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isoflurane and Injury, Ischemia-Reperfusion

isoflurane has been researched along with Injury, Ischemia-Reperfusion in 115 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Research Excerpts

ExcerptRelevanceReference
" In the previous study, the neuroprotection of isoflurane postconditioning (ISPOC) against cerebral ischemia-reperfusion (I/R) injury has been addressed, with particular relevance to the role of BMP7."8.02Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats. ( Dai, Z; Fan, S; Ge, M; Li, Y; Qin, X; Shao, X; Wang, R; Wang, S; Yin, J; Zhai, J, 2021)
"Isoflurane has been studied in ischemia-reperfusion injury, while the regulatory mechanism by which isoflurane regulates microRNA(miR)-9-3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated."8.02Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B. ( Guo, L; Song, S; Wang, H; Wang, Y, 2021)
"Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified."7.96TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020)
" This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury."7.88Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018)
"Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups."7.85Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017)
"Our results demonstrate that the administration of inhaled isoflurane in spinal cord ischemia-reperfusion injury impairs the recovery of motor function."7.85Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats. ( Fang, SY; Lam, CF; Lee, JS; Roan, JN; Tsai, YC, 2017)
"Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear."7.85Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy. ( Ding, Z; Gao, M; Li, J; Liu, S; Lu, T; Pan, X; Rao, Z; Sun, J; Yu, D; Zhang, H, 2017)
"Hepatic ischemia induced significant degree of I/R injuries in both isoflurane and sevoflurane non-IP groups."7.85Ischemic Preconditioning Produces Comparable Protection Against Hepatic Ischemia/Reperfusion Injury Under Isoflurane and Sevoflurane Anesthesia in Rats. ( Gwak, MS; Han, S; Jeong, JS; Kim, D; Kim, GS; Kim, KY; Ko, JS; Ryu, S; Shin, BS, 2017)
"Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury."7.81Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury. ( Keppler, U; Menger, MD; Moussavian, MR; Schilling, MK; Strowitzki, MJ; von Heesen, M, 2015)
"The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1."7.79The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. ( Brown, KM; D'Agati, VD; Ham, A; Kim, JY; Kim, M; Lee, HT, 2013)
"To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia."7.79Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia? ( Carraretto, AR; Carvalho, LR; Castiglia, YM; Deffune, E; Golim, Mde A; Souza, AV; Vianna Filho, PT; Vianna, PT, 2013)
"To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia/reperfusion injury in rats anesthetized with isoflurane."7.78Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane. ( Braz, LG; Castiglia, YM; Fabris, VE; Mansano, AM; Silva, LM; Vianna, PT, 2012)
"Our data suggested that isoflurane preconditioning provided a protection against renal ischemic-reperfusion injury which is very likely due to hypoxia inducible factor-1 α upregulation."7.77Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice. ( Cheng, J; Huang, H; Liu, J; Ma, D; Vizcaychipi, MP; Zhang, L; Zhao, H, 2011)
"St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats."7.76Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010)
"The purpose of this investigation was to examine the effect of isoflurane, remifentanil, and preconditioning in renal ischemia/reperfusion injury (IRI)."7.75Remifentanil, isoflurane, and preconditioning attenuate renal ischemia/reperfusion injury in rats. ( Beier, S; Braz, JR; Castiglia, YM; de Assis Golim, M; Deffune, E; Reinoldes Bizarria Guilherme, G; Vianna Filho, PT; Vianna, PT; Viero, RM; Vitória, A, 2009)
"Preconditioning with emulsified isoflurane protects the liver from ischemia/reperfusion injury and this effect me be mediated by Kupffer cells."7.74[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats]. ( Li, Q; Lü, H; Ren, HM; Xu, LY; Yang, LQ; Yu, WF; Zhu, M, 2007)
"This study provides first evidence that pretreatment with the nontoxic and clinically approved anesthetic isoflurane induces hepatic HO-1 expression, and thereby protects rat livers from ischemia/reperfusion injury."7.74Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. ( Geiger, KK; Halverscheid, L; Hoetzel, A; Humar, M; Loop, T; Pannen, BH; Schmidt, R; Tritschler, E, 2007)
"Desflurane shows better preservation of mitochondrial function at 4 h after cerebral ischemia reperfusion injury, indicated by inhibition of mitochondrial swelling, increase of membrane potential, and improvement of functions of mitochondria respiratory complexes I + III and IV when compared with halothane."7.74Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats. ( Cui, X; Ding, W; Li, W; Wei, X; Zhang, B; Zhou, H, 2008)
" In the current study, we investigated whether isoflurane inhalation during warm ischemia could attenuate ischemia reperfusion injury (IRI) of the lung."7.73Isoflurane inhalation after circulatory arrest protects against warm ischemia reperfusion injury of the lungs. ( Bando, T; Chen, F; Fujinaga, T; Fukuse, T; Hamakawa, H; Hanaoka, N; Nakamura, T; Omasa, M; Sakai, H; Ueda, S; Wada, H; Zhang, J, 2006)
"To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia."7.72The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004)
"This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity."7.69Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997)
"Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats."5.91Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023)
"Ischaemic stroke is a severe disease worldwide."5.72Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022)
"Pretreatment with isoflurane suppressed renal NF-κB activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1β, and tumor necrosis factor-α) both in the kidneys and circulation."5.40Isoflurane preconditioning ameliorates renal ischemia-reperfusion injury through antiinflammatory and antiapoptotic actions in rats. ( Guo, X; Li, M; Li, Z; Liang, Y; Mo, N; Wang, J; Wang, Y; Zhuang, Z, 2014)
"Isoflurane has an acute preconditioning effectiveness against ischemia in kidney, but this beneficial effectiveness can only last for 2-3 hours."5.36[Isoflurane produces delayed preconditioning against renal ischemia/reperfusion injury via hypoxia inducible factor 1 alpha activation]. ( Cheng, J; Huang, H; Liu, J; Ma, D; Zhang, L, 2010)
"Ischemia was evident by reduced portal vein flow and oxygen consumption, and caused an increase in lactate production."5.29Effects of halothane, isoflurane and sevoflurane on ischemia-reperfusion injury in the perfused liver of fasted rats. ( Imai, M; Inaba, H; Kon, S, 1996)
