Page last updated: 2024-10-29

isoflurane and Depression

isoflurane has been researched along with Depression in 5 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"We employed the CUMS model of depression to assess the rapid antidepressant effect of isoflurane by the forced swimming test (FST), the sucrose preference test (SPT), and the novelty suppressed feeding test (NSFT)."3.91Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice. ( Jin, JY; Jin, SJ; Si, XM; Tian, YH; Wang, WC; Xu, H; Zhang, L; Zhang, SS; Zhao, JX, 2019)
"Depression is a profound mental disorder that dampens the mood and undermines volition, which exhibited an increased incidence over the years."3.01A synopsis of multitarget therapeutic effects of anesthetics on depression. ( Wu, G; Xu, H, 2023)
"Isoflurane was previously the major clinical anesthetic agent but is now mainly used for veterinary anesthesia."1.42Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice. ( Asakura, A; Goto, T; Kobayashi, A; Miyazaki, T; Takase, K; Uchimoto, K; Yonezaki, K, 2015)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Wu, G1
Xu, H2
Herbst, LS1
Gaigher, T1
Siqueira, AA1
Joca, SRL1
Sampaio, KN1
Beijamini, V1
Zhang, SS1
Tian, YH1
Jin, SJ1
Wang, WC1
Zhao, JX1
Si, XM1
Zhang, L1
Jin, JY1
Yonezaki, K1
Uchimoto, K1
Miyazaki, T1
Asakura, A1
Kobayashi, A1
Takase, K1
Goto, T1
Sackey, PV1
Martling, CR1
Carlswärd, C1
Sundin, O1
Radell, PJ1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Mirus™ for Sedation in Resuscitation[NCT02889055]9 participants (Actual)Observational2016-01-17Terminated (stopped due to Safety profile was not satisfying with sevolflurane)
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296]Phase 3235 participants (Anticipated)Interventional2022-06-30Recruiting
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385]Phase 3235 participants (Anticipated)Interventional2022-04-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for isoflurane and Depression

ArticleYear
A synopsis of multitarget therapeutic effects of anesthetics on depression.
    European journal of pharmacology, 2023, Oct-15, Volume: 957

    Topics: Anesthetics; Depression; Humans; Isoflurane; Ketamine; Propofol; Receptors, AMPA; Receptors, N-Methy

2023

Trials

1 trial available for isoflurane and Depression

ArticleYear
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008
Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition Disorders; Conscious Sedation; Delusions; Depress

2008

Other Studies

3 other studies available for isoflurane and Depression

ArticleYear
New evidence for refinement of anesthetic choice in procedures preceding the forced swimming test and the elevated plus-maze.
    Behavioural brain research, 2019, 08-05, Volume: 368

    Topics: Anesthetics, General; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal

2019
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.
    Psychopharmacology, 2019, Volume: 236, Issue:11

    Topics: Anesthetics, Inhalation; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressi

2019
Postanesthetic effects of isoflurane on behavioral phenotypes of adult male C57BL/6J mice.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Anxiety; Attention; Behavior, Animal; Depression; Isoflurane; Male

2015