isoflurane has been researched along with Injury, Myocardial Reperfusion in 117 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we compared sevoflurane and isoflurane with particular reference to their hemodynamic effects and ability to modify the effects of acute severe myocardial ischemia and reperfusion on ventricular arrhythmias and mortality in a porcine model of myocardial infarction." | 9.15 | Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. ( Ajenjo-Silverio, JM; Altónaga, JR; Cuellas-Ramón, C; de Prado, AP; Fernández-Vázquez, F; Gonzalo-Orden, JM; Orden, A; Regueiro-Purriños, M, 2011) |
| "The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury." | 7.72 | Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. ( Alcindor, D; Kersten, JR; Krolikowski, JG; Ludwig, LM; Pagel, PS; Pratt, PF; Tanaka, K; Warltier, DC, 2004) |
| " Here we compared sevoflurane and isoflurane with particular reference to their hemodynamic effects and ability to modify the effects of acute severe myocardial ischemia and reperfusion on ventricular arrhythmias and mortality in a porcine model of myocardial infarction." | 5.15 | Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction. ( Ajenjo-Silverio, JM; Altónaga, JR; Cuellas-Ramón, C; de Prado, AP; Fernández-Vázquez, F; Gonzalo-Orden, JM; Orden, A; Regueiro-Purriños, M, 2011) |
| "Isoflurane can, through inhibiting the p38 MAPK signaling pathway, effectively protect the cardiac function of rats from myocardial ischemia-reperfusion injury, reduce the area of myocardial infarction, alleviate the pathological damage in myocardial cells and reduce the oxidative stress response." | 3.91 | Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway. ( Chong, H; Peng, DD; Wang, G; Zheng, SQ; Zhou, Y; Zhu, F, 2019) |
| "Hyperglycemia can blunt the cardioprotective effects of isoflurane in the setting of ischemia-reperfusion injury." | 3.83 | High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission. ( Bai, X; Bosnjak, ZJ; Canfield, SG; Godshaw, B; Twaroski, D; Zaja, I, 2016) |
| " In contrast to ketamine/xylazine, this represents a more physiological, translatable strategy for suppression of cardiomyocyte (18)F-FDG uptake when targeting myocardial inflammation." | 3.81 | Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice. ( Bankstahl, JP; Bengel, FM; Thackeray, JT; Wang, Y; Wollert, KC, 2015) |
| "Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone." | 3.80 | Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3. ( Hamaguchi, E; Horikawa, YT; Kambe, N; Kasai, A; Kitahata, H; Sakai, Y; Tanaka, K; Tsutsumi, R; Tsutsumi, YM, 2014) |
| "The rat models were established and divided in acute myocardial ischemia model (myocardial ischemia 30 min, 1 h, 2 h groups), ischemia-reperfusion model (ischemia-reperfusion group), and isoflurane-pretreated ischemia-reperfusion model (isoflurane-pretreated group), respectively." | 3.80 | [Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats]. ( Liang, Z; Yan, P; Zhang, GQ; Zhang, XJ, 2014) |
| "Pretreatment with isoflurane decreased myocardial infarction size in young rats (3-5 months) but not in old rats (20-24 months)." | 3.76 | Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart. ( Brink, PR; Glass, PS; Liu, L; Rebecchi, MJ; Tan, M; Zhu, J, 2010) |
| "Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling." | 3.73 | Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. ( Kersten, JR; Krolikowski, JG; Pagel, PS; Pratt, PF; Venkatapuram, S; Wang, C; Warltier, DC; Weihrauch, D, 2006) |
| "The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury." | 3.72 | Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. ( Alcindor, D; Kersten, JR; Krolikowski, JG; Ludwig, LM; Pagel, PS; Pratt, PF; Tanaka, K; Warltier, DC, 2004) |
| "The authors investigated the effects of halothane (HAL) and isoflurane (ISO) on cardiac depression produced by global hypoxia and the recovery of function following reoxygenation is isolated guinea pig hearts perfused with Krebs' solution at constant pressure." | 3.68 | Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart. ( Bosnjak, ZJ; Kampine, JP; Marijic, J; Stowe, DF; Turner, LA, 1990) |
| "Isoflurane was administered in the pre-cardiopulmonary bypass (CPB) period to the isoflurane group." | 2.70 | Does isoflurane optimize myocardial protection during cardiopulmonary bypass? ( Baraka, A; Chehab, IR; Haroun-Bizri, S; Kassas, CM; Khoury, SS, 2001) |
