Page last updated: 2024-10-29

isoflurane and Consciousness, Loss of

isoflurane has been researched along with Consciousness, Loss of in 34 studies

Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Research Excerpts

ExcerptRelevanceReference
" Time to achieve recumbency, LORR, quiescent electromyograph, isoelectric electrocorticograph, heart rate and apnea were recorded."3.83Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats. ( Chisholm, JM; Pang, DS, 2016)
"Isoflurane is a commonly used anesthetic drug; however, its effects on cortical sensory processing, in particular around LOC, are not well understood."1.72Spatiotemporal patterns of population response in the visual cortex under isoflurane: from wakefulness to loss of consciousness. ( Ben Yehoshua, E; Golomb, NG; Margalit, SN; Raz, A; Slovin, H; Tsur, O, 2022)
"Isoflurane in oxygen was given to provide 0."1.28Isoflurane anesthesia prevents unconscious learning. ( Bennett, HL; Dwyer, R; Eger, EI; Peterson, N, 1992)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (8.82)18.2507
2000's8 (23.53)29.6817
2010's11 (32.35)24.3611
2020's12 (35.29)2.80

Authors

AuthorsStudies
Margalit, SN1
Golomb, NG1
Tsur, O1
Ben Yehoshua, E1
Raz, A1
Slovin, H1
Wang, Z1
Zhang, F1
Yue, L1
Hu, L1
Li, X2
Xu, B1
Liang, Z1
Magnuson, EE1
Lian, M1
Latty, CJ1
Pinzuti, E1
Wollstadt, P3
Tüscher, O1
Wibral, M3
Lin, J1
Cheng, X1
Wang, H1
Du, L1
Zhao, G1
Xie, C1
Paasonen, J1
Laakso, H1
Pirttimäki, T1
Stenroos, P1
Salo, RA1
Zhurakovskaya, E1
Lehto, LJ1
Tanila, H1
Garwood, M1
Michaeli, S1
Idiyatullin, D1
Mangia, S1
Gröhn, O1
Zhang, X2
Baer, AG1
Price, JM1
Jones, PC1
Garcia, BJ1
Romero, J1
Cliff, AM1
Mi, W1
Brown, JB1
Jacobson, DA1
Lydic, R1
Baghdoyan, HA1
Standage, D1
Areshenkoff, CN1
Nashed, JY1
Hutchison, RM2
Hutchison, M2
Heinke, D1
Menon, RS2
Everling, S2
Gallivan, JP1
Reitz, SL1
Wasilczuk, AZ1
Beh, GH1
Proekt, A1
Kelz, MB3
Guo, J1
Ran, M1
Gao, Z1
Wang, D1
Li, H1
Zhao, S1
Sun, W1
Dong, H1
Hu, J1
Mashour, GA2
Palanca, BJ1
Basner, M1
Li, D1
Wang, W1
Blain-Moraes, S1
Lin, N1
Maier, K1
Muench, M1
Tarnal, V1
Vanini, G1
Ochroch, EA1
Hogg, R1
Schwartz, M1
Maybrier, H1
Hardie, R1
Janke, E1
Golmirzaie, G1
Picton, P1
McKinstry-Wu, AR1
Avidan, MS1
Xiong, B1
Karim, F1
Eloy, DJ1
Ye, JH1
Sellers, KK2
Rudelt, L1
Priesemann, V1
Hutt, A2
Fröhlich, F2
Baria, AT1
Centeno, MV1
Ghantous, ME1
Chang, PC1
Procissi, D1
Apkarian, AV1
Finley, J1
Manning, KY1
Chisholm, JM1
Pang, DS1
Ma, Y2
Hamilton, C2
Zhang, N2
Zecharia, AY1
Franks, NP1
Moore, JT1
Chen, J1
Han, B1
Meng, QC1
Veasey, SC1
Beck, SG1
McCallum, JB1
Pillay, S1
Vizuete, JA1
Mouradian, G1
Hudetz, AG2
Stekiel, TA1
White, NS1
Alkire, MT2
Imas, OA1
Ropella, KM1
Wood, JD1
Dierckens, E1
Fleyfel, M1
Robin, E1
Legrand, A1
Borel, M1
Gambier, L1
Vallet, B1
Lebuffe, G1
Baldini, G1
Bagry, H1
Carli, F1
Molaee-Ardekani, B1
Senhadji, L1
Shamsollahi, MB1
Wodey, E1
Vosoughi-Vahdat, B1
Pagel, PS1
Harkin, CP1
Hettrick, DA1
Warltier, DC1
Haier, RJ1
Fallon, JH1
Cariani, P1
van Heerden, PV1
Bukofzer, M1
Edge, KR1
Morrell, DF1
Dwyer, R1
Bennett, HL1
Eger, EI1
Peterson, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Reconstructing Consciousness and Cognition[NCT01911195]60 participants (Actual)Interventional2013-07-31Completed
Monitoring Awareness and Pain Under Anesthesia Using a New EEG Based System[NCT02938325]90 participants (Anticipated)Observational2017-01-01Recruiting
The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty[NCT02576015]380 participants (Anticipated)Interventional2016-03-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for isoflurane and Consciousness, Loss of

