isoflurane has been researched along with Epilepsy in 16 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the epileptogenic properties of sevoflurane to isoflurane in patients with epilepsy." | 7.70 | The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy. ( Iijima, T; Iwao, Y; Nakamura, Z; Sankawa, H, 2000) |
| "The following is a double blind, randomized cross over study to compare the effects of isoflurane and propofol with or without nitrous oxide on electrocorticographic activity in patients undergoing epilepsy surgery." | 5.16 | Comparison of the effects of different anesthetic techniques on electrocorticography in patients undergoing epilepsy surgery - a bispectral index guided study. ( Bindra, A; Chandra, PS; Chouhan, RS; Dash, HH; Prabhakar, H; Tripathi, M, 2012) |
| "The large inspired concentration of sevoflurane (S) during mask induction of anesthesia can induce epileptiform electroencephalogram (EEG) associated with tachycardia." | 5.11 | A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram. ( Jäntti, VH; Korttila, KT; Paloheimo, MPJ; Särkelä, M; Seitsonen, ER; Vakkuri, AP; Yli-Hankala, AM, 2005) |
| "We investigated 18F-FDG uptake phase in conscious rats followed by a static scan as well as dynamic scans under continuous isoflurane, medetomidine-midazolam-fentanyl (MMF), or propofol anesthesia." | 4.02 | Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis. ( Bankstahl, JP; Bankstahl, M; Bascuñana, P; Jahreis, I; Ross, TL, 2021) |
| " We compared the epileptogenic properties of sevoflurane to isoflurane in patients with epilepsy." | 3.70 | The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy. ( Iijima, T; Iwao, Y; Nakamura, Z; Sankawa, H, 2000) |
| " Furthermore, most preclinical antiepileptogenic studies lack information needed for translation, such as dose-blood level relationship, brain target engagement, and dose-response, and many use treatment parameters that cannot be applied clinically, for example, treatment initiation before or at the time of injury and dosing higher than tolerated human equivalent dosing." | 2.66 | Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? ( Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M, 2020) |
| "Seizure outcome was graded: I (seizure free without medication), II (seizure free with medication), III (> 50% seizure reduction) or IV (< 50% seizure reduction)." | 1.35 | Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience. ( Al-Ghanem, SS; Al-Oweidi, AS; Al-Qudah, AA; Tamimi, AF, 2009) |
| "With isoflurane there was a reduced tendency for activity to be transmitted from one region within the hippocampus to the other." | 1.28 | An experimental study of the effect of isoflurane on epileptiform bursts. ( Berg-Johnsen, J; Hegstad, E; Langmoen, IA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jahreis, I | 1 |
| Bascuñana, P | 1 |
| Ross, TL | 1 |
| Bankstahl, JP | 1 |
| Bankstahl, M | 1 |
| Klein, P | 1 |
| Friedman, A | 1 |
| Hameed, MQ | 1 |
| Kaminski, RM | 1 |
| Bar-Klein, G | 1 |
| Klitgaard, H | 1 |
| Koepp, M | 1 |
| Jozwiak, S | 1 |
| Prince, DA | 2 |
| Rotenberg, A | 1 |
| Twyman, R | 1 |
| Vezzani, A | 1 |
| Wong, M | 1 |
| Löscher, W | 1 |
| Warren, AEL | 1 |
| Davidson, A | 1 |
| Vogrin, SJ | 1 |
| Harvey, AS | 1 |
| Bailey, C | 1 |
| Dalic, LJ | 1 |
| Abbott, DF | 1 |
| Archer, JS | 1 |
| Kacar Bayram, A | 1 |
| Yan, Q | 1 |
| Isitan, C | 1 |
| Rao, S | 1 |
| Spencer, DD | 1 |
| Alkawadri, R | 1 |
| Faria, LC | 1 |
| Gu, F | 1 |
| Parada, I | 1 |
| Barres, B | 1 |
| Luo, ZD | 1 |
| Heinemann, U | 1 |
| Ma, H | 1 |
| Zhao, M | 1 |
| Suh, M | 1 |
| Schwartz, TH | 1 |
| Al-Ghanem, SS | 1 |
| Al-Oweidi, AS | 1 |
| Tamimi, AF | 1 |
| Al-Qudah, AA | 1 |
| Bindra, A | 1 |
| Chouhan, RS | 1 |
| Prabhakar, H | 1 |
| Dash, HH | 1 |
| Chandra, PS | 1 |
| Tripathi, M | 1 |
| Fukuda, M | 1 |
| Vazquez, AL | 1 |
| Zong, X | 1 |
| Kim, SG | 1 |
| Vakkuri, AP | 1 |
| Seitsonen, ER | 1 |
| Jäntti, VH | 1 |
| Särkelä, M | 1 |
| Korttila, KT | 1 |
| Paloheimo, MPJ | 1 |
| Yli-Hankala, AM | 1 |
| Nott, MR | 1 |
| Halfacre, J | 1 |
| Iijima, T | 1 |
| Nakamura, Z | 1 |
| Iwao, Y | 1 |
| Sankawa, H | 1 |
| Langmoen, IA | 1 |
| Hegstad, E | 1 |
| Berg-Johnsen, J | 1 |
| Ito, BM | 1 |
| Sato, S | 1 |
| Kufta, CV | 1 |
| Tran, D | 1 |
| Colicchio, G | 1 |
| Perilli, V | 1 |
| Perotti, V | 1 |
| Pietrini, D | 1 |
| Della Corte, F | 1 |
| Bracali, AM | 1 |
2 reviews available for isoflurane and Epilepsy
| Article | Year |
|---|---|
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Cef | 2020 |
Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions.
Topics: Electrocorticography; Electroencephalography; Epilepsy; Humans; Isoflurane; Reproducibility of Resul | 2021 |
2 trials available for isoflurane and Epilepsy
| Article | Year |
|---|---|
Comparison of the effects of different anesthetic techniques on electrocorticography in patients undergoing epilepsy surgery - a bispectral index guided study.
Topics: Adolescent; Adult; Anesthetics, Combined; Brain; Child; Child, Preschool; Cross-Over Studies; Double | 2012 |
A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Desflurane; Double-Blind Method; Electrocardiog | 2005 |
12 other studies available for isoflurane and Epilepsy
| Article | Year |
|---|---|
Choice of anesthesia and data analysis method strongly increases sensitivity of 18F-FDG PET imaging during experimental epileptogenesis.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Epilepsy; Female; Flu | 2021 |
Combined Isoflurane-Remifentanil Anaesthesia Permits Resting-State fMRI in Children with Severe Epilepsy and Intellectual Disability.
Topics: Anesthesia; Child; Epilepsy; Humans; Intellectual Disability; Isoflurane; Magnetic Resonance Imaging | 2020 |
Epileptiform activity and behavioral arrests in mice overexpressing the calcium channel subunit α2δ-1.
Topics: Animals; Anticonvulsants; Astrocytes; Calcium Channels; Epilepsy; Ethosuximide; Hippocampus; Isoflur | 2017 |
New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).
Topics: Anesthetics, Inhalation; Blood-Brain Barrier; Brain; Brain Diseases, Metabolic; Brain Edema; Epileps | 2008 |
Hemodynamic surrogates for excitatory membrane potential change during interictal epileptiform events in rat neocortex.
Topics: Anesthetics, Inhalation; Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Elec | 2009 |
Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience.
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Child; Craniotomy; Electroencephalography; Epil | 2009 |
Effects of the α₂-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Animals; Brain Waves; Cerebral Arteri | 2013 |
Anaesthesia for dental conservation in a patient with tuberous sclerosis.
Topics: Adult; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; D | 1996 |
The epileptogenic properties of the volatile anesthetics sevoflurane and isoflurane in patients with epilepsy.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anticonvulsants; Carbon Dioxide; Child; Delta Rhythm; El | 2000 |
An experimental study of the effect of isoflurane on epileptiform bursts.
Topics: Animals; Electroencephalography; Epilepsy; Hippocampus; In Vitro Techniques; Isoflurane; Neurons, Af | 1992 |
Effect of isoflurane and enflurane on the electrocorticogram of epileptic patients.
Topics: Action Potentials; Adolescent; Adult; Brain; Electroencephalography; Enflurane; Epilepsy; Female; Hu | 1988 |
[Electroencephalographic effects of isoflurane in epileptic patients].
Topics: Anesthesia, Inhalation; Electroencephalography; Epilepsy; Humans; Isoflurane | 1987 |