| "Isoflurane has demonstrated to exert protective impacts against ischemia/reperfusion (I/R) injury in some organs." | 1.62 | MicroRNA-21 mediates the protective role of emulsified isoflurane against myocardial ischemia/reperfusion injury in mice by targeting SPP1. ( Fu, X; Yuan, J, 2021) |
| "Desflurane had lower uptake than propofol (65 ± 21 × 10 vs 165 ± 51 × 10 g·mL·min/μmol; P = ." | 1.48 | Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition. ( Andrews, DT; Heiberg, J; Royse, AG; Royse, CF, 2018) |
| "Isoflurane has been demonstrated to limit myocardial ischemic injury." | 1.42 | Isoflurane protects the myocardium against ischemic injury via the preservation of mitochondrial respiration and its supramolecular organization. ( Fang, C; Liem, D; Lotz, C; Ping, P; Zhang, J, 2015) |
| "Isoflurane pretreatment was observed to attenuate the release of LDH and CK‑MB, and enhance the phosphorylation of ALDH2." | 1.42 | Protein kinase C signaling pathway involvement in cardioprotection during isoflurane pretreatment. ( Lang, XE; Li, H, 2015) |
| "Pretreatment with isoflurane prior to ischemia reduced LDH and CK-MB levels and infarct size, while it increased phosphorylation of ALDH2, which could be blocked by the ALDH2 inhibitor, cyanamide." | 1.39 | Isoflurane preconditioning confers cardioprotection by activation of ALDH2. ( Jin, JH; Lang, XE; Li, QS; Lv, JY; Wang, X; Zhang, KR, 2013) |
| "Desflurane (6%) was administered during the first 5 min of reoxygenation either alone or in the presence of calphostin C (PKC inhibitor) or 5-hydroxydecanoate (5-HD) (mitoK(ATP) channel antagonist)." | 1.37 | Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes. ( Buléon, C; Galera, P; Gérard, JL; Hanouz, JL; Lemoine, S; Massetti, M; Zhu, L, 2011) |
| "Isoflurane treatment and the consequent augmentation of O-GlcNAc concentrations reduced the infarct size (26 ± 5% [mean ± SD], P < 0." | 1.37 | Role of the O-linked β-N-acetylglucosamine in the cardioprotection induced by isoflurane. ( Hirose, K; Katayama, E; Kinoshita, M; Oshita, S; Shono, M; Tanaka, K; Tsutsumi, R; Tsutsumi, YM, 2011) |
| "Desflurane in vitro was able to postcondition diabetic (both ID and NID) human myocardium at 6 and 9%, but not at 3%." | 1.36 | Desflurane-induced postconditioning of diabetic human right atrial myocardium in vitro. ( Babatasi, G; Durand, C; Gérard, JL; Hanouz, JL; Ivasceau, C; Lemoine, S; Lepage, O; Massetti, M; Zhu, L, 2010) |
| "Hyperglycemia is known to inhibit ischemic and anesthetic preconditioning." | 1.36 | Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. ( Gozal, Y; Navot, N; Raphael, J; Zuo, Z, 2010) |
| "Desflurane was administered alone or with pretreatment of rapamycin, a 70-kDa ribosomal protein S6 kinase inhibitor, NG-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, and atractyloside, the mitochondrial permeability transition pore opener." | 1.36 | Role of 70-kDa ribosomal protein S6 kinase, nitric oxide synthase, glycogen synthase kinase-3 beta, and mitochondrial permeability transition pore in desflurane-induced postconditioning in isolated human right atria. ( Babatasi, G; Beauchef, G; Galera, P; Gérard, JL; Hanouz, JL; Ivascau, C; Lemoine, S; Lepage, O; Massetti, M; Zhu, L, 2010) |
| "Isoflurane group was exposed to 2." | 1.35 | [Effect of isoflurane delayed preconditioning on myocardial ischemia reperfusion injury in rabbits]. ( Chang, YT; Duan, KM; Jin, LY; Li, ZJ; Ran, K; Zou, DQ, 2008) |
| "Isoflurane has been shown to mimic ischaemic preconditioning (IPC)." | 1.33 | Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion. ( Berenshtein, E; Chevion, M; Drenger, B; Elami, A; Gozal, Y; Kitrossky, N, 2005) |
| "Isoflurane-treated mice subjected to ischemia and 2 weeks of reperfusion showed less expression of proapoptotic genes, significantly decreased expression of cleaved caspase-3, and significantly decreased deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling-positive nuclei compared with the control group." | 1.33 | Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. ( Head, BP; Lai, NC; Patel, HH; Roth, DM; Takahashi, T; Tsutsumi, YM, 2006) |
| "When isoflurane--2% was administered only during reperfusion, IS was not changed in control (53 +/- 3%) but combination with PCD reduced IS to 23 +/- 4% (P < 0." | 1.33 | Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism. ( Berdeaux, A; Ghaleh, B; Tessier-Vetzel, D; Tissier, R; Waintraub, X, 2006) |
| "Isoflurane was discontinued 15 min before coronary occlusion (memory period)." | 1.32 | Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species. ( Kersten, JR; Ludwig, LM; Pagel, PS; Warltier, DC; Weihrauch, D, 2004) |
