isoflurane has been researched along with Infarction, Middle Cerebral Artery in 44 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified." | 7.96 | TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020) |
| " This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury." | 7.88 | Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018) |
| " An indiscriminate use of isoflurane-based surgical anesthesia with or without nitrous oxide may act as an unconstrained, untraceable source of data variability, potentially causing false-positive or false-negative results." | 7.85 | Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats. ( Gaidhani, N; Schreihofer, D; Sun, F; Uteshev, VV, 2017) |
| " We compared microregional O2 balance in cerebral ischemia-reperfusion during pentobarbital and isoflurane anesthesia." | 7.81 | Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia. ( Barsoum, S; Chi, OZ; Liu, X; Rah, KH; Weiss, HR, 2015) |
| "Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N = 5) or isoflurane (N = 5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery (MCA)." | 7.80 | Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. ( Alarcon, W; Bezerra, FJ; Brown, M; Karki, K; Keenan, KA; Knight, RA; Nagaraja, TN, 2014) |
| "Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats." | 7.75 | Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. ( Li, L; Zuo, Z, 2009) |
| "The effect of isoflurane on neuronal apoptosis was investigated in rats subjected to focal cerebral ischemia." | 7.72 | Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Patel, PM; Spurlock, MP, 2004) |
| "To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia." | 7.72 | The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 5.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Ischaemic stroke is a severe disease worldwide." | 5.72 | Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022) |
| "Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was utilized to measure the infarct volume and brain edema and immunofluorescence staining was used to detect the MCAO-induced TLR4 expression and localization." | 5.42 | Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism. ( Chao, Y; Chen, L; Gao, C; Kuai, J; Lv, M; Ren, P; Sun, X; Wang, Q; Xiao, Z, 2015) |
| "Rats were prepared for temporary middle cerebral artery occlusion (MCAO)." | 5.34 | Isoflurane provides long-term protection against focal cerebral ischemia in the rat. ( Ishida, K; Pearlstein, RD; Sakai, H; Sheng, H; Warner, DS; Yates, RB, 2007) |
| " Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g)." | 5.17 | Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model. ( Bleilevens, C; Dang, J; Goetzenich, A; Hein, M; Kipp, M; Roehl, AB; Rossaint, R; Tolba, R; Zoremba, N, 2013) |
| "The mechanisms of brain protection during ischaemic reperfusion injury induced by isoflurane (ISO) post-conditioning are unclear." | 4.02 | Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway. ( Ge, M; Li, N; Li, Y; Qin, X; Wang, S; Xu, F; Yin, J; Zhai, J; Zhang, Q; Zhou, W, 2021) |
| "Isoflurane postconditioning alleviates cerebral ischemic-reperfusion injury (CIRI), but the underlying mechanism has not been fully clarified." | 3.96 | TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. ( Chen, L; Li, Y; Ma, K; Si, J; Wang, S; Yang, C; Yang, Y; Yin, J, 2020) |
| " This study aimed to investigate the relationship between AQP4, bone morphogenetic protein 4 (BMP4)/Smad1/5/8 signaling pathway and isoflurane post-conditiong, which has effects on brain edema in rats with cerebral ischemia/reperfusion (I/R) injury." | 3.88 | Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway. ( Dai, Z; Ge, M; Li, Y; Liu, X; Ma, K; Peng, L; Si, J; Wang, S; Xie, L; Yin, J; Yuan, M; Zhang, G, 2018) |
| " An indiscriminate use of isoflurane-based surgical anesthesia with or without nitrous oxide may act as an unconstrained, untraceable source of data variability, potentially causing false-positive or false-negative results." | 3.85 | Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats. ( Gaidhani, N; Schreihofer, D; Sun, F; Uteshev, VV, 2017) |
| " We compared microregional O2 balance in cerebral ischemia-reperfusion during pentobarbital and isoflurane anesthesia." | 3.81 | Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia. ( Barsoum, S; Chi, OZ; Liu, X; Rah, KH; Weiss, HR, 2015) |
| "Cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability by arterial spin labeling (ASL)- and dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI), respectively were repeatedly measured under either halothane (N = 5) or isoflurane (N = 5) anesthesia in a rat stroke model of embolic occlusion of middle cerebral artery (MCA)." | 3.80 | Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke. ( Alarcon, W; Bezerra, FJ; Brown, M; Karki, K; Keenan, KA; Knight, RA; Nagaraja, TN, 2014) |
| "Because the potential neuroprotective effect of isoflurane is controversial, we attempted to study whether isoflurane after treatment provides neuroprotection in a rat model of hyperglycemia-induced ischemic hemorrhagic transformation." | 3.77 | Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion. ( He, Z; Hu, Q; Ma, Q; Tang, J; Zhan, Y; Zhang, J; Zhou, C, 2011) |
| "Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats." | 3.75 | Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. ( Li, L; Zuo, Z, 2009) |
| "Using an IPC of 2 5-minute MCAO episodes, the reduction in infarct volume from the test MCAO was maximal with a 72-hour delay in striatum (70%) and cerebral cortex (64%) when halothane was used for surgical anesthesia." | 3.74 | Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse. ( Huang, J; Klaus, JA; Koehler, RC; Yang, ZJ; Zhang, J, 2008) |
| "The effect of isoflurane on neuronal apoptosis was investigated in rats subjected to focal cerebral ischemia." | 3.72 | Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. ( Cole, DJ; Drummond, JC; Kawaguchi, M; Kelly, PJ; Patel, PM; Spurlock, MP, 2004) |
| "To obtain more information on the cerebral ischemia and reperfusion injury under desflurane anesthesia, we compared the infarct volume and lactate dehydrogenase (LDH) activity in rats subjected to focal cerebral ischemia during different concentration of desflurane anesthesia." | 3.72 | The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury. ( Chih, CL; Huang, SS; Hung, WC; Lin, SM; Mok, MS; Tsai, SK, 2004) |
| "Isoflurane post-treatment may enhance autophagy by activating the AMPK/ULK1 signaling pathway and further inhibit the release of inflammatory factors from NLRP3 inflammasomes, thereby ameliorating neurological function and cognitive impairment and exerting a protective effect on the brain in CIRI rats." | 1.91 | Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats. ( Li, N; Li, Y; Ma, K; Qin, X; Wang, R; Wang, S; Yin, J; Zhai, J; Zhang, X, 2023) |
| "Ischaemic stroke is a severe disease worldwide." | 1.72 | Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice. ( Guo, WJ; Hong, P; Huang, XX; Li, FX; Lin, HB; Tang, ZY; Wang, JW; Xu, SY; Zhang, HF; Zhang, YJ, 2022) |
| "Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h." | 1.46 | Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia. ( Chen, KB; Lai, TW; Lee, YD; Liao, KH; Liu, YC; Pan, YL; Poon, KS; Wang, HL, 2017) |
| "Using a middle cerebral artery occlusion (MCAO) model, triphenyltetrazolium chloride staining was utilized to measure the infarct volume and brain edema and immunofluorescence staining was used to detect the MCAO-induced TLR4 expression and localization." | 1.42 | Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism. ( Chao, Y; Chen, L; Gao, C; Kuai, J; Lv, M; Ren, P; Sun, X; Wang, Q; Xiao, Z, 2015) |
| "Here, we showed that isoflurane reduced brain infarct volumes and improved neurological functions of wild-type mice after a 90-min MCAO." | 1.39 | Glutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice. ( Deng, J; Li, L; Zuo, Z, 2013) |
| "Mice then underwent 2 h of middle cerebral artery occlusion and were evaluated 22 h later for infarct volume." | 1.36 | Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice. ( Herson, PS; Hurn, PD; Libal, NL; Murphy, SJ; Palmateer, JM; Wang, L; Zhang, L; Zhu, W, 2010) |
| "Filamentous middle cerebral artery occlusion (fMCAO) is the most frequently used focal cerebral ischemia model in rodents." | 1.35 | Filamentous middle cerebral artery occlusion causes ischemic damage to the retina in mice. ( Guo, Q; Namura, S; Steele, EC, 2008) |
| "Isoflurane was applied after OGD." | 1.35 | Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. ( Jung, HH; Lee, JJ; Li, L; Zuo, Z, 2008) |
| "Rats were prepared for temporary middle cerebral artery occlusion (MCAO)." | 1.34 | Isoflurane provides long-term protection against focal cerebral ischemia in the rat. ( Ishida, K; Pearlstein, RD; Sakai, H; Sheng, H; Warner, DS; Yates, RB, 2007) |
| "The effects of middle cerebral artery occlusion (MCAO) on neuronal and astrocytic intermediary metabolism were studied in rats 30, 60, 120, and 240 minutes after MCAO using in vivo injection of [1-13C]glucose and [1,2- 13C]acetate combined with ex vivo 13C magnetic resonance spectroscopy and high-performance liquid chromatography analysis of the ischemic core (lateral caudoputamen and lower parietal cortex) and penumbra (upper frontoparietal cortex)." | 1.31 | Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival. ( Håberg, A; Haraldseth, O; Qu, H; Saether, O; Sonnewald, U; Unsgård, G, 2001) |
| "The animals were subjected to permanent middle cerebral artery occlusion (MCAO) at 0, 12, 24, or 48 hours after AP." | 1.31 | Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. ( Dirnagl, U; Fütterer, C; Isaev, NK; Kapinya, KJ; Löwl, D; Maurer, M; Waschke, KF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (34.09) | 29.6817 |
| 2010's | 21 (47.73) | 24.3611 |
| 2020's | 8 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, YJ | 1 |
| Guo, WJ | 1 |
| Tang, ZY | 1 |
| Lin, HB | 1 |
| Hong, P | 1 |
| Wang, JW | 1 |
| Huang, XX | 1 |
| Li, FX | 1 |
| Xu, SY | 1 |
| Zhang, HF | 1 |
| Mousavi, SM | 1 |
| Karimi-Haghighi, S | 1 |
| Chavoshinezhad, S | 1 |
| Pandamooz, S | 1 |
| Belém-Filho, IJA | 1 |
| Keshavarz, S | 2 |
| Bayat, M | 1 |
| Hooshmandi, E | 1 |
| Rahimi Jaberi, A | 1 |
| Salehi, MS | 1 |
| Borhani-Haghighi, A | 1 |
| Gu, C | 3 |
| Liu, J | 4 |
| Li, Y | 8 |
| Zhang, Q | 4 |
| Lin, C | 3 |
| Huang, J | 4 |
| Duan, W | 3 |
| Deng, Y | 3 |
| Ahmed, W | 3 |
| Li, R | 3 |
| Long, J | 3 |
| Khan, AA | 3 |
| Chen, L | 5 |
| Nemati, M | 1 |
| Saied Salehi, M | 1 |
| Naseh, M | 1 |
| Zhai, J | 2 |
| Li, N | 2 |
| Zhang, X | 1 |
| Ma, K | 3 |
| Wang, R | 1 |
| Qin, X | 2 |
| Yin, J | 7 |
| Wang, S | 6 |
| Lee, SH | 1 |
| Lee, JJ | 2 |
| Kim, GH | 1 |
| Kim, JA | 1 |
| Cho, HS | 1 |
| Peng, L | 3 |
| Ge, M | 3 |
| Han, Z | 1 |
| Wang, Y | 1 |
| Zhang, M | 1 |
| Xie, L | 2 |
| Chen, G | 1 |
| Kamat, PK | 1 |
| Ahmad, AS | 1 |
| Doré, S | 1 |
| Yang, Y | 1 |
| Si, J | 2 |
| Yang, C | 1 |
| Xu, F | 1 |
| Zhou, W | 1 |
| Gaidhani, N | 1 |
| Sun, F | 1 |
| Schreihofer, D | 1 |
| Uteshev, VV | 1 |
| Cai, M | 2 |
| Yang, Q | 1 |
| Li, G | 1 |
| Sun, S | 2 |
| Chen, Y | 1 |
| Tian, L | 1 |
| Dong, H | 2 |
| Yuan, M | 1 |
| Dai, Z | 1 |
| Liu, X | 2 |
| Zhang, G | 1 |
| Zhao, G | 1 |
| Yang, L | 1 |
| Xiong, L | 1 |
| Lay, CC | 1 |
| Jacobs, N | 1 |
| Hancock, AM | 1 |
| Zhou, Y | 1 |
| Frostig, RD | 1 |
| Li, L | 4 |
| Deng, J | 1 |
| Zuo, Z | 5 |
| Takagaki, M | 1 |
| Feuerstein, D | 1 |
| Kumagai, T | 1 |
| Gramer, M | 1 |
| Yoshimine, T | 1 |
| Graf, R | 1 |
| Bezerra, FJ | 1 |
| Brown, M | 1 |
| Alarcon, W | 1 |
| Karki, K | 1 |
| Knight, RA | 1 |
| Keenan, KA | 1 |
| Nagaraja, TN | 1 |
| Li, H | 1 |
| Feng, C | 1 |
| Taheri, S | 1 |
| Shunmugavel, A | 1 |
| Clark, D | 1 |
| Shi, H | 1 |
| Xiao, Z | 1 |
| Ren, P | 1 |
| Chao, Y | 1 |
| Wang, Q | 1 |
| Kuai, J | 1 |
| Lv, M | 1 |
| Gao, C | 1 |
| Sun, X | 1 |
| Chi, OZ | 1 |
| Barsoum, S | 1 |
| Rah, KH | 1 |
| Weiss, HR | 1 |
| Zhang, H | 1 |
| Xiong, X | 1 |
| Gu, L | 1 |
| Li, F | 1 |
| Wan, Y | 1 |
| Xu, S | 1 |
| Kudo, K | 1 |
| Zhao, L | 1 |
| Nowak, TS | 1 |
| Liu, YC | 1 |
| Lee, YD | 1 |
| Wang, HL | 1 |
| Liao, KH | 1 |
| Chen, KB | 1 |
| Poon, KS | 1 |
| Pan, YL | 1 |
| Lai, TW | 1 |
| Zhao, H | 1 |
| Mayhan, WG | 1 |
| Sun, H | 1 |
| Zhu, W | 1 |
| Wang, L | 2 |
| Zhang, L | 1 |
| Palmateer, JM | 1 |
| Libal, NL | 1 |
| Hurn, PD | 2 |
| Herson, PS | 1 |
| Murphy, SJ | 2 |
| Hu, Q | 1 |
| Ma, Q | 1 |
| Zhan, Y | 1 |
| He, Z | 1 |
| Tang, J | 1 |
| Zhou, C | 1 |
| Zhang, J | 2 |
| Bedirli, N | 1 |
| Bagriacik, EU | 1 |
| Emmez, H | 1 |
| Yilmaz, G | 1 |
| Unal, Y | 1 |
| Ozkose, Z | 1 |
| Bleilevens, C | 1 |
| Roehl, AB | 1 |
| Goetzenich, A | 1 |
| Zoremba, N | 1 |
| Kipp, M | 1 |
| Dang, J | 1 |
| Tolba, R | 1 |
| Rossaint, R | 1 |
| Hein, M | 1 |
| Kawaguchi, M | 1 |
| Drummond, JC | 2 |
| Cole, DJ | 2 |
| Kelly, PJ | 1 |
| Spurlock, MP | 1 |
| Patel, PM | 2 |
| Tsai, SK | 1 |
| Lin, SM | 1 |
| Hung, WC | 1 |
| Mok, MS | 1 |
| Chih, CL | 1 |
| Huang, SS | 1 |
| Inoue, S | 1 |
| Davis, DP | 1 |
| Theodorsson, A | 1 |
| Holm, L | 1 |
| Theodorsson, E | 1 |
| Sakai, H | 1 |
| Sheng, H | 1 |
| Yates, RB | 1 |
| Ishida, K | 1 |
| Pearlstein, RD | 1 |
| Warner, DS | 1 |
| Kitano, H | 1 |
| Young, JM | 1 |
| Cheng, J | 1 |
| Luckl, J | 1 |
| Keating, J | 1 |
| Greenberg, JH | 1 |
| Yang, ZJ | 1 |
| Klaus, JA | 1 |
| Koehler, RC | 1 |
| Steele, EC | 1 |
| Guo, Q | 1 |
| Namura, S | 1 |
| Jung, HH | 1 |
| Håberg, A | 1 |
| Qu, H | 1 |
| Saether, O | 1 |
| Unsgård, G | 1 |
| Haraldseth, O | 1 |
| Sonnewald, U | 1 |
| Kapinya, KJ | 1 |
| Löwl, D | 1 |
| Fütterer, C | 1 |
| Maurer, M | 1 |
| Waschke, KF | 1 |
| Isaev, NK | 1 |
| Dirnagl, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for isoflurane and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Effect of anesthesia and cerebral blood flow on neuronal injury in a rat middle cerebral artery occlusion (MCAO) model.
Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Brain Edema; Brain Injuries; Cerebral Infarction; | 2013 |
43 other studies available for isoflurane and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice.
Topics: Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Humans; Infarction, Middle Cerebral Artery | 2022 |
The impacts of anesthetic regimens on the middle cerebral artery occlusion outcomes in male rats.
Topics: Anesthetics; Animals; Humans; Infarction, Middle Cerebral Artery; Isoflurane; Ketamine; Male; Rats; | 2022 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model.
Topics: Anesthesia; Animals; Disease Models, Animal; Infarction, Middle Cerebral Artery; Isoflurane; Ketamin | 2023 |
The impact of anesthetic drugs on hemodynamic parameters and neurological outcomes following temporal middle cerebral artery occlusion in rats.
Topics: Anesthetics; Animals; Brain Ischemia; Chloral Hydrate; Halothane; Hemodynamics; Infarction, Middle C | 2023 |
Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Brain Ischem | 2023 |
Role of reactive oxygen species at reperfusion stage in isoflurane preconditioning-induced neuroprotection.
Topics: Anesthetics, Inhalation; Animals; Cell Survival; Infarction, Middle Cerebral Artery; Isoflurane; Mal | 2019 |
TGF-β2/Smad3 Signaling Pathway Activation Through Enhancing VEGF and CD34 Ameliorates Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats.
Topics: Animals; Antigens, CD34; Apoptosis; Cerebral Cortex; Hippocampus; Infarction, Middle Cerebral Artery | 2019 |
Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke.
Topics: Analgesics; Anesthetics; Animals; Brain Infarction; Brain Ischemia; Extremities; Halothane; Infarcti | 2020 |
TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C.
Topics: Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Isoflurane; Male; MEF2 Transcription Fa | 2020 |
Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Cell Movement; Cell Proliferation; Gene | 2021 |
Duration of isoflurane-based surgical anesthesia determines severity of brain injury and neurological deficits after a transient focal ischemia in young adult rats.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Brain; Disease Models, Animal; Infarction, Middle Cere | 2017 |
Activation of cannabinoid receptor 1 is involved in protection against mitochondrial dysfunction and cerebral ischaemic tolerance induced by isoflurane preconditioning.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebra | 2017 |
Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling pathway.
Topics: Animals; Aquaporin 4; Bone Morphogenetic Protein 4; Brain Ischemia; Down-Regulation; Gene Expression | 2018 |
TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat.
Topics: Acute Disease; Animals; Brain Ischemia; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; | 2019 |
Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia.
Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Disease Models, Animal; Infarction, Middle Cerebr | 2013 |
Glutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice.
Topics: Animals; Brain Infarction; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; | 2013 |
Isoflurane suppresses cortical spreading depolarizations compared to propofol--implications for sedation of neurocritical care patients.
Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Disease Models, Animal; Dose-Re | 2014 |
Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebrovascular Circulation; | 2014 |
Inhibition of brain ischemia-caused notch activation in microglia may contribute to isoflurane postconditioning-induced neuroprotection in male rats.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; CD11b Antigen; Cell Hypoxia; Cell Line; Cytokines; Diseas | 2014 |
Isoflurane reduces the ischemia reperfusion injury surge: a longitudinal study with MRI.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Diffusion Magnetic Resonance Imaging; Diseas | 2014 |
Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism.
Topics: Animals; Astrocytes; Brain Injuries; Brain Ischemia; Disease Models, Animal; Humans; Infarction, Mid | 2015 |
Local O2 Balance in Cerebral Ischemia-Reperfusion Improved during Pentobarbital Compared with Isoflurane Anesthesia.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Infarction, Mi | 2015 |
Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents; Brain; Chemistry, Pharmaceutical; Cy | 2016 |
Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke.
Topics: Anesthetics, Inhalation; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Infarctio | 2016 |
Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Arterial Occlusive Diseases; Blood-Brain B | 2017 |
A modified suture technique produces consistent cerebral infarction in rats.
Topics: Analysis of Variance; Anesthetics; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Mod | 2008 |
Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Desflurane; Infarction, Middle Cerebral Art | 2009 |
Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice.
Topics: Androgens; Anesthetics, Inhalation; Animals; Aromatase; Aromatase Inhibitors; Brain; Dihydrotestoste | 2010 |
Isoflurane enhanced hemorrhagic transformation by impairing antioxidant enzymes in hyperglycemic rats with middle cerebral artery occlusion.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Brain Ischemia; Catalase; Cerebral Hemorrhage; Hyper | 2011 |
Sevoflurane and isoflurane preconditioning provides neuroprotection by inhibition of apoptosis-related mRNA expression in a rat model of focal cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Edem | 2012 |
Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain Ischemia; Caspase 3; Caspase 9; Caspases; DNA Fra | 2004 |
The effect of desflurane on ameliorating cerebral infarction in rats subjected to focal cerebral ischemia-reperfusion injury.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Desflurane; Hemodynamics; Humans; Infarct | 2004 |
Combination of isoflurane and caspase inhibition reduces cerebral injury in rats subjected to focal cerebral ischemia.
Topics: Amino Acid Chloromethyl Ketones; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Brain; Brain | 2004 |
Modern anesthesia and peroperative monitoring methods reduce per- and postoperative mortality during transient occlusion of the middle cerebral artery in rats.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Disease Models, Animal; Female; Infarction | 2005 |
Isoflurane provides long-term protection against focal cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Brain Ischemia; Infarction, Middle Cerebral Artery | 2007 |
Gender-specific response to isoflurane preconditioning in focal cerebral ischemia.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Blotting, Western; Brain; Female; Infarction, Middle | 2007 |
Alpha-chloralose is a suitable anesthetic for chronic focal cerebral ischemia studies in the rat: a comparative study.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Brain; Brain Injuries; Brain Ischemia; Cerebrovascula | 2008 |
Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Brain; Cell Survival; Cerebral Cortex; Corpus Striatum | 2008 |
Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain.
Topics: Anesthetics, Inhalation; Animals; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist P | 2008 |
Filamentous middle cerebral artery occlusion causes ischemic damage to the retina in mice.
Topics: Amaurosis Fugax; Animals; Apoptosis; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; | 2008 |
Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.
Topics: Anesthetics, Inhalation; Animals; Brain; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide | 2008 |
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
Topics: Acetate-CoA Ligase; Alanine; Anesthetics, Inhalation; Animals; Aspartic Acid; Astrocytes; Blood Gluc | 2001 |
Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent.
Topics: Anesthetics, Inhalation; Animals; Body Temperature; Brain; Brain Infarction; Brain Ischemia; Cells, | 2002 |