Page last updated: 2024-10-29

isoflurane and Hemorrhage

isoflurane has been researched along with Hemorrhage in 34 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Hemorrhage: Bleeding or escape of blood from a vessel.

Research Excerpts

ExcerptRelevanceReference
"Dogs were randomly assigned to determine the MAC of isoflurane in a normovolemic or hypovolemic state with a minimum of 18 days between trials."9.12The effect of hypovolemia due to hemorrhage on the minimum alveolar concentration of isoflurane in the dog. ( Dyson, DH; Kerr, CL; Mattson, SF; Mirakhur, KK, 2006)
"To compare the cardiorespiratory changes induced by equipotent concentrations of halothane (HAL), isoflurane (ISO) and sevoflurane (SEVO) before and after hemorrhage."9.12A study of the effect of hemorrhage on the cardiorespiratory actions of halothane, isoflurane and sevoflurane in the dog. ( Braz, JR; Cruz, ML; Luna, SP; Massone, F; Nogueira, CS; Teixeira Neto, FJ, 2007)
" The aim of this study was to compare the effects of isoflurane, sevoflurane and desflurane on pulse pressure variation and stroke volume variation in pigs undergoing hemorrhage."7.81Pulse pressure variation and stroke volume variation under different inhaled concentrations of isoflurane, sevoflurane and desflurane in pigs undergoing hemorrhage. ( Auler, JO; Fantoni, DT; Hamaji, MW; Ida, KK; Oshiro, AH; Otsuki, DA; Rosa, KT, 2015)
"Acute pulmonary hemorrhage developed during isoflurane anesthesia in 2 Himalayan cats undergoing routine dental cleaning and prophylaxis."7.74Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( Dearborn, DG; Distler, AM; Mader, DR; Yike, I, 2007)
" The authors investigated the influence of hypovolemia on the effect of an inhalation anesthetic, isoflurane, in a swine hemorrhage model."7.73Influence of hypovolemia on the electroencephalographic effect of isoflurane in a swine model. ( Fukuda, K; Kurita, T; Morita, K; Sanjo, Y; Sato, S; Takata, K; Uraoka, M, 2005)
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."7.72Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
"We assessed the changes in heart rate variability (HRV) and blood pressure variability (BPV) as indices of autonomic nervous system and volume status during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs."7.71Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs. ( Kawase, M; Kimura, T; Kobayashi, M; Komatsu, T; Nishiwaki, K; Shimada, Y, 2002)
"The hemodynamic and acid-base responses to graded hemorrhage were determined in awake and anesthetized sheep at baseline and after 15 and 18 days of chronic cocaine exposure."7.69Effect of chronic cocaine administration on the hemodynamic response to acute hemorrhage in awake and anesthetized sheep. ( Bernards, CM; Cullen, BF; Kern, C; Powers, KM, 1997)
"Effects of a nitric oxide (NO) synthase inhibitor on regional cerebral vascular resistance (rCVR) and regional cerebral blood flow (rCBF) were studied during a severe hemorrhage in conscious and in isoflurane anesthetized groups of rats."7.68Diminished effect of inhibition of nitric oxide synthase on regional cerebral vascular resistance in conscious and in isoflurane anesthetized rats during hemorrhage. ( Chi, OZ; Sinha, AK; Wei, HM; Weiss, HR, 1993)
"Exogenously administered vasopressors (sympathomimetics) were evaluated in isoflurane-anesthetized dogs to determine the effects of these drugs on cardiovascular function before and after hemorrhage."7.67Cardiovascular effects of vasopressors in isoflurane-anesthetized dogs before and after hemorrhage. ( Bednarski, RM; Curtis, MB; Majors, L, 1989)
"The influence of isoflurane on intestinal reflex vasoconstriction during hemorrhage was investigated in cats (n = 10) during basal chloralose-nitrous oxide anesthesia."7.67Effects of isoflurane on feline intestinal blood flow during hemorrhage-induced hypovolemia. ( Biber, B; Henriksson, BA; Martner, J; Raner, C; Winsö, O, 1989)
"5 MAC inspired isoflurane anesthesia combined with hypotension induced by hemorrhage and CBF3; during isoflurane and hemorrhage plus phenylephrine infused to restore mean arterial pressure (MAP) to baseline."7.67Phenylephrine increases regional cerebral blood flow following hemorrhage during isoflurane-oxygen anesthesia. ( Malo, LA; Mutch, WA; Ringaert, KR, 1989)
"Dogs were randomly assigned to determine the MAC of isoflurane in a normovolemic or hypovolemic state with a minimum of 18 days between trials."5.12The effect of hypovolemia due to hemorrhage on the minimum alveolar concentration of isoflurane in the dog. ( Dyson, DH; Kerr, CL; Mattson, SF; Mirakhur, KK, 2006)
"To compare the cardiorespiratory changes induced by equipotent concentrations of halothane (HAL), isoflurane (ISO) and sevoflurane (SEVO) before and after hemorrhage."5.12A study of the effect of hemorrhage on the cardiorespiratory actions of halothane, isoflurane and sevoflurane in the dog. ( Braz, JR; Cruz, ML; Luna, SP; Massone, F; Nogueira, CS; Teixeira Neto, FJ, 2007)