| "Isoflurane was administered for 30 min and discontinued 30 min before left anterior descending coronary artery occlusion." | 1.31 | Is isoflurane-induced preconditioning dose related? ( Kehl, F; Kersten, JR; Krolikowski, JG; Mraovic, B; Pagel, PS; Warltier, DC, 2002) |
| "Isoflurane was administered for 30 min before and during LAD occlusions and reperfusions and was discontinued at the onset of final reperfusion." | 1.30 | Role of adenosine in isoflurane-induced cardioprotection. ( Gross, GJ; Kersten, JR; Mei, DA; Orth, KG; Pagel, PS; Warltier, DC, 1997) |
| "Isoflurane was discontinued at the onset of the final reperfusion period." | 1.29 | Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels. ( Gross, GJ; Hettrick, DA; Kersten, JR; Pagel, PS; Schmeling, TJ; Warltier, DC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.85) | 18.7374 |
| 1990's | 13 (11.11) | 18.2507 |
| 2000's | 43 (36.75) | 29.6817 |
| 2010's | 55 (47.01) | 24.3611 |
| 2020's | 5 (4.27) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, H | 3 |
| Qing, X | 1 |
| Li, H | 5 |
| Raupach, A | 1 |
| Torregroza, C | 1 |
| Niestegge, J | 1 |
| Feige, K | 1 |
| Klemm-Meyer, S | 1 |
| Bauer, I | 1 |
| Brandenburger, T | 1 |
| Grievink, H | 1 |
| Heinen, A | 1 |
| Huhn, R | 1 |
| Logan, SM | 1 |
| Gupta, A | 1 |
| Wang, A | 1 |
| Levy, RJ | 1 |
| Storey, KB | 1 |
| Su, Y | 1 |
| Chen, G | 1 |
| Zhang, F | 1 |
| Wang, L | 1 |
| Feng, Z | 1 |
| Gao, X | 1 |
| Yuan, J | 1 |
| Fu, X | 1 |
| Harisseh, R | 2 |
| Chiari, P | 3 |
| Villedieu, C | 1 |
| Sueur, P | 1 |
| Abrial, M | 3 |
| Fellahi, JL | 1 |
| Ovize, M | 3 |
| Gharib, A | 3 |
| Onk, D | 1 |
| Ozcelik, F | 1 |
| Kuyrukluyıldız, U | 1 |
| Gunay, M | 1 |
| Onk, A | 1 |
| Ayazoglu, TA | 1 |
| Coban, A | 1 |
| Alagol, A | 1 |
| Liu, Y | 3 |
| Paterson, M | 2 |
| Baumgardt, SL | 1 |
| Irwin, MG | 4 |
| Xia, Z | 4 |
| Bosnjak, ZJ | 7 |
| Ge, ZD | 5 |
| Heiberg, J | 1 |
| Royse, CF | 2 |
| Royse, AG | 2 |
| Andrews, DT | 2 |
| Tolkmitt, KJ | 1 |
| Simsekyilmaz, S | 1 |
| Schipke, J | 1 |
| Mühlfeld, C | 1 |
| Preissner, KT | 1 |
| Böning, A | 1 |
| Zhou, Y | 1 |
| Peng, DD | 1 |
| Chong, H | 1 |
| Zheng, SQ | 1 |
| Zhu, F | 1 |
| Wang, G | 1 |
| Chen, W | 1 |
| Chen, XY | 1 |
| Wang, Y | 3 |
| Wang, HY | 1 |
| Zhou, WJ | 1 |
| Yu, T | 1 |
| Lang, XE | 3 |
| Wang, X | 3 |
| Zhang, KR | 1 |
| Lv, JY | 1 |
| Jin, JH | 2 |
| Li, QS | 1 |
| Hu, ZY | 3 |
| Peng, XY | 1 |
| Liu, F | 1 |
| Liu, J | 7 |
| Abbott, GW | 1 |
| Fang, YD | 1 |
| Huang, YS | 1 |
| Baotic, I | 3 |
| Sedlic, F | 3 |
| Coon, A | 1 |
| Weihrauch, D | 8 |
| Warltier, DC | 21 |
| Kersten, JR | 19 |
| Agnić, I | 1 |
| Vukojević, K | 1 |
| Saraga-Babić, M | 1 |
| Filipović, N | 1 |
| Grković, I | 1 |
| De Paulis, D | 1 |
| Teixeira, G | 2 |
| Couture-Lepetit, E | 2 |
| Argaud, L | 1 |
| Muravyeva, M | 1 |
| Bienengraeber, M | 7 |
| Lazar, J | 1 |
| Tsutsumi, YM | 7 |
| Tsutsumi, R | 3 |
| Horikawa, YT | 3 |
| Sakai, Y | 2 |
| Hamaguchi, E | 2 |
| Kitahata, H | 1 |
| Kasai, A | 2 |
| Kambe, N | 1 |
| Tanaka, K | 6 |
| Wang, J | 1 |
| Schilling, JM | 1 |
| Niesman, IR | 2 |
| Headrick, JP | 1 |
| Finley, JC | 1 |
| Kwan, E | 1 |
| Patel, PM | 2 |
| Head, BP | 3 |
| Roth, DM | 6 |
| Yue, Y | 1 |
| Patel, HH | 6 |
| Lotz, C | 3 |
| Zhang, J | 1 |
| Fang, C | 1 |
| Liem, D | 1 |
| Ping, P | 1 |
| Thackeray, JT | 1 |
| Bankstahl, JP | 1 |
| Wollert, KC | 1 |
| Bengel, FM | 1 |
| Ma, L | 1 |
| Kong, F | 1 |
| Ge, H | 1 |
| Gong, F | 1 |
| Xu, L | 1 |
| Hu, B | 1 |
| Sun, R | 1 |
| Zhang, GQ | 1 |
| Liang, Z | 1 |
| Yan, P | 1 |
| Zhang, XJ | 1 |
| Fukuta, K | 1 |
| Procknow, J | 1 |
| Vasquez-Vivar, J | 1 |
| Sudhakaran, S | 1 |
| Ran, K | 4 |
| Zou, DQ | 3 |
| Xiao, YY | 1 |
| Chang, YT | 3 |
| Duan, KM | 2 |
| Ou, YW | 1 |
| Li, ZJ | 2 |
| Qiao, S | 1 |
| Olson, JM | 1 |
| Yan, Y | 1 |
| Zaja, I | 2 |
| Riess, ML | 1 |
| Liang, M | 1 |
| Stary, CM | 1 |
| Tian, Y | 1 |
| Liu, P | 1 |
| Xu, JM | 1 |
| Tian, G | 1 |
| Fauconnier, J | 1 |
| Pillot, B | 1 |
| Lacampagne, A | 1 |
| Tourneur, Y | 1 |
| Lemoine, S | 4 |
| Tritapepe, L | 2 |
| Hanouz, JL | 4 |
| Puddu, PE | 1 |
| Wojtovich, AP | 1 |
| Smith, CO | 1 |
| Urciuoli, WR | 1 |
| Wang, YT | 1 |
| Xia, XM | 1 |
| Brookes, PS | 1 |
| Nehrke, K | 1 |
| Liu, S | 1 |
| Mao, X | 1 |
| Wang, S | 1 |
| Wong, SS | 1 |
| Canfield, SG | 1 |
| Godshaw, B | 1 |
| Twaroski, D | 1 |
| Bai, X | 1 |
| Zhou, C | 1 |
| Song, H | 1 |
| Qiu, Y | 1 |
