Compounds > isoflurane
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isoflurane and Liver Diseases

isoflurane has been researched along with Liver Diseases in 27 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Liver Diseases: Pathological processes of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Isoflurane has been studied in ischemia-reperfusion injury, while the regulatory mechanism by which isoflurane regulates microRNA(miR)-9-3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated."8.02Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B. ( Guo, L; Song, S; Wang, H; Wang, Y, 2021)
"Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear."7.85Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy. ( Ding, Z; Gao, M; Li, J; Liu, S; Lu, T; Pan, X; Rao, Z; Sun, J; Yu, D; Zhang, H, 2017)
"Male Sprague-Dawley (SD) rats were randomly divided into five groups: a control group, a hemorrhagic shock (HS) group, an intralipid (IL) group, an isoflurane (Iso) group, and an emulsified isoflurane (E-Iso) group."7.77Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock. ( Cheng, J; Du, G; Duan, Z; Li, Z; Lin, H; Liu, J; Luo, N; Zhang, L, 2011)
"To investigate the protective effect of pretreatment with Kupffer cell mediated emulsified isoflurane on ischemia/reperfusion injury in liver."7.74[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats]. ( Li, Q; Lü, H; Ren, HM; Xu, LY; Yang, LQ; Yu, WF; Zhu, M, 2007)
"A previously healthy but obese 26-yr-old woman was diagnosed as having hepatic dysfunction 17 days after the third of three consecutive exposures to isoflurane anesthesia for paranasal sinus surgery."7.68Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report. ( Brunt, EM; Holtmann, B; Marsh, JW; Peters, MG; White, H, 1991)
"Ketamine has hepatoprotective effects, while isoflurane does not."5.33Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2. ( Gonzalez, EA; Helmer, KS; Mercer, DW; Robinson, EK; Suliburk, JW, 2005)
"A 76-year-old Caucasian woman developed fulminant hepatic necrosis 6 days after an uneventful operation under isoflurane anaesthesia."4.80Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature. ( Beringer, TR; O'Rourke, D; Scott, GO; Turner, GB, 2000)
"The severity of liver dysfunction based on MELD score affected the intraoperative remifentanil requirement during LT."4.12The Requirement of Isoflurane and Remifentanil During Liver Transplantation Using Bispectral Index and Surgical Pleth Index: An Observational Study. ( Kim, GS; Park, IH; Park, M, 2022)
"Isoflurane has been studied in ischemia-reperfusion injury, while the regulatory mechanism by which isoflurane regulates microRNA(miR)-9-3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated."4.02Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B. ( Guo, L; Song, S; Wang, H; Wang, Y, 2021)
"Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear."3.85Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy. ( Ding, Z; Gao, M; Li, J; Liu, S; Lu, T; Pan, X; Rao, Z; Sun, J; Yu, D; Zhang, H, 2017)
"Male Sprague-Dawley (SD) rats were randomly divided into five groups: a control group, a hemorrhagic shock (HS) group, an intralipid (IL) group, an isoflurane (Iso) group, and an emulsified isoflurane (E-Iso) group."3.77Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock. ( Cheng, J; Du, G; Duan, Z; Li, Z; Lin, H; Liu, J; Luo, N; Zhang, L, 2011)
"To investigate the protective effect of pretreatment with Kupffer cell mediated emulsified isoflurane on ischemia/reperfusion injury in liver."3.74[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats]. ( Li, Q; Lü, H; Ren, HM; Xu, LY; Yang, LQ; Yu, WF; Zhu, M, 2007)
"A previously healthy but obese 26-yr-old woman was diagnosed as having hepatic dysfunction 17 days after the third of three consecutive exposures to isoflurane anesthesia for paranasal sinus surgery."3.68Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report. ( Brunt, EM; Holtmann, B; Marsh, JW; Peters, MG; White, H, 1991)
"Ketamine has hepatoprotective effects, while isoflurane does not."1.33Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2. ( Gonzalez, EA; Helmer, KS; Mercer, DW; Robinson, EK; Suliburk, JW, 2005)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19909 (33.33)18.7374
1990's6 (22.22)18.2507
2000's4 (14.81)29.6817
2010's6 (22.22)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Park, M1
Park, IH1
Kim, GS2
Wang, H1
Guo, L1
Wang, Y1
Song, S1
Rao, Z1
Pan, X1
Zhang, H1
Sun, J1
Li, J1
Lu, T1
Gao, M1
Liu, S1
Yu, D1
Ding, Z1
Dabir, S1
Mohammad-Taheri, Z1
Parsa, T1
Abbasi-Nazari, M1
Radpay, B1
Radmand, G1
Kang, JG1
Ko, JS1
Gwak, MS1
Kim, YR1
Lee, SK1
Zhang, L1
Luo, N1
Liu, J1
Duan, Z1
Du, G1
Cheng, J1
Lin, H1
Li, Z1
Khafagy, HF1
Hussein, NA1
Radwan, KG1
Refaat, AI1
Hafez, HS1
Essawy, FM1
Kamel, HH1
Kim, M2
Park, SW1
D'Agati, VD1
Lee, HT1
Suliburk, JW1
Helmer, KS1
Gonzalez, EA1
Robinson, EK1
Mercer, DW1
Lü, H1
Yang, LQ1
Yu, WF1
Li, Q1
Ren, HM1
Zhu, M1
Xu, LY1
Li Volti, G1
Galvano, F1
Scacco, A1
Vanella, L1
Murabito, P1
Gullo, A1
Biondi, A1
Gazzolo, D1
Vadalà, S1
Jones, RM2
Harper, MH2
Johnson, BH2
Eger, EI5
Van Dyke, RA1
Zaleski, L1
Abello, D1
Gold, MI1
Bito, H1
Ikeda, K1
Gong, D1
Koblin, DD1
Bowland, T1
Ionescu, P2
Laster, MJ1
Weiskopf, RB2
Turner, GB1
O'Rourke, D1
Scott, GO1
Beringer, TR1
Yasuda, N1
Cahalan, MK2
Freire, B1
Peterson, N1
Lockhart, SH1
Rampil, IJ1
Laster, M1
Diamond, JG1
Power, SJ1
Bajorek, PK1
Munday, I1
Brunt, EM1
White, H1
Marsh, JW1
Holtmann, B1
Peters, MG1
Fisher, NA1
Iwata, RT1
Smuckler, EA2
Gil, F1
Fiserova-Bergerova, V1
Altman, NH1
Stoelting, RK1
Becker, GL1
Miletich, DJ1
Albrecht, RF1
Brandom, BW1
Stiller, RL1
Cook, DR1
Woelfel, SK1
Chakravorti, S1
Lai, A1
Fassoulaki, A1
Ferrell, LD1
Eger, RR1

