isoflurane has been researched along with Critical Illness in 12 studies
Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen 4-week-old piglets were given 1 of 2 anesthetic protocols: total IV anesthesia (TIVA) (midazolam 1 mg/kg/h and fentanyl 100 μg/kg/h, n = 8) or ISO (isoflurane 1." | 3.79 | The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model. ( Bruins, B; Friess, SH; Kilbaugh, TJ; Margulies, SS, 2013) |
| "Isoflurane is a useful agent for prolonged sedation of ventilated patients and does not have any adverse effect on the cardiorespiratory system or on hepatic, renal or adrenal function." | 2.67 | Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety. ( Spencer, EM; Willatts, SM, 1992) |
| "Isoflurane has shown better control of intensive care sedation than propofol or midazolam and seems to be a useful alternative." | 1.43 | Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis. ( Bellgardt, M; Bomberg, H; Dasch, B; Herzog-Niescery, J; Meiser, A; Steinfort, C; Uhl, W; Vogelsang, H; Volk, T; Wagenpfeil, S; Weber, TP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Georgevici, AI | 1 |
| Kyprianou, T | 1 |
| Herzog-Niescery, J | 2 |
| Procopiuc, L | 1 |
| Loganathan, S | 1 |
| Weber, TP | 2 |
| Bellgardt, M | 4 |
| Kermad, A | 1 |
| Speltz, J | 1 |
| Danziger, G | 1 |
| Mertke, T | 1 |
| Bals, R | 1 |
| Volk, T | 3 |
| Lepper, PM | 1 |
| Meiser, A | 4 |
| Bomberg, H | 3 |
| Meiser, F | 1 |
| Zimmer, S | 1 |
| Sessler, DI | 1 |
| Groesdonk, HV | 1 |
| Bruins, B | 1 |
| Kilbaugh, TJ | 1 |
| Margulies, SS | 1 |
| Friess, SH | 1 |
| Eifinger, F | 1 |
| Hünseler, C | 1 |
| Roth, B | 1 |
| Vierzig, A | 1 |
| Oberthuer, A | 1 |
| Mehler, K | 1 |
| Kribs, A | 1 |
| Menzel, C | 1 |
| Trieschmann, U | 1 |
| Dasch, B | 1 |
| Vogelsang, H | 1 |
| Steinfort, C | 1 |
| Uhl, W | 1 |
| Wagenpfeil, S | 2 |
| Li, X | 1 |
| Wang, R | 1 |
| Soukup, J | 1 |
| Schärff, K | 1 |
| Kubosch, K | 1 |
| Pohl, C | 1 |
| Bomplitz, M | 1 |
| Kompardt, J | 1 |
| Sackey, PV | 1 |
| Radell, PJ | 1 |
| Granath, F | 1 |
| Martling, CR | 1 |
| Willatts, SM | 2 |
| Spencer, EM | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Depth of Long Term ICU Sedation Under 0,5 MAC Isoflurane, Sevoflurane or Desflurane Using MIRUS, an Automated Delivery System for Volatile Anaesthetics[NCT03860129] | 30 participants (Actual) | Interventional | 2014-12-10 | Completed | |||
| Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients: a Pilot Open-label Randomized Controlled Study[NCT05559970] | 40 participants (Anticipated) | Interventional | 2022-11-15 | Recruiting | |||
| A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238] | Phase 3 | 97 participants (Actual) | Interventional | 2021-01-14 | Completed | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| Evaluation of Mirus™ for Sedation in Resuscitation[NCT02889055] | 9 participants (Actual) | Observational | 2016-01-17 | Terminated (stopped due to Safety profile was not satisfying with sevolflurane) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for isoflurane and Critical Illness
| Article | Year |
|---|---|
State of the art: sedation concepts with volatile anesthetics in critically Ill patients.
Topics: Anesthetics, Inhalation; Clinical Trials as Topic; Critical Illness; Drug Delivery Systems; Humans; | 2009 |
Sedation for ventilation in the critically ill. A role for isoflurane?
Topics: Cardiovascular System; Conscious Sedation; Critical Care; Critical Illness; Humans; Isoflurane; Kidn | 1994 |
3 trials available for isoflurane and Critical Illness
| Article | Year |
|---|---|
Negative drift of sedation depth in critically ill patients receiving constant minimum alveolar concentration of isoflurane, sevoflurane, or desflurane: a randomized controlled trial.
Topics: Aged; Critical Illness; Desflurane; Drug Monitoring; Electroencephalography; Female; Humans; Hypnoti | 2021 |
Bispectral index as a predictor of sedation depth during isoflurane or midazolam sedation in ICU patients.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia; Conscious Sedation; Critical Illness; Dose-Response Rela | 2007 |
Isoflurane for prolonged sedation in the intensive care unit; efficacy and safety.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Critical Illness; Drug Monitoring; England; Female; Hemo | 1992 |
7 other studies available for isoflurane and Critical Illness
| Article | Year |
|---|---|
Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients-a retrospective chart review.
Topics: Conscious Sedation; COVID-19; Critical Illness; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2021 |
Halving the volume of AnaConDa: initial clinical experience with a new small-volume anaesthetic reflector in critically ill patients-a quality improvement project.
Topics: Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Critical Illness; Cross-Over Studies; Deep Se | 2018 |
The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2013 |
Observations on the effects of inhaled isoflurane in long-term sedation of critically Ill children using a modified AnaConDa©-system.
Topics: Anesthesia, Inhalation; Conscious Sedation; Critical Illness; Female; Humans; Infant; Intensive Care | 2013 |
Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Critical Illness; | 2016 |
Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Critical Illness; | 2016 |
Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Critical Illness; | 2016 |
Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Critical Illness; | 2016 |
Reply to: survival after long-term isoflurane sedation in critically ill surgical patients.
Topics: Anesthesia; Conscious Sedation; Critical Illness; Humans; Hypnotics and Sedatives; Isoflurane; Respi | 2017 |
Survival after long-term isoflurane sedation in critically ill surgical patients.
Topics: Anesthesia; Conscious Sedation; Critical Illness; Humans; Hypnotics and Sedatives; Isoflurane; Respi | 2017 |