| Rao, Y | 2 |
| Wang, YL | 2 |
| Chen, YQ | 1 |
| Zhang, WS | 2 |
| Smul, TM | 2 |
| Lange, M | 3 |
| Redel, A | 3 |
| Stumpner, J | 3 |
| Lotz, CA | 1 |
| Roewer, N | 3 |
| Kehl, F | 6 |
| Luo, NF | 1 |
| Tischer-Zeitz, T | 2 |
| De Hert, S | 1 |
| Vlasselaers, D | 1 |
| Barbé, R | 1 |
| Ory, JP | 1 |
| Dekegel, D | 1 |
| Donnadonni, R | 1 |
| Demeere, JL | 1 |
| Mulier, J | 1 |
| Wouters, P | 1 |
| Hein, M | 1 |
| Roehl, AB | 1 |
| Baumert, JH | 1 |
| Bleilevens, C | 1 |
| Fischer, S | 1 |
| Steendijk, P | 1 |
| Rossaint, R | 1 |
| Durand, C | 1 |
| Zhu, L | 3 |
| Ivasceau, C | 1 |
| Lepage, O | 2 |
| Babatasi, G | 2 |
| Massetti, M | 3 |
| Gérard, JL | 3 |
| Pravdic, D | 2 |
| Pratt, PF | 4 |
| Auchampach, JA | 1 |
| Gross, GJ | 3 |
| Yang, MC | 1 |
| Chen, YP | 1 |
| Cao, DJ | 1 |
| Qian, X | 1 |
| Li, P | 1 |
| Raphael, J | 1 |
| Gozal, Y | 2 |
| Navot, N | 1 |
| Zuo, Z | 1 |
| Kawaraguchi, Y | 1 |
| Kidd, MW | 2 |
| Chin-Lee, B | 1 |
| Mio, Y | 2 |
| Zhu, J | 1 |
| Rebecchi, MJ | 1 |
| Tan, M | 1 |
| Glass, PS | 1 |
| Brink, PR | 1 |
| Liu, L | 2 |
| Karlsson, LO | 1 |
| Zhou, AX | 1 |
| Larsson, E | 1 |
| Aström-Olsson, K | 1 |
| Månsson, C | 1 |
| Akyürek, LM | 1 |
| Grip, L | 1 |
| Chang, Y | 2 |
| Beauchef, G | 1 |
| Ivascau, C | 1 |
| Galera, P | 2 |
| Kingma, JG | 1 |
| Simard, D | 1 |
| Voisine, P | 1 |
| Rouleau, JR | 1 |
| Liu, ZG | 1 |
| Xia, ZY | 2 |
| Chen, XD | 1 |
| Luo, T | 1 |
| Pagel, PS | 15 |
| Hudetz, JA | 1 |
| Schmidt, J | 1 |
| Huang, Z | 1 |
| Zhong, X | 1 |
| Ji, S | 1 |
| Wong, GT | 1 |
| Finegan, BA | 1 |
| Regueiro-Purriños, M | 1 |
| Fernández-Vázquez, F | 1 |
| de Prado, AP | 1 |
| Altónaga, JR | 1 |
| Cuellas-Ramón, C | 1 |
| Ajenjo-Silverio, JM | 1 |
| Orden, A | 1 |
| Gonzalo-Orden, JM | 1 |
| Buléon, C | 1 |
| Hirose, K | 1 |
| Shono, M | 1 |
| Katayama, E | 1 |
| Kinoshita, M | 1 |
| Oshita, S | 1 |
| Agarwal, B | 1 |
| Camara, AK | 1 |
| Stowe, DF | 2 |
| Dash, RK | 1 |
| Chang, DJ | 1 |
| Chang, CH | 1 |
| Kim, JS | 1 |
| Hong, YW | 1 |
| Lee, WK | 1 |
| Shim, YH | 1 |
| Krolikowski, JG | 11 |
| Gu, W | 2 |
| Toller, W | 1 |
| Thompson, K | 1 |
| Wisenberg, G | 1 |
| Sykes, J | 1 |
| Thompson, RT | 1 |
| Ludwig, LM | 3 |
| Alcindor, D | 1 |
| Dworschak, M | 2 |
| Breukelmann, D | 2 |
| Hannon, JD | 2 |
| Chiari, PC | 2 |
| Trillo, RA | 1 |
| Puri, N | 1 |
| Järvinen, O | 1 |
| Kuukasjärvi, P | 1 |
| Laurikka, J | 1 |
| Wei, M | 1 |
| Rinne, T | 1 |
| Honkonen, EL | 1 |
| Tarkka, M | 1 |
| Obal, D | 2 |
| Weber, NC | 1 |
| Zacharowski, K | 1 |
| Toma, O | 1 |
| Dettwiler, S | 1 |
| Wolter, JI | 1 |
| Kratz, M | 1 |
| Müllenheim, J | 1 |
| Preckel, B | 4 |
| Schlack, W | 4 |
| Tsai, SK | 1 |
| Lin, SM | 1 |
| Huang, CH | 1 |
| Hung, WC | 1 |
| Chih, CL | 1 |
| Huang, SS | 1 |
| Bienengraeber, MW | 1 |
| Chevion, M | 1 |
| Elami, A | 1 |
| Berenshtein, E | 1 |
| Kitrossky, N | 1 |
| Drenger, B | 1 |
| Lucchinetti, E | 4 |
| da Silva, R | 1 |
| Pasch, T | 1 |
| Schaub, MC | 3 |
| Zaugg, M | 4 |
| Qian, LP | 1 |
| Zhu, SS | 1 |
| Cao, JL | 1 |
| Zeng, YM | 1 |
| Masui, K | 1 |
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| Furuya, A | 1 |
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| Takahashi, T | 1 |
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| Neff, DA | 1 |
| Tessier-Vetzel, D | 1 |
| Tissier, R | 1 |
| Waintraub, X | 1 |
| Ghaleh, B | 1 |
| Berdeaux, A | 1 |
| Guarracino, F | 1 |
| Landoni, G | 1 |
| Pompei, F | 1 |
| Leoni, A | 1 |
| Aletti, G | 1 |
| Scandroglio, AM | 1 |
| Maselli, D | 1 |
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| Marchetti, C | 1 |
| Crescenzi, G | 1 |
| Zangrillo, A | 1 |
| Venkatapuram, S | 1 |
| Wang, C | 1 |
| Chen, CH | 1 |
| Liu, K | 1 |
| Chan, JY | 1 |
| Yokoyama, T | 1 |
| Horikawa, Y | 1 |
| Zhu, R | 1 |
| Lu, XH | 1 |
| Jennings, MM | 1 |
| Hagiwara, Y | 1 |
| Ishikawa, Y | 1 |
| Insel, PA | 1 |
| Jamnicki, M | 1 |
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| Feng, J | 1 |
| Zhu, M | 1 |
| Zaugg, K | 1 |
| Jin, LY | 1 |
| Louvier, N | 1 |
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| Buljubasic, N | 1 |
| Coetzee, A | 1 |
| Skein, W | 1 |
| Genade, S | 1 |
| Lochner, A | 1 |
| Schmeling, TJ | 1 |
| Hettrick, DA | 1 |
| Orth, KG | 1 |
| Mei, DA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849] | 175 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| [NCT00005395] | 0 participants | Observational | 1995-09-30 | Completed | |||