Reviews

2 reviews available for isoflurane and Liver Diseases

ArticleYear
Clinical comparison of inhalation anaesthetic agents.
    British journal of anaesthesia, 1984, Volume: 56 Suppl 1

    Topics: Anesthesia, Inhalation; Cardiovascular Diseases; Coronary Disease; Drug Interactions; Enflurane; Fem

1984
Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature.
    European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:8

    Topics: Aged; Amputation, Surgical; Anesthesia, General; Anesthetics, Inhalation; Chemical and Drug Induced

2000

Trials

3 trials available for isoflurane and Liver Diseases

ArticleYear
Effect of general and epidural anesthesia on hemostasis and fibrinolysis in hepatic patients.
    Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:5

    Topics: Adult; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Loca

2010
Desflurane versus isoflurane in patients with chronic hepatic and renal disease.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:2

    Topics: Aged; Anesthesia, Inhalation; Chronic Disease; Desflurane; Evaluation Studies as Topic; Humans; Isof

1993
Renal and hepatic function in surgical patients after low-flow sevoflurane or isoflurane anesthesia.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:1

    Topics: Adult; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation; Aspartate Aminotran

1996

Other Studies

22 other studies available for isoflurane and Liver Diseases

ArticleYear
The Requirement of Isoflurane and Remifentanil During Liver Transplantation Using Bispectral Index and Surgical Pleth Index: An Observational Study.
    Transplantation proceedings, 2022, Volume: 54, Issue:3

    Topics: Anesthetics, Inhalation; End Stage Liver Disease; Humans; Isoflurane; Liver Diseases; Liver Transpla

2022
Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B.
    Cell cycle (Georgetown, Tex.), 2021, Volume: 20, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Models, Animal; Fibronectins; Ge

2021
Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Ischemia; Ischemic Preconditioning; Isoflurane; L

2017
Effects of propofol versus isoflurane on liver function after open thoracotomy.
    Asian cardiovascular & thoracic annals, 2015, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Anesthesia, Intravenous; Anesthetics,

2015
The relationship between inhalational anesthetic requirements and the severity of liver disease in liver transplant recipients according to three phases of liver transplantation.
    Transplantation proceedings, 2010, Volume: 42, Issue:3

    Topics: Adult; Anesthetics, Inhalation; Desflurane; Female; Hepatitis C; Humans; Isoflurane; Liver Cirrhosis

2010
Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock.
    The Journal of surgical research, 2011, Volume: 171, Issue:2

    Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Disease Models, A

2011
Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Acute Kidney Injury; Anesthetics, Inhalation; Animals; Enzyme Activation; Intestinal Diseases; Intes

2011
Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2.
    Surgery, 2005, Volume: 138, Issue:2

    Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhi

2005
[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats].
    Zhonghua yi xue za zhi, 2007, Sep-18, Volume: 87, Issue:35

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Disease Models, Animal; Emulsions; Injec

2007
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
    Annals of surgery, 2008, Volume: 247, Issue:4

    Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease

2008
Celiac plexus block does not alter hepatic injury in rats.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:5

    Topics: Anesthetics; Animals; Bupivacaine; Celiac Plexus; Chemical and Drug Induced Liver Injury; Drug Inter

1984
Hepatic centrilobular necrosis in rats after exposure to halothane, enflurane, or isoflurane.
    Anesthesia and analgesia, 1982, Volume: 61, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Enflurane; Glutathione; Halothane; Isoflurane; Live

1982
Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:5

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Biomarkers; Chemical and Drug Induced Liver Inj

1997
Desflurane does not produce hepatic or renal injury in human volunteers.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:4

    Topics: Adult; Anesthetics; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Desflurane; Hum

1992
A prospective study of liver function in infants and children exposed to daily isoflurane for several weeks.
    Anaesthesia, 1991, Volume: 46, Issue:8

    Topics: Alkaline Phosphatase; Anesthesia, General; Aspartate Aminotransferases; Bilirubin; Chemical and Drug

1991
Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report.
    Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:6

    Topics: Adult; Anesthesia; Chemical and Drug Induced Liver Injury; Female; Humans; Isoflurane; Liver; Liver

1991
Hepatic necrosis associated with herpes virus after isoflurane anesthesia.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:11

    Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Herpesviridae Infections; Humans; I

1985
Hepatic protection from chemical injury by isoflurane.
    Anesthesia and analgesia, 1988, Volume: 67, Issue:9

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug

1988
Isoflurane and postoperative hepatic dysfunction.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1987, Volume: 34, Issue:3 ( Pt 1)

    Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Isoflurane; Liver Diseases; Postoperative Com

1987
Halogenated anesthetics increase oxygen consumption in isolated hepatocytes from phenobarbital-treated rats.
    Anesthesiology, 1987, Volume: 67, Issue:2

    Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En

1987
Pharmacokinetics of atracurium in anaesthetized infants and children.
    British journal of anaesthesia, 1986, Volume: 58, Issue:11

    Topics: Anesthesia, Inhalation; Atracurium; Child; Child, Preschool; Humans; Infant; Isoflurane; Isoquinolin

1986
Nitrous oxide does not hinder the repair of halothane-induced hepatic injury in the rat.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bretylium Compounds; Chemical an

1985