ArticleYear
Depth of anesthesia with desflurane does not influence the endocrine-metabolic response to pelvic surgery.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:1

    Topics: Adult; Analgesia, Patient-Controlled; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Glucose

2008
Rapid inhalational induction of anaesthesia with isoflurane or halothane in humidified oxygen.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:3

    Topics: Adult; Anesthesia, Inhalation; Blood Pressure; Double-Blind Method; Female; Halothane; Humans; Humid

1992

Other Studies

32 other studies available for isoflurane and Consciousness, Loss of

ArticleYear
Spatiotemporal patterns of population response in the visual cortex under isoflurane: from wakefulness to loss of consciousness.
    Cerebral cortex (New York, N.Y. : 1991), 2022, 12-08, Volume: 32, Issue:24

    Topics: Anesthetics; Animals; Consciousness; Isoflurane; Mice; Unconsciousness; Visual Cortex; Wakefulness

2022
Cortical complexity and connectivity during isoflurane-induced general anesthesia: a rat study.
    Journal of neural engineering, 2022, 05-12, Volume: 19, Issue:3

    Topics: Anesthesia, General; Animals; Consciousness; Electroencephalography; Isoflurane; Rats; Unconsciousne

2022
Simple Field Anesthesia for Free-Ranging Microtines.
    Journal of wildlife diseases, 2022, 07-01, Volume: 58, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Arvicolinae; Isoflurane; Rodent Diseases; Unconsciousn

2022
Information theoretic evidence for layer- and frequency-specific changes in cortical information processing under anesthesia.
    PLoS computational biology, 2023, Volume: 19, Issue:1

    Topics: Anesthesia; Animals; Brain; Electroencephalography; Ferrets; Isoflurane; Unconsciousness

2023
Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery.
    BMC anesthesiology, 2023, 06-20, Volume: 23, Issue:1

    Topics: Anesthesia, General; Animals; Astrocytes; Basal Forebrain; Consciousness; Isoflurane; Mice; Unconsci

2023
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat.
    NeuroImage, 2020, 02-01, Volume: 206

    Topics: Anesthetics, Inhalation; Animals; Artifacts; Echo-Planar Imaging; Electroencephalography; Fourier An

2020
Neurotransmitter networks in mouse prefrontal cortex are reconfigured by isoflurane anesthesia.
    Journal of neurophysiology, 2020, 06-01, Volume: 123, Issue:6

    Topics: Acetylcholine; Adenosine; Anesthesia; Anesthetics, Inhalation; Animals; Isoflurane; Machine Learning

2020
Dynamic Reconfiguration, Fragmentation, and Integration of Whole-Brain Modular Structure across Depths of Unconsciousness.
    Cerebral cortex (New York, N.Y. : 1991), 2020, 09-03, Volume: 30, Issue:10

    Topics: Animals; Brain; Brain Mapping; Consciousness; Haplorhini; Isoflurane; Magnetic Resonance Imaging; Ne

2020
Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness.
    Current biology : CB, 2021, 01-25, Volume: 31, Issue:2

    Topics: Administration, Inhalation; Anesthesia, Inhalation; Animals; Arousal; Electroencephalography; Female

2021
Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia.
    EBioMedicine, 2021, Volume: 65

    Topics: Anesthetics, Inhalation; Animals; Calcium; Electroencephalography; gamma-Aminobutyric Acid; Glutamic

2021
Recovery of consciousness and cognition after general anesthesia in humans.
    eLife, 2021, 05-10, Volume: 10

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Brain; Cognition; Consciousness; Electroence

2021
Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats.
    Neuroscience letters, 2021, 09-25, Volume: 762

    Topics: Alleles; Anesthetics, Inhalation; Animals; Central Nervous System Depressants; Cerebellum; Ethanol;

2021
Breakdown of local information processing may underlie isoflurane anesthesia effects.
    PLoS computational biology, 2017, Volume: 13, Issue:6

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Consciousness; Female; Ferrets; Isoflurane; Mental Pro