| Comparison of Desflurane and Propofol Anesthesia for Off-Pump Coronary Artery Bypass Grafting Surgery[NCT00528515] | Phase 4 | 80 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| Sevoflurane and Cardiac Protection in High Risk Patients Undergoing Cardiac Surgery. A Randomized Controlled Study.[NCT00821262] | Phase 4 | 200 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for isoflurane and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The mechanisms of cardio-protective effects of desflurane and sevoflurane at the time of reperfusion: anaesthetic post-conditioning potentially translatable to humans?
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Desflurane; Humans; Is | 2016 |
Delayed cardioprotection by inhaled anesthetics.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Dogs; Humans; Ischemic Preconditioning, Myocar | 2011 |
[Prevention of ischemia/reperfusion injury −Postconditioning−].
Topics: Anesthetics, Inhalation; Animals; Humans; Ischemic Postconditioning; Ischemic Preconditioning; Isofl | 2010 |
Mechanisms of cardioprotection by isoflurane against I/R injury.
Topics: Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoflurane; KATP Channels; Myocardial Reperfusion | 2013 |
[Do halogenated anesthetics protect from ischemic and reperfusion myocardial injuries?].
Topics: Animals; Calcium Channels; Cats; Dogs; Enflurane; Free Radicals; Halothane; Heart; Isoflurane; Myoca | 1994 |
10 trials available for isoflurane and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
The effect of desflurane and propofol protocols on preconditioning.
Topics: Administration, Inhalation; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Cor | 2017 |
Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans.
Topics: Adult; Animals; Captopril; Drug Synergism; Female; Humans; Ischemic Preconditioning; Ischemic Precon | 2015 |
Desflurane-induced cardioprotection against ischemia-reperfusion injury depends on timing.
Topics: Animals; Cardiotonic Agents; Desflurane; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myo | 2009 |
A comparison of volatile and non volatile agents for cardioprotection during on-pump coronary surgery.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiopulmonary Bypass; Cardiotonic Agents; | 2009 |
Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Antioxidants; Coronary Artery Bypass; Cytok | 2011 |
Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction.
Topics: Anesthetics, Inhalation; Animal Welfare; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Fema | 2011 |
Isoflurane produces only minor preconditioning in coronary artery bypass grafting.
Topics: Aged; Anesthetics, Inhalation; Cardiotonic Agents; Chemoprevention; Coronary Artery Bypass; Creatine | 2004 |
Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2006 |
Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2006 |
Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2006 |
Myocardial damage prevented by volatile anesthetics: a multicenter randomized controlled study.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2006 |
[Influence of isoflurane and sevoflurane on metabolism of oxygen free radicals in cardiac valve replacement].
Topics: Adult; Anesthetics, Inhalation; Female; Free Radicals; Heart Valve Diseases; Heart Valve Prosthesis | 1998 |
Does isoflurane optimize myocardial protection during cardiopulmonary bypass?
Topics: Anesthetics, Inhalation; Arrhythmias, Cardiac; Cardiac Output; Cardiopulmonary Bypass; Cardiotonic A | 2001 |
102 other studies available for isoflurane and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Isoflurane Preconditioning Protects the Myocardium Against Ischemia and Reperfusion Injury by Upregulating GRM1 Expression.
Topics: Anesthetics, Inhalation; Animals; Ischemic Preconditioning; Isoflurane; Mice; Myocardial Ischemia; M | 2020 |
MiR-21-5p but not miR-1-3p expression is modulated by preconditioning in a rat model of myocardial infarction.
Topics: Animals; Apoptosis Regulatory Proteins; Disease Models, Animal; Heme Oxygenase-1; Hypoxia-Inducible | 2020 |
Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart.
Topics: Animals; Animals, Newborn; Apoptosis; Carbon Monoxide; Gene Expression; Heart; Isoflurane; Mice, Inb | 2021 |
Isoflurane Alleviates Myocardial Injury Induced by Hypoxia/Reoxygenation by Regulating miR-18a-5p.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Cyclin D2; Down-Regulation; Isoflur | 2021 |
MicroRNA-21 mediates the protective role of emulsified isoflurane against myocardial ischemia/reperfusion injury in mice by targeting SPP1.