" Desflurane, with the characteristics of rapid onset and minimal metabolism, may provide better analgesia and safety for labour pain control."5.08Desflurane analgesia for vaginal delivery. ( Abboud, TK; Donovan, MM; Peres Da Silva, E; Swart, F; Yakal, K; Zhu, J, 1995)
" The aim of this study was to compare the effects of isoflurane, sevoflurane and desflurane on pulse pressure variation and stroke volume variation in pigs undergoing hemorrhage."3.81Pulse pressure variation and stroke volume variation under different inhaled concentrations of isoflurane, sevoflurane and desflurane in pigs undergoing hemorrhage. ( Auler, JO; Fantoni, DT; Hamaji, MW; Ida, KK; Oshiro, AH; Otsuki, DA; Rosa, KT, 2015)
"Acute pulmonary hemorrhage developed during isoflurane anesthesia in 2 Himalayan cats undergoing routine dental cleaning and prophylaxis."3.74Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( Dearborn, DG; Distler, AM; Mader, DR; Yike, I, 2007)
" The authors investigated the influence of hypovolemia on the effect of an inhalation anesthetic, isoflurane, in a swine hemorrhage model."3.73Influence of hypovolemia on the electroencephalographic effect of isoflurane in a swine model. ( Fukuda, K; Kurita, T; Morita, K; Sanjo, Y; Sato, S; Takata, K; Uraoka, M, 2005)
"The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia."3.72Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both. ( Boemke, W; Francis, RC; Frerking, I; Höhne, C; Kaczmarczyk, G; Swenson, ER; Vogler, P, 2004)
"We assessed the changes in heart rate variability (HRV) and blood pressure variability (BPV) as indices of autonomic nervous system and volume status during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs."3.71Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs. ( Kawase, M; Kimura, T; Kobayashi, M; Komatsu, T; Nishiwaki, K; Shimada, Y, 2002)
"The hemodynamic and acid-base responses to graded hemorrhage were determined in awake and anesthetized sheep at baseline and after 15 and 18 days of chronic cocaine exposure."3.69Effect of chronic cocaine administration on the hemodynamic response to acute hemorrhage in awake and anesthetized sheep. ( Bernards, CM; Cullen, BF; Kern, C; Powers, KM, 1997)
"Effects of a nitric oxide (NO) synthase inhibitor on regional cerebral vascular resistance (rCVR) and regional cerebral blood flow (rCBF) were studied during a severe hemorrhage in conscious and in isoflurane anesthetized groups of rats."3.68Diminished effect of inhibition of nitric oxide synthase on regional cerebral vascular resistance in conscious and in isoflurane anesthetized rats during hemorrhage. ( Chi, OZ; Sinha, AK; Wei, HM; Weiss, HR, 1993)
"4% isoflurane baseline anesthetic and were then rendered hypotensive by either increasing the isoflurane concentration (dISO), or by adding sodium nitroprusside (SNP), or 2-chloroadenosine (2AD) to the baseline anesthetic, decreasing the MAP to 51 mmHg; hemorrhaged animals had hypotension produced in the same manner as for the hypotensive animals, but additionally were bled 20% of estimated blood volume during deliberate hypotension produced with either deep isoflurane (dISOH), sodium nitroprusside (SNPH), or 2-chloroadenosine (2ADH)."3.68The influence of hemorrhage on organ perfusion during deliberate hypotension in rats. ( Durieux, ME; Longnecker, DE; Monk, CR; Sperry, RJ, 1992)
"Exogenously administered vasopressors (sympathomimetics) were evaluated in isoflurane-anesthetized dogs to determine the effects of these drugs on cardiovascular function before and after hemorrhage."3.67Cardiovascular effects of vasopressors in isoflurane-anesthetized dogs before and after hemorrhage. ( Bednarski, RM; Curtis, MB; Majors, L, 1989)
"The influence of isoflurane on intestinal reflex vasoconstriction during hemorrhage was investigated in cats (n = 10) during basal chloralose-nitrous oxide anesthesia."3.67Effects of isoflurane on feline intestinal blood flow during hemorrhage-induced hypovolemia. ( Biber, B; Henriksson, BA; Martner, J; Raner, C; Winsö, O, 1989)
"5 MAC inspired isoflurane anesthesia combined with hypotension induced by hemorrhage and CBF3; during isoflurane and hemorrhage plus phenylephrine infused to restore mean arterial pressure (MAP) to baseline."3.67Phenylephrine increases regional cerebral blood flow following hemorrhage during isoflurane-oxygen anesthesia. ( Malo, LA; Mutch, WA; Ringaert, KR, 1989)
"Perioperative bleeding is one of the major comorbidities associated with surgery."2.72The Role of Anesthetic Selection in Perioperative Bleeding. ( DiNardo, JA; Koutsogiannaki, S; Yuki, K, 2021)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19907 (20.59)18.7374
1990's9 (26.47)18.2507
2000's9 (26.47)29.6817
2010's6 (17.65)24.3611
2020's3 (8.82)2.80