" In the previous study, the neuroprotection of isoflurane postconditioning (ISPOC) against cerebral ischemia-reperfusion (I/R) injury has been addressed, with particular relevance to the role of BMP7."4.02Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats. ( Dai, Z; Fan, S; Ge, M; Li, Y; Qin, X; Shao, X; Wang, R; Wang, S; Yin, J; Zhai, J, 2021)
"The mechanisms of brain protection during ischaemic reperfusion injury induced by isoflurane (ISO) post-conditioning are unclear."4.02Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway. ( Ge, M; Li, N; Li, Y; Qin, X; Wang, S; Xu, F; Yin, J; Zhai, J; Zhang, Q; Zhou, W, 2021)
"Isoflurane has been studied in ischemia-reperfusion injury, while the regulatory mechanism by which isoflurane regulates microRNA(miR)-9-3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated."4.02Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B. ( Guo, L; Song, S; Wang, H; Wang, Y, 2021)
"Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified."3.96TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020)
" This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury."3.88Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018)
"Isoflurane has a pharmacological preconditioning effect against ischemia injury in the heart, kidney, and brain, but whether and how isoflurane preconditioning protects livers against ischemia and reperfusion (IR) injury is unclear."3.85Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy. ( Ding, Z; Gao, M; Li, J; Liu, S; Lu, T; Pan, X; Rao, Z; Sun, J; Yu, D; Zhang, H, 2017)
"Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups."3.85Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017)
"Hepatic ischemia induced significant degree of I/R injuries in both isoflurane and sevoflurane non-IP groups."3.85Ischemic Preconditioning Produces Comparable Protection Against Hepatic Ischemia/Reperfusion Injury Under Isoflurane and Sevoflurane Anesthesia in Rats. ( Gwak, MS; Han, S; Jeong, JS; Kim, D; Kim, GS; Kim, KY; Ko, JS; Ryu, S; Shin, BS, 2017)
"Our results demonstrate that the administration of inhaled isoflurane in spinal cord ischemia-reperfusion injury impairs the recovery of motor function."3.85Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats. ( Fang, SY; Lam, CF; Lee, JS; Roan, JN; Tsai, YC, 2017)
"Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury."3.81Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury. ( Keppler, U; Menger, MD; Moussavian, MR; Schilling, MK; Strowitzki, MJ; von Heesen, M, 2015)
"To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia."3.79Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia? ( Carraretto, AR; Carvalho, LR; Castiglia, YM; Deffune, E; Golim, Mde A; Souza, AV; Vianna Filho, PT; Vianna, PT, 2013)
" show that isoflurane uses a tubule-based transforming growth factor-β/CD73-dependent process that generates adenosine to protect mice from ischemic acute kidney injury (AKI) with effects to prevent the 'no-reflow phenomenon' and decrease inflammation."3.79The conundrum of protection from AKI by adenosine in rodent clamp ischemia models. ( Venkatachalam, MA; Weinberg, JM, 2013)
"The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1."3.79The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. ( Brown, KM; D'Agati, VD; Ham, A; Kim, JY; Kim, M; Lee, HT, 2013)
"Our previous clinical study reported that isoflurane preconditioning and high-dose propofol posttreatment attenuated myocardial ischemia/reperfusion injury of patients in surgery with cardiopulmonary bypass (CPB)."3.78Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass. ( Irwin, MG; Li, H; Li, Q; Li, T; Liu, J; Wu, W; Xia, Z; Xiang, X; You, Z; Zhou, R; Zhu, D, 2012)
"To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia/reperfusion injury in rats anesthetized with isoflurane."3.78Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane. ( Braz, LG; Castiglia, YM; Fabris, VE; Mansano, AM; Silva, LM; Vianna, PT, 2012)
"The purpose of this investigation was to examine the effect of caffeic acid phenethyl ester (CAPE) in renal ischemia/reperfusion injury in rats anesthetized with isoflurane (iso)."3.78Caffeic acid phenethyl ester effects in the kidney during ischemia and reperfusion in rats anesthetized with isoflurane. ( Carvalho, LR; Castiglia, YM; Correa, RR; de Oliveira, CC; de Souza, AV; Roso, NC; Scatena, LM; Vianna, PT, 2012)
"Clinic relevant doses of isoflurane attenuate ischemia reperfusion injury in rats by increasing the HO-1 expression and activity."3.77Isoflurane preconditioning at clinically relevant doses induce protective effects of heme oxygenase-1 on hepatic ischemia reperfusion in rats. ( Chen, G; Liu, Y; Lv, H; Lv, X; Tao, K; Wu, F; Yang, L; Yang, T; Yu, W, 2011)
"Our data suggested that isoflurane preconditioning provided a protection against renal ischemic-reperfusion injury which is very likely due to hypoxia inducible factor-1 α upregulation."3.77Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice. ( Cheng, J; Huang, H; Liu, J; Ma, D; Vizcaychipi, MP; Zhang, L; Zhao, H, 2011)
" We used isoflurane as a pharmacological stimulus to enhance EC protection of CM against hypoxia and reoxygenation injury."3.77Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. ( Baotic, I; Bienengraeber, M; Brzezinska, AK; Kersten, JR; Leucker, TM; Muravyeva, M; Pratt, PF; Warltier, DC; Weihrauch, D, 2011)
"St Thomas cardioplegia solution supplemented with emulsified isoflurane enhanced its cardioprotection in an isolated heart ischemia reperfusion injury model in rats."3.76Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats. ( Huang, H; Li, T; Liu, J; Liu, S; Yanfang, C; Zhang, W, 2010)
"In this study, we sought to clarify the role of inhibiting ubiquitin-conjugated protein aggregation in the formation of a neuroprotective effect after isoflurane preconditioning using a transient global cerebral ischemia-reperfusion injury mouse model."3.76Isoflurane preconditioning induces neuroprotection by attenuating ubiquitin-conjugated protein aggregation in a mouse model of transient global cerebral ischemia. ( Dong, HL; Ma, R; Tong, L; Xiong, L; Yuan, LB; Zhang, HP; Zhao, RN, 2010)
"These data suggest that Pim-1 kinase mediates at least in part desflurane-induced preconditioning and IPC against myocardial infarction in mice."3.75Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction. ( Blomeyer, CA; Kehl, F; Kellermann, A; Lange, M; Lotz, CA; Redel, A; Roewer, N; Smul, TM; Stumpner, J, 2009)
"The purpose of this investigation was to examine the effect of isoflurane, remifentanil, and preconditioning in renal ischemia/reperfusion injury (IRI)."3.75Remifentanil, isoflurane, and preconditioning attenuate renal ischemia/reperfusion injury in rats. ( Beier, S; Braz, JR; Castiglia, YM; de Assis Golim, M; Deffune, E; Reinoldes Bizarria Guilherme, G; Vianna Filho, PT; Vianna, PT; Viero, RM; Vitória, A, 2009)
