Page last updated: 2024-10-29

isoflurane and Epilepsy

isoflurane has been researched along with Epilepsy in 16 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
" We compared the epileptogenic properties of sevoflurane to isoflurane in patients with epilepsy."7.70The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy. ( Iijima, T; Iwao, Y; Nakamura, Z; Sankawa, H, 2000)
"The following is a double blind, randomized cross over study to compare the effects of isoflurane and propofol with or without nitrous oxide on electrocorticographic activity in patients undergoing epilepsy surgery."5.16Comparison of the effects of different anesthetic techniques on electrocorticography in patients undergoing epilepsy surgery - a bispectral index guided study. ( Bindra, A; Chandra, PS; Chouhan, RS; Dash, HH; Prabhakar, H; Tripathi, M, 2012)
"The large inspired concentration of sevoflurane (S) during mask induction of anesthesia can induce epileptiform electroencephalogram (EEG) associated with tachycardia."5.11A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram. ( Jäntti, VH; Korttila, KT; Paloheimo, MPJ; Särkelä, M; Seitsonen, ER; Vakkuri, AP; Yli-Hankala, AM, 2005)
"We investigated 18F-FDG uptake phase in conscious rats followed by a static scan as well as dynamic scans under continuous isoflurane, medetomidine-midazolam-fentanyl (MMF), or propofol anesthesia."4.02Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis. ( Bankstahl, JP; Bankstahl, M; Bascuñana, P; Jahreis, I; Ross, TL, 2021)
" We compared the epileptogenic properties of sevoflurane to isoflurane in patients with epilepsy."3.70The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy. ( Iijima, T; Iwao, Y; Nakamura, Z; Sankawa, H, 2000)
" Furthermore, most preclinical antiepileptogenic studies lack information needed for translation, such as dose-blood level relationship, brain target engagement, and dose-response, and many use treatment parameters that cannot be applied clinically, for example, treatment initiation before or at the time of injury and dosing higher than tolerated human equivalent dosing."2.66Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? ( Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M, 2020)
"Seizure outcome was graded: I (seizure free without medication), II (seizure free with medication), III (> 50% seizure reduction) or IV (< 50% seizure reduction)."1.35Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience. ( Al-Ghanem, SS; Al-Oweidi, AS; Al-Qudah, AA; Tamimi, AF, 2009)
"With isoflurane there was a reduced tendency for activity to be transmitted from one region within the hippocampus to the other."1.28An experimental study of the effect of isoflurane on epileptiform bursts. ( Berg-Johnsen, J; Hegstad, E; Langmoen, IA, 1992)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's2 (12.50)18.2507
2000's5 (31.25)29.6817
2010's3 (18.75)24.3611
2020's4 (25.00)2.80

Authors

AuthorsStudies
Jahreis, I1
Bascuñana, P1
Ross, TL1
Bankstahl, JP1
Bankstahl, M1
Klein, P1
Friedman, A1
Hameed, MQ1
Kaminski, RM1
Bar-Klein, G1
Klitgaard, H1
Koepp, M1
Jozwiak, S1
Prince, DA2
Rotenberg, A1
Twyman, R1
Vezzani, A1
Wong, M1
Löscher, W1
Warren, AEL1
Davidson, A1
Vogrin, SJ1
Harvey, AS1
Bailey, C1
Dalic, LJ1
Abbott, DF1
Archer, JS1
Kacar Bayram, A1
Yan, Q1
Isitan, C1
Rao, S1
Spencer, DD1
Alkawadri, R1
Faria, LC1
Gu, F1
Parada, I1
Barres, B1
Luo, ZD1
Heinemann, U1
Ma, H1
Zhao, M1
Suh, M1
Schwartz, TH1
Al-Ghanem, SS1
Al-Oweidi, AS1
Tamimi, AF1
Al-Qudah, AA1
Bindra, A1
Chouhan, RS1
Prabhakar, H1
Dash, HH1
Chandra, PS1
Tripathi, M1
Fukuda, M1
Vazquez, AL1
Zong, X1
Kim, SG1
Vakkuri, AP1
Seitsonen, ER1
Jäntti, VH1
Särkelä, M1
Korttila, KT1
Paloheimo, MPJ1
Yli-Hankala, AM1
Nott, MR1
Halfacre, J1
Iijima, T1
Nakamura, Z1
Iwao, Y1
Sankawa, H1
Langmoen, IA1
Hegstad, E1
Berg-Johnsen, J1
Ito, BM1
Sato, S1
Kufta, CV1
Tran, D1
Colicchio, G1
Perilli, V1
Perotti, V1
Pietrini, D1
Della Corte, F1
Bracali, AM1