Authors

AuthorsStudies
Davis, JA1
Bopp, AC1
Henwood, MK1
Bean, P1
Grau, JW1
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X4
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J4
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X4
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H5
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y6
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y7
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
Zhu, N1
Li, Y4
Du, Q1
Hao, P1
Cao, X1
Li, CX1
Zhao, S1
Luo, XM1
Feng, JX1
Gonzalez-Cotto, M1
Guo, L1
Karwan, M1
Sen, SK1
Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
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Deng, Z1
Xie, Y2
Tang, J3
Chen, Z2
Luo, W1
Xiong, D1
Zhao, D1
Fang, J1
Zhou, Z1
Niu, PP1
Song, B1
Xu, YM1
Zhang, Z2
Qiu, N1
Yin, J1
Zhang, J3
Guo, W1
Liu, M2
Liu, T2
Chen, D5
Luo, K1
He, Z2
Zheng, G1
Xu, F1
Sun, W1
Yin, F1
van Hest, JCM1
Du, L2
Shi, X1
Kang, S1
Duan, W1
Zhang, S2
Feng, J2
Qi, N1
Shen, G1
Ren, H1
Shang, Q1
Zhao, W2
Yang, Z2
Jiang, X2
Alame, M1
Cornillot, E1
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Tosato, G1
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Chen, W1
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Ma, Q2
Xu, Y1
Dong, Q1
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Huang, P1
Liao, R1
Chen, X3
Cao, Q1
Yuan, X1
Nie, W1
Yang, J2
Shao, B1
Ma, X1
Bi, Z1
Liang, X1
Tie, Y1
Mo, F1
Xie, D1
Wei, Y1
Wei, X2
Dokla, EME1
Fang, CS1
Chu, PC1
Chang, CS1
Abouzid, KAM1
Chen, CS1
Blaszczyk, R1
Brzezinska, J1
Dymek, B1
Stanczak, PS1
Mazurkiewicz, M1
Olczak, J1
Nowicka, J1
Dzwonek, K1
Zagozdzon, A1
Golab, J1
Golebiowski, A1
Xin, Z1
Himmelbauer, MK1
Jones, JH1
Enyedy, I1
Gilfillan, R1
Hesson, T1
King, K1
Marcotte, DJ1
Murugan, P1
Santoro, JC1
Gonzalez-Lopez de Turiso, F1
Pedron, J1
Boudot, C1
Brossas, JY1
Pinault, E1
Bourgeade-Delmas, S1
Sournia-Saquet, A1
Boutet-Robinet, E1
Destere, A1
Tronnet, A1
Bergé, J1
Bonduelle, C1
Deraeve, C1
Pratviel, G1
Stigliani, JL1
Paris, L1
Mazier, D1
Corvaisier, S1
Since, M1
Malzert-Fréon, A1
Wyllie, S1
Milne, R1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]Phase 4160 participants (Actual)Interventional2009-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

(NCT01048658)
Timeframe: Post-procedure, within 30 minutes

InterventionParticipants (Count of Participants)
Sevoflurane13
No Sevoflurane11

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

InterventionParticipants (Count of Participants)
Sevoflurane20
No Sevoflurane13

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

InterventionParticipants (Count of Participants)
Sevoflurane12
No Sevoflurane6

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Interventionminutes (Mean)
Sevoflurane7.0
No Sevoflurane7.3