"Desflurane shows better preservation of mitochondrial function at 4 h after cerebral ischemia reperfusion injury, indicated by inhibition of mitochondrial swelling, increase of membrane potential, and improvement of functions of mitochondria respiratory complexes I + III and IV when compared with halothane."3.74Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats. ( Cui, X; Ding, W; Li, W; Wei, X; Zhang, B; Zhou, H, 2008)
"Preconditioning with emulsified isoflurane protects the liver from ischemia/reperfusion injury and this effect me be mediated by Kupffer cells."3.74[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats]. ( Li, Q; Lü, H; Ren, HM; Xu, LY; Yang, LQ; Yu, WF; Zhu, M, 2007)
"This study provides first evidence that pretreatment with the nontoxic and clinically approved anesthetic isoflurane induces hepatic HO-1 expression, and thereby protects rat livers from ischemia/reperfusion injury."3.74Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. ( Geiger, KK; Halverscheid, L; Hoetzel, A; Humar, M; Loop, T; Pannen, BH; Schmidt, R; Tritschler, E, 2007)
"Repeated exposure to isoflurane suppressed myocardial myoglobin release caused by both ischemia and reperfusion injury."3.74Isoflurane attenuates myoglobin release during ischemic and/or reperfusion periods. ( Akiyama, T; Kitagawa, H; Mori, H; Nosaka, S; Yamazaki, T, 2008)
" In the current study, we investigated whether isoflurane inhalation during warm ischemia could attenuate ischemia reperfusion injury (IRI) of the lung."3.73Isoflurane inhalation after circulatory arrest protects against warm ischemia reperfusion injury of the lungs. ( Bando, T; Chen, F; Fujinaga, T; Fukuse, T; Hamakawa, H; Hanaoka, N; Nakamura, T; Omasa, M; Sakai, H; Ueda, S; Wada, H; Zhang, J, 2006)
"To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia."3.72The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004)
"This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity."3.69Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997)
"Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome."2.72Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation. ( Bosch, DJ; Leuvenink, HGD; Nieuwenhuijs-Moeke, GJ, 2021)
"Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats."1.91Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023)
"Ischaemic stroke is a severe disease worldwide."1.72Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022)
"Isoflurane (ISO) is an anesthesia and can result in neuron injury."1.62Silencing of miR-302b-3p alleviates isoflurane-induced neuronal injury by regulating PTEN expression and AKT pathway. ( Fan, X; Li, L; Lu, S, 2021)
"Desflurane had lower uptake than propofol (65 ± 21 × 10 vs 165 ± 51 × 10 g·mL·min/μmol; P = ."1.48Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition. ( Andrews, DT; Heiberg, J; Royse, AG; Royse, CF, 2018)
"Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h."1.46Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia. ( Chen, KB; Lai, TW; Lee, YD; Liao, KH; Liu, YC; Pan, YL; Poon, KS; Wang, HL, 2017)
"Post-cardiac arrest myocardial dysfunction and brain injury are the main clinical features of this complex pathophysiological process."1.42Cardiocerebral protection by emulsified isoflurane during cardiopulmonary resuscitation. ( Li, Y; Wu, MJ; Yu, H; Zhang, YJ, 2015)
"Pretreatment with isoflurane suppressed renal NF-κB activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1β, and tumor necrosis factor-α) both in the kidneys and circulation."1.40Isoflurane preconditioning ameliorates renal ischemia-reperfusion injury through antiinflammatory and antiapoptotic actions in rats. ( Guo, X; Li, M; Li, Z; Liang, Y; Mo, N; Wang, J; Wang, Y; Zhuang, Z, 2014)
"Isoflurane has an acute preconditioning effectiveness against ischemia in kidney, but this beneficial effectiveness can only last for 2-3 hours."1.36[Isoflurane produces delayed preconditioning against renal ischemia/reperfusion injury via hypoxia inducible factor 1 alpha activation]. ( Cheng, J; Huang, H; Liu, J; Ma, D; Zhang, L, 2010)
"Posttreatment with isoflurane, but not desflurane, reduced this cell injury."1.35Isoflurane induces a postconditioning effect on bovine pulmonary arterial endothelial cells exposed to oxygen-glucose deprivation. ( Kim, JA; Li, L; Zuo, Z, 2009)
"Filamentous middle cerebral artery occlusion (fMCAO) is the most frequently used focal cerebral ischemia model in rodents."1.35Filamentous middle cerebral artery occlusion causes ischemic damage to the retina in mice. ( Guo, Q; Namura, S; Steele, EC, 2008)
" Compared with ISO group alone, hepatic I/R combined with LPS resulted in severer liver injury, with the levels of ALT, AST in serum, MPO activity in the liver tissue, and hepatic and serum TNF-alpha level were all increased (all P<0."1.35[Isoflurane pretreatment reduced liver injury induced by ischemia/reperfusion combined with lipopolysaccharide in rats]. ( Huang, SD; Li, Q; Lv, X; Wu, FX; Yang, LQ; Yu, WF, 2008)
"Isoflurane was applied after OGD."1.35Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. ( Jung, HH; Lee, JJ; Li, L; Zuo, Z, 2008)
"We examined in a rabbit model of transient spinal cord ischemia (SCI) whether isoflurane (Iso) preconditioning induces ischemic tolerance to SCI in a dose-response manner, and whether this effect is dependent on mitochondrial adenosine triphosphate-dependent potassium (K(ATP)) channel."1.33Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel. ( Hwang, JW; Jeon, YT; Kang, H; Kim, CS; Lim, SW; Oh, YS; Park, HP, 2005)
"Isoflurane has a pharmacological preconditioning effect against ischemia in the heart and brain, but whether this also occurs in the kidney is unclear."1.33Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK. ( Hashiguchi, H; Koji, T; Matsumoto, M; Miyoshi, H; Morooka, H; Sumikawa, K, 2005)
"Neurologic deficit scores (NDS) and brain infarct volumes were evaluated at 24 h."1.32Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral ischemia in rats. ( Hou, L; Lu, Z; Wu, M; Xiong, L; Zhang, X; Zheng, Y; Zhu, Z, 2003)
"Desflurane was associated with significantly increased alveolar-capillary membrane permeability after aortic occlusion-reperfusion when compared with the fentanyl plus droperidol anesthesia or sham-operated groups (P < 0."1.30Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury. ( Baird, MS; Freeman, BA; McAdams, ML; Nielsen, VG, 1998)
"Sevoflurane-treated hearts (1 and 2 MAC) also showed decreased adhesion of PMNs (23 +/- 2."1.30Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system. ( Becker, BF; Conzen, PF; Flaucher, A; Gerlach, E; Kowalski, C; Peter, K; Zahler, S, 1997)
"Ischemia was evident by reduced portal vein flow and oxygen consumption, and caused an increase in lactate production."1.29Effects of halothane, isoflurane and sevoflurane on ischemia-reperfusion injury in the perfused liver of fasted rats. ( Imai, M; Inaba, H; Kon, S, 1996)

