isoflurane has been researched along with Glioma in 15 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "H4 human neuroglioma cells (H4 cells) were treated with 2% isoflurane or the control condition plus saline or 50 mM glucose for 6 or 3 hours." | 7.80 | Glucose may attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells. ( Cheng, B; Dong, Y; Li, T; Pan, C; Sun, Y; Xie, Z; Zhang, Y, 2014) |
| "H4 human neuroglioma cells (H4 cells), and mouse primary neurones and microglia were treated with 2% isoflurane or 4." | 7.79 | Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. ( Dong, Y; Xie, Z; Yang, L; Zhang, J; Zhang, L; Zhang, Y, 2013) |
| "H4 human neuroglioma cells were treated with saline or 2-DG (5 mM) for 1 hour followed by a control condition or 2% isoflurane for 6 hours." | 7.77 | 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells. ( Dong, Y; Ichinose, F; Liang, W; McAuliffe, S; Pan, C; Xie, Z; Xu, Z; Yue, Y; Zhang, J; Zhang, Y, 2011) |
| "Rat cultured C6 glioma cells that express excitatory amino acid transporter type 3 (EAAT3) were exposed to isoflurane at various concentrations (0." | 7.72 | Isoflurane enhances the expression and activity of glutamate transporter type 3 in C6 glioma cells. ( Huang, Y; Zuo, Z, 2003) |
| "Isoflurane has been demonstrated to induce mitochondrial damage and cell apoptosis." | 5.56 | Ulinastatin alleviates mitochondrial damage and cell apoptosis induced by isoflurane in human neuroglioma H4 cells. ( Guo, M; Li, J; Lin, D; Xu, H; Yao, Y; Zhu, X, 2020) |
| " Twenty-nine patients undergoing craniotomy for frontotemporal gliomas were randomized to receive intravenous anesthesia with propofol or inhalational anesthesia with isoflurane." | 5.12 | Cerebrovascular reactivity to carbon dioxide in the normal and abnormal cerebral hemispheres under anesthesia in patients with frontotemporal gliomas. ( Pillai, SV; Rao, GS, 2006) |
| "5, 25, and 50 μmol/L and pretreatment times of 12 h and 24 h on isoflurane-induced caspase-3 activation in H4 naïve and stably transfected H4 human neuroglioma cells that express full-length human amyloid precursor protein (APP) (H4-APP cells)." | 3.81 | Ginsenoside Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction. ( Ding, GN; Hong, FX; Miao, HH; Tian, M; Xie, ZC; Zhen, Y, 2015) |
| "H4 human neuroglioma cells (H4 cells) were treated with 2% isoflurane or the control condition plus saline or 50 mM glucose for 6 or 3 hours." | 3.80 | Glucose may attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells. ( Cheng, B; Dong, Y; Li, T; Pan, C; Sun, Y; Xie, Z; Zhang, Y, 2014) |
| "H4 human neuroglioma cells (H4 cells), and mouse primary neurones and microglia were treated with 2% isoflurane or 4." | 3.79 | Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. ( Dong, Y; Xie, Z; Yang, L; Zhang, J; Zhang, L; Zhang, Y, 2013) |
| "H4 human neuroglioma cells were treated with saline or 2-DG (5 mM) for 1 hour followed by a control condition or 2% isoflurane for 6 hours." | 3.77 | 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells. ( Dong, Y; Ichinose, F; Liang, W; McAuliffe, S; Pan, C; Xie, Z; Xu, Z; Yue, Y; Zhang, J; Zhang, Y, 2011) |
| "Treatment of rat glioma C6 cells with the beta-receptor agonist isoproterenol induces a massive increase in cAMP." | 3.74 | Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. ( Gambaryan, S; Roewer, N; Tas, PW, 2007) |
| "H4 human neuroglioma cells stably transfected to express human full-length wild-type amyloid precursor protein (APP) were exposed to 2% isoflurane for 6 h." | 3.73 | The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. ( Alfille, P; Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Tanzi, RE; Xie, Z, 2006) |
| "Rat cultured C6 glioma cells that express excitatory amino acid transporter type 3 (EAAT3) were exposed to isoflurane at various concentrations (0." | 3.72 | Isoflurane enhances the expression and activity of glutamate transporter type 3 in C6 glioma cells. ( Huang, Y; Zuo, Z, 2003) |
| "Isoflurane has been demonstrated to induce mitochondrial damage and cell apoptosis." | 1.56 | Ulinastatin alleviates mitochondrial damage and cell apoptosis induced by isoflurane in human neuroglioma H4 cells. ( Guo, M; Li, J; Lin, D; Xu, H; Yao, Y; Zhu, X, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 4 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 5 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
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| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
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| Garcia, EM | 1 |
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| Walsh, SW | 1 |
| Jefferson, KK | 1 |
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| Lee, JH | 2 |
| Yoo, JS | 1 |
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| Lee, EJ | 1 |
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| Delorme, M | 1 |
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| Gilson, E | 1 |
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| Zhang, Y | 10 |
| Hu, Z | 1 |
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| Gestwicki, JE | 1 |
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| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
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| Dong, C | 2 |
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| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
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| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
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| de Jong, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) | |||
| Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Intervention | units on a scale 0-3 (Mean) |
|---|---|
| Furosemide | 1.5 |
| Placebo | 1.3 |
1 review available for isoflurane and Glioma
4 trials available for isoflurane and Glioma
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Cerebrovascular reactivity to carbon dioxide in the normal and abnormal cerebral hemispheres under anesthesia in patients with frontotemporal gliomas.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Brain Neoplasms; Carbon Dioxid | 2006 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
Isoflurane plus nitrous oxide versus propofol for recording of motor evoked potentials after high frequency repetitive electrical stimulation.
Topics: Adolescent; Adult; Alfentanil; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebellar Neoplas | 1998 |
11 other studies available for isoflurane and Glioma
| Article | Year |
|---|---|
Ulinastatin alleviates mitochondrial damage and cell apoptosis induced by isoflurane in human neuroglioma H4 cells.
Topics: Anesthetics, Inhalation; Apoptosis; Cell Line, Tumor; Electron Transport Chain Complex Proteins; Gli | 2020 |
Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells.
Topics: Anesthetics, Inhalation; Animals; Antimetabolites; Cell Nucleus; Cells, Cultured; Deoxyglucose; Glio | 2013 |
Glucose may attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Caspase 3; Cell Line, Tumor; Cell Survival; Cytopro | 2014 |
Ginsenoside Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction.
Topics: Amyloid beta-Protein Precursor; Caspase 3; Cell Line, Tumor; Gene Expression Regulation, Enzymologic | 2015 |
2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells.
Topics: Cell Line, Tumor; Cytoprotection; Cytotoxins; Deoxyglucose; Glioma; Humans; Isoflurane; Reactive Oxy | 2011 |
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; A | 2011 |
Isoflurane enhances the expression and activity of glutamate transporter type 3 in C6 glioma cells.
Topics: Actins; Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Cell Line, Tumor; Dose-R | 2003 |
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Apoptosis; Blotting, | 2006 |
Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.
Topics: Adrenergic beta-Agonists; Amides; Anesthetics, Inhalation; Animals; Cell Line, Tumor; Cell Shape; Cu | 2007 |
Antiproliferative actions of inhalational anesthetics: comparisons to the valproate teratogen.
Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Cell Division; Dimethyl Sulfoxide; Enflurane; F | 2000 |
The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage.
Topics: Anesthetics; Animals; Glioma; Guanidine; Guanidines; Halothane; Hybridomas; Isoflurane; Neuroblastom | 1989 |