Patient and Provider Satisfaction With Anesthesia

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

,
Interventioncm (Mean)
Provider SatisfactionPatient Satisfaction
No Sevoflurane9.38.2
Sevoflurane9.48.4

Reviews

2 reviews available for isoflurane and Hemorrhage

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
The Role of Anesthetic Selection in Perioperative Bleeding.
    BioMed research international, 2021, Volume: 2021

    Topics: Anesthesia; Anesthesiology; Anesthetics; Blood Coagulation; Desflurane; Hemorrhage; Hemostasis; Huma

2021

Trials

7 trials available for isoflurane and Hemorrhage

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score.
    Veterinary anaesthesia and analgesia, 2020, Volume: 47, Issue:4

    Topics: Anesthesia; Anesthetics; Animals; Blood Pressure; Buprenorphine; Cat Diseases; Cats; Cross-Over Stud

2020
Population Kinetics of 0.9% Saline Distribution in Hemorrhaged Awake and Isoflurane-anesthetized Volunteers.
    Anesthesiology, 2019, Volume: 131, Issue:3

    Topics: Adult; Anesthetics, Inhalation; Cross-Over Studies; Female; Fluid Therapy; Hemorrhage; Humans; Isofl

2019
The effect of hypovolemia due to hemorrhage on the minimum alveolar concentration of isoflurane in the dog.
    Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:5

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Cross-Over Studies; Dogs; Female; Hemorrha

2006
A study of the effect of hemorrhage on the cardiorespiratory actions of halothane, isoflurane and sevoflurane in the dog.
    Veterinary anaesthesia and analgesia, 2007, Volume: 34, Issue:2

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Dogs; Halothane; Heart Rat

2007
Desflurane analgesia for vaginal delivery.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:2

    Topics: Acid-Base Equilibrium; Adaptation, Physiological; Adult; Analgesia, Obstetrical; Anesthetics, Inhala

1995
Isoflurane or halothane for cesarean section: comparative maternal and neonatal effects.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:7

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Obstetrical; Apgar Score; Cesarean Section; Female; Fluor

1989

Other Studies

26 other studies available for isoflurane and Hemorrhage

ArticleYear
General Anesthesia Blocks Pain-Induced Hemorrhage and Locomotor Deficits After Spinal Cord Injury in Rats.
    Journal of neurotrauma, 2023, Volume: 40, Issue:23-24

    Topics: Anesthesia, General; Anesthetics; Animals; Contusions; Hemorrhage; Humans; Isoflurane; Pain; Pentoba

2023
Effects of 6% Tetrastarch and Lactated Ringer's Solution on Extravascular Lung Water and Markers of Acute Renal Injury in Hemorrhaged, Isoflurane-Anesthetized Healthy Dogs.
    Journal of veterinary internal medicine, 2018, Volume: 32, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Cardiac Output; Creatinine; Cross-Over Studies; Dogs; Extravascula

2018
Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses.
    British journal of anaesthesia, 2014, Volume: 113, Issue:4

    Topics: Algorithms; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Volu

2014
Pulse pressure variation and stroke volume variation under different inhaled concentrations of isoflurane, sevoflurane and desflurane in pigs undergoing hemorrhage.
    Clinics (Sao Paulo, Brazil), 2015, Volume: 70, Issue:12

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Desflurane; Dose-Response Relationship, Drug; Fema

2015
Endothelin receptor subtype A blockade does not affect the haemodynamic recovery from haemorrhage during xenon/remifentanil or isoflurane/remifentanil anaesthesia in dogs.
    Veterinary anaesthesia and analgesia, 2010, Volume: 37, Issue:3

    Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, I

2010
The cardiopulmonary effects of severe blood loss in anesthetized horses.
    Veterinary anaesthesia and analgesia, 2003, Volume: 30, Issue:2

    Topics: Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Blood Gas Analysis

2003
Hemorrhage during isoflurane-nitrous oxide anesthesia: effects of endothelin-A or angiotensin II receptor blockade or both.
    Anesthesiology, 2004, Volume: 100, Issue:4

    Topics: Anesthesia; Angiotensin II; Animals; Blood Pressure; Cardiac Output; Catecholamines; Dogs; Female; G

2004
Influence of hypovolemia on the electroencephalographic effect of isoflurane in a swine model.
    Anesthesiology, 2005, Volume: 102, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Blood Gas Analysis; Dose-Response Relationship, Drug; Electroencep

