Page last updated: 2024-10-29

isoflurane and Down Syndrome

isoflurane has been researched along with Down Syndrome in 1 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research Excerpts

ExcerptRelevanceReference
"Additionally, trisomy 21 (P = 0."2.76Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study. ( Bodian, C; Chakravarti, S; Hollinger, I; Hossain, S; Kin, N; Krol, M; Mittnacht, AJ; Nguyen, K; Srivastava, S; Weismann, C, 2011)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kin, N1
Weismann, C1
Srivastava, S1
Chakravarti, S1
Bodian, C1
Hossain, S1
Krol, M1
Hollinger, I1
Nguyen, K1
Mittnacht, AJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults[NCT03901612]Phase 40 participants (Actual)Interventional2019-01-05Withdrawn (stopped due to covid and surgeon left)
Bilateral Erector Spinae Plane (ESP) Catheters Versus Single Shot ESP Block for Open Heart Surgery in Infants[NCT03593642]40 participants (Actual)Interventional2018-10-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for isoflurane and Down Syndrome

ArticleYear
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011