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Studies (115)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (10.43)18.2507
2000's30 (26.09)29.6817
2010's60 (52.17)24.3611
2020's13 (11.30)2.80

Authors

AuthorsStudies
Zhang, YJ2
Guo, WJ1
Tang, ZY1
Lin, HB1
Hong, P1
Wang, JW1
Huang, XX1
Li, FX1
Xu, SY1
Zhang, HF1
Zhu, X2
Yang, M3
Yang, L5
Clarysse, M1
Accarie, A1
Farré, R1
Canovai, E1
Monbaliu, D1
Gunst, J1
De Hertogh, G1
Vanuytsel, T1
Pirenne, J1
Ceulemans, LJ1
Zhai, J3
Li, N4
Zhang, X11
Li, Y14
Ma, K6
Wang, R3
Qin, X3
Yin, J11
Wang, S10
Lee, SH1
Lee, JJ3
Kim, GH1
Kim, JA2
Cho, HS1
Peng, L3
Ge, M7
Han, Z3
Wang, Y11
Zhang, M3
Xie, L4
Chen, G2
Kamat, PK1
Ahmad, AS1
Doré, S1
Liu, G1
Qiao, S1
Yu, Y3
Hou, D1
Yang, Y4
Chen, L4
Si, J5
Yang, C4
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J8
Huang, L2
Hu, K1
Liu, H4
Wang, H5
Guo, Z1
Song, Y1
Huang, H7
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q6
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X5
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J8
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X5
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z4
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M2
Xu, G1
Xu, N1
Liu, S3
He, H1
Dong, X2
Yang, Q1
Duan, S1
Han, J2
Zhang, C3
Yang, X1
Li, W4
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H6
Yao, L2
Sun, L4
Zhu, Z2
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS3
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y6
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X2
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L10
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J3
Li, J8
Du, S1
Zhou, H2
Cui, J1
Wu, W2
Liu, Y8
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S2
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L2
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H4
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J4
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
Zhu, N1
Du, Q1
Hao, P1
Cao, X1
Li, CX1
Zhao, S1
Luo, XM1
Feng, JX1
Gonzalez-Cotto, M1
Guo, L2
Karwan, M1
Sen, SK1
Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
Qu, F1
Deng, Z1
Xie, Y2
Tang, J3
Chen, Z3
Luo, W1
Xiong, D1
Zhao, D1
Fang, J1
Zhou, Z1
Niu, PP1
Song, B1
Xu, YM1
Zhang, Z2
Qiu, N1
Zhang, J4
Guo, W1
Liu, M2
Liu, T2
Chen, D5
Luo, K1
He, Z2
Zheng, G1
Xu, F3
Sun, W1
Yin, F1
van Hest, JCM1
Du, L2
Shi, X1
Kang, S1
Duan, W1
Zhang, S3
Feng, J3
Qi, N1
Shen, G1
Ren, H1
Shang, Q1
Zhao, W2
Yang, Z2
Jiang, X2
Alame, M1
Cornillot, E1
Cacheux, V1
Tosato, G1
Four, M1
De Oliveira, L1
Gofflot, S1
Delvenne, P1
Turtoi, E1
Cabello-Aguilar, S1
Nishiyama, M1
Turtoi, A1
Costes-Martineau, V1
Colinge, J1
Guo, Q2
Quan, M1
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Bai, J1
Han, R1
Cai, Y1
Lv, YQ1
Chen, Q1
Lyu, HD1
Deng, L1
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Xiao, X1
De Langhe, S1
Billadeau, DD1
Lou, Z1
Zhang, JS1
Xue, Z2
Shen, XD1
Gao, F1
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Kupiec-Weglinski, JW1
Ji, H1
Otano, I1
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Minute, L1
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Migueliz, I1
Molina, C1
Azpilikueta, A1
de Andrea, CE1
Etxeberria, I1
Sanmamed, MF1
Teijeira, Á1
Berraondo, P1
Melero, I1
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Xie, X1
Yu, Q1
Zhou, C1
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Chen, W1
Yin, Y1
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Hsu, JL1
Zhou, Q1
Hu, B1
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Ma, Q2
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Huang, P1
Liao, R1
Chen, X4
Cao, Q1
Yuan, X1
Nie, W1
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Shao, B1
Ma, X1
Bi, Z1
Liang, X1
Tie, Y1
Mo, F1
Xie, D1
Wei, Y1
Wei, X3
Dokla, EME1
Fang, CS1
Chu, PC1
Chang, CS1
Abouzid, KAM1
Chen, CS1
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Brzezinska, J1
Dymek, B1
Stanczak, PS1
Mazurkiewicz, M1
Olczak, J1
Nowicka, J1
Dzwonek, K1
Zagozdzon, A1
Golab, J1
Golebiowski, A1
Xin, Z1
Himmelbauer, MK1
Jones, JH1
Enyedy, I1
Gilfillan, R1
Hesson, T1
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Marcotte, DJ1
Murugan, P1
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Gonzalez-Lopez de Turiso, F1
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Boudot, C1
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Pinault, E1
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Koski, KG1
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Kim, SJ2
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Guo, Y1
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Wang, Q3
Kawazoe, Y1
Jena, P1
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Xu, X1
Ma, G1
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Liang, GH1
Yu, YK1
Wang, HR1
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Cena, H1
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Han, X1
Zhou, Y3
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Zhang, W2
Ruan, Z1
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Kong, F1
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Lee, EY1
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Yu, HG1
Leslie, I1
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Larkin, J1
Pickering, L1
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Fogleman, AD1
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Mazzucchelli, TG1
Kajiyama, H1
Suzuki, S1
Shimbo, A1
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Kikkawa, F1
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Kolte, AP1
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Selvaraju, S1
Mech, A1
Sejian, V1
DeSilva, S1
Vaidya, SS1
Mao, C1
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Cheng, H1
Zhang, G3
Jiang, F1
Meng, X1
Elnour, IE1
Lan, X1
Song, E1
Rohde, S1
Antonides, CFJ1
Muslem, R1
de Woestijne, PCV1
der Meulen, MHV1
Kraemer, US1
Dalinghaus, M1
Bogers, AJJC1
Pourmand, A1
Ghassemi, M1
Sumon, K1
Amini, SB1
Hood, C1
Sikka, N1
Duan, H1
Chen, WP1
Fan, M1
Wang, WP1
Yu, L1
Tan, SJ1
Xin, S1
Wan, LJ1
Guo, YG1
Tanda, S1
Gingl, K1
Ličbinský, R1
Hegrová, J1
Goessler, W1
Li, ZL1
Zhou, YL1
Yan, W2
Luo, L1
Su, ZZ1
Fan, MZ1
Wang, SR1
Zhao, WG1
Xu, D1
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Jiang, Z1
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Jakob, SM1
Takala, J1
Gattinoni, L1
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Hu, BC1
Wen, Z1
Hu, D1
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Chu, Q1
Wu, MC1
Lu, X1
Wang, D2
Hu, M1
Shen, H1
Yao, M1
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Kulich, P1
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Qiao, L1
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Zhao, FL1
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Wang, HY1
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Jintao, X1
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Zhang, T1
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Wang, BY1
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Yao, T1
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Zhang, YW1
Wang, SP1
Shi, AX1
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Zhang, ZH1
Zhu, XF1
Zaller, N1
Gao, P1
Sun, YH1
Zhang, HB1
Lu, S1
Fan, X1
Shao, X1
Dai, Z5
Zhou, W1
Nieuwenhuijs-Moeke, GJ1
Bosch, DJ1
Leuvenink, HGD1
Song, S1
Feng, Z1
Chen, Y2
Wen, D1
Lemos, SV1
Vianna, IG1
Castiglia, YM5
Golim, MA1
Souza, AV2
Carvalho, LR3
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Nascimento, PD1
Módolo, NS1
Vianna, PT5
Nickkholgh, A1
Maluf, D1
Rao, Z1
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Lu, T1
Yu, D2
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Jeong, JS1
Kim, D1
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Ryu, S2
Shin, BS1
Kim, GS2
Gwak, MS2
Ko, JS2
Mangus, RS1
Kinsella, SB1
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Royse, CF1
Royse, AG1
Andrews, DT1
Zhao, G1
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Lee, HT6
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Yuan, LB2
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Ma, R2
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Shan, J1
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Zhao, H2
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Zhou, JH1
Zhang, TT1
Song, DD1
Xia, YF1
Qin, ZH1
Sheng, R1
Cui, D1
Lin, H1
Jiao, Y1
Yan, N1
Wu, B1
Ren, Y1
Gao, J1
Fang, SY1
Roan, JN1
Liu, YC1
Lee, YD1
Wang, HL1
Liao, KH1
Chen, KB1
Poon, KS1
Pan, YL1
Lai, TW1
Menting, TP1
Ergun, M1
Bruintjes, MH1
Wever, KE1
Lomme, RM1
van Goor, H1
Warlé, MC1
Zhu, M2
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Gehrig, P1
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Lucchinetti, E1
Zaugg, M1
Chuang, JH1
Liu, K1
Chan, JY1
Zuo, Z4
Stumpner, J1
Redel, A1
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Kehl, F1
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Lange, M1
Braz, JR1
Viero, RM1
Beier, S1
Vitória, A1
Reinoldes Bizarria Guilherme, G1
de Assis Golim, M1
Yanfang, C1
Li, T2
Ma, D2
Tao, KM1
Yang, LQ3
Liu, YT1
Tao, Y1
Song, JC1
Wu, FX3
Yu, WF4
Mazoit, JX1
Roulleau, P1
Baujard, C1
Park, SW2
Lv, X3
Tao, K1
Yang, T1
Yu, W1
Lv, H1
Vizcaychipi, MP1
Wang, ZM1
Huang, SD2
Song, SH1
Leucker, TM1
Bienengraeber, M1
Muravyeva, M1
Baotic, I1
Weihrauch, D1
Brzezinska, AK1
Warltier, DC1
Kersten, JR1
Pratt, PF1
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Zoll, J1
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Li, Q3
Zhu, D1
Xiang, X1
Irwin, MG1
Xia, Z1
Yin, X1
Su, B1
Song, W1
Wu, H1
Mansano, AM1
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Braz, LG1
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de Caestecker, MP1
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Correa, RR1
Scatena, LM1
de Souza, AV1
de Oliveira, CC1
Müller-Edenborn, B1
Roth-Zʼgraggen, B1
Bartnicka, K1
Borgeat, A1
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Borsig, L1
Beck-Schimmer, B1
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Zacharowski, K1
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Kapinya, KJ1
Prass, K1
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Wu, M1
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Lu, Z1
Tsai, SK1
Lin, SM1
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Huang, SS1
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Kang, H1
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Yamazaki, T1
Akiyama, T1
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Pearce, WJ2
Nielsen, VG1
Baird, MS1
McAdams, ML1
Freeman, BA1
Kanaya, N1
Nakayama, M1
Kobayashi, I1
Fujita, S1
Namiki, A1
Liu, R2
Ishibe, Y2
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Rolf, N1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Long-term Survival in Elderly Patients After Cancer Surgery: a Randomized Controlled Trial[NCT02660411]1,228 participants (Actual)Interventional2015-04-01Completed
Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on 5-year Survival in Elderly Patients After Cancer Surgery: a Randomized Controlled Trial[NCT05343260]1,228 participants (Actual)Interventional2015-04-01Active, not recruiting
Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843]Phase 413 participants (Actual)Interventional2009-01-31Completed
Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study[NCT03729011]Phase 4672 participants (Anticipated)Interventional2019-01-09Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for isoflurane and Injury, Ischemia-Reperfusion

