isoflurane has been researched along with Encephalopathy, Toxic in 23 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isoflurane (ISO) has been widely used in clinical anesthesia, and exposure to ISO leads to cognitive dysfunction." | 8.12 | MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia. ( Dai, S; Qian, D; Sun, Y; Wang, L; Yuan, Y, 2022) |
| "Isoflurane (ISO) has been widely used in clinical anesthesia, and exposure to ISO leads to cognitive dysfunction." | 4.12 | MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia. ( Dai, S; Qian, D; Sun, Y; Wang, L; Yuan, Y, 2022) |
| "5 h exposures of NHPs to isoflurane during infancy are associated with decreased close social behaviour after multiple exposures and more anxiety-related behaviours and increased behavioural inhibition after single exposure, but they do not affect the cognitive domains tested." | 4.02 | Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates. ( Bemis, A; Brambrink, AM; Coleman, K; Dissen, GA; Fair, DA; Glickman, B; Martin, LD; Neudecker, V; Neuringer, M; Perez-Zoghbi, JF; Robertson, N; Schenning, KJ, 2021) |
| "Routine general anesthesia is considered to be safe in healthy individuals." | 1.51 | Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse. ( Bornstein, R; Ford, JM; Freed, A; Howard, CRA; Johnson, SC; Li, L; Morgan, PG; Pan, A; Sedensky, MM; Stokes, JC; Sun, GX; Witkowski, M, 2019) |
| "Isoflurane is a commonly-used general anesthetic." | 1.46 | Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats. ( Fang, X; Gao, J; Han, Q; Li, S; Luo, A; Yan, J; Zhao, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 10 (43.48) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, T | 1 |
| Zhou, B | 1 |
| Sun, J | 1 |
| Song, J | 1 |
| Nie, L | 1 |
| Zhu, K | 1 |
| Jung, S | 1 |
| Kayser, EB | 2 |
| Johnson, SC | 2 |
| Li, L | 2 |
| Worstman, HM | 1 |
| Sun, GX | 2 |
| Sedensky, MM | 4 |
| Morgan, PG | 4 |
| Wang, LK | 1 |
| Yang, XD | 1 |
| Zhou, D | 1 |
| Cheng, T | 1 |
| Zhang, X | 2 |
| Wu, HY | 1 |
| Zuo, C | 1 |
| Ma, J | 1 |
| Pan, Y | 1 |
| Zheng, D | 1 |
| Chen, C | 1 |
| Ruan, N | 1 |
| Su, Y | 1 |
| Nan, H | 1 |
| Lian, Q | 1 |
| Lin, H | 1 |
| Qian, D | 1 |
| Dai, S | 1 |
| Sun, Y | 1 |
| Yuan, Y | 1 |
| Wang, L | 1 |
| Shen, T | 1 |
| Shang, Y | 1 |
| Wu, Q | 1 |
| Ren, H | 1 |
| He, W | 1 |
| Chi, S | 1 |
| Jin, X | 1 |
| Lu, J | 1 |
| Zheng, W | 1 |
| Yan, J | 2 |
| Zhang, D | 1 |
| Neag, MA | 1 |
| Mitre, AO | 1 |
| Catinean, A | 1 |
| Mitre, CI | 1 |
| Neudecker, V | 1 |
| Perez-Zoghbi, JF | 1 |
| Coleman, K | 1 |
| Neuringer, M | 1 |
| Robertson, N | 1 |
| Bemis, A | 1 |
| Glickman, B | 1 |
| Schenning, KJ | 2 |
| Fair, DA | 1 |
| Martin, LD | 2 |
| Dissen, GA | 2 |
| Brambrink, AM | 2 |
| Borgstedt, L | 1 |
| Blobner, M | 1 |
| Musiol, M | 1 |
| Bratke, S | 1 |
| Syryca, F | 1 |
| Rammes, G | 1 |
| Jungwirth, B | 1 |
| Schmid, S | 1 |
| Yuan, JH | 1 |
| Pan, F | 1 |
| Chen, J | 1 |
| Chen, CE | 1 |
| Xie, DP | 1 |
| Jiang, XZ | 1 |
| Guo, SJ | 1 |
| Zhou, J | 1 |
| Fang, X | 1 |
| Li, S | 1 |
| Han, Q | 1 |
| Zhao, Y | 1 |
| Gao, J | 1 |
| Luo, A | 1 |
| Noguchi, KK | 1 |
| Johnson, SA | 1 |
| Manzella, FM | 1 |
| Olney, JW | 1 |
| Pan, A | 1 |
| Freed, A | 1 |
| Stokes, JC | 1 |
| Bornstein, R | 1 |
| Witkowski, M | 1 |
| Ford, JM | 1 |
| Howard, CRA | 1 |
| Kajimoto, M | 1 |
| Atkinson, DB | 1 |
| Ledee, DR | 1 |
| Isern, NG | 1 |
| Des Rosiers, C | 1 |
| Portman, MA | 1 |
| Jevtovic-Todorovic, V | 1 |
| Liu, J | 1 |
| Wang, P | 1 |
| Zhang, W | 1 |
| Gu, G | 1 |
| Li, G | 1 |
| Xue, Q | 1 |
| Luo, Y | 1 |
| Hu, X | 1 |
| Yu, B | 1 |
| DeYoung, TP | 1 |
| Li, JC | 1 |
| Tang, X | 1 |
| Ward, CG | 1 |
| Dworkin, BR | 1 |
| Eckenhoff, MF | 1 |
| Kofke, WA | 1 |
| Chai, D | 1 |
| Jiang, H | 1 |
| Li, Q | 1 |
| Lemkuil, BP | 1 |
| Head, BP | 1 |
| Pearn, ML | 1 |
| Patel, HH | 1 |
| Drummond, JC | 1 |
| Patel, PM | 1 |
| Gentry, KR | 1 |
| Steele, LM | 1 |
| Mavroudis, G | 1 |
| Prior, MJ | 1 |
| Lister, T | 1 |
