isoflurane and Coronary Artery Disease

isoflurane has been researched along with Coronary Artery Disease in 9 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.

Research

Studies (9)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Clavien-Dindo Grade IIIb or Higher - Number of Complications

In patients with Clavien-Dindo >/= IIIb complications, number of such complications per patient. (NCT02635347)
Timeframe: Post-op days 0-30

Hospital LOS

Number of days in hospital post-transplant. Starting at post-op day 0 and ending on the calendar date that the patient is leaves the hospital, dies, or post-op day 90, whichever is soonest. (NCT02635347)
Timeframe: Post-op days 0 up to 90 days

Intensive Care Unit (ICU) Length of Stay (LOS)

Number of days in ICU post-transplant. Starting at post-op day 0 and ending on the calendar date that the patient is transferred out of ICU, dies, or post-op day 90, whichever is soonest. (NCT02635347)
Timeframe: Post-op days 0 up to 90 days

Intervention-related Pain Score

Median intervention-related pain score during each of the post-operative interventions, in extubated patients who are able to communicate. Using the Numerical Rating Scale (NRS, Ferrieira-Valente MA PAIN Volume 152, 2011), patients were asked to rate their pain following the intervention on a scale of 0-10 with 0 being no pain experienced to 10 as the maximum pain felt. (NCT02635347)
Timeframe: Post-op days 1-4

Liver Allograft Survival

Percentage of patients with functioning allograft at 90 days post-transplant (NCT02635347)
Timeframe: Post-op day 90

Number of Subjects Not Completing Intervention Protocol

Number of subjects that received fewer than 6 interventions,. (NCT02635347)
Timeframe: Pre-op - Post-op day 4

Patient Survival

Percentage of patients alive at 90 days post-transplant (NCT02635347)
Timeframe: Post-op day 90

Percentage of Participants Completing Entire Intervention Protocol

Proportion of enrolled liver recipients that complete all 6 remote ischemic conditioning (RIC) interventions. (NCT02635347)
Timeframe: Pre-op - Post-op day 4

Percentage of Participants Who Developed Acute Kidney Injury (AKI) Stages 2 or 3

"Percentage of participants who developed Acute Kidney Injury (AKI)~Based on Kidney Disease - Improving Global Outcomes (KDIGO) criteria, AKI criteria are:~Stage 2:~- 2.0-2.9 fold rise in serum creatinine from baseline~Stage 3:~> 3.0 fold rise in serum creatinine from baseline, or~Serum creatinine of > 4.0 mg/dL, with an acute (<48 hours) increase of 0.3 mg/dL in serum creatinine or subacute (< 7 days) increase in serum creatinine of 0.5 mg/dL, or~Initiation of renal replacement therapy." (NCT02635347)
Timeframe: Post-op days 0-7

Percentage of Participants Who Developed Early Allograft Dysfunction (EAD)

"Percentage of participants who developed Early Allograft Dysfunction (EAD) which is defined as:~Aspartate Transaminase (AST) or Alanine Transaminase (ALT)> 2,000 U/L at any point within the first seven post-transplant days, or~Total Bilirubin (TB) > 10 mg/dL on postoperative day 7,or~International Normalized Ratio (INR)> 1.6 on postoperative day 7." (NCT02635347)
Timeframe: Post-op days 0-7

Percentage of Participants Who Developed Prolonged Respiratory Insufficiency (PRI)

"Percentage of Participants who developed Prolonged Respiratory Insufficiency (PRI) defined as:~Ventilator support for >2 postoperative days after transplant, or~Reintubation after extubation, within 7 days of transplant. Patients who require brief re-intubation for an endoscopic, radiologic, or surgical procedure would not be considered to have PRI if they are extubated within 2 days of the end of the procedure." (NCT02635347)
Timeframe: Post-op days 0-7

Presence of Clavien-Dindo Grade IIIb or Higher Complications

"Percentage of patients with Clavien-Dindo >/= grade III b complications (Dindo D, Demartines N, Clavien P, Annals of Surgery 2004).~The Clavien-Dindo Complications grade ranges from Grade I (Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic and radiological interventions Allowed therapeutic regimens are: drugs as antiemetics, antipyretics, analgetics, diuretics and electrolytes and physiotherapy. This grade also includes wound infections opened at the bedside) to Grade V (Death). Grade IIIb would be any intervention requiring general anesthesia." (NCT02635347)
Timeframe: Post-op days 0-30

Time to Dialysis Discontinuation

In patients who are receiving dialysis pre-op, time to discontinuation of dialysis, if occurring within 90 days of transplantation. (NCT02635347)
Timeframe: Post-op days 0-90

Withdrawal of Consent Due to Pain

- Withdrawal of consent due to discomfort/pain in the lower extremity (NCT02635347)
Timeframe: Pre-op - Post-op day 7

Trials

4 trials available for isoflurane and Coronary Artery Disease

Other Studies

5 other studies available for isoflurane and Coronary Artery Disease