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.
    International journal of molecular sciences, 2021, Mar-08, Volume: 22, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Humans; Isoflurane; Kidney; Kidney Transplantation; Reperfusion In

2021
Emerging graft protective strategies in clinical liver transplantation.
    Expert review of gastroenterology & hepatology, 2017, Volume: 11, Issue:7

    Topics: Anesthetics, Inhalation; Anti-Inflammatory Agents; Desflurane; Graft Rejection; Graft Survival; Huma

2017

Trials

4 trials available for isoflurane and Injury, Ischemia-Reperfusion

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Comparison of antioxidant effects of isoflurane and propofol in patients undergoing donor hepatectomy.
    Transplantation proceedings, 2015, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia; Antioxidants; Biomarkers; Female; Hepatectomy; Humans; Isoflura

2015
Comparison of the neuroprotective effects and recovery profiles of isoflurane, sevoflurane and desflurane as neurosurgical pre-conditioning on ischemia/reperfusion cerebral injury.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:2

    Topics: Aged; Cerebrovascular Circulation; Desflurane; Female; Hemodynamics; Humans; Isoflurane; Male; Methy

2015
Propofol attenuates formation of lipid peroxides in tourniquet-induced ischaemia-reperfusion injury.
    British journal of anaesthesia, 1997, Volume: 78, Issue:3

    Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Elective Surgical Procedures; Extremities;

1997

Other Studies

109 other studies available for isoflurane and Injury, Ischemia-Reperfusion

ArticleYear
Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Humans; Infarction, Middle Cerebral Artery

2022
Isoflurane Postconditioning Alleviates Ischemic Neuronal Injury Via MiR-384-5p Regulated Autophagy.
    Neuroscience, 2023, 05-01, Volume: 517

    Topics: Animals; Apoptosis; Autophagy; Brain Ischemia; Glucose; Isoflurane; Mice; MicroRNAs; Neurons; Rats;

2023
Protective Effect of Oxygen and Isoflurane in Rodent Model of Intestinal Ischemia-Reperfusion Injury.
    International journal of molecular sciences, 2023, Jan-30, Volume: 24, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Ischemia; Isoflurane; Male; Oxygen; Rats; Rats, Sprague-Dawley; Re

2023
Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats.
    Journal of molecular neuroscience : MN, 2023, Volume: 73, Issue:7-8

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Brain Ischem

2023
Role of reactive oxygen species at reperfusion stage in isoflurane preconditioning-induced neuroprotection.
    Brain research, 2019, 11-15, Volume: 1723

    Topics: Anesthetics, Inhalation; Animals; Cell Survival; Infarction, Middle Cerebral Artery; Isoflurane; Mal

2019
TGF-β2/Smad3 Signaling Pathway Activation Through Enhancing VEGF and CD34 Ameliorates Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.
    Neurochemical research, 2019, Volume: 44, Issue:11

    Topics: Animals; Antigens, CD34; Apoptosis; Cerebral Cortex; Hippocampus; Infarction, Middle Cerebral Artery

2019
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Analgesics; Anesthetics; Animals; Brain Infarction; Brain Ischemia; Extremities; Halothane; Infarcti

2020
Isoflurane improves cerebral ischemia-reperfusion injury in rats via activating MAPK signaling pathway.
    Journal of neurosurgical sciences, 2021, Volume: 65, Issue:1

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Isoflurane; MAP Kinase Signaling System; Rats; Repe

2021
TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C.
    Cellular and molecular neurobiology, 2020, Volume: 40, Issue:8

    Topics: Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Isoflurane; Male; MEF2 Transcription Fa

2020
Silencing of miR-302b-3p alleviates isoflurane-induced neuronal injury by regulating PTEN expression and AKT pathway.
    Brain research bulletin, 2021, Volume: 168

    Topics: Animals; Apoptosis; Humans; Isoflurane; MicroRNAs; Neurons; Proto-Oncogene Proteins c-akt; PTEN Phos

2021
Isoflurane post-conditioning attenuates cerebral ischemia/reperfusion injury by reducing apoptotic through activating the BMP7/SMAD signaling pathway in rats.
    Journal of chemical neuroanatomy, 2021, Volume: 112

    Topics: Animals; Apoptosis; Bone Morphogenetic Protein 7; Brain Ischemia; Ischemic Postconditioning; Isoflur

2021
Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:8

    Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Cell Movement; Cell Proliferation; Gene

2021
Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B.
    Cell cycle (Georgetown, Tex.), 2021, Volume: 20, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Disease Models, Animal; Fibronectins; Ge

