isoflurane has been researched along with Long QT Syndrome in 14 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In female patients pretreated with anthracyclines for breast cancer, the tendency to QTc prolongation during isoflurane-containing general anaesthesia was more strongly expressed than in patients without previous chemotherapy." | 7.72 | Is prolongation of the QTc interval during isoflurane anaesthesia more prominent in women pretreated with anthracyclines for breast cancer? ( Owczuk, R; Sawicka, W; Swierblewski, M; Wujtewicz, M; Wujtewicz, MA, 2004) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 7.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| " In the patient described in this article, heart block occurred and the Q-Tc interval became prolonged after muscle relaxant reversal with neostigmine; both were considered to be related to the combination of agents used in the case, as well as to other predisposing factors such as morbid obesity." | 4.84 | Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. ( Shields, JA, 2008) |
| "In female patients pretreated with anthracyclines for breast cancer, the tendency to QTc prolongation during isoflurane-containing general anaesthesia was more strongly expressed than in patients without previous chemotherapy." | 3.72 | Is prolongation of the QTc interval during isoflurane anaesthesia more prominent in women pretreated with anthracyclines for breast cancer? ( Owczuk, R; Sawicka, W; Swierblewski, M; Wujtewicz, M; Wujtewicz, MA, 2004) |
| " In order to study the effects of anesthetic agents on the inducibility of TdP, arrhythmias were induced by programmed electrical stimulation (PES) before and after cumulative intravenous administration of quinidine under anesthesia with sodium pentobarbital, halothane, or isoflurane." | 3.71 | Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. ( Imai, R; Tamura, T; Yamamoto, K; Yamamoto, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Nagasawa, Y | 1 |
| Sakai, K | 1 |
| Kurimoto, R | 1 |
| Kawakami, S | 1 |
| Aimoto, M | 1 |
| Takahara, A | 1 |
| Limprasutr, V | 1 |
| Saengklub, N | 1 |
| Meedech, P | 1 |
| Kijtawornrat, A | 1 |
| Hamlin, RL | 1 |
| Mikuni, I | 1 |
| Torres, CG | 1 |
| Bakshi, T | 1 |
| Tampo, A | 1 |
| Carlson, BE | 1 |
| Bienengraeber, MW | 1 |
| Kwok, WM | 1 |
| Kim, SH | 1 |
| Park, SY | 1 |
| Chae, WS | 1 |
| Jin, HC | 1 |
| Lee, JS | 1 |
| Kim, YI | 1 |
| Decher, N | 1 |
| Wemhöner, K | 1 |
| Rinné, S | 1 |
| Netter, MF | 1 |
| Zuzarte, M | 1 |
| Aller, MI | 2 |
| Kaufmann, SG | 1 |
| Li, XT | 1 |
| Meuth, SG | 1 |
| Daut, J | 1 |
| Sachse, FB | 1 |
| Maier, SK | 1 |
| Petric, S | 1 |
| Clasen, L | 1 |
| van Wessel, C | 1 |
| Geduldig, N | 1 |
| Ding, Z | 1 |
| Schullenberg, M | 1 |
| Mersmann, J | 1 |
| Zacharowski, K | 1 |
| Schmidt, KG | 1 |
| Donner, BC | 1 |
| Owczuk, R | 1 |
| Wujtewicz, MA | 1 |
| Sawicka, W | 1 |
| Wujtewicz, M | 1 |
| Swierblewski, M | 1 |
| Tashibu, H | 1 |
| Miyazaki, H | 1 |
| Aoki, K | 1 |
| Akie, Y | 1 |
| Yamamoto, K | 2 |
| Venkatesan, T | 1 |
| Shields, JA | 1 |
| Michaloudis, D | 1 |
| Fraidakis, O | 1 |
| Lefaki, T | 1 |
| Kanakoudis, F | 1 |
| Askitopoulou, H | 1 |
| Tamura, T | 1 |
| Imai, R | 1 |
| Yamamoto, M | 1 |
| Wilton, NC | 1 |
| Hantler, CB | 1 |
| Poussel, JF | 1 |
| Brabis, A | 1 |
1 review available for isoflurane and Long QT Syndrome
| Article | Year |
|---|---|
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalati | 2008 |
2 trials available for isoflurane and Long QT Syndrome
| Article | Year |
|---|---|
Effect of desflurane at less than 1 MAC on QT interval prolongation induced by tracheal intubation.
Topics: Adult; Anesthetics, Inhalation; Awareness; Blood Pressure; Cholecystectomy, Laparoscopic; Desflurane | 2010 |
Anaesthesia and the QT interval in humans: effects of halothane and isoflurane in premedicated children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child, Preschool; Electrocardiography; Female; Halothane; H | 1998 |
11 other studies available for isoflurane and Long QT Syndrome
| Article | Year |
|---|---|
Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Electrocardiography; Fluoroquinolones; Guinea P | 2020 |
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cro | 2017 |
Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant.
Topics: Action Potentials; Anesthetics, Inhalation; HEK293 Cells; Humans; Isoflurane; Long QT Syndrome; Muta | 2015 |
Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Electrophysiological Phenomena; Heart Rate; Hem | 2011 |
In vivo electrophysiological characterization of TASK-1 deficient mice.
Topics: Adrenergic beta-Agonists; Anesthetics; Animals; Atrial Function; Baroreflex; Electric Stimulation; E | 2012 |
Is prolongation of the QTc interval during isoflurane anaesthesia more prominent in women pretreated with anthracyclines for breast cancer?
Topics: Anesthetics, Inhalation; Anthracyclines; Antibiotics, Antineoplastic; Breast Neoplasms; Drug Interac | 2004 |
QT PRODACT: in vivo QT assay in anesthetized dog for detecting the potential for QT interval prolongation by human pharmaceuticals.
Topics: Anesthetics, Inhalation; Animals; Databases, Factual; Dogs; Drug-Related Side Effects and Adverse Re | 2005 |
Desflurane's effect on QTc interval: electrophysiological mechanisms need to be explored.
Topics: Desflurane; Electrocardiography; Heart Rate; Humans; Isoflurane; Long QT Syndrome | 2006 |
Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.
Topics: Acute Disease; Anesthesia; Anesthetics, Inhalation; Animals; Astemizole; Atrioventricular Node; Cath | 2001 |
Congenital long QT syndrome: changes in QT interval during anesthesia with thiopental, vecuronium, fentanyl, and isoflurane.
Topics: Adult; Anesthesia; Arrhythmias, Cardiac; Electrocardiography; Female; Fentanyl; Heart; Humans; Hyste | 1987 |
[Congenital long-QT syndrome and isoflurane].
Topics: Adolescent; Anesthesia, Inhalation; Arrhythmias, Cardiac; Humans; Isoflurane; Long QT Syndrome; Male | 1986 |