isoflurane has been researched along with Huntington Disease in 2 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isoflurane is known to increase β-amyloid aggregation and neuronal damage." | 1.37 | The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease. ( Eckenhoff, MF; Liang, G; Wang, Q; Wang, S; Wei, H; Yang, H, 2011) |
| " The injection coordinates and the dosage of quinolinic acid were identical." | 1.35 | Ketamine anaesthesia interferes with the quinolinic acid-induced lesion in a rat model of Huntington's disease. ( Büchele, F; Döbrössy, M; Jiang, W; Nikkhah, G; Papazoglou, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, W | 1 |
| Büchele, F | 1 |
| Papazoglou, A | 1 |
| Döbrössy, M | 1 |
| Nikkhah, G | 1 |
| Wang, Q | 1 |
| Liang, G | 1 |
| Yang, H | 1 |
| Wang, S | 1 |
| Eckenhoff, MF | 1 |
| Wei, H | 1 |
2 other studies available for isoflurane and Huntington Disease
| Article | Year |
|---|---|
Ketamine anaesthesia interferes with the quinolinic acid-induced lesion in a rat model of Huntington's disease.
Topics: Anesthetics, Inhalation; Animals; Antiparkinson Agents; Apomorphine; Brain; Disease Models, Animal; | 2009 |
The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cell Survival; Cells, Cultured; Corpus Striatum; Desflura | 2011 |