| Nolan, CC | 1 |
| Ray, DE | 1 |
1 review available for isoflurane and Encephalopathy, Toxic
| Article | Year |
|---|---|
An Overview on the Mechanisms of Neuroprotection and Neurotoxicity of Isoflurane and Sevoflurane in Experimental Studies.
Topics: Animals; Humans; Isoflurane; Neuroprotection; Neuroprotective Agents; Neurotoxicity Syndromes; Sevof | 2020 |
22 other studies available for isoflurane and Encephalopathy, Toxic
| Article | Year |
|---|---|
Fraxetin suppresses reactive oxygen species-dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane-induced neurotoxicity in hippocampal neuronal cells.
Topics: Animals; Apoptosis; Autophagy; Coumarins; Hippocampus; Isoflurane; Neurotoxicity Syndromes; Phosphat | 2022 |
Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice.
Topics: Anesthetics, Inhalation; Animals; Caenorhabditis elegans; Caspase 3; Endoplasmic Reticulum Stress; G | 2022 |
Prenatal Isoflurane Exposure Induces Developmental Neurotoxicity in Rats: the Role of Gut Microbiota.
Topics: Animals; Brain-Derived Neurotrophic Factor; Female; Gastrointestinal Microbiome; Hippocampus; Humans | 2022 |
Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; | 2022 |
MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia.
Topics: Anesthesia; Animals; Apoptosis; Inflammation; Isoflurane; MicroRNAs; Neurotoxicity Syndromes; Rats; | 2022 |
The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cell Line; Cell Survival; Flavonoids; Hippocampus; Isof | 2020 |
Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.
Topics: Alzheimer Disease; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene | 2020 |
Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain; C | 2021 |
Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Behavior, Animal; Brain; | 2020 |
Neuroprotection by plumbagin involves BDNF-TrkB-PI3K/Akt and ERK1/2/JNK pathways in isoflurane-induced neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; Do | 2017 |
Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats.
Topics: Anesthetics, Inhalation; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; cdc42 G | 2017 |
Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Disease Models, Animal; Female | 2017 |
Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Haplor | 2019 |
Propofol compared with isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex.
Topics: Administration, Inhalation; Anesthetics, General; Animals; Animals, Newborn; Cerebral Cortex; Energy | 2014 |
Good gas, bad gas: isoflurane, carbon monoxide, and which is which?
Topics: Anesthetics, Inhalation; Carbon Monoxide; Gasotransmitters; Humans; Isoflurane; Nerve Degeneration; | 2014 |
Effects of different concentration and duration time of isoflurane on acute and long-term neurocognitive function of young adult C57BL/6 mouse.
Topics: Administration, Inhalation; Age Factors; Anesthetics, Inhalation; Animals; Apoptosis; Behavior, Anim | 2014 |
S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Hippocampus; Isoflurane; Learning Disabilities; | 2015 |
Absence of Neuropathology With Prolonged Isoflurane Sedation in Healthy Adult Rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Blood Glucose; Conscious Sedation; | 2017 |
Isoflurane neurotoxicity involves activation of hypoxia inducible factor-1α via intracellular calcium in neonatal rodents.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Calcium; Calcium Signaling; Cells, Cu | 2016 |
Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization.
Topics: Actins; Anesthetics, Inhalation; Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polya | 2011 |
Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Apoptosis Regulatory Proteins; Behavior, Ani | 2013 |
Neurochemical and oedematous changes in 1,3-dinitrobenzene-induced astroglial injury in rat brain from a 1H-nuclear magnetic resonance perspective.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Astrocytes; Brain; Brain Chemistry; Brain Edema; Dinit | 2006 |