2021
The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages.
    International immunopharmacology, 2021, Volume: 99

    Topics: Anesthetics, Inhalation; Animals; Calcium; Cytokines; Inflammasomes; Ischemic Preconditioning; Isofl

2021
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats.
    Acta cirurgica brasileira, 2017, Volume: 32, Issue:3

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Cell Survival; Cyclosporine;

2017
Isoflurane Preconditioning Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Ischemia; Ischemic Preconditioning; Isoflurane; L

2017
Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Aquaporin 4; Bone Morphogenetic Protein 4; Brain Ischemia; Down-Regulation; Gene Expression

2018
Ischemic Preconditioning Produces Comparable Protection Against Hepatic Ischemia/Reperfusion Injury Under Isoflurane and Sevoflurane Anesthesia in Rats.
    Transplantation proceedings, 2017, Volume: 49, Issue:9

    Topics: Anesthetics, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Ischemia; Ischemic Precond

2017
Impact of Volatile Anesthetic Agents on Early Clinical Outcomes in Liver Transplantation.
    Transplantation proceedings, 2018, Volume: 50, Issue:5

    Topics: Anesthetics, Inhalation; Desflurane; Female; Graft Survival; Humans; Isoflurane; Liver; Liver Functi

2018
Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition.
    Anesthesia and analgesia, 2018, Volume: 127, Issue:2

    Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cardiotonic Agents; Deoxyglucose; Desflurane; Drug Ad

2018
TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat.
    Rejuvenation research, 2019, Volume: 22, Issue:4

    Topics: Acute Disease; Animals; Brain Ischemia; Down-Regulation; Extracellular Signal-Regulated MAP Kinases;

2019
Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 110

    Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Ischemic Postconditioning; Isoflurane; Male; Rats;

2019
The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury.
    Kidney international, 2013, Volume: 84, Issue:1

    Topics: 5'-Nucleotidase; Acute Kidney Injury; Adenosine; Anesthetics, Inhalation; Animals; Antibodies, Neutr

2013
Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia?
    Acta cirurgica brasileira, 2013, Volume: 28, Issue:3

    Topics: Acute Disease; Anesthesia; Anesthetics; Animals; Cell Survival; Creatinine; Flow Cytometry; Hypergly

2013
The protective effect of ischemic preconditioning against hepatic ischemic-reperfusion injury under isoflurane anesthesia in rats.
    Transplantation proceedings, 2013, Volume: 45, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Ischemic Preconditioning; Isoflurane; Liver; Male; Rats; Rats, Spr

2013
The conundrum of protection from AKI by adenosine in rodent clamp ischemia models.
    Kidney international, 2013, Volume: 84, Issue:1

    Topics: 5'-Nucleotidase; Acute Kidney Injury; Anesthetics, Inhalation; Animals; GPI-Linked Proteins; Humans;

2013
The neuroprotective effects of isoflurane preconditioning in a murine transient global cerebral ischemia-reperfusion model: the role of the Notch signaling pathway.
    Neuromolecular medicine, 2014, Volume: 16, Issue:1

    Topics: Animals; Apoptosis; Ataxia; Basic Helix-Loop-Helix Transcription Factors; CA1 Region, Hippocampal; C

2014
Preconditioning renoprotective effect of isoflurane in a rat model of virtual renal transplant.
    The Journal of surgical research, 2014, Jun-01, Volume: 189, Issue:1

    Topics: Acetylcysteine; Acute Kidney Injury; Anesthetics, Inhalation; Animals; Free Radical Scavengers; Isch

2014
Intravenous pretreatment with emulsified isoflurane preconditioning protects kidneys against ischemia/reperfusion injury in rats.
    BMC anesthesiology, 2014, Volume: 14

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Emulsions; Inflammation; Ischemic

2014
[The effects of preconditioning and postconditioning with isoflurane on focal cerebral ischemi/reperfusion injury in rats].
    Zhonghua wei zhong bing ji jiu yi xue, 2014, Volume: 26, Issue:6

    Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Interleukin-1beta; Ischemic Postconditioning

2014
The Role of SUMO-Conjugating Enzyme Ubc9 in the Neuroprotection of Isoflurane Preconditioning Against Ischemic Neuronal Injury.
    Molecular neurobiology, 2015, Volume: 51, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Disease Models, Animal; Humans; Ischemic Precondit

2015
Isoflurane preconditioning ameliorates renal ischemia-reperfusion injury through antiinflammatory and antiapoptotic actions in rats.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Ischemic Preconditioning; Isoflurane; Kidney; Male; Ra

2014
Isoflurane reduces the ischemia reperfusion injury surge: a longitudinal study with MRI.
    Brain research, 2014, Oct-24, Volume: 1586

    Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Diffusion Magnetic Resonance Imaging; Diseas

2014
Isoflurane but not sevoflurane or desflurane aggravates injury to neurons in vitro and in vivo via p75NTR-NF-ĸB activation.
    Anesthesia and analgesia, 2014, Volume: 119, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Binding Sites; Cell Death; Cell Hypoxia; Cell Line, Tumor; Desflur

2014
Cardiocerebral protection by emulsified isoflurane during cardiopulmonary resuscitation.
    Medical hypotheses, 2015, Volume: 84, Issue:1

    Topics: Cardiopulmonary Resuscitation; Heart Arrest; Humans; Hypothermia, Induced; Ischemic Postconditioning

2015
Isoflurane does not protect from brain death-associated aggravation of cold hepatic ischemia-reperfusion injury.
    Annals of transplantation, 2015, Jan-19, Volume: 20

    Topics: Animals; Brain Death; Humans; Isoflurane; Liver; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2015
Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Blood Gas Analysis; Cerebrovascular Circulation; Disease Models, A

2015
Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation.
    Scientific reports, 2015, Jun-18, Volume: 5

    Topics: Animals; Apoptosis; Biomarkers; Brain Infarction; Cells, Cultured; Chaperonin 60; Disease Models, An

2015
Inhalation anesthesia of rats: influence of the fraction of inspired oxygen on limb ischemia/reperfusion injury.
    Laboratory animals, 2016, Volume: 50, Issue:3

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Hindlimb; Isoflurane; Male; Muscles; Oxida

2016
Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 78

    Topics: Animals; Anthracenes; Behavior, Animal; Brain Ischemia; CA1 Region, Hippocampal; In Situ Nick-End La

2016
Isoflurane preconditioning protects rat brain from ischemia reperfusion injury via up-regulating the HIF-1α expression through Akt/mTOR/s6K activation.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, Feb-29, Volume: 62, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Brain; Cell Line; Cell Survival; Disease Models, Animal; Hypo

2016
TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis.
    Scientific reports, 2016, 06-03, Volume: 6

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Cerebral Cortex; Gene Expression

2016
Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Cell Hypoxia; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Glucose; Hip

2016
NOD2 mediates isoflurane preconditioning-induced protection of myocardial injury.
    Neuroscience letters, 2017, 01-10, Volume: 637

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Isoflurane; Mitogen-Activated Protein Kinases; M

2017
Isoflurane Impairs Motor Function Recovery by Increasing Neuroapoptosis and Degeneration During Spinal Ischemia-Reperfusion Injury in Rats.
    Anesthesia and analgesia, 2017, Volume: 124, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 3; Disease Models, An