Topics: Animals; Apoptosis; Isoflurane; Mice; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; O | 2021 |
Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and Desflurane.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Cyclophilins; Cytoprotection; Desflurane; | 2017 |
Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning.
Topics: Animals; Cell Communication; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Endothel | 2019 |
Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cardiotonic Agents; Deoxyglucose; Desflurane; Drug Ad | 2018 |
Influence of Medication-Induced Preconditioning or Remote Ischemic Preconditioning on the Intrinsic Vascular Extracellular RNA/Ribonuclease System in Cardioprotection.
Topics: Anesthetics; Animals; Buprenorphine; Cell-Free Nucleic Acids; Hemodynamics; Hindlimb; Ischemic Preco | 2019 |
Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Heart Function Tests; Isoflurane; Male; | 2019 |
Mechanism of Emulsified Isoflurane Postconditioning-Induced Activation of the Nrf2-Antioxidant Response Element Signaling Pathway During Myocardial Ischemia-Reperfusion: The Relationship With Reactive Oxygen Species.
Topics: Animals; Antioxidant Response Elements; Antioxidants; Disease Models, Animal; Emulsions; Heme Oxygen | 2019 |
Isoflurane preconditioning confers cardioprotection by activation of ALDH2.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiotonic Agents; Creatine | 2013 |
Emulsified isoflurane protects rat heart in situ after regional ischemia and reperfusion.
Topics: Anesthetics, Inhalation; Animals; Cytochromes c; Disease Models, Animal; Emulsions; Energy Metabolis | 2014 |
Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Emulsions; Ischemic Postconditioning; Isoflurane; Ma | 2013 |
Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia.
Topics: Acute Disease; Animals; Apolipoprotein A-I; Blood Glucose; Caveolin 1; Cells, Cultured; Coronary Ves | 2013 |
Isoflurane post-conditioning stimulates the proliferative phase of myocardial recovery in an ischemia-reperfusion model of heart injury in rats.
Topics: Anesthetics, Inhalation; Animals; Disease Models, Animal; Female; Ischemic Postconditioning; Isoflur | 2014 |
Cyclosporine A at reperfusion fails to reduce infarct size in the in vivo rat heart.
Topics: Anesthetics, Inhalation; Animals; Cyclosporine; Disease Models, Animal; Enzyme Inhibitors; Ischemic | 2013 |
Cardioprotection during diabetes: the role of mitochondrial DNA.
Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; | 2014 |
Geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism is dependent on caveolae and caveolin-3.
Topics: Anesthetics, Inhalation; Animals; Caveolae; Caveolin 3; Diterpenes; Drug Synergism; Isoflurane; Male | 2014 |
Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.
Topics: Animals; Caveolae; Caveolins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Bindi | 2014 |
Isoflurane protects the myocardium against ischemic injury via the preservation of mitochondrial respiration and its supramolecular organization.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Electron Transport; Ischemic Preconditioning, | 2015 |
Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice.
Topics: Anesthetics, General; Animals; Anticoagulants; Fasting; Fluorodeoxyglucose F18; Glucose; Heparin; In | 2015 |
Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling.
Topics: Animals; Apoptosis; Caspase 3; Cyclooxygenase 2; Hemodynamics; Humans; Hypertrophy, Left Ventricular | 2014 |
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats].
Topics: Animals; Biomarkers; Cathepsin L; Isoflurane; Myocardial Infarction; Myocardial Ischemia; Myocardial | 2014 |
Protein kinase C signaling pathway involvement in cardioprotection during isoflurane pretreatment.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cardiotonic Agents; Creatine | 2015 |
Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolin-3 expression.
Topics: Anesthetics, Inhalation; Animals; Caveolin 3; Drug Therapy, Combination; Exenatide; Glucagon-Like Pe | 2015 |
Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats.
Topics: Anesthetics, Inhalation; Animals; GTP Cyclohydrolase; Isoflurane; Male; Myocardial Ischemia; Myocard | 2015 |
Effects of isoflurane preconditioning in the delayed phase on myocardial tumor necrosis factor alpha levels and caspase-3 protein expression in a rabbit model of ischemia-reperfusion injury.
Topics: Animals; Caspase 3; Ischemic Preconditioning; Isoflurane; Male; Models, Animal; Myocardial Reperfusi | 2015 |
MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, Knoc | 2015 |
Epigenetics: The Epicenter for Future Anesthesia Research?
Topics: Animals; Isoflurane; Male; MicroRNAs; Mitochondrial Membrane Transport Proteins; Myocardial Reperfus | 2015 |
Involvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cyclophilins; Electron Transport Complex I; Ischemic Prec | 2015 |
Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.
Topics: Anesthetics, Inhalation; Animals; Biological Transport, Active; HEK293 Cells; Humans; Ischemic Preco | 2016 |
Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Helicases; Ischemic Postcondit | 2016 |
High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission.
Topics: Anesthetics, Inhalation; Antioxidants; Biomarkers; Cell Differentiation; Cell Survival; Cells, Cultu | 2016 |
Adding Emulsified Isoflurane to Cardioplegia Solution Produces Cardiac Protection in a Dog Cardiopulmonary Bypass Model.
Topics: Animals; bcl-2-Associated X Protein; Cardioplegic Solutions; Cardiopulmonary Bypass; Creatine Kinase | 2016 |
Protective effects of emulsified isoflurane after myocardial ischemia-reperfusion injury and its mechanism in rabbits.
Topics: Animals; Emulsions; Isoflurane; Lipid Peroxidation; Male; Myocardial Infarction; Myocardial Reperfus | 2009 |
The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase | 2009 |
Comparison of isoflurane-, sevoflurane-, and desflurane-induced pre- and postconditioning against myocardial infarction in mice in vivo.
