brain; Caspase 3; Fas Ligand Protein; fas Receptor; In Situ Nick-End Labeling; I | 2015 |
Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Animals, Newborn; Brain-Derived Neurotrophic | 2016 |
Isoflurane in the presence or absence of surgery increases hippocampal cytokines associated with memory deficits and responses to brain injury in rats.
Topics: Animals; Conditioning, Classical; Cytokines; Fear; Hippocampus; Isoflurane; Laparotomy; Male; Memory | 2016 |
Isoflurane neurotoxicity involves activation of hypoxia inducible factor-1α via intracellular calcium in neonatal rodents.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Cells, Cu | 2016 |
Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.
Topics: Anesthetics, Inhalation; Animals; Brain; CA3 Region, Hippocampal; Carbon Monoxide; Female; Isofluran | 2017 |
Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure.
Topics: Anesthetics, Inhalation; Animals; Avoidance Learning; Disease Models, Animal; Hippocampus; Histamine | 2017 |
Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice.
Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Hippocampus; Isoflurane; Male; Maze Learning; M | 2017 |
Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats.
Topics: Anesthetics, Inhalation; Animals; Blood Gas Analysis; Carbon Dioxide; Cell Differentiation; Cell Pro | 2009 |
Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Bromodeoxyuridine; Cell Death; Cell Differentiation; | 2009 |
Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Animals; Cell Differentiation; Cell Proliferation; Child | 2010 |
Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.
Topics: Anesthetics, Inhalation; Animals; Cognition; Epitopes; Hippocampus; Isoflurane; Male; Maze Learning; | 2010 |
Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708.
Topics: Animals; Cohort Studies; Drug Inverse Agonism; Fear; Female; GABA Agonists; GABA-A Receptor Agonists | 2010 |
Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice.
Topics: Anesthetics, Inhalation; Animals; HSP27 Heat-Shock Proteins; Interleukin-1beta; Isoflurane; Male; Me | 2011 |
Hypoxia inducible factor-1α is involved in the neurodegeneration induced by isoflurane in the brain of neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Calcium; Cell Survival; Cells, | 2012 |
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil.
Topics: Acetylcholinesterase; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blotting, Western; Choli | 2011 |
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi | 2012 |
Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.
Topics: Anesthesia, General; Animals; Drug Inverse Agonism; GABA-A Receptor Antagonists; Imidazoles; Isoflur | 2012 |
Isoflurane causes neocortical but not hippocampal-dependent memory impairment in mice.
Topics: Amnesia; Anesthetics, Inhalation; Animals; Behavior, Animal; Buprenorphine; Conditioning, Operant; E | 2012 |
Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment.
Topics: Aging; Anesthetics, Inhalation; Animals; Blotting, Western; Excitatory Amino Acid Transporter 1; Exc | 2013 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats.
Topics: Aging; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Animals; Isoflurane; Male | 2004 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |