Page last updated: 2024-10-29

isoflurane and Hyperventilation

isoflurane has been researched along with Hyperventilation in 24 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.

Research Excerpts

ExcerptRelevanceReference
"The mean value of the jugular bulb oxygen saturation (SjO 2 ) significantly decreased, and the oxygen extraction ratio (O 2 ER) significantly increased under isoflurane or propofol anesthesia during hyperventilation compared with those during normoventilation (SjO 2 : t = -2."9.20Effects of Moderate Hyperventilation on Jugular Bulb Gases under Propofol or Isoflurane Anesthesia during Supratentorial Craniotomy. ( Ji, N; Li, SQ; Luo, F; Meng, L, 2015)
"During the first 10 minutes after the administration of desflurane, the Ades was highest in the hyperventilation group, and this value was significantly different from those obtained for the normal and hypoventilation groups."9.16Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2012)
"The purpose of this study was to compare the degree of increase in middle cerebral artery (MCA) blood flow velocity after tourniquet deflation when modulating hyperventilation during orthopedic surgery under sevoflurane, isoflurane, or propofol anesthesia."9.14Differential effects of hyperventilation on cerebral blood flow velocity after tourniquet deflation during sevoflurane, isoflurane, or propofol anesthesia. ( Hinohara, H; Ide, M; Kadoi, Y; Kuroda, M; Mizutani, A; Saito, S, 2010)
" During isoflurane anesthesia, we investigated the effects of hypocapnia and the effects of a phenylephrine infusion, on aZFP and RAP."7.75The effects of hypocapnia and the cerebral autoregulatory response on cerebrovascular resistance and apparent zero flow pressure during isoflurane anesthesia. ( McCulloch, TJ; Turner, MJ, 2009)
"We evaluated the differences in emergence time in 20 surgical patients undergoing 1 MAC of isoflurane under mild hypocapnia (ETco2 approximately 28 mmHg) and mild hypercapnia (ETco2 approximately 55 mmHg)."7.74Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."7.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Using computerized tomography, we measured absolute cerebral blood flow (CBF) and cerebral blood volume (CBV) in tumor, peri-tumor, and contralateral normal regions, at normocapnia and hypocapnia, in 16 rabbits with brain tumors (VX2 carcinoma), under isoflurane or propofol anesthesia."7.71Cerebral blood volume and blood flow responses to hyperventilation in brain tumors during isoflurane or propofol anesthesia. ( Cenic, A; Craen, RA; Gelb, AW; Lee, TY, 2002)
"During the first 10 minutes after the administration of desflurane, the Ades was highest in the hyperventilation group, and this value was significantly different from those obtained for the normal and hypoventilation groups."5.16Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2012)
" Twenty-nine patients undergoing craniotomy for frontotemporal gliomas were randomized to receive intravenous anesthesia with propofol or inhalational anesthesia with isoflurane."5.12Cerebrovascular reactivity to carbon dioxide in the normal and abnormal cerebral hemispheres under anesthesia in patients with frontotemporal gliomas. ( Pillai, SV; Rao, GS, 2006)
"The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane."5.10Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003)
" During isoflurane anesthesia, we investigated the effects of hypocapnia and the effects of a phenylephrine infusion, on aZFP and RAP."3.75The effects of hypocapnia and the cerebral autoregulatory response on cerebrovascular resistance and apparent zero flow pressure during isoflurane anesthesia. ( McCulloch, TJ; Turner, MJ, 2009)
"We evaluated the differences in emergence time in 20 surgical patients undergoing 1 MAC of isoflurane under mild hypocapnia (ETco2 approximately 28 mmHg) and mild hypercapnia (ETco2 approximately 55 mmHg)."3.74Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."3.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Using computerized tomography, we measured absolute cerebral blood flow (CBF) and cerebral blood volume (CBV) in tumor, peri-tumor, and contralateral normal regions, at normocapnia and hypocapnia, in 16 rabbits with brain tumors (VX2 carcinoma), under isoflurane or propofol anesthesia."3.71Cerebral blood volume and blood flow responses to hyperventilation in brain tumors during isoflurane or propofol anesthesia. ( Cenic, A; Craen, RA; Gelb, AW; Lee, TY, 2002)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's6 (25.00)18.2507
2000's11 (45.83)29.6817
2010's5 (20.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
In, J1
Meng, L1
Li, SQ1
Ji, N1
Luo, F1
Lu, CC2
Lin, TC2
Yu, MH2
Chen, TL2
Lin, CY1
Chiang, JS1
Ho, ST2
McCulloch, TJ1
Turner, MJ1
Katznelson, R1
Van Rensburg, A1
Friedman, Z1
Wasowicz, M1
Djaiani, GN1
Fedorko, L1
Minkovich, L1
Fisher, JA2
Hinohara, H1
Kadoi, Y1
Ide, M1
Kuroda, M1
Saito, S1
Mizutani, A1
Hsu, CH1
Chen, RM1
Ku, CH1
Petersen, KD1
Landsfeldt, U1
Cold, GE1
Petersen, CB1
Mau, S1
Hauerberg, J1
Holst, P1
Olsen, KS1
Oshima, T1
Dohi, S1
Rao, GS1
Pillai, SV1
Sakata, DJ3
Gopalakrishnan, NA3
Orr, JA3
White, JL2
Westenskow, DR3
McJames, S1
Sjögren, D1
Sollevi, A1
Ebberyd, A1
Lindahl, SG1
Dahan, A1
van Kleef, J1
van den Elsen, M1
Valk, R1
Berkenbosch, A1
Zhou, HH1
Turndorf, H1
Brenet, O1
Granry, JC1
Poirier, N1
Le Gall, R1
Chong, KY1
Craen, RA2
Murkin, JM1
Lee, D1
Eliasziw, M1
Gelb, AW2
Sasano, H1
Vesely, AE1
Iscoe, S1
Tesler, JC1
Cenic, A1
Lee, TY1
Algotsson, L1
Messeter, K1
Rosén, I1
Holmin, T1
Lutz, LJ1
Milde, JH1
Milde, LN1
Frei, FJ1
Thomson, DA1
Zbinden, AM1
Benthuysen, JL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087]Phase 448 participants (Actual)Interventional2015-09-30Completed
Effect of Fresh Gas Flow on Emergence Time in the Patients Undergoing Transurethral Resection of Bladder Tumor: A Randomized Controlled Clinical Trial[NCT05376631]54 participants (Actual)Interventional2022-05-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for isoflurane and Hyperventilation

ArticleYear
Effects of Moderate Hyperventilation on Jugular Bulb Gases under Propofol or Isoflurane Anesthesia during Supratentorial Craniotomy.
    Chinese medical journal, 2015, May-20, Volume: 128, Issue:10

    Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Arterial Pressure; Blood

2015
Effects of changes in alveolar ventilation on isoflurane arterial blood concentration and its uptake into the human body.
    Pharmacology, 2009, Volume: 83, Issue:3

    Topics: Adult; Anesthetics, Inhalation; Cardiac Output; Female; Humans; Hyperventilation; Hypoventilation; I

2009
Isocapnic hyperpnoea shortens postanesthetic care unit stay after isoflurane anesthesia.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:2

    Topics: Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Elective Surgical Procedures; Female; Gy

2010
Differential effects of hyperventilation on cerebral blood flow velocity after tourniquet deflation during sevoflurane, isoflurane, or propofol anesthesia.
    Journal of anesthesia, 2010, Volume: 24, Issue:4

    Topics: Adult; Aged; Anesthesia; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulation; Humans; H

2010
Hyperventilation accelerates the rise of arterial blood concentrations of desflurane in gynecologic patients.
    Clinics (Sao Paulo, Brazil), 2012, Volume: 67, Issue:9

    Topics: Adult; Anesthetics, Inhalation; Chromatography, Gas; Desflurane; Female; Genital Diseases, Female; H

2012
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest

2003
Cerebrovascular reactivity to carbon dioxide in the normal and abnormal cerebral hemispheres under anesthesia in patients with frontotemporal gliomas.
    Journal of neurosurgical anesthesiology, 2006, Volume: 18, Issue:3

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Brain Neoplasms; Carbon Dioxid