2005
Isoflurane inhibits compensatory intravascular volume expansion after hemorrhage in sheep.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Blood Volume; Capillary Permeability; Female; Hemorrhage; Hydrosta

2006
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum).
    Journal of the American Veterinary Medical Association, 2007, Sep-01, Volume: 231, Issue:5

    Topics: Air Microbiology; Anesthetics, Inhalation; Animals; Cat Diseases; Cats; Fatal Outcome; Female; Hemor

2007
The effect of halothane, isoflurane, and blood loss on hepatotoxicity and hepatic oxygen availability in phenobarbital-pretreated hypoxic rats.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:11

    Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage; Isoflurane; Liver; Liver Cir

1984
Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:7

    Topics: Anesthesia, Inhalation; Animals; Dogs; Enflurane; Halothane; Hemodynamics; Hemorrhage; Isoflurane; K

1981
Diminished effect of inhibition of nitric oxide synthase on regional cerebral vascular resistance in conscious and in isoflurane anesthetized rats during hemorrhage.
    Brain research, 1993, Dec-10, Volume: 630, Issue:1-2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Brain; Hemorrhage; Isoflurane; NG-Nit

1993
Effects of inhalation anesthetics on myocardial and hepatic energy metabolism in normotensive and spontaneously hypertensive rats subjected to hemorrhage.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:2

    Topics: Adenosine Triphosphate; Alkalosis; Anesthesia, Inhalation; Anesthetics; Animals; Blood Pressure; Ene

1994
Organ perfusion during deliberate hypotension and superimposed hemorrhage.
    Anesthesiology, 1993, Volume: 79, Issue:1

    Topics: 2-Chloroadenosine; Animals; Blood Circulation; Blood Pressure; Hemodynamics; Hemorrhage; Humans; Hyp

1993
Effect of chronic cocaine administration on the hemodynamic response to acute hemorrhage in awake and anesthetized sheep.
    The Journal of trauma, 1997, Volume: 42, Issue:1

    Topics: Anesthesia, General; Animals; Cocaine; Dose-Response Relationship, Drug; Hemodynamics; Hemorrhage; I

1997
Ischaemic optic neuropathy after spinal fusion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Loss, Surgi

1998
Influence of neurohumoral blockade on heart rate and blood pressure responses to haemorrhage in isoflurane anaesthetized rats.
    Acta physiologica Scandinavica, 2000, Volume: 169, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme

2000
Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Autonomic Nervous System; Blood Pressure;

2002
[Effects of halogenated anesthetics on splanchnic hemodynamic in normo- and hypovolemic cirrhotic rats].
    Annales francaises d'anesthesie et de reanimation, 1992, Volume: 11, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Enflurane; Halothane; Hemodynamics; Hemorrhage; Isoflurane; Liver C

1992
The influence of hemorrhage on organ perfusion during deliberate hypotension in rats.
    Anesthesiology, 1992, Volume: 77, Issue:6

    Topics: 2-Chloroadenosine; Animals; Blood Circulation; Hemodynamics; Hemorrhage; Hypotension, Controlled; Is

1992
Blood flow and tissue oxygen pressures of liver and pancreas in rats: effects of volatile anesthetics and of hemorrhage.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:3

    Topics: Anesthetics; Animals; Blood Pressure; Cardiac Output; Enflurane; Halothane; Hemodynamics; Hemoglobin

1992
Cardiovascular effects of vasopressors in isoflurane-anesthetized dogs before and after hemorrhage.
    American journal of veterinary research, 1989, Volume: 50, Issue:11

    Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Cardiac Output; Dobutamine; Dog Diseases; Dogs; Epi

1989
Regional cerebral blood flow following hemorrhage during isoflurane anesthesia in the rabbit: comparison of techniques to support blood pressure.
    Anesthesiology, 1989, Volume: 70, Issue:6

    Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Blood Volume; Cardiac Output; Cerebrovascular Circu

1989
Effects of isoflurane on feline intestinal blood flow during hemorrhage-induced hypovolemia.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:6

    Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Cats; Hemorrhage; Homeostasis; Hypotension; Isoflur

1989
Phenylephrine increases regional cerebral blood flow following hemorrhage during isoflurane-oxygen anesthesia.
    Anesthesiology, 1989, Volume: 70, Issue:2

    Topics: Anesthesia, Inhalation; Animals; Cerebrovascular Circulation; Hemorrhage; Isoflurane; Male; Oxygen;

1989