2017
Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Arterial Occlusive Diseases; Blood-Brain B

2017
Repeated remote ischemic preconditioning and isoflurane anesthesia in an experimental model of renal ischemia-reperfusion injury.
    BMC anesthesiology, 2017, Jan-28, Volume: 17, Issue:1

    Topics: Animals; Creatinine; Disease Models, Animal; Ischemic Preconditioning; Isoflurane; Kidney; Male; Pro

2017
Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function.
    Cardiovascular research, 2008, Oct-01, Volume: 80, Issue:1

    Topics: Adenine Nucleotide Translocator 1; Animals; In Vitro Techniques; Ischemic Preconditioning, Myocardia

2008
Nitric oxide triggers delayed anesthetic preconditioning-induced cardiac protection via activation of nuclear factor-kappaB and upregulation of inducible nitric oxide synthase.
    Shock (Augusta, Ga.), 2008, Volume: 30, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Gene Expression Regulation, Enzymologic; Heart; Ischemic Precondit

2008
Isoflurane induces a postconditioning effect on bovine pulmonary arterial endothelial cells exposed to oxygen-glucose deprivation.
    European journal of pharmacology, 2009, Aug-01, Volume: 615, Issue:1-3

    Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cattle; Cell Hypoxia; Cell Survival; Cells, Cultured; D

2009
Differential role of Pim-1 kinase in anesthetic-induced and ischemic preconditioning against myocardial infarction.
    Anesthesiology, 2009, Volume: 111, Issue:6

    Topics: Anesthetics, Inhalation; Animals; bcl-Associated Death Protein; Blood Pressure; Blotting, Western; C

2009
Remifentanil, isoflurane, and preconditioning attenuate renal ischemia/reperfusion injury in rats.
    Transplantation proceedings, 2009, Volume: 41, Issue:10

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Creatinine; Ischemic Precondi

2009
Cardioprotection afforded by St Thomas solution is enhanced by emulsified isoflurane in an isolated heart ischemia reperfusion injury model in rats.
    Journal of cardiothoracic and vascular anesthesia, 2010, Volume: 24, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Creatine K

2010
[Isoflurane produces delayed preconditioning against renal ischemia/reperfusion injury via hypoxia inducible factor 1 alpha activation].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2010, Volume: 24, Issue:4

    Topics: Animals; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning; Isoflurane; Kidney; Ma

2010
Isoflurane preconditioning induces neuroprotection by attenuating ubiquitin-conjugated protein aggregation in a mouse model of transient global cerebral ischemia.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; CA1 Region, Hippocampal; Cell Survival; Cerebrovascular Circu

2010
Volatile anesthetics might be more beneficial than propofol for postoperative liver function in cirrhotic patients receiving hepatectomy.
    Medical hypotheses, 2010, Volume: 75, Issue:6

    Topics: Anesthetics, Inhalation; Desflurane; Heme Oxygenase (Decyclizing); Hepatectomy; Humans; Hypoxia-Indu

2010
Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain: isoflurane or ischemia-reperfusion?
    Anesthesiology, 2010, Volume: 113, Issue:5

    Topics: Animals; Animals, Newborn; Apoptosis; Blood Pressure; Brain; Isoflurane; Macaca mulatta; Reperfusion

2010
Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Acute Kidney Injury; Anesthetics, Inhalation; Animals; Enzyme Activation; Intestinal Diseases; Intes

2011
Isoflurane preconditioning at clinically relevant doses induce protective effects of heme oxygenase-1 on hepatic ischemia reperfusion in rats.
    BMC gastroenterology, 2011, Mar-31, Volume: 11

    Topics: Animals; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hemin; Ischemic Preconditioning; Isofluran

2011
Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice.
    Life sciences, 2011, Jun-20, Volume: 88, Issue:25-26

    Topics: Animals; Apoptosis; Blotting, Western; Creatinine; Disease Models, Animal; Erythropoietin; Hypoxia-I

2011
Emulsified isoflurane preconditioning reduces lung injury induced by hepatic ischemia/reperfusion in rats.
    International journal of medical sciences, 2011, Volume: 8, Issue:5

    Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Intercellular Adhesion Mole

2011
Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:5

    Topics: Animals; Butadienes; Cell Survival; Coculture Techniques; Endothelial Cells; Endothelium, Vascular;

2011
Isoflurane preconditioning protects neurons from male and female mice against oxygen and glucose deprivation and is modulated by estradiol only in neurons from female mice.
    Neuroscience, 2011, Dec-29, Volume: 199

    Topics: Animals; Brain Ischemia; Cell Survival; Estradiol; Estrogen Antagonists; Female; Glucose; Hypoxia, B

2011
Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability.
    Neuroscience, 2011, Dec-29, Volume: 199

    Topics: Animals; Blotting, Western; Brain Ischemia; Enzyme Activation; Ischemic Postconditioning; Isoflurane

2011
Isoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Gastrointestinal Tract; Isoflurane; Liver; Lung; Male; Mitochondri

2011
Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass.
    European journal of pharmacology, 2012, Feb-29, Volume: 677, Issue:1-3

    Topics: Animals; Cardiopulmonary Bypass; Cardiotonic Agents; Dogs; Drug Interactions; Heart; Hemodynamics; I

2012
Isoflurane post-conditioning protects against intestinal ischemia-reperfusion injury and multiorgan dysfunction via transforming growth factor-β1 generation.
    Annals of surgery, 2012, Volume: 255, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Intestines; Ischemic Postconditioning; Isoflurane; Male; Mice; Mic

2012
TREK1 activation mediates spinal cord ischemic tolerance induced by isoflurane preconditioning in rats.
    Neuroscience letters, 2012, May-02, Volume: 515, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Ischemic Preconditioning; Isoflurane; Male; Neurons; Neuroprotecti

2012
Prevention of renal ischemia/reperfusion injury in rats using acetylcysteine after anesthesia with isoflurane.
    Acta cirurgica brasileira, 2012, Volume: 27, Issue:4

    Topics: Acetylcysteine; Anesthetics, Inhalation; Animals; Creatinine; Isoflurane; Kidney; Kidney Tubules; Ma

2012
Ischemia-reperfusion injury of the mouse kidney.
    Methods in molecular biology (Clifton, N.J.), 2012, Volume: 886

    Topics: Anesthetics, General; Animals; Disease Models, Animal; Female; Hypnotics and Sedatives; Isoflurane;

2012
Caffeic acid phenethyl ester effects in the kidney during ischemia and reperfusion in rats anesthetized with isoflurane.
    Transplantation proceedings, 2012, Volume: 44, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Biomarkers; Caffeic Acids; Creatinine; Disease Models, Animal; Iso

2012
Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Anesthetics, Inhalation; Colorectal Neoplasms; Desflurane; Down-Regulation; Enzyme-Linked Immunosorb

2012
Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Anesthetics, Inhalation; Colorectal Neoplasms; Desflurane; Down-Regulation; Enzyme-Linked Immunosorb

2012
Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Anesthetics, Inhalation; Colorectal Neoplasms; Desflurane; Down-Regulation; Enzyme-Linked Immunosorb

2012
Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.
    Anesthesiology, 2012, Volume: 117, Issue:2