Topics: Anesthetics, Inhalation; Animals; Desflurane; Ischemic Preconditioning, Myocardial; Isoflurane; Male | 2009 |
Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loops.
Topics: Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Desflurane; Drug Evaluation | 2009 |
Xenon and isoflurane improved biventricular function during right ventricular ischemia and reperfusion.
Topics: Anesthetics, Inhalation; Animals; Cardiac Output; Data Interpretation, Statistical; Isoflurane; Myoc | 2010 |
Desflurane-induced postconditioning of diabetic human right atrial myocardium in vitro.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Desflurane; Diabetes Mellitus; Diabetes Mel | 2010 |
Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Echocardiography; Heart Rate; In Vitro Techniq | 2010 |
[The optimal concentration for the protective effect of emulsified isoflurane on the neonatal rat cardiac myocytes hypoxia/reoxygenation injury of primary culture].
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Emulsion | 2009 |
Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling.
Topics: Anesthetics; Animals; Blood Glucose; Blood Pressure; Creatine Kinase, MB Form; Glucose; Heart; Heart | 2010 |
Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection.
Topics: Animals; Cardiotonic Agents; Caveolin 3; Glucose Transporter Type 4; Ischemic Preconditioning, Myoca | 2010 |
Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Calcium; Cell Death; Cytosol; Hydrogen-Ion | 2010 |
Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart.
Topics: Aging; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Glycogen Synthase Kinase 3; Glycogen Sy | 2010 |
Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model.
Topics: Anesthetics; Animals; Apoptosis Inducing Factor; Caspase 3; Cyclosporine; Disease Models, Animal; Dr | 2010 |
[Effect of isoflurane delayed preconditioning on the expression of Bcl-2 and caspase-3 in myocardium during ischemia reperfusion in rabbits].
Topics: Animals; Apoptosis; Caspase 3; Gene Expression Regulation; Ischemic Preconditioning, Myocardial; Iso | 2010 |
Role of 70-kDa ribosomal protein S6 kinase, nitric oxide synthase, glycogen synthase kinase-3 beta, and mitochondrial permeability transition pore in desflurane-induced postconditioning in isolated human right atria.
Topics: Atrial Function, Right; Desflurane; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hum | 2010 |
Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Autonomic Denervation; Autonomic Nervous Syst | 2011 |
Isoflurane induces expression of vascular endothelial growth factor through activating protein kinase C in myocardial cells.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Isoflur | 2010 |
Peroxisome-proliferator-activated receptor γ mediates the second window of anaesthetic-induced preconditioning.
Topics: Anesthetics, Inhalation; Anilides; Animals; Arteries; Coronary Occlusion; Desflurane; DNA-Binding Pr | 2011 |
Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.
Topics: Aged; Anesthetics, Inhalation; Blotting, Western; Decanoic Acids; Desflurane; Diabetes Mellitus, Typ | 2011 |
Role of the O-linked β-N-acetylglucosamine in the cardioprotection induced by isoflurane.
Topics: Acetylglucosamine; Anesthetics, Inhalation; Animals; Cell Survival; Heart; Ischemic Preconditioning, | 2011 |
Enhanced charge-independent mitochondrial free Ca(2+) and attenuated ADP-induced NADH oxidation by isoflurane: Implications for cardioprotection.
Topics: Adenosine Diphosphate; Animals; Calcium; Energy Metabolism; Isoflurane; Membrane Potential, Mitochon | 2012 |
Isoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway.
Topics: Aging; Animals; Cardiotonic Agents; Drug Evaluation, Preclinical; Glycogen Synthase Kinase 3; Glycog | 2012 |
Isoflurane does not produce a second window of preconditioning against myocardial infarction in vivo.
Topics: Anesthetics, Inhalation; Animals; Calibration; Coronary Circulation; Dogs; Female; Heart; Hemodynami | 2002 |
Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Coronary Circulation; Dogs; Female; Hemo | 2002 |
Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Blotting, Western; Celecoxib; Coronary Circulation | 2004 |
Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species.
Topics: Anesthetics, Inhalation; Animals; Coronary Circulation; Fluorescent Antibody Technique; Hemodynamics | 2004 |
The impact of isoflurane during simulated ischemia/reoxygenation on intracellular calcium, contractile function, and arrhythmia in ventricular myocytes.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cytosol; Electric Stimulation; Fluorescent Dyes; Free Rad | 2004 |
Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Chemistry, Pharmaceu | 2004 |
Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Cell Membrane; Cytosol; Dose-Response Relation | 2005 |
Effect of desflurane-induced preconditioning following ischemia-reperfusion on nitric oxide release in rabbits.
Topics: Anesthetics, Inhalation; Animals; Creatine Kinase; Desflurane; Enzyme Inhibitors; Hemodynamics; Isof | 2004 |
Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits.
Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activa | 2005 |
Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; Antidotes; Blood Pressure; Catechols; Deferoxamine; Dogs; Heart Ra | 2005 |
Anaesthetic preconditioning but not postconditioning prevents early activation of the deleterious cardiac remodelling programme: evidence of opposing genomic responses in cardioprotection by pre- and postconditioning.
Topics: Anesthetics; Animals; Gene Expression Profiling; Ischemic Preconditioning, Myocardial; Isoflurane; M | 2005 |
Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts.
Topics: Animals; Cytochromes c; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Ischemic | 2005 |
The effect of isoflurane during reoxygenation on the sarcoplasmic reticulum and cellular injury in isolated ventricular myocytes.
Topics: Anesthetics, Inhalation; Animals; Calcium; Calcium-Transporting ATPases; Cell Hypoxia; Cytosol; Hear | 2006 |
Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits.
Topics: Animals; In Situ Nick-End Labeling; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Morphine | 2005 |
Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels.