2006
Slow ventilatory dynamics after isocapnic hypoxia and voluntary hyperventilation in humans: effects of isoflurane.
    British journal of anaesthesia, 1996, Volume: 76, Issue:3

    Topics: Adult; Anesthetics, Inhalation; Carbon Dioxide; Female; Humans; Hyperventilation; Hypoxia; Isofluran

1996
Hyper- and hypoventilation affects spinal motor neuron excitability during isoflurane anesthesia.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:2

    Topics: Action Potentials; Adult; Anesthesia, General; Anesthetics, Inhalation; Female; H-Reflex; Humans; Hy

1998
Naloxone therapy in spinal trauma: anesthetic effects.
    Anesthesiology, 1987, Volume: 66, Issue:2

    Topics: Adult; Anesthesia, General; Clinical Trials as Topic; Drug Evaluation; Humans; Hyperventilation; Int

1987

Other Studies

14 other studies available for isoflurane and Hyperventilation

ArticleYear
Hyperventilation increases the rate of the rise in arterial blood desflurane concentration during induction - a Gas Man® simulation.
    Clinics (Sao Paulo, Brazil), 2013, Volume: 68, Issue:3

    Topics: Anesthetics, Inhalation; Female; Genital Diseases, Female; Humans; Hyperventilation; Isoflurane

2013
The effects of hypocapnia and the cerebral autoregulatory response on cerebrovascular resistance and apparent zero flow pressure during isoflurane anesthesia.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Anesthetics, Inhalation; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Fourier A

2009
Isoflurane facilitates hiccup-like reflex through gamma aminobutyric acid (GABA)A- and suppresses through GABAB-receptors in pentobarbital-anesthetized cats.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Bicuculline; Blood Pressure; Cats; Cisterna Magna; Ele

2004
Hypercapnic hyperventilation shortens emergence time from isoflurane anesthesia.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:3

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesiology; Carbon Dioxide; Female; H

2007
Hypercapnia shortens emergence time from inhaled anesthesia in pigs.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbon Dioxide

2007
Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Desflurane; Female; Humans; Hypercapnia; Hyperventilation; Isoflu

2007
Poikilocapnic hypoxic ventilatory response in humans during 0.85 MAC isoflurane anesthesia.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:2

    Topics: Adult; Anesthesia, Inhalation; Carbon Dioxide; Female; Humans; Hyperventilation; Hypoxia; Isoflurane

1994
-The effect of desflurane on cerebral blood flow velocity and cerebrovascular reactivity to CO2 in children-.
    Annales francaises d'anesthesie et de reanimation, 1998, Volume: 17, Issue:3

    Topics: Adult; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Flow Velocity;

1998
Rate of change of cerebral blood flow velocity with hyperventilation during anesthesia in humans.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:2

    Topics: Adult; Anesthesia, Inhalation; Blood Flow Velocity; Cerebrovascular Circulation; Female; Halothane;

2000
A simple apparatus for accelerating recovery from inhaled volatile anesthetics.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Apnea; Carbon

2001
Cerebral blood volume and blood flow responses to hyperventilation in brain tumors during isoflurane or propofol anesthesia.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:3

    Topics: Anesthesia; Animals; Blood Volume; Brain Neoplasms; Cerebrovascular Circulation; Hyperventilation; I

2002
Effects of nitrous oxide on cerebral haemodynamics and metabolism during isoflurane anaesthesia in man.
    Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:1

    Topics: Adult; Anesthesia, Inhalation; Brain; Carbon Dioxide; Cerebrovascular Circulation; Electroencephalog

1992
The response of the canine cerebral circulation to hyperventilation during anesthesia with desflurane.
    Anesthesiology, 1991, Volume: 74, Issue:3

    Topics: Anesthesia, Inhalation; Animals; Carbon Dioxide; Cerebrovascular Circulation; Desflurane; Dogs; Hemo

1991
Influence of ventilatory and circulatory changes on the pharmacokinetics of halothane and isoflurane.
    Experientia, 1988, Feb-15, Volume: 44, Issue:2

    Topics: Animals; Blood Circulation; Dogs; Halothane; Hemodynamics; Hyperventilation; Hypotension; Isoflurane

1988