Reviews

2 reviews available for isoflurane and Epilepsy

ArticleYear
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Cef

2020
Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions.
    Epilepsy & behavior : E&B, 2021, Volume: 118

    Topics: Electrocorticography; Electroencephalography; Epilepsy; Humans; Isoflurane; Reproducibility of Resul

2021

Trials

2 trials available for isoflurane and Epilepsy

ArticleYear
Comparison of the effects of different anesthetic techniques on electrocorticography in patients undergoing epilepsy surgery - a bispectral index guided study.
    Seizure, 2012, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Anesthetics, Combined; Brain; Child; Child, Preschool; Cross-Over Studies; Double

2012
A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:2

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Desflurane; Double-Blind Method; Electrocardiog

2005

Other Studies

12 other studies available for isoflurane and Epilepsy

ArticleYear
Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Epilepsy; Female; Flu

2021
Combined Isoflurane-Remifentanil Anaesthesia Permits Resting-State fMRI in Children with Severe Epilepsy and Intellectual Disability.
    Brain topography, 2020, Volume: 33, Issue:5

    Topics: Anesthesia; Child; Epilepsy; Humans; Intellectual Disability; Isoflurane; Magnetic Resonance Imaging

2020
Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1.
    Neurobiology of disease, 2017, Volume: 102

    Topics: Animals; Anticonvulsants; Astrocytes; Calcium Channels; Epilepsy; Ethosuximide; Hippocampus; Isoflur

2017
New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).
    The European journal of neuroscience, 2008, Volume: 28, Issue:7

    Topics: Anesthetics, Inhalation; Blood-Brain Barrier; Brain; Brain Diseases, Metabolic; Brain Edema; Epileps

2008
Hemodynamic surrogates for excitatory membrane potential change during interictal epileptiform events in rat neocortex.
    Journal of neurophysiology, 2009, Volume: 101, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Elec

2009
Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience.
    Middle East journal of anaesthesiology, 2009, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Child; Craniotomy; Electroencephalography; Epil

2009
Effects of the α₂-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex.
    The European journal of neuroscience, 2013, Volume: 37, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Animals; Brain Waves; Cerebral Arteri

2013
Anaesthesia for dental conservation in a patient with tuberous sclerosis.
    European journal of anaesthesiology, 1996, Volume: 13, Issue:4

    Topics: Adult; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; D

1996
The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Anesthetics, Inhalation; Anticonvulsants; Carbon Dioxide; Child; Delta Rhythm; El

2000
An experimental study of the effect of isoflurane on epileptiform bursts.
    Epilepsy research, 1992, Volume: 11, Issue:3

    Topics: Animals; Electroencephalography; Epilepsy; Hippocampus; In Vitro Techniques; Isoflurane; Neurons, Af

1992
Effect of isoflurane and enflurane on the electrocorticogram of epileptic patients.
    Neurology, 1988, Volume: 38, Issue:6

    Topics: Action Potentials; Adolescent; Adult; Brain; Electroencephalography; Enflurane; Epilepsy; Female; Hu

1988
[Electroencephalographic effects of isoflurane in epileptic patients].
    Minerva anestesiologica, 1987, Volume: 53, Issue:5

    Topics: Anesthesia, Inhalation; Electroencephalography; Epilepsy; Humans; Isoflurane

1987