    Topics: Anesthetics, Inhalation; Colorectal Neoplasms; Desflurane; Down-Regulation; Enzyme-Linked Immunosorb

2012
In vivo electrophysiological characterization of TASK-1 deficient mice.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:3

    Topics: Adrenergic beta-Agonists; Anesthetics; Animals; Atrial Function; Baroreflex; Electric Stimulation; E

2012
Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism?
    Neuroreport, 2002, Aug-07, Volume: 13, Issue:11

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Hypoxia; Isoflurane; Male; Mice; M

2002
Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral ischemia in rats.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:1

    Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Blood Gas Analysis; Body Temper

2003
The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury.
    Life sciences, 2004, Apr-02, Volume: 74, Issue:20

    Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Desflurane; Hemodynamics; Humans; Infarct

2004
Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel.
    Neuroscience letters, 2005, Oct-21, Volume: 387, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Anterior Horn Cells; Cell Death; Cell Survival; Disease Models, An

2005
Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Extracellular Signal-Regulated MAP Kinases; Isoflurane; JNK Mitoge

2005
[Protective effect of isoflurane pretreatment against pulmonary injury in canines undergoing cardiopulmonary bypass].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2005, Volume: 30, Issue:5

    Topics: Animals; Cardiopulmonary Bypass; Dogs; Female; Isoflurane; Lung; Male; Random Allocation; Reperfusio

2005
Isoflurane preconditioning protects human neuroblastoma SH-SY5Y cells against in vitro simulated ischemia-reperfusion through the activation of extracellular signal-regulated kinases pathway.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Butadienes; Cell Hypoxia; Cell Line, Tumor; Cell Survival; DNA, Single-Stranded; Dose-Response Relat

2006
Post-conditioning by a short administration of desflurane reduced renal reperfusion injury after differing of ischaemia times in rats.
    British journal of anaesthesia, 2006, Volume: 97, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Creatinine; Cystatin C; Cystatins; Desflurane; Ectodysplasins; Iso

2006
Renal protection with isoflurane.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Extracellular Signal-Regulated MAP Kinases; Ischemia; Isoflurane;

2006
Isoflurane inhalation after circulatory arrest protects against warm ischemia reperfusion injury of the lungs.
    Transplantation, 2006, Nov-15, Volume: 82, Issue:9

    Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Blood Circulation; Caspase 9; Cell Res

2006
Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:7

    Topics: Animals; Base Sequence; Caveolin 1; DNA Primers; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, K

2007
Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury.
    Annals of surgery, 2007, Volume: 245, Issue:6

    Topics: Analysis of Variance; Anesthetics; Animals; Blood Flow Velocity; Blotting, Northern; Blotting, Weste

2007
Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Granulocyte Colony-Stimulating Factor; Inflammation; Interleukin-3; Isoflurane; Kidney; Kid

2007
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Cell Line; Creatinine; Enzyme Inhibitors; Humans; Isoflurane; Kidn

2007
[Protection of liver against ischemia/reperfusion injury by Kupffer cell mediated emulsified isoflurane preconditioning: experiment with rats].
    Zhonghua yi xue za zhi, 2007, Sep-18, Volume: 87, Issue:35

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Disease Models, Animal; Emulsions; Injec

2007
Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury model.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:3

    Topics: Adenosine Triphosphate; Alanine Transaminase; Anesthetics, Inhalation; Animals; Aspartate Aminotrans

2008
Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Desfl

2008
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
    Annals of surgery, 2008, Volume: 247, Issue:4

    Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease

2008
Isoflurane attenuates myoglobin release during ischemic and/or reperfusion periods.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Heart R

2008
Desflurane preconditioning inhibits endothelial nuclear factor-kappa-B activation by targeting the proximal end of tumor necrosis factor-alpha signaling.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:5

    Topics: Active Transport, Cell Nucleus; Anesthetics, Inhalation; Cell Line; Desflurane; Endothelial Cells; E

2008
Filamentous middle cerebral artery occlusion causes ischemic damage to the retina in mice.
    Stroke, 2008, Volume: 39, Issue:7

    Topics: Amaurosis Fugax; Animals; Apoptosis; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery;

2008
[Isoflurane pretreatment reduced liver injury induced by ischemia/reperfusion combined with lipopolysaccharide in rats].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2008, Volume: 20, Issue:5

    Topics: Alanine Transaminase; Animals; Disease Models, Animal; Isoflurane; Lipopolysaccharides; Liver; Male;

2008
Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.
    Anesthesiology, 2008, Volume: 108, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Brain; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide

2008
Effects of halothane, isoflurane and sevoflurane on ischemia-reperfusion injury in the perfused liver of fasted rats.
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:10

    Topics: Anesthetics, Inhalation; Animals; Ethers; Halothane; Ischemia; Isoflurane; L-Lactate Dehydrogenase;

1996
Isoflurane and halothane increase adenosine triphosphate preservation, but do not provide additive recovery of function after ischemia, in preconditioned rat hearts.
    Anesthesiology, 1997, Volume: 86, Issue:1

    Topics: Adenosine Triphosphate; Animals; Blood Pressure; Halothane; Hemodynamics; Isoflurane; Male; Myocardi

1997
Isoflurane attenuates early neutrophil-independent hypoxia-reoxygenation injuries in the reperfused liver in fasted rats.
    Anesthesiology, 1997, Volume: 86, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Carbohydrate Metabolism; Cytochrome c Group; Fasting; Isoflurane;

1997
Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system.
    Anesthesiology, 1997, Volume: 86, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Cell Adhesion; Cells, Cultured; Coronary Vessels; Endothelium, Vas

1997
A method for long duration anaesthesia for a new hindlimb ischaemia-reperfusion model in mice.
    Laboratory animals, 1997, Volume: 31, Issue:2

    Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals; Body Temperature; Buprenorphine; D

1997
Propofol neuroprotection in a rat model of ischaemia reperfusion injury.
    European journal of anaesthesiology, 1997, Volume: 14, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antioxidants; Brain; Brain I

1997
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.
    Stroke, 1998, Volume: 29, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Antioxidants; Arterial Occlusive Diseases; Biopterins; Brain Ische

1998
Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury.
    Anesthesiology, 1998, Volume: 88, Issue:6

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Capillary Permeability; Desflurane; Drop

1998
Effect of isoflurane on epinephrine-induced arrhythmias in ischemic-reperfused dog hearts.
    Research communications in molecular pathology and pharmacology, 1998, Volume: 100, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Calcium Channel Blo

1998
Isoflurane administration before ischemia and during reperfusion attenuates ischemia/reperfusion-induced injury of isolated rabbit lungs.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Anesthetics, Inhalation; Animals; In Vitro Techniques; Isoflurane; Lung; Male; Pulmonary Circulation

1999
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion in the rat pup.
    Pediatric research, 1999, Volume: 46, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Isoflurane; Male; Nitric Oxide Synthase; Rat

1999
Isoflurane-sevoflurane adminstration before ischemia attenuates ischemia-reperfusion-induced injury in isolated rat lungs.
    Anesthesiology, 2000, Volume: 92, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Capillary Permeability; In Vitro Techniques; Isoflurane; L-Lactate

2000
Recovery from myocardial stunning is faster with desflurane compared with propofol in chronically instrumented dogs.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:6

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; Desflurane; Dogs; Female

2000