Topics: Anesthetics, Inhalation; Animals; Ion Channels; Isoflurane; Male; Mitochondrial Membrane Transport P | 2005 |
Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated hearts.
Topics: Anesthetics, Inhalation; Animals; Decanoic Acids; Hemodynamics; Hydroxy Acids; Ischemic Precondition | 2006 |
Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo.
Topics: Anesthetics, Inhalation; Animals; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemic P | 2006 |
Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cardiac Catheterization; Heart; Heart Rate; Isoflurane; | 2006 |
Isoflurane and other commonly used anaesthetics do not protect the isolated buffer perfused mouse heart from ischemia-reperfusion injury.
Topics: Anesthetics, Inhalation; Animals; Anticoagulants; Heart Function Tests; Heparin; In Vitro Techniques | 2006 |
Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.
Topics: Animals; Drug Synergism; Glycogen Synthase Kinases; Isoflurane; Male; Myocardial Infarction; Myocard | 2006 |
Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Heart Rate; Ischemic P | 2006 |
Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.
Topics: Animals; Benzothiazoles; Glycogen Synthase Kinases; Ischemic Preconditioning, Myocardial; Isoflurane | 2006 |
Anesthetic preconditioning confers acute cardioprotection via up-regulation of manganese superoxide dismutase and preservation of mitochondrial respiratory enzyme activity.
Topics: Adenosine Triphosphate; Anesthetics; Animals; Decanoic Acids; Hydroxy Acids; Ischemic Preconditionin | 2008 |
Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Free Radical Scavengers; Hemodynamics; Ischemic Precon | 2007 |
[Protective effect of heat-shock protein 27 on myocardium with isoflurane preconditioning in myocardial ischemia/reperfusion injury of myocardium in rabbit].
Topics: Animals; Disease Models, Animal; HSP27 Heat-Shock Proteins; Ischemic Preconditioning, Myocardial; Is | 2007 |
Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury.
Topics: Animals; beta-Cyclodextrins; Cardiotonic Agents; Caveolae; Caveolin 3; Cell Hypoxia; Colchicine; Iso | 2008 |
Preconditioning by isoflurane retains its protection against ischemia-reperfusion injury in postinfarct remodeled rat hearts.
Topics: Anesthetics, Inhalation; Animals; Cardiotonic Agents; Chromones; Coronary Vessels; Decanoic Acids; D | 2008 |
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB.
Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; Cardiovascular Agents; Colorimetry; Cycl | 2008 |
[Effect of isoflurane delayed preconditioning on myocardial ischemia reperfusion injury in rabbits].
Topics: Animals; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Myocardial Reperfusion Injury; Myoc | 2008 |
Emulsified intravenous versus evaporated inhaled isoflurane for heart protection: old wine in a new bottle or true innovation?
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Chemistry, Pharmaceutical; Coronary Ve | 2008 |
Emulsified isoflurane produces cardiac protection after ischemia-reperfusion injury in rabbits.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Coronary Vessels; Creatine Kinase; Cyt | 2008 |
Volatile anesthetics and myocardial stunning.
Topics: Animals; Halothane; Isoflurane; Myocardial Reperfusion Injury; Rabbits | 1993 |
Enflurane and isoflurane reduce reperfusion dysfunction in the isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Depression, Chemical; Enflurane; In Vitro Techniques; Isoflurane; M | 1993 |
Mechanism of myocardial protection by isoflurane. Role of adenosine triphosphate-regulated potassium (KATP) channels.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Coronary Circulation; Dogs; Drug Interacti | 1996 |
Role of adenosine in isoflurane-induced cardioprotection.
Topics: Anesthetics, Inhalation; Animals; Dogs; Hemodynamics; Isoflurane; Myocardial Reperfusion Injury; Pur | 1997 |
Beneficial effect of concomitant administration of isoflurane and nicorandil.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Therapy, Co | 1997 |
Enflurane and isoflurane, but not halothane, protect against myocardial reperfusion injury after cardioplegic arrest with HTK solution in the isolated rat heart.
Topics: Anesthetics, Inhalation; Animals; Cardioplegic Solutions; Creatine Kinase; Enflurane; Glucose; Halot | 1998 |
Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo.
Topics: Anesthetics, Inhalation; Animals; Coronary Disease; Desflurane; Enflurane; Hemodynamics; Isoflurane; | 1998 |
Sevoflurane and isoflurane protect the reperfused guinea pig heart by reducing postischemic adhesion of polymorphonuclear neutrophils.
Topics: Anesthetics, Inhalation; Animals; Cell Adhesion; Coronary Circulation; Guinea Pigs; Hemodynamics; Is | 1999 |
Beneficial effects of sevoflurane and desflurane against myocardial reperfusion injury after cardioplegic arrest.
Topics: Anesthetics, Inhalation; Animals; Creatine Kinase; Desflurane; Diastole; Glucose; Heart Arrest, Indu | 1999 |
Is isoflurane-induced preconditioning dose related?
Topics: Anesthetics, Inhalation; Animals; Collateral Circulation; Coronary Circulation; Dogs; Dose-Response | 2002 |
Isoflurane-induced preconditioning is attenuated by diabetes.
Topics: Anesthetics, Inhalation; Animals; Blood Glucose; Constriction; Coronary Vessels; Diabetes Mellitus, | 2002 |
Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Guinea Pigs; Halothane; Heart; Heart Rate; Hyp | 1990 |
Effect of halothane and isoflurane on postischemic "stunned" myocardium in the dog.
Topics: Animals; Dogs; Halothane; Hemodynamics; Isoflurane; Myocardial Contraction; Myocardial Reperfusion I | 1990 |
Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane.
Topics: Anesthesia; Animals; Consciousness; Coronary Disease; Dogs; Female; Halothane; Isoflurane; Male; Myo | 1988 |