2017
BOLD temporal variability differentiates wakefulness from anesthesia-induced unconsciousness.
    Journal of neurophysiology, 2018, 03-01, Volume: 119, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Brain; Consciousness; Image Processing, Computer-Assisted; Isoflur

2018
Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.
    Medical hypotheses, 2019, Volume: 124

    Topics: AMP-Activated Protein Kinases; Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Brain M

2019
Role of cortical feedback signalling in consciousness and anaesthetic-induced unconsciousness.
    British journal of anaesthesia, 2019, Volume: 123, Issue:4

    Topics: Anesthetics; Animals; Consciousness; Isoflurane; Mice; Neocortex; Unconsciousness

2019
Isoflurane induces dose-dependent alterations in the cortical connectivity profiles and dynamic properties of the brain's functional architecture.
    Human brain mapping, 2014, Volume: 35, Issue:12

    Topics: Anesthetics, Inhalation; Animals; Brain; Brain Mapping; Dose-Response Relationship, Drug; Female; Is

2014
Anesthesia-related changes in information transfer may be caused by reduction in local information generation.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2015, Volume: 2015

    Topics: Anesthesia; Animals; Brain; Entropy; Ferrets; Isoflurane; Prefrontal Cortex; Unconsciousness; Visual

2015
Assessment of Carbon Dioxide, Carbon Dioxide/Oxygen, Isoflurane and Pentobarbital Killing Methods in Adult Female Sprague-Dawley Rats.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adjuvants, Anesthesia; Animals; Apnea; Bradycardia; Carbon Dioxide; Electrocardiography; Electrocort

2016
Dynamic Connectivity Patterns in Conscious and Unconscious Brain.
    Brain connectivity, 2017, Volume: 7, Issue:1

    Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Brain; Brain Mapping; Consciousness; Dose-Re

2017
Global reduction of information exchange during anesthetic-induced unconsciousness.
    Brain structure & function, 2017, Volume: 222, Issue:7

    Topics: Anesthetics, Inhalation; Animals; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationshi

2017
General anesthesia and ascending arousal pathways.
    Anesthesiology, 2009, Volume: 111, Issue:4

    Topics: Afferent Pathways; Anesthesia, General; Anesthetics, Inhalation; Animals; Arousal; Basal Nucleus of

2009
Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis.
    Current biology : CB, 2012, Nov-06, Volume: 22, Issue:21

    Topics: Anesthetics; Animals; Halothane; Hypnosis, Anesthetic; Hypnotics and Sedatives; Isoflurane; Mice; Ne

2012
Strain differences in cortical electroencephalogram associated with isoflurane-induced loss of consciousness.
    Anesthesiology, 2013, Volume: 118, Issue:2

    Topics: Algorithms; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal; Dose-Respons

2013
Impaired thalamocortical connectivity in humans during general-anesthetic-induced unconsciousness.
    NeuroImage, 2003, Volume: 19, Issue:2 Pt 1

    Topics: Anesthesia, General; Blood Glucose; Brain Mapping; Cerebral Cortex; Computer Simulation; Dominance,

2003
Isoflurane disrupts anterio-posterior phase synchronization of flash-induced field potentials in the rat.
    Neuroscience letters, 2006, Jul-24, Volume: 402, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Cortical Synchronization; Evoked Potentials; Isoflurane; Male; Mot

2006
[Is entropy a monitor for the guidance of intraoperative analgesia?].
    Annales francaises d'anesthesie et de reanimation, 2007, Volume: 26, Issue:2

    Topics: Adult; Analgesia; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics,

2007
Delta waves differently modulate high frequency components of EEG oscillations in various unconsciousness levels.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2007, Volume: 2007

    Topics: Biological Clocks; Brain; Child; Conscious Sedation; Delta Rhythm; Desflurane; Humans; Hypnotics and

2007
Levosimendan (OR-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs.
    Anesthesiology, 1994, Volume: 81, Issue:4

    Topics: Anesthetics; Animals; Autonomic Nervous System; Blood Pressure; Cardiac Output; Cardiotonic Agents;

1994
Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness.
    Consciousness and cognition, 2000, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Anesthesia, General; Anesthetics, Inhalation; Cerebral Cortex; Energy Metabolism;

2000
Anesthesia, neural information processing, and conscious awareness.
    Consciousness and cognition, 2000, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Anesthesia, General; Anesthetics, Inhalation; Awareness; Brain Mapping; Cerebral

2000
Isoflurane anesthesia prevents unconscious learning.
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Adult; Anesthesia, General; Female; Humans; Isoflurane; Learning; Male; Middle Aged; Nitrous Oxide;

1992